| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sona Zare, Alireza Jafarzadeh, Solmaz Zare, Amir Shamlo. Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review. Stem cell research & therapy. vol 16. issue 1. 2025-04-12. PMID:40221781. |
mesenchymal stem cell (msc)-derived conditioned media is emerging as a promising alternative to stem cell therapy, owing to its abundant content of growth factors and cytokines. |
2025-04-12 |
2025-04-15 |
human |
| Xiaoying Pan, Xiaowen Xing, Zhengguo Ji, Jianzhong Zhang, Qiaomi Chen, Weifan Yin, Yueyue Zang, Yong Yang, Zhiqiang Liu, Yongde X. Dual-responsive stem cell microspheres modified with BDNF for enhanced neural repair in diabetic erectile dysfunction. Journal of controlled release : official journal of the Controlled Release Society. vol 379. 2025-01-17. PMID:39761859. |
using the pelvic ganglion as an in vitro model, conditioned medium derived from stimuli-responsive msc microspheres (srms) significantly promoted the growth of axons and alleviated the death of neural and smooth muscle cells. |
2025-01-17 |
2025-01-20 |
rat |
| Catarina S Silva, Marta R Casanova, Pedro Ferreirinha, Alain da Silva Morais, Hugo Osório, Ana C Lima, Joana F Fangueiro, Mariana T Cerqueira, Rui L Reis, Nuno L Alves, Albino Martins, Nuno M Neve. The effect of conditioned medium from human amniotic membrane-derived mesenchymal stem cells on thymus involution. Life sciences. vol 362. 2025-01-09. PMID:39761741. |
this work aims at studying the effect of human amniotic membrane-derived msc conditioned media (hammsc cm) on aged thymus. |
2025-01-09 |
2025-01-13 |
human |
| Natsuki Yamaguchi, Eri Horio, Jukito Sonoda, Miu Yamagishi, Satomi Miyakawa, Fumihiro Murakami, Hideaki Hasegawa, Yasuhiro Katahira, Izuru Mizoguchi, Yasuyuki Fujii, Daichi Chikazu, Takayuki Yoshimot. Immortalization of Mesenchymal Stem Cells for Application in Regenerative Medicine and Their Potential Risks of Tumorigenesis. International journal of molecular sciences. vol 25. issue 24. 2025-01-08. PMID:39769322. |
this has led to increasing interest in cell-free therapy, where only the conditioned medium (also called secretome) from msc cultures is used for regenerative applications. |
2025-01-08 |
2025-01-13 |
Not clear |
| Chuhan Zhang, Peiyi Lv, Qiuying Liang, Jian Zhou, Buling Wu, Wenan X. Conditioned Medium Derived From Human Dental Follicle Mesenchymal Stem Cells Alleviates Macrophage Proinflammatory Responses Through MAPK-ERK-EGR1 Axis. Stem cells international. vol 2024. 2024-12-09. PMID:39650749. |
our findings demonstrated successful msc extraction from dental follicles, with the conditioned medium suppressing proinflammatory macrophage functions and influencing macrophage subtyping. |
2024-12-09 |
2024-12-12 |
human |
| Priscilla Berni, Valentina Andreoli, Virna Conti, Roberto Ramoni, Giuseppina Basini, Gabriele Scattini, Luisa Pascucci, Martina Pellegrini, Maurizio Del Bue, Gian Paolo Squassino, Francesca Paino, Augusto Pessina, Giulio Alessandri, Paolo Pirazzoli, Antonio Bosetto, Stefano Groll. Evaluation of a Novel Mechanical Device for the Production of Microfragmented Adipose Tissue for Veterinary Regenerative Medicine: A Proof-of-Concept. International journal of molecular sciences. vol 25. issue 21. 2024-11-09. PMID:39519405. |
conditioned medium derived from microfat culture was evaluated for its ability to promote msc vitality. |
2024-11-09 |
2024-11-17 |
Not clear |
| Mai M Assi, Mohammed E Grawish, Heba Mahmoud Elsabaa, Mohamad E Helal, Samah K Ezza. Therapeutic potential of hyaluronic acid hydrogel combined with bone marrow stem cells-conditioned medium on arthritic rats' TMJs. Scientific reports. vol 14. issue 1. 2024-11-05. PMID:39500985. |
conditioned media (cm) is derived from mesenchymal stem cells (msc) culture and contains biologically active components. |
2024-11-05 |
2024-11-08 |
rat |
| Myeongjin Song, Kyung Min Lim, Kwonwoo Song, Geun-Ho Kang, Se Jong Kim, Youngseo Lee, Sujin Yu, Ki-Heon Jeong, Ssang-Goo Ch. Efficient Treatment of Psoriasis Using Conditioned Media from Mesenchymal Stem Cell Spheroids Cultured to Produce Transforming Growth Factor- International journal of stem cells. 2024-10-13. PMID:39396918. |
therefore, this study aimed to develop a safe and easy-to-use emulsion cream for treating psoriasis using msc conditioned media (cm) containing evs. |
2024-10-13 |
2024-10-16 |
mouse |
| Megan J Fahey, Rebecca M Harman, Matthew A Thomas, Brenna R Pugliese, Jeanine Peters-Kennedy, Michelle L Delco, Gerlinde R Van de Wall. Preliminary in vivo investigation of the mesenchymal stromal cell secretome as a novel treatment for methicillin-resistant Staphylococcus aureus in equine skin wounds. Veterinary surgery : VS. 2024-10-05. PMID:39367671. |
secretome), collected as conditioned media (mesenchymal stromal cell-conditioned media, msc cm), in a novel in vivo model of methicillin-resistant staphylococcus aureus (mrsa)-inoculated equine thorax wounds. |
2024-10-05 |
2024-10-07 |
Not clear |
| Marianela Brizio, Mathieu Mancini, Maximilien Lora, Sydney Joy, Shirley Zhu, Benoit Brilland, Dieter P Reinhardt, Dominique Farge, David Langlais, Inés Colmegn. Cytokine priming enhances the antifibrotic effects of human adipose derived mesenchymal stromal cells conditioned medium. Stem cell research & therapy. vol 15. issue 1. 2024-09-28. PMID:39334258. |
multipotent mesenchymal stromal cells (msc) have antifibrotic properties mediated by secreted factors present in their conditioned medium (msc-cm). |
2024-09-28 |
2024-10-01 |
human |
| Richard Burt, Aditi Dey, Ayse Akarca, Hermione Allen, Rodothea Amerikanou, Samantha Atkinson, David Auty, Jenny Chatzigerou, Emily Annie Cutler, Jose Afonso Guerra-Assuncao, Kristina Kirschner, Ruchi Kumari, Jiten Manji, Teresa Marafioti, Juma Ward, Adele K Fieldin. Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer associated fibroblasts. Blood advances. 2024-09-03. PMID:39226456. |
in the present study, we show that exposure of msc to all cell lines, patient-derived xenografts and primary cells or their conditioned media can also trigger caf formation. |
2024-09-03 |
2024-09-06 |
Not clear |
| Richard Burt, Aditi Dey, Ayse Akarca, Hermione Allen, Rodothea Amerikanou, Samantha Atkinson, David Auty, Jenny Chatzigerou, Emily Annie Cutler, Jose Afonso Guerra-Assuncao, Kristina Kirschner, Ruchi Kumari, Jiten Manji, Teresa Marafioti, Juma Ward, Adele K Fieldin. Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer associated fibroblasts. Blood advances. 2024-09-03. PMID:39226456. |
we show that inhibition of dsrna formation in all cells by treatment with low-dose ethidium or the mitochondrial transcription inhibitor imt1 or degradation of dsrna in conditioned media by 100°c exposure ablates the ability of the all conditioned media to stimulate msc to caf transition. |
2024-09-03 |
2024-09-06 |
Not clear |
| Courteney Tunstead, Evelina Volkova, Hazel Dunbar, Ian J Hawthorne, Alison Bell, Louise Crowe, Joanne C Masterson, Claudia C Dos Santos, Bairbre McNicholas, John G Laffey, Karen Englis. The ARDS microenvironment enhances MSC-induced repair via VEGF in experimental acute lung inflammation. Molecular therapy : the journal of the American Society of Gene Therapy. 2024-08-07. PMID:39108095. |
our findings show that hyper-inflammatory ards pre-licensed msc conditioned medium (msc-cm |
2024-08-07 |
2024-08-09 |
Not clear |
| Zeinab Jaleh, Behnaz Rahimi, Aidin Shahrezaei, Maryam Sohani, Jacqueline Sagen, Farinaz Nasirinezha. Exploring the Therapeutic Potential of Mesenchymal Stem Cells-derived conditioned medium: An In-depth Analysis of Pain Alleviation, Spinal CCL2 Levels, and Oxidative Stress. Cell biochemistry and biophysics. 2024-07-20. PMID:39031248. |
this study aimed to evaluate the potential of mesenchymal stromal cell (msc)-derived conditioned medium in alleviating neuropathic pain induced by sciatic nerve compression injury in adult male rats. |
2024-07-20 |
2024-07-24 |
rat |
| Monika A Rosochowicz, Michał S Lach, Magdalena Richter, Inga Jagiełło, Wiktoria M Suchorska, Tomasz Trzecia. The iPSC secretome is beneficial for in vitro propagation of primary osteoarthritic chondrocytes cell lines. Biochemical and biophysical research communications. vol 730. 2024-07-14. PMID:39003867. |
the conditioned medium (cm) from different subpopulations of stem cells (mesenchymal stromal cells (msc) or induced pluripotent stem cells (ipsc)) could be a gamechanger. |
2024-07-14 |
2024-07-18 |
Not clear |
| Chiara Del Prete, Chiara Montano, Natascia Cocchia, Mariaelena de Chiara, Bianca Gasparrini, Maria Pia Pasolin. Use of regenerative medicine in the treatment of endometritis in mares: A systematic review and meta-analysis. Theriogenology. vol 227. 2024-07-11. PMID:38991434. |
all studies exploring the use of regenerative medicine therapies (i.e., plasma products, autologous conditioned serum, mesenchymal stem cells mscs, and msc derivatives) in the treatment of pbie/cde were included, regardless of the specific protocol used, the evaluated outcomes, or the diagnostic method employed. |
2024-07-11 |
2024-07-14 |
Not clear |
| Aarthi Rajesh, Esther Da Eun Ju, Kelly A Oxford, Rebecca M Harman, Gerlinde R Van de Wall. The mesenchymal stromal cell secretome promotes tissue regeneration and increases macrophage infiltration in acute and methicillin-resistant Staphylococcus aureus-infected skin wounds in vivo. Cytotherapy. 2024-06-30. PMID:38944795. |
the msc secretome, collected as conditioned medium (cm), was evaluated in vivo using mouse models of acute and mrsa-infected skin wounds. |
2024-06-30 |
2024-07-02 |
mouse |
| Elaheh Shahi, Arezou Khosrojerdi, Sara Soudi, Ahmad Zavaran Hossein. Mesenchymal stem cell-conditioned medium prevents inflammation-induced liver and lung damage in septic mice. International immunopharmacology. vol 137. 2024-06-14. PMID:38875996. |
the limitations of msc therapy have led to increased attention to cell derivatives such as conditioned medium (cm). |
2024-06-14 |
2024-06-17 |
mouse |
| Shin Enosawa, Sho Kobayashi, Eiji Kobayash. Proposal of Simplified Standardization of the Cell-Growth-Promoting Activity of Human Adipose Tissue Mesenchymal Stromal Cell Culture Supernatants. International journal of molecular sciences. vol 25. issue 10. 2024-05-25. PMID:38791236. |
the conditioned medium (cm) obtained from mesenchymal stromal cell (msc) culture has excellent cell growth-promoting activity and is used for cosmetics and healthcare products. |
2024-05-25 |
2024-05-27 |
human |
| Sreya Mitra, Vasudeva Tati, Sayan Basu, Sachin Shukl. Role of Mesenchymal Stem Cell-Derived Conditioned Medium in Modulating the Benzalkonium Chloride-Induced Cytotoxic Effects in Cultured Corneal Epithelial Cells Current eye research. 2024-04-22. PMID:38646923. |
this study aims to explore the role of mesenchymal stem cell (msc)-derived conditioned medium in modulating the bak-induced cytotoxic effects in cultured human corneal epithelial cells (hcecs) as a cell-free therapeutic agent. |
2024-04-22 |
2024-04-24 |
human |