| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Ding, Hui-Hui Zhou, Quan-Rui Ma, Zhong-Yi He, Jiang-Bo Ma, Yin-Ming Liu, Yi-Wei Zhang, Yu-Qing He, Juan Li. Expression of NR1 and apoptosis levels in the hippocampal cells of mice treated with MK‑801. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28990059. |
in addition, early and total apoptosis detected in the hippocampal nerve cells was significantly increased in the mk‑801 group when compared with the blank group, which was reversible following treatment with nmda. |
2018-06-26 |
2023-08-13 |
mouse |
| Juan Ding, Hui-Hui Zhou, Quan-Rui Ma, Zhong-Yi He, Jiang-Bo Ma, Yin-Ming Liu, Yi-Wei Zhang, Yu-Qing He, Juan Li. Expression of NR1 and apoptosis levels in the hippocampal cells of mice treated with MK‑801. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28990059. |
these results indicated that nmda may regulate the expression of nr1 and suppress apoptosis in hippocampal nerve cells in schizophrenia‑like mice. |
2018-06-26 |
2023-08-13 |
mouse |
| Yingjie Sun, Dandan Song, Mei Wang, Keyan Chen, Tiezheng Zhan. α7 nicotinic acetylcholine receptor agonist attenuates the cerebral injury in a rat model of cardiopulmonary bypass by activating the Akt/GSK3β pathway. Molecular medicine reports. vol 16. issue 6. 2018-06-25. PMID:28944927. |
the present study demonstrated that α7nachr agonist treatment was able to alleviate pathological damage and inhibit hippocampal cell apoptosis and inflammatory response. |
2018-06-25 |
2023-08-13 |
rat |
| Yan Cai, Wei Jiang, Ai-Ling Zhou, Min Zhou, Ling X. [Effect of oxymatrine on apoptosis of hippocampal neurons by p38/JNK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 4. 2018-06-21. PMID:28959845. |
[effect of oxymatrine on apoptosis of hippocampal neurons by p38/jnk signaling pathway]. |
2018-06-21 |
2023-08-13 |
Not clear |
| Yan Cai, Wei Jiang, Ai-Ling Zhou, Min Zhou, Ling X. [Effect of oxymatrine on apoptosis of hippocampal neurons by p38/JNK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 4. 2018-06-21. PMID:28959845. |
to investigate the effect and mechanism of oxymatrine(omt) on hippocampal neurons apoptosis. |
2018-06-21 |
2023-08-13 |
Not clear |
| Yan Cai, Wei Jiang, Ai-Ling Zhou, Min Zhou, Ling X. [Effect of oxymatrine on apoptosis of hippocampal neurons by p38/JNK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 4. 2018-06-21. PMID:28959845. |
hoechst 33342 staining was used to observe the apoptotic morphology of hippocampal neurons.the mrna expression levels of bax, bcl-2, and caspase-3 were detected by real-time quantitative pcr(rt-qpcr), and the protein expression levels of p38, p-p38, jnk, p-jnk, bax, bcl-2 and caspase-3 were detected by western blot.the results showed that, hippocampal neurons all grew well after treatment by different doses (0.37-6.0 g•l⁻¹) of omt for 24 h. stimulation from lps increased the release of ldh(p<0.01), improved the jnk and p38 phosphorylation levels(p<0.01), increased the proportion of bax/bcl-2 and the expression of caspase-3(p<0.01), and promoted the apoptosis of hippocampal neurons. |
2018-06-21 |
2023-08-13 |
Not clear |
| Yan Cai, Wei Jiang, Ai-Ling Zhou, Min Zhou, Ling X. [Effect of oxymatrine on apoptosis of hippocampal neurons by p38/JNK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 4. 2018-06-21. PMID:28959845. |
omt pretreatment could significantly reduce the release of ldh induced by lps stimulation(p<0.05 or p<0.01), reduce the p38 and jnk phosphorylation, decrease the expression of caspase-3 and bax/bcl-2(p<0.01), and diminish the apoptosis of hippocampal neurons.in conclusion, omt could reduce the lps-induced phosphorylation of p38 and jnk, down-regulate the bax/bcl-2 ratio and expression of caspase-3, thus inhibiting apoptosis of hippocampal neurons. |
2018-06-21 |
2023-08-13 |
Not clear |
| Rukmani Pandey, Vipin Rai, Juhi Mishra, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhya. From the Cover: Arsenic Induces Hippocampal Neuronal Apoptosis and Cognitive Impairments via an Up-Regulated BMP2/Smad-Dependent Reduced BDNF/TrkB Signaling in Rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 159. issue 1. 2018-06-19. PMID:28903487. |
from the cover: arsenic induces hippocampal neuronal apoptosis and cognitive impairments via an up-regulated bmp2/smad-dependent reduced bdnf/trkb signaling in rats. |
2018-06-19 |
2023-08-13 |
rat |
| Rukmani Pandey, Vipin Rai, Juhi Mishra, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhya. From the Cover: Arsenic Induces Hippocampal Neuronal Apoptosis and Cognitive Impairments via an Up-Regulated BMP2/Smad-Dependent Reduced BDNF/TrkB Signaling in Rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 159. issue 1. 2018-06-19. PMID:28903487. |
here, we identified that chronic exposure to environmentally relevant doses of arsenic increased apoptosis, characterized by caspase-3 activation, poly(adp-ribose) polymerase cleavage and terminal deoxynucleotidyl transferase dutp nick-end labeling of rat hippocampal neurons, marked by neun. |
2018-06-19 |
2023-08-13 |
rat |
| Rukmani Pandey, Vipin Rai, Juhi Mishra, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhya. From the Cover: Arsenic Induces Hippocampal Neuronal Apoptosis and Cognitive Impairments via an Up-Regulated BMP2/Smad-Dependent Reduced BDNF/TrkB Signaling in Rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 159. issue 1. 2018-06-19. PMID:28903487. |
bmp2-silencing and treatment with bmp antagonist, noggin, attenuated the arsenic-induced apoptosis and loss in hippocampal neurons. |
2018-06-19 |
2023-08-13 |
rat |
| Rukmani Pandey, Vipin Rai, Juhi Mishra, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhya. From the Cover: Arsenic Induces Hippocampal Neuronal Apoptosis and Cognitive Impairments via an Up-Regulated BMP2/Smad-Dependent Reduced BDNF/TrkB Signaling in Rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 159. issue 1. 2018-06-19. PMID:28903487. |
overall, our study proves that arsenic promotes hippocampal neuronal apoptosis through an up-regulated bmp2/smad-dependent attenuation of bdnf/trkb pathway, inducing cognitive deficits. |
2018-06-19 |
2023-08-13 |
rat |
| Yutong Liu, Juan Li, Kaige Xu, Jingjing Gu, Lu Huang, Lei Zhang, N Liu, Jiming Kong, Malcolm Xing, Lin Zhang, Lu Zhan. Characterization of superparamagnetic iron oxide nanoparticle-induced apoptosis in PC12 cells and mouse hippocampus and striatum. Toxicology letters. vol 292. 2018-06-12. PMID:29715513. |
characterization of superparamagnetic iron oxide nanoparticle-induced apoptosis in pc12 cells and mouse hippocampus and striatum. |
2018-06-12 |
2023-08-13 |
mouse |
| Masatoshi Kakizaki, Rihito Watanab. IL-10 expression in pyramidal neurons after neuropathogenic coronaviral infection. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 5. 2018-06-11. PMID:28493345. |
the apoptosis of pyramidal neurons in ca2 and ca3 subregions of the hippocampus is induced after infection with mu-3 virus (mu-3), a neuropathogenic strain of the jhm virus (jhmv), at 4-5 days post-inoculation (dpi). |
2018-06-11 |
2023-08-13 |
Not clear |
| Masatoshi Kakizaki, Rihito Watanab. IL-10 expression in pyramidal neurons after neuropathogenic coronaviral infection. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 5. 2018-06-11. PMID:28493345. |
therefore, it is considered that the apoptotic lesions occur through the indirect effects of infection, and not as a result of direct infection with mu-3, similar to the reported neuronal apoptosis in the hippocampus after other types of infection. |
2018-06-11 |
2023-08-13 |
Not clear |
| Wen-Jin Chen, Jian-Kui Du, Xing Hu, Qing Yu, Dong-Xia Li, Chang-Nan Wang, Xiao-Yan Zhu, Yu-Jian Li. Protective effects of resveratrol on mitochondrial function in the hippocampus improves inflammation-induced depressive-like behavior. Physiology & behavior. vol 182. 2018-06-11. PMID:28964807. |
moreover, resveratrol alleviated the lps-induced apoptosis of hippocampal cells. |
2018-06-11 |
2023-08-13 |
mouse |
| Wen-Jin Chen, Jian-Kui Du, Xing Hu, Qing Yu, Dong-Xia Li, Chang-Nan Wang, Xiao-Yan Zhu, Yu-Jian Li. Protective effects of resveratrol on mitochondrial function in the hippocampus improves inflammation-induced depressive-like behavior. Physiology & behavior. vol 182. 2018-06-11. PMID:28964807. |
the antidepressant action of resveratrol was accomplished through the interruption of mitochondrial oxidative stress and the prevention of cell apoptosis in the hippocampus. |
2018-06-11 |
2023-08-13 |
mouse |
| Qun Wu, Qinxue Dai, Liuming Jiang, Yichuan Wang, Tao Yang, Jianxia Miao, Junlu Wang, Yu Ha. Downregulation of microRNA-448 improves isoflurane-induced learning and memory impairment in rats. Molecular medicine reports. vol 16. issue 2. 2018-06-11. PMID:29067448. |
influences of isoflurane on neuron apoptosis and mir‑448 expression in rat hippocampus tissue were analyzed by flow cytometry and reverse transcription‑quantitative polymerase chain reaction, respectively. |
2018-06-11 |
2023-08-13 |
rat |
| Qun Wu, Qinxue Dai, Liuming Jiang, Yichuan Wang, Tao Yang, Jianxia Miao, Junlu Wang, Yu Ha. Downregulation of microRNA-448 improves isoflurane-induced learning and memory impairment in rats. Molecular medicine reports. vol 16. issue 2. 2018-06-11. PMID:29067448. |
in addition, isoflurane treatment induced neuron apoptosis and mir‑448 was highly expressed in the hippocampal tissue of isoflurane‑treated rats. |
2018-06-11 |
2023-08-13 |
rat |
| Alireza Gharebaghi, Iraj Amiri, Iraj Salehi, Siamak Shahidi, Alireza Komaki, Mehdi Mehdizadeh, Fahimeh Ghasemi Moravej, Sara Soleimani As. Treadmill exercise attenuates 3,4-methylenedioxymethamphetamine-induced memory impairment through a decrease apoptosis in male rat hippocampus. Journal of neuroscience research. vol 95. issue 12. 2018-06-08. PMID:28493333. |
treadmill exercise attenuates 3,4-methylenedioxymethamphetamine-induced memory impairment through a decrease apoptosis in male rat hippocampus. |
2018-06-08 |
2023-08-13 |
rat |
| Alireza Gharebaghi, Iraj Amiri, Iraj Salehi, Siamak Shahidi, Alireza Komaki, Mehdi Mehdizadeh, Fahimeh Ghasemi Moravej, Sara Soleimani As. Treadmill exercise attenuates 3,4-methylenedioxymethamphetamine-induced memory impairment through a decrease apoptosis in male rat hippocampus. Journal of neuroscience research. vol 95. issue 12. 2018-06-08. PMID:28493333. |
3,4-methylenedioxymethamphetamine (mdma) leads to apoptosis in the hippocampus with consequent induction of learning and memory impairment. |
2018-06-08 |
2023-08-13 |
rat |