| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya-Bo Feng, You-Ting Lin, Yu-Xiang Han, Yue-Jiu Pang, Jing-Jing Xu, Yuan Xue, Hong Ya. 2R,4R-APDC, a Metabotropic Glutamate Receptor Agonist, Reduced Neuronal Apoptosis by Upregulating MicroRNA-128 in a Rat Model After Seizures. Neurochemical research. vol 43. issue 3. 2018-08-30. PMID:29497903. |
this study aimed to study the protective effect of (2r,4r)-4-aminopyrrolidine-2,4-dicarboxylate (2r,4r-apdc), a selective metabotropic glutamate receptor agonist, against hippocampal neuronal apoptosis induced by seizures in a rat model of pilocarpine-induced epilepsy. |
2018-08-30 |
2023-08-13 |
rat |
| Ya-Bo Feng, You-Ting Lin, Yu-Xiang Han, Yue-Jiu Pang, Jing-Jing Xu, Yuan Xue, Hong Ya. 2R,4R-APDC, a Metabotropic Glutamate Receptor Agonist, Reduced Neuronal Apoptosis by Upregulating MicroRNA-128 in a Rat Model After Seizures. Neurochemical research. vol 43. issue 3. 2018-08-30. PMID:29497903. |
tunel assay was performed to examine neuronal apoptosis in hippocampus. |
2018-08-30 |
2023-08-13 |
rat |
| Ya-Bo Feng, You-Ting Lin, Yu-Xiang Han, Yue-Jiu Pang, Jing-Jing Xu, Yuan Xue, Hong Ya. 2R,4R-APDC, a Metabotropic Glutamate Receptor Agonist, Reduced Neuronal Apoptosis by Upregulating MicroRNA-128 in a Rat Model After Seizures. Neurochemical research. vol 43. issue 3. 2018-08-30. PMID:29497903. |
in conclusion, 2r,4r-apdc protected hippocampal cells from cell apoptosis after seizures, possibly by upregulating mir-128. |
2018-08-30 |
2023-08-13 |
rat |
| Z M Jiang, H B Qiu, S Q Wang, J Guo, Z W Yang, S B Zho. Ganoderic acid A potentiates the antioxidant effect and protection of mitochondrial membranes and reduces the apoptosis rate in primary hippocampal neurons in magnesium free medium. Die Pharmazie. vol 73. issue 2. 2018-08-29. PMID:29442010. |
ganoderic acid a potentiates the antioxidant effect and protection of mitochondrial membranes and reduces the apoptosis rate in primary hippocampal neurons in magnesium free medium. |
2018-08-29 |
2023-08-13 |
Not clear |
| Z M Jiang, H B Qiu, S Q Wang, J Guo, Z W Yang, S B Zho. Ganoderic acid A potentiates the antioxidant effect and protection of mitochondrial membranes and reduces the apoptosis rate in primary hippocampal neurons in magnesium free medium. Die Pharmazie. vol 73. issue 2. 2018-08-29. PMID:29442010. |
it was found that the sod activity and mitochondrial membrane potential (118.84 u/mg protein and 244.08 Δψm) of the epileptic hippocampal neurons were significantly lower than control values (135.95 u/mg protein and 409.81 Δψm), associated with an increase of cell apoptosis (31.88% vs. 8.84%). |
2018-08-29 |
2023-08-13 |
Not clear |
| Z M Jiang, H B Qiu, S Q Wang, J Guo, Z W Yang, S B Zho. Ganoderic acid A potentiates the antioxidant effect and protection of mitochondrial membranes and reduces the apoptosis rate in primary hippocampal neurons in magnesium free medium. Die Pharmazie. vol 73. issue 2. 2018-08-29. PMID:29442010. |
results indicated that ga-a significantly improved sod activity, while both ga-a/ga-b tranquillized the mitochondrial membrane potential of hippocampal neurons, and thereby protected these neurons by inhibiting apoptosis. |
2018-08-29 |
2023-08-13 |
Not clear |
| Mengyang Wang, Faliang Duan, Jinglei Wu, Qiang Min, Qiaochun Huang, Ming Luo, Zhuqiang H. Effect of cyclooxygenase‑2 inhibition on the development of post‑traumatic stress disorder in rats. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29393449. |
terminal deoxynucleotidyl transferase mediated dutp nick end labeling staining was used to observe the apoptosis of rat hippocampal neurons. |
2018-08-27 |
2023-08-13 |
rat |
| Mengyang Wang, Faliang Duan, Jinglei Wu, Qiang Min, Qiaochun Huang, Ming Luo, Zhuqiang H. Effect of cyclooxygenase‑2 inhibition on the development of post‑traumatic stress disorder in rats. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29393449. |
the apoptosis of hippocampus in rats with ptsd was significantly increased compared with the control group and following treatment with cox‑2 inhibitor, apoptosis was decreased. |
2018-08-27 |
2023-08-13 |
rat |
| Jin-Lin Shang, Qing Cheng, Sheng-Jie Duan, Lu Li, Li-Ya Ji. Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436629. |
the data revealed that malat1 increased in the hippocampus of mice in the rw‑treated i/r group and that this was associated with neurological, learning and memory improvement, reduced infarction volumes, decreased apoptosis and alterations to expression levels of apoptosis‑associated proteins. |
2018-08-27 |
2023-08-13 |
mouse |
| Jin-Lin Shang, Qing Cheng, Sheng-Jie Duan, Lu Li, Li-Ya Ji. Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436629. |
the current findings suggested that voluntary rw protected hippocampal neurons from i/r injury and promoted cognitive restoration, which was associated with lncrna malat1‑mediated apoptosis inhibition. |
2018-08-27 |
2023-08-13 |
mouse |
| Hui Zhao, Meimei Bu, Binglu Li, Yong Zhan. Lipoic acid inhibited desflurane-induced hippocampal neuronal apoptosis through Caspase3 and NF-KappaB dependent pathway. Tissue & cell. vol 50. 2018-08-24. PMID:29429516. |
lipoic acid inhibited desflurane-induced hippocampal neuronal apoptosis through caspase3 and nf-kappab dependent pathway. |
2018-08-24 |
2023-08-13 |
Not clear |
| Lingxing Wang, Honghong Huang, Hongchao Cai, Yafang Che. Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring. Folia neuropathologica. vol 55. issue 4. 2018-08-23. PMID:29363906. |
cell apoptosis in the hippocampus was detected by tdt-mediated dutp-biotin nick-end labeling (tunel) staining. |
2018-08-23 |
2023-08-13 |
rat |
| Lingxing Wang, Honghong Huang, Hongchao Cai, Yafang Che. Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring. Folia neuropathologica. vol 55. issue 4. 2018-08-23. PMID:29363906. |
conclusions: these findings suggest that maternal hypoxia may exacerbate hippocampal cell apoptosis in rat offspring after mcao via alterations in the expression of cytochrome c, caspase-3, bax, and bcl-2, which ultimately affects ischemic stroke prognosis. |
2018-08-23 |
2023-08-13 |
rat |
| Xiaoyu Xiao, Yingxian Zhu, Juyuan Bu, Guowei Li, Zibin Liang, Lukun Yang, Bingzong Ho. The autophagy inhibitor 3-methyladenine restores sevoflurane anesthesiainduced cognitive dysfunction and neurons apoptosis. Die Pharmazie. vol 72. issue 4. 2018-08-22. PMID:29441990. |
moreover, hippocampal neuronal cell apoptosis and expression of autophagy related genes were detected. |
2018-08-22 |
2023-08-13 |
mouse |
| Lei Shi, Zaizong Wang, Xianjin Liu, Mao Li, Shangfei Zhang, Xiaobin Son. Bax inhibitor-1 is required for resisting the Early Brain Injury induced by subarachnoid hemorrhage through regulating IRE1-JNK pathway. Neurological research. vol 40. issue 3. 2018-08-20. PMID:29334839. |
results we found that bi-1 knockdown increased histological injury and the percentages of tunel-positive neuron in hippocampal, promoted the expressions of endoplasmic reticulum (er) stress proteins inositol-requiring enzyme 1α (ire1α) and tnf receptor-associated factor 2 (traf2), and increased the activation levels of apoptosis signal-regulating kinase 1 (ask1) and c-jun n-terminal kinase (jnk) in the hippocampus of sah rats compared with rats in sah + vehicle group. |
2018-08-20 |
2023-08-13 |
rat |
| Qing-Hua Ma, Liu-Fang Jiang, Jian-Liang Mao, Wen-Xin Xu, Min Huan. Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. Molecular medicine reports. vol 17. issue 3. 2018-08-15. PMID:29257340. |
treatment with vildagliptin improved memory deficits and decreased neuronal apoptosis in the hippocampus. |
2018-08-15 |
2023-08-13 |
rat |
| Feifei Wang, Jinhui Wang, Jinghong An, Guoming Yuan, Xiaolei Hao, Yi Zhan. Resveratrol ameliorates depressive disorder through the NETRIN1-mediated extracellular signal-regulated kinase/cAMP signal transduction pathway. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328454. |
in addition, the apoptosis of hippocampal neuron cells was inhibited by the upregulation of anti‑apoptotic genes, including p53, b‑cell lymphoma‑2 (bcl‑2) and bcl‑2‑associated death promoter, and the downregulation of the cleaved caspase‑3 and caspase‑9. |
2018-08-14 |
2023-08-13 |
mouse |
| Feifei Wang, Jinhui Wang, Jinghong An, Guoming Yuan, Xiaolei Hao, Yi Zhan. Resveratrol ameliorates depressive disorder through the NETRIN1-mediated extracellular signal-regulated kinase/cAMP signal transduction pathway. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328454. |
the analysis of the mechanism revealed that that resveratrol treatment suppressed the apoptosis of hippocampal neuron cells through the netrin1‑mediated extracellular signal‑regulated kinase/camp signal transduction pathway. |
2018-08-14 |
2023-08-13 |
mouse |
| Ai Nogami-Hara, Masaki Nagao, Kotaro Takasaki, Nobuaki Egashira, Risako Fujikawa, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Funda Bolukbasi Hatip, Izzettin Hatip-Al-Khatib, Katsunori Iwasak. The Japanese Angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia. Journal of ethnopharmacology. vol 214. 2018-08-13. PMID:29269276. |
the japanese angelica acutiloba root and yokukansan increase hippocampal acetylcholine level, prevent apoptosis and improve memory in a rat model of repeated cerebral ischemia. |
2018-08-13 |
2023-08-13 |
rat |
| Jing Xu, Yaping Huai, Nan Meng, Yanhong Dong, Zhijuan Liu, Qianqian Qi, Ming Hu, Mingyue Fan, Wei Jin, Peiyuan L. L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28620824. |
preoperative or postoperative l-nbp administration in mice receiving rcir promoted hippocampal expression of phospho-akt and phospho-mtor (suggesting activation of akt/mtor signaling), increased the bcl-2/bax ratio (indicating suppression of apoptosis) and reduced the lc3-ii/lc3-i ratio (implying inhibition of autophagy). |
2018-08-07 |
2023-08-13 |
mouse |