| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Wei, E Rudjito, N Fahy, J A Verhaar, S Clockaerts, Y M Bastiaansen-Jenniskens, G J van Osc. The infrapatellar fat pad from diseased joints inhibits chondrogenesis of mesenchymal stem cells. European cells & materials. vol 30. 2016-08-08. PMID:26629970. |
we evaluated the effect of different types of conditioned medium on msc chondrogenesis. |
2016-08-08 |
2023-08-13 |
Not clear |
| S Geyh, M Rodríguez-Paredes, P Jäger, C Khandanpour, R-P Cadeddu, J Gutekunst, C M Wilk, R Fenk, C Zilkens, D Hermsen, U Germing, G Kobbe, F Lyko, R Haas, T Schroede. Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia. Leukemia. vol 30. issue 3. 2016-07-19. PMID:26601782. |
in line with this, cultivation of healthy msc in conditioned medium from four aml cell lines resulted in decreased proliferation and osteogenic differentiation. |
2016-07-19 |
2023-08-13 |
Not clear |
| David M Smadja, Marilyne Levy, Lan Huang, Elisa Rossi, Adeline Blandinières, Dominique Israel-Biet, Pascale Gaussem, Joyce Bischof. Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells. Thrombosis and haemostasis. vol 114. issue 4. 2016-07-12. PMID:26062754. |
in vitro, ecfc proliferation was stimulated by conditioned media from treprostinil-pretreated msc, and this effect was inhibited either by the use of vegf-a blocking antibodies or sirna vegf-a in msc. |
2016-07-12 |
2023-08-13 |
mouse |
| Xiaokang Li, Hui Zhao, Chunxiao Qi, Yang Zeng, Feng Xu, Yanan D. Direct intercellular communications dominate the interaction between adipose-derived MSCs and myofibroblasts against cardiac fibrosis. Protein & cell. vol 6. issue 10. 2016-07-11. PMID:26271509. |
here in order to decipher the potential mechanism of msc therapy for cardiac fibrosis, we investigated the interplay between mscs and cardiac myofibroblasts (mfbs) using interactive co-culture method, with comparison to paracrine approaches, namely treatment by msc conditioned medium and gap co-culture method. |
2016-07-11 |
2023-08-13 |
Not clear |
| Ting Xu, Yufeng Zhou, Lipeng Qiu, Danh C Do, Yilin Zhao, Zhuang Cui, Heng Wang, Xiaopeng Liu, Arjun Saradna, Xu Cao, Mei Wan, Peisong Ga. Aryl Hydrocarbon Receptor Protects Lungs from Cockroach Allergen-Induced Inflammation by Modulating Mesenchymal Stem Cells. Journal of immunology (Baltimore, Md. : 1950). vol 195. issue 12. 2016-06-27. PMID:26561548. |
epithelial conditioned medium prepared from cockroach extract-challenged epithelial cells significantly induced msc migration, which was further enhanced by tcdd. |
2016-06-27 |
2023-08-13 |
mouse |
| Andrea Gray, Timothy Maguire, Rene Schloss, Martin L Yarmus. Identification of IL-1β and LPS as optimal activators of monolayer and alginate-encapsulated mesenchymal stromal cell immunomodulation using design of experiments and statistical methods. Biotechnology progress. vol 31. issue 4. 2016-05-09. PMID:25958832. |
we utilized fractional factorial design of experiments to screen a panel of 6 molecules (lipopolysaccharide [lps], polyinosinic-polycytidylic acid [poly(i:c)], interleukin [il]-6, il-1β, interferon [ifn]-β, and ifn-γ), individually and in combinations, for the upregulation of msc pge2 secretion and attenuation of macrophage secretion of tumor necrosis factor (tnf)-α, a pro-inflammatory molecule, by activated-msc conditioned medium (cm). |
2016-05-09 |
2023-08-13 |
Not clear |
| Chao Yang, Deqiang Lei, Weixiang Ouyang, Jinghua Ren, Huiyu Li, Jingqiong Hu, Shiang Huan. Conditioned media from human adipose tissue-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells efficiently induced the apoptosis and differentiation in human glioma cell lines in vitro. BioMed research international. vol 2014. 2016-05-02. PMID:24971310. |
we found (1) msc conditioned media can significantly inhibit the growth of human u251 glioma cell line; (2) msc conditioned media can significantly induce apoptosis in human u251 cell line; (3) real-time pcr experiments showed significant upregulation of apoptotic genes of both caspase-3 and caspase-9 and significant downregulation of antiapoptotic genes such as survivin and xiap after msc conditioned media induction in u 251 cells; (4) furthermore, mscs conditioned media culture induced rapid and complete differentiation in u251 cells. |
2016-05-02 |
2023-08-13 |
human |
| G D Sagaradze, O A Grigorieva, A Yu Efimenko, A A Chaplenko, S N Suslina, V Yu Sysoeva, N I Kalinina, Zh A Akopyan, V A Tkachu. [Therapeutic potential of human mesenchymal stromal cells secreted components: a problem with standartization]. Biomeditsinskaia khimiia. vol 61. issue 6. 2016-04-08. PMID:26716748. |
developed approaches were tested on the samples of conditioned media contained products secreted by msc isolated from subcutaneous adipose tissue of 30 donors. |
2016-04-08 |
2023-08-13 |
human |
| Yulyana Yulyana, Ivy A W Ho, Kian Chuan Sia, Jennifer P Newman, Xin Yi Toh, Berwini B Endaya, Jerry K Y Chan, Massimiliano Gnecchi, Hung Huynh, Alexander Y F Chung, Kiat Hon Lim, Hui Sun Leong, Narayanan Gopalakrishna Iyer, Kam Man Hui, Paula Y P La. Paracrine factors of human fetal MSCs inhibit liver cancer growth through reduced activation of IGF-1R/PI3K/Akt signaling. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 4. 2016-04-05. PMID:25619723. |
herein, we showed that conditioned media derived from human fetal msc (cm-hfmscs) expressed high level of the insulin growth factor binding proteins igfbps and can sequester free insulin-like growth factors (igfs) to inhibit hcc cell proliferation. |
2016-04-05 |
2023-08-13 |
human |
| Xinyang Hu, Ling Zhang, Jing Jin, Wei Zhu, Yinchuan Xu, Yan Wu, Yingchao Wang, Han Chen, Keith A Webster, Huiqiang Chen, Hong Yu, Jian'an Wan. Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem cells (Dayton, Ohio). vol 33. issue 6. 2016-03-15. PMID:25754303. |
conditioned medium from msc(hpa) increased endothelial cell migration and promoted greater tube formation relative to that from the msc(null) groups. |
2016-03-15 |
2023-08-13 |
human |
| Xinyang Hu, Ling Zhang, Jing Jin, Wei Zhu, Yinchuan Xu, Yan Wu, Yingchao Wang, Han Chen, Keith A Webster, Huiqiang Chen, Hong Yu, Jian'an Wan. Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem cells (Dayton, Ohio). vol 33. issue 6. 2016-03-15. PMID:25754303. |
vascular endothelial growth factor receptor 2 (vegfr2, flk-1) and its downstream signaling pathway (p38mapk/hsp27) were significantly increased in human umbilical vein endothelial cells (huvecs) after treatment with msc(hpa) conditioned medium. |
2016-03-15 |
2023-08-13 |
human |
| Xinyang Hu, Ling Zhang, Jing Jin, Wei Zhu, Yinchuan Xu, Yan Wu, Yingchao Wang, Han Chen, Keith A Webster, Huiqiang Chen, Hong Yu, Jian'an Wan. Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem cells (Dayton, Ohio). vol 33. issue 6. 2016-03-15. PMID:25754303. |
each of these responses was decreased by cocultured with msc(hpa-kd) conditioned medium. |
2016-03-15 |
2023-08-13 |
human |
| Xinyang Hu, Ling Zhang, Jing Jin, Wei Zhu, Yinchuan Xu, Yan Wu, Yingchao Wang, Han Chen, Keith A Webster, Huiqiang Chen, Hong Yu, Jian'an Wan. Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem cells (Dayton, Ohio). vol 33. issue 6. 2016-03-15. PMID:25754303. |
msc(hpa) conditioned medium activated hypoxia-inducible factor-2α (hif-2α) and increased in parallel the transcript level of flk-1 as determined by chromatin immunoprecipitation-pcr and luciferase assays. |
2016-03-15 |
2023-08-13 |
human |
| Xinyang Hu, Ling Zhang, Jing Jin, Wei Zhu, Yinchuan Xu, Yan Wu, Yingchao Wang, Han Chen, Keith A Webster, Huiqiang Chen, Hong Yu, Jian'an Wan. Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem cells (Dayton, Ohio). vol 33. issue 6. 2016-03-15. PMID:25754303. |
all angiogenic effects of msc(hpa) conditioned medium were abolished by knockdown of integrin β1, hif-2α, and flk-1 in huvecs with selective shrnas. |
2016-03-15 |
2023-08-13 |
human |
| Marialaura Madrigal, Kosagisharaf S Rao, Neil H Riorda. A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods. Journal of translational medicine. vol 12. 2016-03-14. PMID:25304688. |
finally we review in detail the most important factors present in conditioned medium of msc that can be considered protagonists of msc physiological effects including hgf, tgf-b, vegf, tsg-6, pge2 and galectins 1, and 9. |
2016-03-14 |
2023-08-13 |
Not clear |
| Natalia Kalinina, Galina Klink, Eugeniy Glukhanyuk, Tatiana Lopatina, Anastassia Efimenko, Zhanna Akopyan, Vsevolod Tkachu. miR-92a regulates angiogenic activity of adipose-derived mesenchymal stromal cells. Experimental cell research. vol 339. issue 1. 2016-03-08. PMID:26477824. |
the replenishment of hgf but not angiopoietin-1 has restored the ability of conditioned medium from mir-92a overexpressing msc to stimulate the tube formation. |
2016-03-08 |
2023-08-13 |
human |
| Esma Lejmi, Nadja Perriraz, Sophie Clément, Philippe Morel, Reto Baertschiger, Panayiotis Christofilopoulos, Raphael Meier, Domenico Bosco, Léo H Bühler, Carmen Gonelle-Gisper. Inflammatory Chemokines MIP-1δ and MIP-3α Are Involved in the Migration of Multipotent Mesenchymal Stromal Cells Induced by Hepatoma Cells. Stem cells and development. vol 24. issue 10. 2016-02-22. PMID:25579056. |
here, we investigated the migration of human msc induced by conditioned medium of huh-7 hepatoma cells (huh-7 cm). |
2016-02-22 |
2023-08-13 |
human |
| Anastassia Efimenko, Georgiy Sagaradze, Zhanna Akopyan, Tatiana Lopatina, Natalia Kalinin. Data supporting that miR-92a suppresses angiogenic activity of adipose-derived mesenchymal stromal cells by down-regulating hepatocyte growth factor. Data in brief. vol 6. 2016-02-10. PMID:26862575. |
these are followed by the data regarding the effect of conditioned medium of msc transfected with pre-mir-92a, anti-mir-92a or scramble oligos on huvec viability as well as their tube formation efficiency. |
2016-02-10 |
2023-08-13 |
human |
| Mitchell R Clarke, Floriane M Imhoff, Sarah K Bair. Mesenchymal stem cells inhibit breast cancer cell migration and invasion through secretion of tissue inhibitor of metalloproteinase-1 and -2. Molecular carcinogenesis. vol 54. issue 10. 2015-12-07. PMID:24819588. |
mda-mb-231 and t47d cells were co-cultured in a transwell insert above mscs or msc conditioned media and their migration or invasion through matrigel measured. |
2015-12-07 |
2023-08-13 |
Not clear |
| Jae Chul Lee, Choong Ik Cha, Dong-Sik Kim, Soo Young Cho. Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats. Journal of pathology and translational medicine. vol 49. issue 6. 2015-11-27. PMID:26471341. |
as low survival rates and potential tumorigenicity of implanted cells could undermine the mesenchymal stem cell (msc) cell-based therapy, we chose to investigate the use of conditioned medium (cm) from a culture of msc cells as a feasible alternative. |
2015-11-27 |
2023-08-13 |
human |