| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linfeng Wang, Shengcan Li, Han Xiao, Tao Zhang, Yuqian Liu, Jianzhong Hu, Daqi Xu, Hongbin L. TGF-β1 derived from macrophages contributes to load-induced tendon-bone healing in the murine rotator cuff repair model by promoting chondrogenesis. Bone & joint research. vol 12. issue 3. 2023-04-13. PMID:37051812. |
the conditioned media from mechanically stimulated bmdms (ms-cm) enhanced msc chondrogenic differentiation, and mechanically stimulated bmdms generated more tgf-β1. |
2023-04-13 |
2023-08-14 |
mouse |
| Anindya Mukhopadhya, Dimitrios Tsiapalis, Niamh McNamee, Brian Talbot, Lorraine O'Driscol. Doxorubicin Loading into Milk and Mesenchymal Stem Cells' Extracellular Vesicles as Drug Delivery Vehicles. Pharmaceutics. vol 15. issue 3. 2023-03-29. PMID:36986579. |
while mesenchymal/stromal stem cell (msc) conditioned medium (cm) and milk are potentially safe and scalable sources of evs for this purpose, the suitability of msc evs and milk evs as drug delivery vehicles has never been compared and so was the objective of this study. |
2023-03-29 |
2023-08-14 |
Not clear |
| Siddharth Shanbhag, Carina Kampleitner, Niyaz Al-Sharabi, Samih Mohamed-Ahmed, Karol Ali Apaza Alccayhuaman, Patrick Heimel, Stefan Tangl, Andreas Beinlich, Neha Rana, Mariano Sanz, Einar K Kristoffersen, Kamal Mustafa, Reinhard Grube. Functionalizing Collagen Membranes with MSC-Conditioned Media Promotes Guided Bone Regeneration in Rat Calvarial Defects. Cells. vol 12. issue 5. 2023-03-11. PMID:36899904. |
functionalizing biomaterials with conditioned media (cm) from mesenchymal stromal cells (msc) is a promising strategy for enhancing the outcomes of guided bone regeneration (gbr). |
2023-03-11 |
2023-08-14 |
human |
| Yuxuan Fan, Zhui Yu, Lulu Lin, Zhihong Xu, Hanhui Liu, Yinping L. [Regulatory effects of umbilical cord mesenchymal stem cells and their conditioned medium on gut microbiota of septic mice]. Zhonghua wei zhong bing ji jiu yi xue. vol 35. issue 1. 2023-03-07. PMID:36880237. |
to investigate and compare the regulatory effects of umbilical cord mesenchymal stem cells (msc) and their conditioned medium (msc-cm) on gut microbiota of septic mice. |
2023-03-07 |
2023-08-14 |
mouse |
| Lynn M Pezzanite, Lyndah Chow, Gregg M Griffenhagen, Luke Bass, Laurie R Goodrich, Renata Impastato, Steven Do. Distinct differences in immunological properties of equine orthobiologics revealed by functional and transcriptomic analysis using an activated macrophage readout system. Frontiers in veterinary science. vol 10. 2023-03-06. PMID:36876001. |
therefore, the goal of this study was to use relevant bioassay systems to directly compare the anti-inflammatory and immunomodulatory activity of three commonly used orthobiological therapies (ots): mesenchymal stromal cells (msc), autologous conditioned serum (acs), and platelet rich plasma (prp). |
2023-03-06 |
2023-08-14 |
Not clear |
| D L Wan. [Some thoughts on the research of mesenchymal stem cell exosomes and wound microenvironment]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 39. issue 2. 2023-03-06. PMID:36878518. |
since researchers have found that the conditioned medium and exosomes of mesenchymal stem cells (mscs) had the biological effects equivalent to those of mscs, msc exosomes (msc-exos), the representative product of mscs' paracrine effect, have become the research focus of the "cell-free" therapy of mscs. |
2023-03-06 |
2023-08-14 |
Not clear |
| Lorenzini Bileyle, Peltzer Juliette, Goulinet Sylvie, Rival Bastien, Lataillade Jean-Jacques, Uzan Georges, Banzet Sébastien, Mauduit Philipp. Producing vesicle-free cell culture additive for human cells extracellular vesicles manufacturing. Journal of controlled release : official journal of the Controlled Release Society. 2023-02-10. PMID:36764527. |
msc could survive at least 216 h, their conditioned medium being collected and changed every 72 h. |
2023-02-10 |
2023-08-14 |
human |
| Basak Isildar, Serbay Ozkan, Merve Ercin, Selda Gezginci-Oktayoglu, Mahmut Oncul, Meral Koyutur. 2D and 3D cultured human umbilical cord-derived mesenchymal stem cell-conditioned medium has a dual effect in type 1 diabetes model in rats: immunomodulation and beta-cell regeneration. Inflammation and regeneration. vol 42. issue 1. 2022-12-01. PMID:36451229. |
in this context, the study aims to investigate the therapeutic effects of msc's secretomes by conditioned medium (cm) obtained from human umbilical cord-derived mscs cultured in 2-dimensional (2d) and 3-dimensional (3d) environments in the t1d model. |
2022-12-01 |
2023-08-14 |
human |
| M I Ezdakova, D K Matveeva, E R Andreev. Short-Term Interaction with Endothelial Cells Enhances Angiogenic Activity of Growth-Arrested Mesenchymal Stromal Cells In Vitro and In Ovo. Bulletin of experimental biology and medicine. 2022-11-27. PMID:36437339. |
we compared angiogenic effects of conditioned medium from mesenchymal stromal cell (msc) monoculture and co-culture of msc with endothelial cells (ec). |
2022-11-27 |
2023-08-14 |
Not clear |
| M I Ezdakova, D K Matveeva, E R Andreev. Short-Term Interaction with Endothelial Cells Enhances Angiogenic Activity of Growth-Arrested Mesenchymal Stromal Cells In Vitro and In Ovo. Bulletin of experimental biology and medicine. 2022-11-27. PMID:36437339. |
conditioned medium from 24-h ec-msc co-cultures significantly stimulated the proliferation and migration of ec in monoculture and growth of the vascular network of the chorioallantoic membrane of the quail embryo in ovo in comparison with the conditioned medium from msc monoculture. |
2022-11-27 |
2023-08-14 |
Not clear |
| Abazar Esmaeili, Samaneh Hosseini, Amir Kamali, Maryam Hosseinzadeh, Faezeh Shekari, Mohamadreza Baghaban Eslamineja. Co-aggregation of MSC/chondrocyte in a dynamic 3D culture elevates the therapeutic effect of secreted extracellular vesicles on osteoarthritis in a rat model. Scientific reports. vol 12. issue 1. 2022-11-18. PMID:36400827. |
msc and chondrocytes were aggregated and co-aggregated by spinner flasks, and their conditioned medium was collected. |
2022-11-18 |
2023-08-14 |
rat |
| Ahmad Samir Arabiyat, Daniel J Yeisley, Viviana Raquel Güiza-Argüello, Fatir Qureshi, Robert A Culibrk, Juergen Hahn, Mariah Hah. Effects of Stromal Cell Conditioned Medium and Anti-purinergic Treatment on Macrophage Phenotype. Tissue engineering. Part C, Methods. 2022-11-04. PMID:36329666. |
the immunomodulatory capacity of the human mesenchymal stromal cell (msc) secretome has been a critical driver for the development of cell-free msc products, such as conditioned medium (cm), for regenerative medicine applications. |
2022-11-04 |
2023-08-14 |
human |
| Siddharth Shanbhag, Niyaz Al-Sharabi, Samih Mohamed-Ahmed, Reinhard Gruber, Einar K Kristoffersen, Kamal Mustaf. Brief communication: Effects of conditioned media from human platelet lysate cultured MSC on osteogenic cell differentiation Frontiers in bioengineering and biotechnology. vol 10. 2022-10-17. PMID:36246352. |
brief communication: effects of conditioned media from human platelet lysate cultured msc on osteogenic cell differentiation culturing mesenchymal stromal cells (msc) in human platelet lysate (hpl) supplemented media can enhance their osteogenic differentiation potential. |
2022-10-17 |
2023-08-14 |
human |
| Siddharth Shanbhag, Niyaz Al-Sharabi, Samih Mohamed-Ahmed, Reinhard Gruber, Einar K Kristoffersen, Kamal Mustaf. Brief communication: Effects of conditioned media from human platelet lysate cultured MSC on osteogenic cell differentiation Frontiers in bioengineering and biotechnology. vol 10. 2022-10-17. PMID:36246352. |
the objective of this study was to test the hypothesis that conditioned media (cm) derived from hpl-cultured msc also have pro-osteogenic effects. |
2022-10-17 |
2023-08-14 |
human |
| Takahiro Teshima, Yuyo Yasumura, Ryohei Suzuki, Hirotaka Matsumot. Antiviral Effects of Adipose Tissue-Derived Mesenchymal Stem Cells Secretome against Feline Calicivirus and Feline Herpesvirus Type 1. Viruses. vol 14. issue 8. 2022-08-26. PMID:36016308. |
in this study, we evaluated the antiviral efficacy of using feline msc secretome as a conditioned medium on fcv and fhv1 viral replication in crandell-reese feline kidney (crfk) cells, and rna sequencing was used to analyze how the crfk cells were altered by the msc secretomes. |
2022-08-26 |
2023-08-14 |
Not clear |
| Afsaneh Asgari Taei, Pariya Khodabakhsh, Sanaz Nasoohi, Maryam Farahmandfar, Leila Dargah. Paracrine Effects of Mesenchymal Stem Cells in Ischemic Stroke: Opportunities and Challenges. Molecular neurobiology. 2022-08-03. PMID:35922728. |
the secretome derivatives, such as conditioned medium (cm) or purified extracellular vesicles (evs), exert remarkable advantages over msc transplantation in stroke treating. |
2022-08-03 |
2023-08-14 |
Not clear |
| Valerie Johnson, Lyndah Chow, Jacqueline Harrison, Sirikul Soontararak, Steven Do. Activated Mesenchymal Stromal Cell Therapy for Treatment of Multi-Drug Resistant Bacterial Infections in Dogs. Frontiers in veterinary science. vol 9. 2022-07-11. PMID:35812842. |
macrophages incubated with conditioned medium from activated msc developed significantly enhanced bactericidal activity. |
2022-07-11 |
2023-08-14 |
Not clear |
| Benson Koh, Kian Leong Tan, Hong Hao Chan, Qi Hao Daniel Looi, Moon Nian Lim, Chee Wun How, Jia Xian Law, Jhi Biau Fo. A Simple Benchtop Filtration Method to Isolate Small Extracellular Vesicles from Human Mesenchymal Stem Cells. Journal of visualized experiments : JoVE. issue 184. 2022-07-11. PMID:35816005. |
this study demonstrates a simple benchtop filtration method to isolate human umbilical cord-derived msc small extracellular vesicles (huc-msc-sevs), successfully separated by ultrafiltration from the conditioned medium of huc-mscs. |
2022-07-11 |
2023-08-14 |
human |
| Chiara Giannasi, Laura Mangiavini, Stefania Niada, Andrea Colombo, Elena Della Morte, Valeria Vismara, Andrea Ambrosanio, Paolo Savadori, Sara Casati, Giuseppe M Peretti, Anna Teresa Brin. Human Osteochondral Explants as an Ex Vivo Model of Osteoarthritis for the Assessment of a Novel Class of Orthobiologics. Pharmaceutics. vol 14. issue 6. 2022-06-24. PMID:35745803. |
in the last decade, the potential of mesenchymal stem cell (msc) secretome, or conditioned medium (cm), has emerged as an alternative to cell therapy. |
2022-06-24 |
2023-08-14 |
human |
| Sholahuddin Rhatomy, Jeanne Adiwinata Pawitan, Trie Kurniawati, Jessica Fiolin, Ismail Hadisoebroto Dilog. Allogeneic umbilical cord mesenchymal stem cell conditioned medium (secretome) for treating posterior cruciate ligament rupture: a prospective single-arm study. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie. 2022-06-14. PMID:35699826. |
this study aimed to evaluate the outcome of arthroscopic administration of allogeneic umbilical cord-derived msc (uc-msc) conditioned medium (secretome) for the treatment of pcl rupture. |
2022-06-14 |
2023-08-14 |
Not clear |