| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| LaTonya J Hickson, Alfonso Eirin, Sabena M Conley, Timucin Taner, Xiaohui Bian, Ahmed Saad, Sandra M Herrmann, Ramila A Mehta, Travis J McKenzie, Todd A Kellogg, James L Kirkland, Tamar Tchkonia, Ishran M Saadiq, Hui Tang, Kyra L Jordan, Xiangyang Zhu, Mathew D Griffin, Andrew D Rule, Andre J van Wijnen, Stephen C Textor, Lilach O Lerma. Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair. Diabetes. vol 70. issue 7. 2021-09-17. PMID:33858824. |
adipose-derived msc from 38 participants with dkd and 16 control subjects were assessed for cell surface markers, trilineage differentiation, rna sequencing (rna-seq), in vitro function (coculture or conditioned medium experiments with t cells and human kidney cells [hk-2]), secretome profile, and cellular senescence abundance. |
2021-09-17 |
2023-08-13 |
human |
| Elsa González-Cubero, María Luisa González-Fernández, Laura Gutiérrez-Velasco, Eliezer Navarro-Ramírez, Vega Villar-Suáre. Isolation and characterization of exosomes from adipose tissue-derived mesenchymal stem cells. Journal of anatomy. vol 238. issue 5. 2021-09-10. PMID:33372709. |
the purposes of this study are: (i) to detect exosomes released into adipose-derived msc conditioned cell culture medium, (ii) to identify exosome morphology, and (iii) to carry out a complete characterization of said exosomes. |
2021-09-10 |
2023-08-13 |
human |
| Gareth R Willis, Angeles Fernandez-Gonzalez, Monica Reis, Vincent Yeung, Xianlan Liu, Maria Ericsson, Nick A Andrews, S Alex Mitsialis, Stella Kourembana. Mesenchymal stromal cell-derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia-induced lung injury. Journal of extracellular vesicles. vol 9. issue 1. 2021-09-09. PMID:32939235. |
in this study, mex were isolated from media conditioned by human wharton's jelly-derived msc cultures. |
2021-09-09 |
2023-08-13 |
mouse |
| Vitale Miceli, Matteo Bulati, Gioacchin Iannolo, Giovanni Zito, Alessia Gallo, Pier Giulio Conald. Therapeutic Properties of Mesenchymal Stromal/Stem Cells: The Need of Cell Priming for Cell-Free Therapies in Regenerative Medicine. International journal of molecular sciences. vol 22. issue 2. 2021-09-09. PMID:33466583. |
hence, msc paracrine action is currently being explored in several clinical settings either using a conditioned medium (cm) or msc-derived exosomes (exos), where these products modulate tissue responses in different types of injuries. |
2021-09-09 |
2023-08-13 |
Not clear |
| Michael B Berger, Kyla B Bosh, Thomas W Jacobs, D Joshua Cohen, Zvi Schwartz, Barbara D Boya. Growth factors produced by bone marrow stromal cells on nanoroughened titanium-aluminum-vanadium surfaces program distal MSCs into osteoblasts via BMP2 signaling. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 39. issue 9. 2021-09-03. PMID:33002223. |
first, unidirectional signaling was assessed by treating human mscs grown on tcps with conditioned media from msc cultures grown on ti6al4v biomimetic surfaces. |
2021-09-03 |
2023-08-13 |
human |
| Daphne Pinheiro, Isabelle Dias, Thiago Freire, Alessandra Alves Thole, Ana Carolina Stumbo, Erika Afonso Costa Cortez, Lais de Carvalho, Simone Nunes de Carvalh. Effects of mesenchymal stem cells conditioned medium treatment in mice with cholestatic liver fibrosis. Life sciences. vol 281. 2021-08-10. PMID:34186042. |
the purpose of this work was to study the effects of mesenchymal stem cells conditioned medium (msc cm) treatment in animals with cholestatic liver fibrosis. |
2021-08-10 |
2023-08-13 |
mouse |
| Agnese Gugliandolo, Luigia Fonticoli, Oriana Trubiani, Thangavelu S Rajan, Guya D Marconi, Placido Bramanti, Emanuela Mazzon, Jacopo Pizzicannella, Francesca Diomed. Oral Bone Tissue Regeneration: Mesenchymal Stem Cells, Secretome, and Biomaterials. International journal of molecular sciences. vol 22. issue 10. 2021-07-01. PMID:34063438. |
however, we discussed also a future perspective in tissue engineering using the msc secretome, namely the conditioned medium and extracellular vesicles. |
2021-07-01 |
2023-08-13 |
Not clear |
| Vitaliy Brunchukov, Tatiana Astrelina, Daria Usupzhanova, Anna Rastorgueva, Irina Kobzeva, Victoria Nikitina, Sergei Lishchuk, Elena Dubova, Konstantin Pavlov, Valentin Brumberg, Marc Benderitter, Alexander Samoylo. Evaluation of the Effectiveness of Mesenchymal Stem Cells of the Placenta and Their Conditioned Medium in Local Radiation Injuries. Cells. vol 9. issue 12. 2021-06-23. PMID:33260310. |
the search for an effective therapy for local radiation injuries (lri) is urgent; one option is mesenchymal stem cells (msc) derived from the placenta and their conditioned medium for the regenerative processes of the skin. |
2021-06-23 |
2023-08-13 |
Not clear |
| Tyler T Cooper, Stephen E Sherman, Gillian I Bell, Thamara Dayarathna, Danielle M McRae, Jun Ma, François Lagugné-Labarthet, Stephen H Pasternak, Gilles A Lajoie, David A Hes. Ultrafiltration and Injection of Islet Regenerative Stimuli Secreted by Pancreatic Mesenchymal Stromal Cells. Stem cells and development. vol 30. issue 5. 2021-06-21. PMID:33403929. |
we have demonstrated that the intrapancreatic injection of concentrated conditioned media (cm) produced by bone marrow msc supports islet regeneration and restored glycemic control in hyperglycemic mice, ultimately providing a platform to elucidate components of the msc secretome. |
2021-06-21 |
2023-08-13 |
mouse |
| Vanessa Kohl, Oliver Drews, Victor Costina, Miriam Bierbaum, Ahmed Jawhar, Henning Roehl, Christel Weiss, Susanne Brendel, Helga Kleiner, Johanna Flach, Birgit Spiess, Wolfgang Seifarth, Daniel Nowak, Wolf-Karsten Hofmann, Alice Fabarius, Henning D Pop. Proteins Marking the Sequence of Genotoxic Signaling from Irradiated Mesenchymal Stromal Cells to CD34+ Cells. International journal of molecular sciences. vol 22. issue 11. 2021-06-18. PMID:34072546. |
here, protein mediators (i) in irradiated human mesenchymal stromal cells (msc) as the nte source, (ii) in msc conditioned supernatant and (iii) in human bone marrow cd34+ cells undergoing genotoxic nte were investigated. |
2021-06-18 |
2023-08-13 |
human |
| Vanessa Kohl, Oliver Drews, Victor Costina, Miriam Bierbaum, Ahmed Jawhar, Henning Roehl, Christel Weiss, Susanne Brendel, Helga Kleiner, Johanna Flach, Birgit Spiess, Wolfgang Seifarth, Daniel Nowak, Wolf-Karsten Hofmann, Alice Fabarius, Henning D Pop. Proteins Marking the Sequence of Genotoxic Signaling from Irradiated Mesenchymal Stromal Cells to CD34+ Cells. International journal of molecular sciences. vol 22. issue 11. 2021-06-18. PMID:34072546. |
in the corresponding msc conditioned medium, the three chaperones grp78, calr, and pdia3 were increased. |
2021-06-18 |
2023-08-13 |
human |
| Vanessa Kohl, Oliver Drews, Victor Costina, Miriam Bierbaum, Ahmed Jawhar, Henning Roehl, Christel Weiss, Susanne Brendel, Helga Kleiner, Johanna Flach, Birgit Spiess, Wolfgang Seifarth, Daniel Nowak, Wolf-Karsten Hofmann, Alice Fabarius, Henning D Pop. Proteins Marking the Sequence of Genotoxic Signaling from Irradiated Mesenchymal Stromal Cells to CD34+ Cells. International journal of molecular sciences. vol 22. issue 11. 2021-06-18. PMID:34072546. |
healthy cd34+ cells cultured in msc conditioned medium suffered from more than a six-fold increase in γh2ax focal staining, indicative for dna double-strand breaks, as well as numerical and structural chromosomal aberrations within three days. |
2021-06-18 |
2023-08-13 |
human |
| Ibtesam R T Al Delfi, Chelsea R Wood, Louis D V Johnson, Martyn D Snow, John F Innes, Peter Myint, William E B Johnso. An In Vitro Comparison of the Neurotrophic and Angiogenic Activity of Human and Canine Adipose-Derived Mesenchymal Stem Cells (MSCs): Translating MSC-Based Therapies for Spinal Cord Injury. Biomolecules. vol 10. issue 9. 2021-06-15. PMID:32916959. |
conditioned medium (cm) from msc cultures was then assessed for its neurotrophic and angiogenic activity using established cell-based assays. |
2021-06-15 |
2023-08-13 |
human |
| Adriana Torres Crigna, Stefanie Uhlig, Susanne Elvers-Hornung, Harald Klüter, Karen Biebac. Human Adipose Tissue-Derived Stromal Cells Suppress Human, but Not Murine Lymphocyte Proliferation, via Indoleamine 2,3-Dioxygenase Activity. Cells. vol 9. issue 11. 2021-06-15. PMID:33167329. |
in this study, we first assessed the immunomodulatory strength of different human msc sources on in vitro stimulated t cells and compared this to interferon-gamma (ifnγ) primed msc conditioned medium (cm) and ev. |
2021-06-15 |
2023-08-13 |
human |
| Fereshteh Ghasemi, Majid Khoshmirsafa, Elahe Safari, Marzieh Asgari, Mehdi Alemrajabi, Shahrzad Nojehdehi, Samane Khorram. Vitamin E and selenium improve mesenchymal stem cell conditioned media immunomodulatory effects. Stem cell investigation. vol 8. 2021-06-15. PMID:34124232. |
this study aims to investigate the effects of msc conditioned media (cm) treated with vit e and se on immune cells. |
2021-06-15 |
2023-08-13 |
Not clear |
| Claudia C Dos Santos, Hajera Amatullah, Chirag M Vaswani, Tatiana Maron-Gutierrez, Michael Kim, Shirley H J Mei, Katalin Szaszi, Ana Paula T Monteiro, Amir K Varkouhi, Raquel Herreroz, Jose Angel Lorente, James N Tsoporis, Sahil Gupta, Amin Ektesabi, Nikolaos Kavantzas, Vasileios Salpeas, John C Marshall, Patricia R M Rocco, Philip A Marsden, Daniel J Weiss, Duncan J Stewart, Pingzhao Hu, W Conrad Lile. Mesenchymal Stromal (stem) Cell (MSC) therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury. The European respiratory journal. 2021-06-11. PMID:34112731. |
msc conditioned media mitigated tnf-induced mir-193b-5p upregulation and ocln downregulation |
2021-06-11 |
2023-08-13 |
mouse |
| Eti Zigman-Hoffman, Benjamin Sredni, Benjamin Meilik, Ella Naparstek, Boris Tartakovsk. Tellurium compound provides pro-apoptotic signaling in drug resistant multiple myeloma. Leukemia & lymphoma. vol 62. issue 5. 2021-05-19. PMID:33334225. |
mass spectrometry analysis of msc's conditioned media revealed that fibronectin, was particularly instrumental in providing anti-apoptotic signals to mm cells. |
2021-05-19 |
2023-08-13 |
Not clear |
| Anne Wuhrer, Stefanie Uhlig, Benjamin Tuschy, Sebastian Berlit, Elena Sperk, Karen Bieback, Marc Sütterli. Wound Fluid from Breast Cancer Patients Undergoing Intraoperative Radiotherapy Exhibits an Altered Cytokine Profile and Impairs Mesenchymal Stromal Cell Function. Cancers. vol 13. issue 9. 2021-05-18. PMID:33946741. |
furthermore, the cytokine profile within conditioned media from wf-treated msc cultures was assessed. |
2021-05-18 |
2023-08-13 |
Not clear |
| Roberta Squecco, Alessia Tani, Flaminia Chellini, Rachele Garella, Eglantina Idrizaj, Irene Rosa, Sandra Zecchi-Orlandini, Mirko Manetti, Chiara Sassol. Bone Marrow-Mesenchymal Stromal Cell Secretome as Conditioned Medium Relieves Experimental Skeletal Muscle Damage Induced by Ex Vivo Eccentric Contraction. International journal of molecular sciences. vol 22. issue 7. 2021-05-10. PMID:33807453. |
hence, we examined the effects of msc secretome as conditioned medium (msc-cm) on ex vivo murine extensor digitorum longus muscle injured by forced eccentric contraction (ec). |
2021-05-10 |
2023-08-13 |
Not clear |
| Ahmad Shabanizadeh, Mohammad Reza Rahmani, Aliakbar Yousefi-Ahmadipour, Fatemeh Asadi, Mohammad Kazemi Arababad. Mesenchymal Stem Cells: The Potential Therapeutic Cell Therapy to Reduce Brain Stroke Side Effects. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 30. issue 5. 2021-04-28. PMID:33631477. |
the mice model of middle cerebral artery occlusion (mcao) was established and put to six groups, including intact (healthy mice without stroke), control (untreated stroke), treated with mouse msc (mmsc), sup (conditioned medium), rj and combination of mmsc and rj (mmsc/rj). |
2021-04-28 |
2023-08-13 |
mouse |