| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Kulebyakina, Nataliya Basalova, Daria Butuzova, Mikhail Arbatsky, Vadim Chechekhin, Natalia Kalinina, Pyotr Tyurin-Kuzmin, Konstantin Kulebyakin, Oleg Klychnikov, Anastasia Efimenk. Balance between Pro- and Antifibrotic Proteins in Mesenchymal Stromal Cell Secretome Fractions Revealed by Proteome and Cell Subpopulation Analysis. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203461. |
we previously demonstrated that the separation of msc secretome, represented by conditioned medium (cm), into subfractions enriched with extracellular vesicles (ev) or soluble factors (sf) boosts ev and sf antifibrotic effect. |
2024-01-11 |
2024-01-13 |
human |
| Neha Saxena, Soura Chakraborty, Sarbajeet Dutta, Garvit Bhardwaj, Nupur Karnik, Omshree Shetty, Sameer Jadhav, Hamim Zafar, Shamik Se. Stiffness-dependent MSC homing and their differentiation to CAFs: Implications in breast cancer invasion. Journal of cell science. 2023-12-18. PMID:38108421. |
using 0.5, 2 and 5 kpa hydrogels mimicking different stages of ecm stiffening, we show that on pre-metastatic stroma mimetic 2 kpa gels, conditioned media secreted by mda-mb-231 tnbc cells drives efficient msc chemotaxis and induces stable caf differentiation in a tgfβ/contractility-dependent manner. |
2023-12-18 |
2023-12-21 |
Not clear |
| Uliana Dyachkova, Maksim Vigovskiy, Nataliya Basalova, Anastasia Efimenko, Olga Grigoriev. M2-Macrophage-Induced Chronic Inflammation Promotes Reversible Mesenchymal Stromal Cell Senescence and Reduces Their Anti-Fibrotic Properties. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069411. |
to confirm this hypothesis, we evaluated the m2-macrophage conditioned medium (cm-m2) effect on human adipose-tissue-derived msc senescence in vitro. |
2023-12-09 |
2023-12-17 |
human |
| Siddharth Shanbhag, Niyaz Al-Sharabi, Carina Kampleitner, Samih Mohamed-Ahmed, Einar K Kristoffersen, Stefan Tangl, Kamal Mustafa, Reinhard Gruber, Mariano San. The use of mesenchymal stromal cell secretome to enhance guided bone regeneration in comparison with leukocyte and platelet-rich fibrin. Clinical oral implants research. 2023-11-15. PMID:37964421. |
the objective of this study was to compare the efficacy of adjunctive use of conditioned media of bone-marrow msc (msc-cm) with collagen barrier membranes vs. adjunctive use of conditioned media of leukocyte- and platelet-rich fibrin (prf-cm), a current growth-factor therapy, for guided bone regeneration (gbr). |
2023-11-15 |
2023-11-20 |
Not clear |
| Anastasia Dessy Harsono, Ismail Hadisoebroto Dilogo, Theddeus Octavianus Hari Prasetyono, Marcel Prasetyo, Retno Asti Werdhani, Sri Widia A Jusman, Nuryati Chairani Siregar, Hardisiswo Soedjan. Clinical evaluation of intralesional umbilical cord-derived mesenchymal stem cells, conditioned medium and triamcinolone acetonide injection for keloid treatment: A pilot study. International wound journal. 2023-10-27. PMID:37885365. |
this study aims to evaluate feasibility of intralesional injection of umbilical cord msc (uc-msc) and conditioned medium (uc-cm) compared to ta for keloid therapy. |
2023-10-27 |
2023-11-08 |
Not clear |
| b' V Smolinsk\\xc3\\xa1, M Boh\\xc3\\xa1\\xc4\\x8d, \\xc4\\xbd Dani\\xc5\\xa1ovi\\xc4\\x8. Current status of the applications of conditioned media derived from mesenchymal stem cells for regenerative medicine. Physiological research. vol 72. issue S3. 2023-10-27. PMID:37888967.' |
defining the secretome of cultured cultivated msc populations by conditioned media analysis will allow us to assess its potential as a novel treatment approach. |
2023-10-27 |
2023-11-08 |
Not clear |
| Santina Acuto, Melania Lo Iacono, Elena Baiamonte, Rosa Lo Re, Aurelio Maggio, Vincenzo Cavalier. An optimized procedure for preparation of conditioned medium from Wharton's jelly mesenchymal stromal cells isolated from umbilical cord. Frontiers in molecular biosciences. vol 10. 2023-10-20. PMID:37854039. |
importantly, under these conditions, the compositional profile and biological effects elicited by the conditioned medium preparations derived from these msc populations do not depend on donor individuality. |
2023-10-20 |
2023-11-08 |
human |
| Julie Ng, Anna E Marneth, Alec Griffith, Daniel Younger, Sailaja Ghanta, Alan Jiao, Gareth Willis, Junwen Han, Jewel Imani, Bailin Niu, Joshua W Keegan, Brandon Hancock, Fei Guo, Yang Shi, Mark A Perrella, James A Ledere. Mesenchymal Stromal Cells Facilitate Neutrophil Trained Immunity by Reprogramming Hematopoietic Stem Cells. Journal of innate immunity. 2023-10-05. PMID:37797588. |
by cut&run chromatin sequencing and cytometry by time of flight (cytof) approaches, we identified that msc conditioned media leaves h3k4me3 histone marks in hscs at genes involved in myelopoiesis and in signaling persistence by the mtor pathway. |
2023-10-05 |
2023-10-07 |
mouse |
| Wesley Harrisson Bouche Djatche, Huimin Zhu, Wenlei Ma, Yue Li, Ziang Li, Hong Zhao, Zhizhen Liu, Hua Qia. Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases. Regenerative medicine. 2023-09-13. PMID:37702008. |
msc secretome, especially in the form of conditioned medium (msc-cm) is now being explored as an alternative to mscs transplantation. |
2023-09-13 |
2023-10-07 |
Not clear |
| Qingji Huo, Kexin Li, Xun Sun, Adam Zhuang, Kazumasa Minami, Keisuke Tamari, Kazuhiko Ogawa, Melissa L Fishel, Bai-Yan Li, Hiroki Yokot. The inhibition of pancreatic cancer progression by K-Ras-overexpressing mesenchymal stem cell-derived secretomes. Scientific reports. vol 13. issue 1. 2023-09-12. PMID:37699930. |
to explore an uncharted function of k-ras proto-oncogene, k-ras was activated in mesenchymal stem cells (mscs) and the effects of msc conditioned medium (cm) on pdac were examined. |
2023-09-12 |
2023-10-07 |
mouse |
| A J Turlo, D E Hammond, K A Ramsbottom, J Soul, A Gillen, K McDonald, M J Peffer. Mesenchymal Stromal Cell secretome is affected by tissue source and donor age. Stem cells (Dayton, Ohio). 2023-08-17. PMID:37591507. |
we used dynamic metabolic labelling with stable isotopes combined with liquid chromatography-tandem mass spectrometry (lc-ms/ms) to identify secreted proteins in msc conditioned media (cm). |
2023-08-17 |
2023-09-07 |
Not clear |
| Shutaro Habata, Ramanaiah Mamillapalli, Abdullah Ucar, Hugh S Taylo. Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice. Stem cells international. vol 2023. 2023-08-07. PMID:37545483. |
control or msc conditioned bm was injected retro-orbitally. |
2023-08-07 |
2023-08-14 |
mouse |
| Shutaro Habata, Ramanaiah Mamillapalli, Abdullah Ucar, Hugh S Taylo. Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice. Stem cells international. vol 2023. 2023-08-07. PMID:37545483. |
immunohistochemistry and immunofluorescence showed that msc conditioned bm reduced the infiltration of macrophages and neutrophils into endometriotic lesions by twofold and decreased the proportion of m1 compared to m2 macrophages, reducing inflammation and likely promoting tissue repair. |
2023-08-07 |
2023-08-14 |
mouse |
| Aeolus Vilar, Margeaux Hodgson-Garms, Gina D Kusuma, Ilze Donderwinkel, James Carthew, Jean L Tan, Rebecca Lim, Jessica E Frit. Substrate mechanical properties bias MSC paracrine activity and therapeutic potential. Acta biomaterialia. 2023-07-08. PMID:37422008. |
the data show that conditioned medium (cm) from mscs cultured on 0.2 kpa (soft) and 100 kpa (stiff) polyacrylamide hydrogels have differing effects on msc proliferation and differentiation, with stiff cm promoting proliferation whilst soft cm promoted differentiation. |
2023-07-08 |
2023-08-14 |
Not clear |
| Piotr Grzegorz Grelewski, Monika Kwaśnicka, Julia Krystyna Ba. Properties of scaffolds as carriers of mesenchymal stem cells for use in bone engineering. Polimery w medycynie. 2023-06-29. PMID:37382219. |
additionally, future perspectives in tissue engineering, such as the msc secretome, that is the conditioned medium (cm), and the extracellular vesicles (evs), are also described in this review. |
2023-06-29 |
2023-08-14 |
Not clear |
| Prakash Gangadaran, Eun Jung Oh, Ramya Lakshmi Rajendran, Ji Min Oh, Hyun Mi Kim, Suin Kwak, Ho Yun Chung, Jaetae Lee, Byeong-Cheol Ahn, Chae Moon Hon. Three-dimensional culture conditioned bone marrow MSC secretome accelerates wound healing in a burn injury mouse model. Biochemical and biophysical research communications. vol 673. 2023-06-26. PMID:37364390. |
three-dimensional culture conditioned bone marrow msc secretome accelerates wound healing in a burn injury mouse model. |
2023-06-26 |
2023-08-14 |
mouse |
| Héctor E González, Sean D McCarthy, Claire Masterson, John G Laffey, Ronan MacLoughlin, Daniel O'Tool. Nebulized mesenchymal stem cell derived conditioned medium ameliorates Frontiers in medicine. vol 10. 2023-06-19. PMID:37332742. |
nebulized mesenchymal stem cell derived conditioned medium ameliorates mesenchymal stem cells (msc) have shown immense therapeutic promise in a range of inflammatory diseases, including acute respiratory distress syndrome (ards), and are rapidly advancing through clinical trials. |
2023-06-19 |
2023-08-14 |
rat |
| Yi Zheng, Xian Dong, Xinyu Wang, Jie Wang, Shuo Chen, Yang He, Jingang An, Linhai He, Yi Zhan. Exosomes Derived from Adipose Tissue-Derived Mesenchymal Stromal Cells Prevent Medication-Related Osteonecrosis of the Jaw through IL-1RA. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37240036. |
exosomes were collected from the conditioned medium (cm) of msc(at)s (msc(at)s-exo) and locally administered into the tooth sockets. |
2023-05-27 |
2023-08-14 |
mouse |
| Tomoko Kamishima, Chie Hirabe, Takanori Ohnishi, Junichi Taguchi, Khin Zay Yar Myint, Shoji Kog. Trichoscopic evaluation of dental pulp stem cell conditioned media for androgenic alopecia. Journal of cosmetic dermatology. 2023-05-08. PMID:37154468. |
conditioned media (cm) derived from mesenchymal stem cells (msc) is known to induce hair regrowth in androgenic alopecia. |
2023-05-08 |
2023-08-14 |
Not clear |
| Chun-De Liao, Hung-Chou Chen, Mao-Hua Huang, Tsan-Hon Liou, Che-Li Lin, Shih-Wei Huan. Comparative Efficacy of Intra-Articular Injection, Physical Therapy, and Combined Treatments on Pain, Function, and Sarcopenia Indices in Knee Osteoarthritis: A Network Meta-Analysis of Randomized Controlled Trials. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047058. |
all rcts which had treatment arms of iai agents (autologous conditioned serum, botulinum neurotoxin type a, corticosteroids, dextrose prolotherapy (dxtp), hyaluronic acid, mesenchymal stem cells (msc), ozone, platelet-rich plasma, plasma rich in growth factor, and stromal vascular fraction of adipose tissue) in combination with pt (exercise therapy, physical agent modalities (electrotherapy, shockwave therapy, thermal therapy), and physical activity training) were included in this nma. |
2023-04-13 |
2023-08-14 |
Not clear |