| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Zeng, Yunyun Shen, Ling Hong, Yanfeng Chen, Xiaofang Shi, Qunli Zeng, Peilin Y. Effects of Single and Repeated Exposure to a 50-Hz 2-mT Electromagnetic Field on Primary Cultured Hippocampal Neurons. Neuroscience bulletin. vol 33. issue 3. 2018-03-09. PMID:28265899. |
moreover, none of the repeated exposure patterns had significant effects on dna damage, apoptosis, or autophagy, which suggested that elf-mf exposure has no severe biological consequences in cultured hippocampal neurons. |
2018-03-09 |
2023-08-13 |
Not clear |
| Weidong Huang, Facai Meng, Jie Cao, Xiaobin Liu, Jie Zhang, Min L. Neuroprotective Role of Exogenous Brain-Derived Neurotrophic Factor in Hypoxia-Hypoglycemia-Induced Hippocampal Neuron Injury via Regulating Trkb/MiR134 Signaling. Journal of molecular neuroscience : MN. vol 62. issue 1. 2018-03-06. PMID:28343294. |
we found that bdnf, p-trkb, and mir-134 expression levels decreased, and that exogenous bdnf increased survival and reduced apoptosis in hypoxic-hypoglycemic hippocampal neurons. |
2018-03-06 |
2023-08-13 |
Not clear |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal bdnf and mrna expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. |
2018-02-26 |
2023-08-13 |
rat |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
we also examined alternations in hippocampal brain-derived neurotrophic factor (bdnf) and mrna expression of apoptosis - related proteins in a rat model of ptsd: the single prolonged stress (sps) model. |
2018-02-26 |
2023-08-13 |
rat |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
sps rats also showed reduced hippocampal bdnf and enhanced apoptosis. |
2018-02-26 |
2023-08-13 |
rat |
| Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pou. Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-traumatic stress disorder. Neurobiology of learning and memory. vol 139. 2018-02-26. PMID:28137660. |
moderate treadmill exercise, fluoxetine and the combined treatment alleviated the sps-induced alterations in terms of anxiety levels, hpa axis inhibition, ia conditioning and extinction, hippocampal bdnf and apoptosis markers. |
2018-02-26 |
2023-08-13 |
rat |
| Yujiao Lu, Yan Dong, Donovan Tucker, Ruimin Wang, Mohammad Ejaz Ahmed, Darrell Brann, Quanguang Zhan. Treadmill Exercise Exerts Neuroprotection and Regulates Microglial Polarization and Oxidative Stress in a Streptozotocin-Induced Rat Model of Sporadic Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 56. issue 4. 2018-02-23. PMID:28157094. |
finally, treadmill exercise strongly attenuated stz-induced mitochondrial dysfunction manifested by a dramatically elevated intra-mitochondrial cytochrome c oxidase activity and atp synthesis, and markedly inhibited neuronal apoptosis in the hippocampus. |
2018-02-23 |
2023-08-13 |
rat |
| Alireza Ebrahimzadeh Bideskan, Abbas Mohammadipour, Alireza Fazel, Hossein Haghir, Houshang Rafatpanah, Mahmoud Hosseini, Aliakbar Rajabzade. Maternal exposure to titanium dioxide nanoparticles during pregnancy and lactation alters offspring hippocampal mRNA BAX and Bcl-2 levels, induces apoptosis and decreases neurogenesis. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 69. issue 6. 2018-02-22. PMID:28254502. |
maternal exposure to titanium dioxide nanoparticles during pregnancy and lactation alters offspring hippocampal mrna bax and bcl-2 levels, induces apoptosis and decreases neurogenesis. |
2018-02-22 |
2023-08-13 |
Not clear |
| Dmitriy A Lanshakov, Ekaterina V Sukhareva, Tatjana S Kalinina, Nikolay N Dygal. Dexamethasone-induced acute excitotoxic cell death in the developing brain. Neurobiology of disease. vol 91. 2018-02-20. PMID:26873551. |
in agreement with this suggestion, low-dose dex treatment (0.2mg/kg) failed to induce apoptosis in the cortex or hippocampus proper of neonatal rats. |
2018-02-20 |
2023-08-13 |
rat |
| Alkisti Mikrogeorgiou, Yoshiaki Sato, Taiki Kondo, Tetsuo Hattori, Yuichiro Sugiyama, Miharu Ito, Akiko Saito, Keiko Nakanishi, Masahiro Tsuji, Tomohiko Kazama, Koichiro Kano, Taro Matsumoto, Masahiro Hayakaw. Dedifferentiated Fat Cells as a Novel Source for Cell Therapy to Target Neonatal Hypoxic-Ischemic Encephalopathy. Developmental neuroscience. vol 39. issue 1-4. 2018-02-13. PMID:28273662. |
the number of cells that stained positive for the apoptosis marker active caspase-3 decreased by 73 and 52% in the hippocampus and temporal cortex areas of the brain, respectively, in the dfat-treated pups. |
2018-02-13 |
2023-08-13 |
rat |
| Ling-Yu Yang, Nigel H Greig, Ya-Ni Huang, Tsung-Hsun Hsieh, David Tweedie, Qian-Sheng Yu, Barry J Hoffer, Yu Luo, Yu-Chieh Kao, Jia-Yi Wan. Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury. Neurobiology of disease. vol 96. 2018-02-09. PMID:27553877. |
neuronal apoptosis in the hippocampus has been detected after tbi. |
2018-02-09 |
2023-08-13 |
rat |
| Ling-Yu Yang, Nigel H Greig, Ya-Ni Huang, Tsung-Hsun Hsieh, David Tweedie, Qian-Sheng Yu, Barry J Hoffer, Yu Luo, Yu-Chieh Kao, Jia-Yi Wan. Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury. Neurobiology of disease. vol 96. 2018-02-09. PMID:27553877. |
to investigate whether p53-dependent apoptosis plays a role in hippocampal neuronal loss and associated cognitive deficits and to define underlying mechanisms, sd rats were subjected to experimental cci tbi followed by the administration of pft-α or pft-α (o) (2mg/kg, i.v.) |
2018-02-09 |
2023-08-13 |
rat |
| Majid Motaghinejad, Manijeh Motevalian, Fatemeh Babalouei, Mohammad Abdollahi, Mansour Heidari, Zahra Madj. Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: Molecular, biochemical and histological evidences. Brain research bulletin. vol 132. 2018-02-09. PMID:28552672. |
possible involvement of creb/bdnf signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: molecular, biochemical and histological evidences. |
2018-02-09 |
2023-08-13 |
rat |
| Xianjuan Kou, Xingran Liu, Xianbing Chen, Jie Li, Xiaoqi Yang, Jingjing Fan, Yi Yang, Ning Che. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway. Oncotarget. vol 7. issue 46. 2018-02-08. PMID:27780933. |
dhm supplementation inhibited d-gal-induced apoptosis and rescued impaired autophagy of neurons in hippocampus tissue. |
2018-02-08 |
2023-08-13 |
rat |
| Bing Li, Rui Chen, Ling Chen, Pingming Qiu, Xiuyun Ai, Enping Huang, Weiye Huang, Chuanxiang Chen, Chao Liu, Zhoumeng Lin, Wei-Bing Xie, Huijun Wan. Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26873849. |
our results showed that meth exposure increased ddit4 expression that was accompanied with increased autophagy and apoptosis in pc12 cells (3 mm) and sh-sy5y cells (2 mm), and in the hippocampus, prefrontal cortex, and striatum of rats. |
2018-02-07 |
2023-08-13 |
human |
| Thais C Vilela, Giselli Scaini, Camila B Furlanetto, Matheus A B Pasquali, João Paulo A Santos, Daniel P Gelain, José Cláudio F Moreira, Patrícia F Schuck, Gustavo C Ferreira, Emilio L Strec. Apoptotic signaling pathways induced by acute administration of branched-chain amino acids in an animal model of maple syrup urine disease. Metabolic brain disease. vol 32. issue 1. 2018-01-31. PMID:27510712. |
on the other hand, acute administration of bcaa in 30-day-old rats increase in bax/bcl-2 ratio followed by an increased caspase-3 activity in cerebral cortex, whereas bcaa induces apoptosis in hippocampus through activation and cleavage of caspase-3 and -8 without changing the bax/bcl-2 ratio. |
2018-01-31 |
2023-08-13 |
rat |
| Thais C Vilela, Giselli Scaini, Camila B Furlanetto, Matheus A B Pasquali, João Paulo A Santos, Daniel P Gelain, José Cláudio F Moreira, Patrícia F Schuck, Gustavo C Ferreira, Emilio L Strec. Apoptotic signaling pathways induced by acute administration of branched-chain amino acids in an animal model of maple syrup urine disease. Metabolic brain disease. vol 32. issue 1. 2018-01-31. PMID:27510712. |
in addition, the current studies also suggest that multiple mechanisms may be involved in bcaa-induced apoptosis in the cerebral cortex and hippocampus. |
2018-01-31 |
2023-08-13 |
rat |
| S L Zup, N S Edwards, M M McCarth. Sex- and age-dependent effects of androgens on glutamate-induced cell death and intracellular calcium regulation in the developing hippocampus. Neuroscience. vol 281. 2018-01-26. PMID:25264034. |
we observed that glutamate did not induce robust or sexually dimorphic apoptosis in cultured hippocampal neurons at an early neonatal time point, but did 5days later - only in males. |
2018-01-26 |
2023-08-13 |
Not clear |
| S L Zup, N S Edwards, M M McCarth. Sex- and age-dependent effects of androgens on glutamate-induced cell death and intracellular calcium regulation in the developing hippocampus. Neuroscience. vol 281. 2018-01-26. PMID:25264034. |
taken together, these data suggest a complex interaction of sex, hormones, calcium regulation and developmental age; however androgens acting during the first week of life are implicated in regulation of hippocampal cell death and may be an underlying mechanism for sexually dimorphic apoptosis. |
2018-01-26 |
2023-08-13 |
Not clear |
| Subhash Dwivedi, N Rajasekar, Kashif Hanif, Chandishwar Nath, Rakesh Shukl. Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway. Molecular neurobiology. vol 53. issue 8. 2018-01-22. PMID:26433376. |
the treatment also restored nrf2 and its downstream antioxidant protein expression (gclc, ho-1) and attenuated oxidative stress (ros, nitrite, gsh), neuroinflammation (nf-κb, tnf-α, il-10), and neuronal apoptosis in the cerebral cortex and hippocampus of oka-treated rats. |
2018-01-22 |
2023-08-13 |
rat |