| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elie Abed, Dominique Labelle, Corine Martineau, Andrew Loghin, Robert Morea. Expression of transient receptor potential (TRP) channels in human and murine osteoblast-like cells. Molecular membrane biology. vol 26. issue 3. 2009-05-18. PMID:19115145. |
the preservation of bone mass relies on adequate proliferation, differentiation, secretion of matrix proteins and rate of apoptosis of the bone-forming osteoblasts. |
2009-05-18 |
2023-08-12 |
human |
| Martin Feelisc. The chemical biology of nitric oxide--an outsider's reflections about its role in osteoarthritis. Osteoarthritis and cartilage. vol 16 Suppl 2. 2009-05-15. PMID:18794015. |
excess formation of nitric oxide (no) has been invoked in the development of osteoarthritis and blamed for triggering chondrocyte apoptosis and matrix destruction. |
2009-05-15 |
2023-08-12 |
Not clear |
| Karen Boisvert-Adamo, Whitney Longmate, Ethan V Abel, Andrew E Apli. Mcl-1 is required for melanoma cell resistance to anoikis. Molecular cancer research : MCR. vol 7. issue 4. 2009-05-14. PMID:19372583. |
the serine/threonine kinase b-raf is mutated in 50% to 70% of melanomas and protects melanoma cells from anoikis, a form of apoptosis induced by lack of adhesion or adhesion to an inappropriate matrix. |
2009-05-14 |
2023-08-12 |
Not clear |
| Pooja Makkar, Raghu Prasad R Metpally, Sreedhara Sangadala, Boojala Vijay B Redd. Modeling and analysis of MH1 domain of Smads and their interaction with promoter DNA sequence motif. Journal of molecular graphics & modelling. vol 27. issue 7. 2009-04-30. PMID:19157940. |
smad protein family members act downstream in the tgf-beta signaling pathway mediating various biological processes, including cell growth, differentiation, matrix production, apoptosis and development. |
2009-04-30 |
2023-08-12 |
mouse |
| Yumiko Emot. Cellular aggregation facilitates anoikis in MDCK cells. The journal of physiological sciences : JPS. vol 58. issue 6. 2009-04-28. PMID:18842164. |
anoikis is a specific type of apoptosis caused by the detachment of anchorage-dependent cells from their supportive matrix. |
2009-04-28 |
2023-08-12 |
Not clear |
| Jean-Yves Jouzeau, David Moulin, Meriem Koufany, Sylvie Sebillaud, Arnaud Bianchi, Patrick Nette. [Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists]. Journal de la Societe de biologie. vol 202. issue 4. 2009-04-27. PMID:19094928. |
however, these promising effects of ppar full agonists were hampered by their ability to reduce the growth factor-dependent synthesis of extracellular matrix components or to induce chondrocyte apoptosis, by the possible contribution of immunosuppressive properties to their anti-arthritic effects, by the increased adipocyte differentiation secondary to prolonged stimulation of ppargamma, and by a variable contribution of ppar subtypes depending on the system. |
2009-04-27 |
2023-08-12 |
Not clear |
| Nadia K Zouq, James A Keeble, Jennefer Lindsay, Anthony J Valentijn, Lu Zhang, Deborah Mills, Christopher E Turner, Charles H Streuli, Andrew P Gilmor. FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. Journal of cell science. vol 122. issue Pt 3. 2009-04-27. PMID:19126677. |
different cell types interpret their distinct extracellular matrix (ecm) environments to bring about specific cell fate decisions, and can differentiate or undergo apoptosis depending on their local adhesive interactions. |
2009-04-27 |
2023-08-12 |
Not clear |
| H B Liu, M T Voso, D Gumiero, J Duong, J J McKendrick, A E Dea. The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression. International journal of oncology. vol 34. issue 2. 2009-04-27. PMID:19148494. |
regulation of a recently identified tumour suppressor gene together with cell cycle, apoptosis and matrix degrading proteases may underpin the molecular mechanism responsible for these effects. |
2009-04-27 |
2023-08-12 |
Not clear |
| Alice A Tomei, Federica Boschetti, Francesca Gervaso, Melody A Swart. 3D collagen cultures under well-defined dynamic strain: a novel strain device with a porous elastomeric support. Biotechnology and bioengineering. vol 103. issue 1. 2009-04-20. PMID:19148875. |
the field of mechanobiology has grown tremendously in the past few decades, and it is now well accepted that dynamic stresses and strains can impact cell and tissue organization, cell-cell and cell-matrix communication, matrix remodeling, cell proliferation and apoptosis, cell migration, and many other cell behaviors in both physiological and pathophysiological situations. |
2009-04-20 |
2023-08-12 |
human |
| Konstantinos Tziomalos, Joshua M Har. Role of xanthine oxidoreductase in cardiac nitroso-redox imbalance. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273066. |
within the heart, xor activity stimulates cardiomyocyte hypertrophy, apoptosis, and impairs matrix structure. |
2009-04-07 |
2023-08-12 |
Not clear |
| Narayana Anilkumar, Alexander Sirker, Ajay M Sha. Redox sensitive signaling pathways in cardiac remodeling, hypertrophy and failure. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273265. |
in particular, the tightly regulated generation of ros by nadph oxidases appears especially important in key signaling events that drive the development of cardiomyocyte hypertrophy, fibrosis, extracellular matrix remodelling and cell apoptosis. |
2009-04-07 |
2023-08-12 |
Not clear |
| Leticia Oliveira-Ferrer, Jessica Hauschild, Walter Fiedler, Carsten Bokemeyer, Johannes Nippgen, Ilhan Celik, Gunter Schuc. Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway. Journal of experimental & clinical cancer research : CR. vol 27. 2009-04-02. PMID:19114005. |
the antiangiogenic agent cilengitide disrupts integrin binding to the extracellular matrix leading to apoptosis of activated endothelial cells. |
2009-04-02 |
2023-08-12 |
Not clear |
| Hong Li, Ashwani Mittal, Pradyut K Paul, Mukesh Kumar, Daya S Srivastava, Suresh C Tyagi, Ashok Kuma. Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of MMP-9 in myopathy. The Journal of biological chemistry. vol 284. issue 7. 2009-03-31. PMID:19074147. |
tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (mmp-9) production in skeletal muscle through the activation of nuclear factor-kappab-inducing kinase and p38 mitogen-activated protein kinase: a potential role of mmp-9 in myopathy. |
2009-03-31 |
2023-08-12 |
mouse |
| Hiroyuki Tsutsui, Shintaro Kinugawa, Shouji Matsushim. Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovascular research. vol 81. issue 3. 2009-03-26. PMID:18854381. |
reactive oxygen species induce myocyte hypertrophy, apoptosis, and interstitial fibrosis by activating matrix metalloproteinases. |
2009-03-26 |
2023-08-12 |
Not clear |
| Hongbing Li, Gibanananda Ray, Byong Hoon Yoo, Mete Erdogan, Kirill V Rose. Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. The Journal of biological chemistry. vol 284. issue 4. 2009-03-23. PMID:18957423. |
resistance of solid tumor cells to anoikis, apoptosis induced by cell detachment from the extracellular matrix, is thought to be critical for the ability of these cells to grow anchorage independently within three-dimensional tumor masses and from metastases. |
2009-03-23 |
2023-08-12 |
Not clear |
| Jianmin Hu, Dongmei Cui, Xiao Yang, Shaowei Wang, Shoulong Hu, Chuanxu Li, Junwen Zen. Bone morphogenetic protein-2: a potential regulator in scleral remodeling. Molecular vision. vol 14. 2009-03-23. PMID:19098993. |
bmp-2 is involved in numerous cellular functions including development, cell proliferation, apoptosis, and extracellular matrix synthesis. |
2009-03-23 |
2023-08-12 |
human |
| Espen J Walker, Gary A Rosenber. TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia. Experimental neurology. vol 216. issue 1. 2009-03-20. PMID:19111539. |
since matrix metalloproteinase-3 (mmp-3) enhances inflammation and tissue inhibitor of metalloproteinases-3 (timp-3) promotes apoptosis in ischemia, we hypothesized that they are involved in neuronal death secondary to transient global ischemia. |
2009-03-20 |
2023-08-12 |
mouse |
| Pamela Klingbeil, Rachid Marhaba, Thorsten Jung, Robert Kirmse, Thomas Ludwig, Margot Zölle. CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance. Molecular cancer research : MCR. vol 7. issue 2. 2009-03-19. PMID:19208744. |
the capacity to generate an adhesive matrix but not apoptosis resistance is restored in asml-cd44v(rsc) cells. |
2009-03-19 |
2023-08-12 |
rat |
| Pamela Klingbeil, Rachid Marhaba, Thorsten Jung, Robert Kirmse, Thomas Ludwig, Margot Zölle. CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance. Molecular cancer research : MCR. vol 7. issue 2. 2009-03-19. PMID:19208744. |
these data argue for a 2-fold effect of cd44v on metastasis formation: cd44v-mediated matrix formation is crucial for the settlement and growth at a secondary site, whereas apoptosis resistance supports the efficacy of metastasis formation. |
2009-03-19 |
2023-08-12 |
rat |
| Qi Fu Li, Yan Bin Zheng, Hai Bo Yang, Song Lin Shi, Zhen Li Zhao, Jin An Che. [Changes of nuclear matrix proteins during apoptosis of human osteosarcoma MG-63 cells induced by curcumin]. Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology. vol 41. issue 6. 2009-03-17. PMID:19137819. |
[changes of nuclear matrix proteins during apoptosis of human osteosarcoma mg-63 cells induced by curcumin]. |
2009-03-17 |
2023-08-12 |
human |