| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabrina Schäfer, André-Guilhem Calas, Maxime Vergouts, Emmanuel Herman. Immunomodulatory influence of bone marrow-derived mesenchymal stem cells on neuroinflammation in astrocyte cultures. Journal of neuroimmunology. vol 249. issue 1-2. 2012-09-10. PMID:22633273. |
in response to this inflammatory trigger, astrocytes showed an increased expression of pro-inflammatory genes (il-1β, tnfα, il-6), which was attenuated by pre-exposure to msc conditioned medium. |
2012-09-10 |
2023-08-12 |
Not clear |
| A Voulgari-Kokota, R Fairless, M Karamita, V Kyrargyri, V Tseveleki, M Evangelidou, B Delorme, P Charbord, R Diem, L Prober. Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function. Experimental neurology. vol 236. issue 1. 2012-08-07. PMID:22561409. |
a 24h pre-culture of mouse primary cortical neurons with msc protected them against glutamate (nmda) receptor-induced death and conditioned medium from msc (msc cm) was sufficient for this effect. |
2012-08-07 |
2023-08-12 |
mouse |
| Young Min Cho, Ju Han Kim, Mingoo Kim, Su Jin Park, Sang Hyeok Koh, Hyo Seop Ahn, Gyeong Hoon Kang, Jung-Bin Lee, Kyong Soo Park, Hong Kyu Le. Mesenchymal stem cells transfer mitochondria to the cells with virtually no mitochondrial function but not with pathogenic mtDNA mutations. PloS one. vol 7. issue 3. 2012-08-02. PMID:22412925. |
conditioned media, which were prepared by treating mtdna-less 143b ρ(0) cells under uridine-free condition, induced increased chemotaxis in msc, which was also supported by transcriptome analysis. |
2012-08-02 |
2023-08-12 |
human |
| Shi Zuo, W Keith Jones, Hongxia Li, Zhisong He, Zeeshan Pasha, Yueting Yang, Yigang Wang, Guo-Chang Fan, Muhammad Ashraf, Meifeng X. Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury. Stem cells and development. vol 21. issue 4. 2012-06-11. PMID:21463175. |
the cell protection mediated by msc(wnt11) was mimicked by treating cm with conditioned medium obtained from msc(wnt11) and abrogated by wnt11- and tgfβ2 neutralizing antibodies. |
2012-06-11 |
2023-08-12 |
rat |
| Hana Haleem-Smith, Evan Argintar, Curtis Bush, Daniel Hampton, William F Postma, Faye H Chen, Todd Rimington, Joshua Lamb, Rocky S Tua. Biological responses of human mesenchymal stem cells to titanium wear debris particles. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 30. issue 6. 2012-05-22. PMID:22083964. |
however, neither il-8 and il-6 treatment nor conditioned medium from ti particle-treated mscs failed to affect msc osteogenic differentiation. |
2012-05-22 |
2023-08-12 |
human |
| Roberta Tasso, Massimiliano Gaetani, Erica Molino, Angela Cattaneo, Massimiliano Monticone, Angela Bachi, Ranieri Cancedd. The role of bFGF on the ability of MSC to activate endogenous regenerative mechanisms in an ectopic bone formation model. Biomaterials. vol 33. issue 7. 2012-05-18. PMID:22169138. |
we developed a novel strategy combining silac-lc-ms/ms quantitative proteomics of conditioned culture media and gene expression profiling to disentangle the major role of msc in modulating the microenvironment toward the damage resolution. |
2012-05-18 |
2023-08-12 |
mouse |
| Min-Jung Park, Jun-Seop Shin, Yong-Hee Kim, So-Hee Hong, Seung-Ha Yang, Jin-Young Shin, Su-Young Kim, Bongi Kim, Jung-Sik Kim, Chung-Gyu Par. Murine mesenchymal stem cells suppress T lymphocyte activation through IL-2 receptor α (CD25) cleavage by producing matrix metalloproteinases. Stem cell reviews and reports. vol 7. issue 2. 2011-09-30. PMID:21103959. |
we found that t lymphocytes incubated with conditioned media of mscs (msc cm) entered into apoptosis and were subjected to cell cycle arrest during the course of activation, and these phenomena were accompanied by the reduction of il-2 production. |
2011-09-30 |
2023-08-12 |
Not clear |
| Jennifer L Halpern, Amy Kilbarger, Conor C Lync. Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor. Cancer letters. vol 308. issue 1. 2011-09-20. PMID:21601983. |
analysis of conditioned media using a cytokine array revealed the presence of numerous cytokines in the msc conditioned media, most notably, the murine orthologs of cxcl1 and cxcl5 that are cognate ligands of the cxcr2 receptor. |
2011-09-20 |
2023-08-12 |
mouse |
| Jennifer L Halpern, Amy Kilbarger, Conor C Lync. Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor. Cancer letters. vol 308. issue 1. 2011-09-20. PMID:21601983. |
further investigation identified that: (1) cxcl1, cxcl5 and cxcr2 mrna and protein were expressed by the mscs and pymt cell lines and; (2) neutralizing antibodies to cxcl1, cxcl5 and cxcr2 or a cxcr2 small molecule inhibitor (sb265610) significantly abrogated the migratory effect of the msc conditioned media on the pymt cells. |
2011-09-20 |
2023-08-12 |
mouse |
| Leo Timmers, Sai Kiang Lim, Imo E Hoefer, Fatih Arslan, Ruenn Chai Lai, Angelique A M van Oorschot, Marie Jose Goumans, Chaylendra Strijder, Sui Kwan Sze, Andree Choo, Jan J Piek, Pieter A Doevendans, Gerard Pasterkamp, Dominique P V de Kleij. Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. Stem cell research. vol 6. issue 3. 2011-08-12. PMID:21419744. |
human msc secretions were collected as conditioned medium (msc-cm) using a clinically compliant protocol. |
2011-08-12 |
2023-08-12 |
human |
| Shibani Pati, Aarif Y Khakoo, Jing Zhao, Fernando Jimenez, Michael H Gerber, Matthew Harting, John B Redell, Raymond Grill, Yoichi Matsuo, Sushovan Guha, Charles S Cox, Marvin S Reitz, John B Holcomb, Pramod K Das. Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling. Stem cells and development. vol 20. issue 1. 2011-04-15. PMID:20446815. |
interestingly, a conditioned medium from huvec-msc cocultures, but not from huvec or msc cells cultured alone, significantly reduced endothelial permeability. |
2011-04-15 |
2023-08-12 |
human |
| Denis Angoulvant, Fabrice Ivanes, René Ferrera, Phoebe G Matthews, Serge Nataf, Michel Oviz. Mesenchymal stem cell conditioned media attenuates in vitro and ex vivo myocardial reperfusion injury. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. vol 30. issue 1. 2011-03-31. PMID:21030271. |
previous studies have suggested that implantation of mesenchymal stem cells (msc) or their conditioned media (msc cm) improves heart function after myocardial infarction. |
2011-03-31 |
2023-08-12 |
Not clear |
| Abolfazl Zarjou, Junghyun Kim, Amie M Traylor, Paul W Sanders, József Balla, Anupam Agarwal, Lisa M Curti. Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1. American journal of physiology. Renal physiology. vol 300. issue 1. 2011-02-09. PMID:21048024. |
in addition, conditioned medium of ho-1+/+ msc rescued functional and morphological changes associated with cisplatin-induced aki, while the ho-1-/--conditioned medium was ineffectual. |
2011-02-09 |
2023-08-12 |
mouse |
| Hongxia Li, Shi Zuo, Zhisong He, Yueting Yang, Zeeshan Pasha, Yigang Wang, Meifeng X. Paracrine factors released by GATA-4 overexpressed mesenchymal stem cells increase angiogenesis and cell survival. American journal of physiology. Heart and circulatory physiology. vol 299. issue 6. 2011-01-13. PMID:20870802. |
human umbilical vein endothelial cells (huvec) treated with msc(gata-4) conditioned medium exhibited increased formation of capillary-like structures and promoted migration, compared with huvecs treated with msc(null) conditioned medium. |
2011-01-13 |
2023-08-12 |
human |
| Guo-Cai Li, Qing-Hai Ye, Yu-Hua Xue, Hai-Jing Sun, Hai-Jun Zhou, Ning Ren, Hu-Liang Jia, Jiong Shi, Jin-Cai Wu, Chun Dai, Qiong-Zhu Dong, Lun-Xiu Qi. Human mesenchymal stem cells inhibit metastasis of a hepatocellular carcinoma model using the MHCC97-H cell line. Cancer science. vol 101. issue 12. 2010-12-15. PMID:20942864. |
co-culture of mhcc97-h cells with msc conditioned medium significantly enhanced in vitro proliferation but inhibited invasiveness. |
2010-12-15 |
2023-08-12 |
mouse |
| Wei Ding, Traci R Knox, Renee C Tschumper, Wenting Wu, Susan M Schwager, Justin C Boysen, Diane F Jelinek, Neil E Ka. Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch. Blood. vol 116. issue 16. 2010-11-29. PMID:20606160. |
in this study, we observed that the conditioned medium (cm) obtained from cll cells was able to induce akt activation in msc. |
2010-11-29 |
2023-08-12 |
Not clear |
| Hongqi Xin, Yi Li, Li Hong Shen, Xianshuang Liu, Xinli Wang, Jing Zhang, Siamak Pourabdollah-Nejad D, Chunling Zhang, Li Zhang, Hao Jiang, Zheng Gang Zhang, Michael Chop. Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse. PloS one. vol 5. issue 2. 2010-09-30. PMID:20140248. |
when primary cortical neurons were cultured in the conditioned medium from msc co-cultured astrocytes, these neurons exhibited a significant increase in neurite outgrowth compared to conditioned medium from astrocytes alone. |
2010-09-30 |
2023-08-12 |
mouse |
| S L Watson, H Marcal, M Sarris, N Di Girolamo, M T C Coroneo, D Wakefiel. The effect of mesenchymal stem cell conditioned media on corneal stromal fibroblast wound healing activities. The British journal of ophthalmology. vol 94. issue 8. 2010-08-19. PMID:19965828. |
to investigate the effects of conditioned media from mesenchymal stem cells (msc) on the wound healing activities of corneal stromal fibroblasts. |
2010-08-19 |
2023-08-12 |
Not clear |
| L Kreja, R E Brenner, A Tautzenberger, A Liedert, B Friemert, C Ehrnthaller, M Huber-Lang, A Ignatiu. Non-resorbing osteoclasts induce migration and osteogenic differentiation of mesenchymal stem cells. Journal of cellular biochemistry. vol 109. issue 2. 2010-08-05. PMID:19950208. |
bone-marrow-derived human msc were exposed to conditioned media (cm) derived from non-resorbing osteoclast cultures, which were generated from human peripheral blood monocytes. |
2010-08-05 |
2023-08-12 |
human |
| Mathilde Soulez, Isabelle Sirois, Nathalie Brassard, Marc-André Raymond, Frédéric Nicodème, Nicolas Noiseux, Yves Durocher, Alexei V Pshezhetsky, Marie-Josée Héber. Epidermal growth factor and perlecan fragments produced by apoptotic endothelial cells co-ordinately activate ERK1/2-dependent antiapoptotic pathways in mesenchymal stem cells. Stem cells (Dayton, Ohio). vol 28. issue 4. 2010-06-18. PMID:20201065. |
serum-free medium conditioned by apoptotic ec increases extracellular signal-regulated kinases 1 and 2 (erk1/2) activation and inhibits apoptosis (evaluated by bcl-xl protein levels and poly (adp-ribose) polymerase cleavage) of human msc. |
2010-06-18 |
2023-08-12 |
human |