| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elenn Soares Ferreira, Laís Gabrielle Vieira, Daniela Macedo Moraes, Beatriz O Amorim, Jackeline Moraes Malheiros, Clement Hamani, Luciene Covola. Long-Term Effects of Anterior Thalamic Nucleus Deep Brain Stimulation on Spatial Learning in the Pilocarpine Model of Temporal Lobe Epilepsy. Neuromodulation : journal of the International Neuromodulation Society. vol 21. issue 2. 2018-08-07. PMID:28960670. |
in the pilocarpine model of epilepsy, ant dbs applied during status epilepticus (se) reduces hippocampal inflammation and apoptosis. |
2018-08-07 |
2023-08-13 |
Not clear |
| Xinxin Wang, Shanshan Ma, Bo Yang, Tuanjie Huang, Nan Meng, Ling Xu, Qu Xing, Yanting Zhang, Kun Zhang, Qinghua Li, Tao Zhang, Junwei Wu, Greta Luyuan Yang, Fangxia Guan, Jian Wan. Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease. Behavioural brain research. vol 339. 2018-08-07. PMID:29102593. |
herein, we report that resveratrol facilitates huc-mscs engraftment in the hippocampus of ad mice and resveratrol enhances the therapeutic effects of huc-mscs in this model as demonstrated by improved learning and memory in the morris water maze, enhanced neurogenesis and alleviated neural apoptosis in the hippocampus of the ad mice. |
2018-08-07 |
2023-08-13 |
mouse |
| Xiao-Xia Fang, Gao-Lin Sun, Yi Zhou, Yi-Hua Qiu, Yu-Ping Pen. TGF-β1 protection against Aβ1-42-induced hippocampal neuronal inflammation and apoptosis by TβR-I. Neuroreport. vol 29. issue 2. 2018-08-06. PMID:29200096. |
tgf-β1 protection against aβ1-42-induced hippocampal neuronal inflammation and apoptosis by tβr-i. |
2018-08-06 |
2023-08-13 |
Not clear |
| Jun-Hui Chen, Ting Wu, Li-Kun Yang, Lei Chen, Jie Zhu, Pei-Pei Li, Xu Hu, Yu-Hai Wan. Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage. Molecular medicine reports. vol 17. issue 1. 2018-07-31. PMID:29257200. |
tunel staining demonstrated that neuronal apoptosis was remarkably reduced in the hippocampus of sah rabbits following treatment with atorvastatin (p<0.05). |
2018-07-31 |
2023-08-13 |
rabbit |
| Wenting Liu, Yan Zhao, Xinyu Zhang, Jiangang J. Simvastatin ameliorates cognitive impairments via inhibition of oxidative stress‑induced apoptosis of hippocampal cells through the ERK/AKT signaling pathway in a rat model of senile dementia. Molecular medicine reports. vol 17. issue 1. 2018-07-31. PMID:29257256. |
simvastatin ameliorates cognitive impairments via inhibition of oxidative stress‑induced apoptosis of hippocampal cells through the erk/akt signaling pathway in a rat model of senile dementia. |
2018-07-31 |
2023-08-13 |
rat |
| Wenting Liu, Yan Zhao, Xinyu Zhang, Jiangang J. Simvastatin ameliorates cognitive impairments via inhibition of oxidative stress‑induced apoptosis of hippocampal cells through the ERK/AKT signaling pathway in a rat model of senile dementia. Molecular medicine reports. vol 17. issue 1. 2018-07-31. PMID:29257256. |
apoptosis of hippocampal cells was suppressed by simvastatin treatment in rats with senile dementia. |
2018-07-31 |
2023-08-13 |
rat |
| Wenting Liu, Yan Zhao, Xinyu Zhang, Jiangang J. Simvastatin ameliorates cognitive impairments via inhibition of oxidative stress‑induced apoptosis of hippocampal cells through the ERK/AKT signaling pathway in a rat model of senile dementia. Molecular medicine reports. vol 17. issue 1. 2018-07-31. PMID:29257256. |
taken together, the preclinical results of the present study indicate that simvastatin is efficient in preventing memory lapse and inhibiting apoptosis of hippocampal cells via the erk/akt signaling pathway, which may in the future improve cognitive decline and dementia in patients. |
2018-07-31 |
2023-08-13 |
rat |
| Peng Wang, Yi Li, Zhengfei Yang, Tao Yu, Guanghui Zheng, Xiangshao Fang, Zitong Huang, Longyuan Jiang, Wanchun Tan. Inhibition of dynamin-related protein 1 has neuroprotective effect comparable with therapeutic hypothermia in a rat model of cardiac arrest. Translational research : the journal of laboratory and clinical medicine. vol 194. 2018-07-31. PMID:29351829. |
in addition, both drp1 inhibition and therapeutic hypothermia decreased cell injury, apoptosis in hippocampal cornu ammonis 1 region and brain mitochondrial dysfunction including adenosine triphosphate production, reactive oxygen species and mitochondrial membrane potential after cardiac arrest. |
2018-07-31 |
2023-08-13 |
rat |
| Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Yousef Rezaei, Hamidreza Pazoki-Toroud. Preconditioning with morphine protects hippocampal CA1 neurons from ischemia-reperfusion injury via activation of the mTOR pathway. Canadian journal of physiology and pharmacology. vol 96. issue 1. 2018-07-27. PMID:28881154. |
chronic morphine treatment attenuated apoptosis and neuronal loss in the hippocampus after i/r injury, which led to improvement in memory (p < 0.05 vs. untreated i/r) and increase in the expression of p-mtor (p < 0.05 vs. untreated i/r) and sod activity (p < 0.05 vs. untreated i/r) in the hippocampus. |
2018-07-27 |
2023-08-13 |
Not clear |
| Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Yousef Rezaei, Hamidreza Pazoki-Toroud. Preconditioning with morphine protects hippocampal CA1 neurons from ischemia-reperfusion injury via activation of the mTOR pathway. Canadian journal of physiology and pharmacology. vol 96. issue 1. 2018-07-27. PMID:28881154. |
these results describe novel findings whereby chronic morphine preconditioning in hippocampal ca1 neurons is mediated by the mtor pathway, and through increased phosphorylation of mtor can alleviate oxidative stress and apoptosis, and eventually protect the hippocampus from i/r injury. |
2018-07-27 |
2023-08-13 |
Not clear |
| Chenli Jiao, Feng Gao, Li Ou, Jinhua Yu, Min Li, Peifeng Wei, Feng Mia. Tetrahydroxy stilbene glycoside (TSG) antagonizes Aβ-induced hippocampal neuron injury by suppressing mitochondrial dysfunction via Nrf2-dependent HO-1 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:28987946. |
here, treatment with non-toxic tsg dose-dependently antagonized aβ-induced cytotoxic death in hippocampal neuronal cells by increasing cell viability and decreasing cell apoptosis. |
2018-07-26 |
2023-08-13 |
mouse |
| Meiling Xu, Qiuhong Fan, Junjun Zhang, Yanfang Chen, Ruizhe Xu, Liesong Chen, Peifeng Zhao, Ye Tia. NFAT3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury. Journal of radiation research. vol 58. issue 6. 2018-07-23. PMID:28992110. |
nfat3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury. |
2018-07-23 |
2023-08-13 |
rat |
| Meiling Xu, Qiuhong Fan, Junjun Zhang, Yanfang Chen, Ruizhe Xu, Liesong Chen, Peifeng Zhao, Ye Tia. NFAT3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury. Journal of radiation research. vol 58. issue 6. 2018-07-23. PMID:28992110. |
in the present study, the nuclear factor of activated t cells isoform 4 (nfat3/c4) was found to play a vital role in excitotoxic hippocampus cell apoptosis induced by radiation. |
2018-07-23 |
2023-08-13 |
rat |
| Meiling Xu, Qiuhong Fan, Junjun Zhang, Yanfang Chen, Ruizhe Xu, Liesong Chen, Peifeng Zhao, Ye Tia. NFAT3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury. Journal of radiation research. vol 58. issue 6. 2018-07-23. PMID:28992110. |
once treated with the nfat3/c4 inhibitor 11r-vivit peptide pre-irradiation, hippocampal proliferation and neuron survival (dentate gyrus cells in particular) were protected from radiation-induced injury, resulting in inhibition of the apoptosis marker bax. |
2018-07-23 |
2023-08-13 |
rat |
| Meiling Xu, Qiuhong Fan, Junjun Zhang, Yanfang Chen, Ruizhe Xu, Liesong Chen, Peifeng Zhao, Ye Tia. NFAT3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury. Journal of radiation research. vol 58. issue 6. 2018-07-23. PMID:28992110. |
our principal aim was to illuminate the role of nfat3/c4-mediated excitotoxicity in hippocampal apoptosis during radiation-induced brain injury. |
2018-07-23 |
2023-08-13 |
rat |
| Zhang Mengying, Xu Yiyue, Pan Tong, Hu Yue, Yanin Limpanont, Huang Ping, Kamolnetr Okanurak, Wu Yanqi, Paron Dekumyoy, Zhou Hongli, Dorn Watthanakulpanich, Wu Zhongdao, Wang Zhi, Lv Zhiyu. Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection. Parasites & vectors. vol 10. issue 1. 2018-07-16. PMID:29258580. |
apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by angiostrongylus cantonensis infection. |
2018-07-16 |
2023-08-13 |
mouse |
| Fan Sun, Yanna Si, Hongguang Bao, Yajie Xu, XiaoXiao Pan, Lingqing Zeng, Ling Jin. Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice. Cellular and molecular neurobiology. vol 37. issue 8. 2018-07-13. PMID:28236057. |
then, cell apoptosis and the levels of cypd, acetylated cypd, sirt-3, interleukin 6 (il-6), tumor necrosis factor-α (tnf-α), and caspase-3 in the hippocampus were determined. |
2018-07-13 |
2023-08-13 |
mouse |
| Zhi Ye, Qing Li, Qulian Guo, Yunchuan Xiong, Dong Guo, Hong Yang, Yan Sh. Ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis. Neuropharmacology. vol 128. 2018-07-13. PMID:28963039. |
ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis. |
2018-07-13 |
2023-08-13 |
mouse |
| Zhi Ye, Qing Li, Qulian Guo, Yunchuan Xiong, Dong Guo, Hong Yang, Yan Sh. Ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis. Neuropharmacology. vol 128. 2018-07-13. PMID:28963039. |
active caspase-3 and -9 proteins, which are responsible for the release of cytochrome c, and the mitochondrial translocation of p53, which is associated with mitochondrial apoptosis, were found to be significantly up-regulated in the ketamine-induced hippocampal neurotoxicity. |
2018-07-13 |
2023-08-13 |
mouse |
| Zhi Ye, Qing Li, Qulian Guo, Yunchuan Xiong, Dong Guo, Hong Yang, Yan Sh. Ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis. Neuropharmacology. vol 128. 2018-07-13. PMID:28963039. |
we conclude that caspase-1-dependent pyroptosis is an important event which may be an essential pathway involved in the mitochondria-associated apoptosis in ketamine-induced hippocampal neurotoxicity. |
2018-07-13 |
2023-08-13 |
mouse |