| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Argyris Tzouvelekis, Geoff Laurent, Demosthenes Bouro. Stem cell therapy in chronic obstructive pulmonary disease. Seeking the Prometheus effect. Current drug targets. vol 14. issue 2. 2013-07-29. PMID:23256721. |
chronic obstructive pulmonary disease is characterized by dramatic alterations in lung architecture associated to an exaggerated inflammatory process, alveolar epithelial cell apoptosis, endothelial dysfunction and extracellular matrix destruction due to a protease and anti-protease imbalance. |
2013-07-29 |
2023-08-12 |
Not clear |
| Chao Li, Benjamin Beck, Baofeng Su, Jeffery Terhune, Eric Peatma. Early mucosal responses in blue catfish (Ictalurus furcatus) skin to Aeromonas hydrophila infection. Fish & shellfish immunology. vol 34. issue 3. 2013-07-26. PMID:23337110. |
we observed dysregulation in a number of genes involved in diverse pathways including those involved in antioxidant responses, apoptosis, cytoskeletal rearrangement, immunity, and extracellular matrix protein diversity and regulation. |
2013-07-26 |
2023-08-12 |
Not clear |
| B V Sunil Kumar, K Aswani Kumar, K Padmanath, Bhaskar Sharma, Meena Katari. Heterologous expression and functional characterization of matrix metalloproteinase-11 from canine mammary tumor. Animal biotechnology. vol 24. issue 1. 2013-07-22. PMID:23394368. |
matrix metalloproteinases (mmps) are reported to be involved in tumor growth, apoptosis, angiogenesis, invasion, and development of metastases. |
2013-07-22 |
2023-08-12 |
dog |
| Stéphane Richard, Betty Gardie, Sophie Couvé, Sophie Ga. Von Hippel-Lindau: how a rare disease illuminates cancer biology. Seminars in cancer biology. vol 23. issue 1. 2013-07-18. PMID:22659535. |
vhl has also major hif-independent functions, specially in regulation of primary cilium, extracellular matrix and apoptosis. |
2013-07-18 |
2023-08-12 |
Not clear |
| Yan Wang, De Ling Li, Xin Bo Zhang, Yuan Hui Duan, Zhi Hong Wu, Dong Sheng Hao, Bao Sheng Chen, Gui Xing Qi. Increase of TNFα-stimulated osteoarthritic chondrocytes apoptosis and decrease of matrix metalloproteinases 9 by NF-κB inhibition. Biomedical and environmental sciences : BES. vol 26. issue 4. 2013-07-18. PMID:23534468. |
increase of tnfα-stimulated osteoarthritic chondrocytes apoptosis and decrease of matrix metalloproteinases 9 by nf-κb inhibition. |
2013-07-18 |
2023-08-12 |
Not clear |
| Yan Wang, De Ling Li, Xin Bo Zhang, Yuan Hui Duan, Zhi Hong Wu, Dong Sheng Hao, Bao Sheng Chen, Gui Xing Qi. Increase of TNFα-stimulated osteoarthritic chondrocytes apoptosis and decrease of matrix metalloproteinases 9 by NF-κB inhibition. Biomedical and environmental sciences : BES. vol 26. issue 4. 2013-07-18. PMID:23534468. |
to investigate the in vitro effect of caffeic acid phenethyl ester (cape), a nf-κb inhibitor, on the apoptosis of osteoarthritic (oa) chondrocytes and on the regulation of the gelatinases matrix metalloproteinase 2 (mmp-2) and matrix metalloproteinase 9 (mmp-9). |
2013-07-18 |
2023-08-12 |
Not clear |
| Lisa McLay, Aftab Ansari, Yuying Liang, Hinh L. Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever. Antiviral research. vol 97. issue 2. 2013-07-08. PMID:23261843. |
each of the four viral gene products (gpc, l polymerase, np, and z matrix protein) and several host-cell factors (e.g., α-dystroglycan) are responsible for mediating viral entry, genome replication, and the inhibition of apoptosis, translation and interferon-beta (ifnβ) production. |
2013-07-08 |
2023-08-12 |
human |
| Ghulam Mohammad, Mohammad Mairaj Siddique. Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy. Journal of ocular biology, diseases, and informatics. vol 5. issue 1. 2013-07-08. PMID:23833698. |
mmps are a large family of proteinases that remodel extracellular matrix components, and under pathological condition, its induction is considered as a negative regulator of cell survival; and in diabetes, latent mmps are activated in the retina and its capillary cells, and activation of mmp-2 and -9 induces apoptosis of retinal capillary cells. |
2013-07-08 |
2023-08-12 |
Not clear |
| Sushama Kamarajugadda, Lauren Stemboroski, Qingsong Cai, Nicholas E Simpson, Sushrusha Nayak, Ming Tan, Jianrong L. Glucose oxidation modulates anoikis and tumor metastasis. Molecular and cellular biology. vol 32. issue 10. 2013-07-05. PMID:22431524. |
cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis or the warburg effect, and the cells resist matrix detachment-induced apoptosis, which is called anoikis, a barrier to metastasis. |
2013-07-05 |
2023-08-12 |
Not clear |
| Chris Brunquell, Hector Biliran, Scott Jennings, Shubha Kale Ireland, Renwei Chen, Erkki Ruoslaht. TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells. Molecular cancer research : MCR. vol 10. issue 11. 2013-07-05. PMID:22952044. |
the induction of apoptosis following loss of cell attachment to the extracellular matrix (anoikis) in untransformed mammary epithelial mcf10a cells was associated with significant downregulation of tle1 expression. |
2013-07-05 |
2023-08-12 |
Not clear |
| Cristina C Clement, David Aphkhazava, Edward Nieves, Myrasol Callaway, Waldemar Olszewski, Olaf Rotzschke, Laura Santambrogi. Protein expression profiles of human lymph and plasma mapped by 2D-DIGE and 1D SDS-PAGE coupled with nanoLC-ESI-MS/MS bottom-up proteomics. Journal of proteomics. vol 78. 2013-07-04. PMID:23202415. |
the enriched proteome of human lymph (72 proteins) consisted of products derived from the extracellular matrix, apoptosis and cellular catabolism. |
2013-07-04 |
2023-08-12 |
human |
| Jingnan Pu, Wei Shi, Zizhang Wang, Ruizhi Wang, Zhenyu Guo, Chongxiao Liu, Jianjun Sun, Ligui Gao, Ren Zho. Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral hemorrhage in rats. Journal of biomedical research. vol 25. issue 4. 2013-07-04. PMID:23554704. |
mc may inhibit the activation of microglia, the inflammatory reaction and factors, matrix metalloproteinases and apoptosis, thus protecting neurons. |
2013-07-04 |
2023-08-12 |
rat |
| Hilary D Miller, Bryan W Clark, David E Hinton, Andrew Whitehead, Stan Martin, Kevin W Kwok, Seth W Kullma. Anchoring ethinylestradiol induced gene expression changes with testicular morphology and reproductive function in the medaka. PloS one. vol 7. issue 12. 2013-07-02. PMID:23300682. |
a pathway analysis of the differentially expressed genes emphasized genes and pathways associated with apoptosis, cell cycle and proliferation, collagen production/extracellular matrix organization, hormone signaling, male reproduction and protein ubiquitination among others. |
2013-07-02 |
2023-08-12 |
Not clear |
| Hui-fang Zhou, Huimin Yan, Judy L Cannon, Luke E Springer, Jonathan M Green, Christine T N Pha. CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice. Journal of immunology (Baltimore, Md. : 1950). vol 190. issue 10. 2013-07-02. PMID:23585675. |
moreover, we found that ifn-γ-producing cd8(+) t cells, but not cd4(+) t cells, promote the development of aneurysm by enhancing cellular apoptosis and matrix metalloprotease activity. |
2013-07-02 |
2023-08-12 |
mouse |
| O O Bilousov, V L Katanaev, S V Demydov, I A Kozeretsk. The downregulation of the miniature gene does not replicate miniature loss-of-function phenotypes in Drosophila melanogaster wing to the full extent. TSitologiia i genetika. vol 47. issue 2. 2013-06-28. PMID:23745366. |
in turn, extracellular matrix protein miniature is also essential for proper progress of apoptosis and, presumably, emt. |
2013-06-28 |
2023-08-12 |
drosophila_melanogaster |
| Clare T M Lai, Pak-cheong Chow, Sophia J Wong, Koon-wing Chan, Yiu-fai Cheun. Circulating annexin A5 levels after atrial switch for transposition of the great arteries: relationship with ventricular deformation and geometry. PloS one. vol 7. issue 12. 2013-06-25. PMID:23284897. |
we therefore tested if levels of circulating markers of inflammation, apoptosis, collagen synthesis, and extracellular matrix degradation are altered in patients after atrial switch operation for transposition of the great arteries. |
2013-06-25 |
2023-08-12 |
Not clear |
| Ying-Hui Zhu, Li Fu, Leilei Chen, Yan-Ru Qin, Haibo Liu, Fajun Xie, Tingting Zeng, Sui-Sui Dong, Jiangchao Li, Yan Li, Yongdong Dai, Dan Xie, Xin-Yuan Gua. Downregulation of the novel tumor suppressor DIRAS1 predicts poor prognosis in esophageal squamous cell carcinoma. Cancer research. vol 73. issue 7. 2013-06-25. PMID:23436800. |
mechanistic investigations suggested that diras1 acted through extracellular signal-regulated kinase (erk1/2; mapk3/1) and p38 mitogen-activated protein kinase (mapk; mapk14) signaling to trigger bad ser112 dephosphorylation and matrix metalloproteinase (mmp)2/9 transcriptional inactivation to promote apoptosis and inhibit metastasis, respectively. |
2013-06-25 |
2023-08-12 |
Not clear |
| Kristina Rudolph, Annegret Serwe, Gerhard Erke. Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone. Cytokine. vol 61. issue 1. 2013-06-19. PMID:23134667. |
tgf-β is a multifunctional cytokine that regulates cell proliferation, differentiation, apoptosis and extracellular matrix production. |
2013-06-19 |
2023-08-12 |
Not clear |
| Quanfang Huang, Renbin Huang, Shijun Zhang, Jun Lin, Ling Wei, Min He, Lang Zhuo, Xing Li. Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats. Toxicology letters. vol 217. issue 2. 2013-06-19. PMID:23274713. |
mechanistically, studies showed that genistein markedly reduced lipid peroxidation, recruited the anti-oxidative defense system, inhibited cyp2el activity, promoted extracellular matrix degradation by modulating the levels of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-2, induced hsc apoptosis by down-regulating b-cell lymphoma 2 mrna, and inhibited the expression of α-smooth muscle actin and transforming growth factor β(1) proteins. |
2013-06-19 |
2023-08-12 |
rat |
| Alfredo Budillon, Carmine Carbone, Elena Di Gennar. Tissue transglutaminase: a new target to reverse cancer drug resistance. Amino acids. vol 44. issue 1. 2013-06-17. PMID:22130737. |
tg2 mediates drug resistance through the activation of survival pathways and the inhibition of apoptosis, but also by regulating extracellular matrix (ecm) formation, the epithelial-to-mesenchymal transition (emt) or autophagy. |
2013-06-17 |
2023-08-12 |
Not clear |