| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sehee Kim, Chanyang Kim, Seungjoon Par. Mdivi-1 Protects Adult Rat Hippocampal Neural Stem Cells against Palmitate-Induced Oxidative Stress and Apoptosis. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28891994. |
mdivi-1 protects adult rat hippocampal neural stem cells against palmitate-induced oxidative stress and apoptosis. |
2018-05-03 |
2023-08-13 |
human |
| Sehee Kim, Chanyang Kim, Seungjoon Par. Mdivi-1 Protects Adult Rat Hippocampal Neural Stem Cells against Palmitate-Induced Oxidative Stress and Apoptosis. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28891994. |
treatment of hippocampal nscs with mdivi-1 attenuated palmitate-induced increase in cell death and apoptosis. |
2018-05-03 |
2023-08-13 |
human |
| Biqiong Zhang, Yaodong Zhang, Tanzhen Xu, Yanyan Yin, Rongrong Huang, Yuchan Wang, Junyan Zhang, Dake Huang, Weizu L. Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro. International immunopharmacology. vol 49. 2018-05-01. PMID:28605710. |
the present results showed that chronic dex exposure significantly increased ldh release and apoptosis, decreased map2 and gr expression in hippocampal neurons. |
2018-05-01 |
2023-08-13 |
Not clear |
| Wenbo Jiang, Yingying Chen, Bai Li, Shuying Ga. DBA-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in the rat hippocampus. Molecular bioSystems. vol 13. issue 9. 2018-04-30. PMID:28731097. |
dba-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in the rat hippocampus. |
2018-04-30 |
2023-08-13 |
rat |
| Shi-Jie Zhang, Ting-Ting Xu, Lin Li, Yu-Min Xu, Zi-Ling Qu, Xin-Chen Wang, Shui-Qing Huang, Yi Luo, Na-Chuan Luo, Ping Lu, Ya-Fei Shi, Xin Yang, Qi Wan. Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28521305. |
in addition, western blot results (bcl-2, bax and caspase-3) and tunel staining show that bsyz prevents neuron from apoptosis, and elevates the expression of neurotrophic factors, including nerve growth factor (ngf), postsynapticdensity 95 (psd95) and synaptophysin (syn), in both hippocampus and cortex. |
2018-04-23 |
2023-08-13 |
mouse |
| Adel Abdel-Moneim, Ahmed I Yousef, Sanaa M Abd El-Twab, Eman S Abdel Reheim, Mohamed B Ashou. Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration in rats. Metabolic brain disease. vol 32. issue 4. 2018-04-23. PMID:28573601. |
treatment of diabetic rats with gallic acid and p-coumaric acid significantly ameliorated glucose tolerance, diminished the brain oxidative stress and improved antioxidant status, declined inflammation and inhibited apoptosis in the hippocampus. |
2018-04-23 |
2023-08-13 |
rat |
| Derong Cui, Hanbing Shang, Xiaoli Zhang, Wei Jiang, Xiaofeng Ji. Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways. Scientific reports. vol 6. 2018-04-11. PMID:27273382. |
we investigated whether autophagy and p53 signaling played a role in the apoptosis of hippocampal neurons following global cerebral ischemia-reperfusion (i/r) injury, in a rat model of 8-min asphyxial cardiac arrest (ca) and resuscitation. |
2018-04-11 |
2023-08-13 |
rat |
| Juan Zhuang, Xin Wen, Yan-Qiu Zhang, Qun Shan, Zi-Feng Zhang, Gui-Hong Zheng, Shao-Hua Fan, Meng-Qiu Li, Dong-Mei Wu, Bin Hu, Jun Lu, Yuan-Lin Zhen. TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice. Brain, behavior, and immunity. vol 65. 2018-04-10. PMID:28532818. |
hippocampus-specific tdp-43 knockdown attenuated hippocampal apoptosis, restored synaptic protein levels and thus improved cognitive dysfunction in bde-47-treated mice. |
2018-04-10 |
2023-08-13 |
mouse |
| Ouafa Najyb, Sonia Do Carmo, Azadeh Alikashani, Eric Rassar. Apolipoprotein D Overexpression Protects Against Kainate-Induced Neurotoxicity in Mice. Molecular neurobiology. vol 54. issue 6. 2018-04-09. PMID:27271124. |
our results show that apod overexpression in h-apod tg mice induces an increased resistance to ka-induced seizures, significantly attenuates inflammatory responses and confers protection against ka-induced cell apoptosis in the hippocampus. |
2018-04-09 |
2023-08-13 |
mouse |
| Qiang Niu, Jingwen Chen, Tao Xia, Pei Li, Guoyu Zhou, Chunyan Xu, Qian Zhao, Lixin Dong, Shun Zhang, Aiguo Wan. Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity. Environmental pollution (Barking, Essex : 1987). vol 233. 2018-04-06. PMID:29100748. |
moreover, naf exposure induced excessive er stress and associated apoptosis, as manifested by elevated ire1α, grp78, cleaved caspase-12 and cleaved-caspase-3, as well as defective autophagy, as shown by increased beclin1, lc3-ii and p62 expression in hippocampus. |
2018-04-06 |
2023-08-13 |
rat |
| Dengke Bao, Jingkai Wang, Xiaobin Pang, Hongliang Li. Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12) Cells. Molecules (Basel, Switzerland). vol 22. issue 7. 2018-04-05. PMID:28684704. |
furthermore, quercetin pretreatment markedly reduced the apoptosis of pc-12 cells and hippocampal neurons. |
2018-04-05 |
2023-08-13 |
rat |
| Min Cao, Tinglin Pu, Linmei Wang, Charles Marshall, Hongliang He, Gang Hu, Ming Xia. Early enriched physical environment reverses impairments of the hippocampus, but not medial prefrontal cortex, of socially-isolated mice. Brain, behavior, and immunity. vol 64. 2018-04-02. PMID:28412142. |
pathological analyses revealed that the enriched environment decreased cellular apoptosis, synaptic protein loss, myelination defect and microglial activation in the hippocampus, but not medial prefrontal cortex (mpfc) of mice housed singly. |
2018-04-02 |
2023-08-13 |
mouse |
| Shun-Chang Fang, Hang Xie, Fang Chen, Mei Hu, Yan Long, Hong-Bin Sun, Ling-Yi Kong, Hao Hong, Su-Su Tan. Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice. Neuroscience. vol 355. 2018-03-28. PMID:28499972. |
the further study showed that these treatments caused significant increase of peroxisome proliferator-activated receptors gamma and decrease of nf-κb p65 in nucleus of hippocampus and cortex, and ameliorated neuroinflammatory response as evidenced by less iba-1-positive cells and lower inflammatory mediators including il-1β, il-6 and tnf-α as well as suppressed neuronal apoptosis as indicated by decreased tunel-positive cells, increased ratio of bcl-2/bax and decreased caspase-3 activity in the hippocampus and cortex. |
2018-03-28 |
2023-08-13 |
mouse |
| Zheng Xu, Yan Lu, Jiaqiang Wang, Xiaowei Ding, Jiawei Chen, Changhong Mia. The protective effect of propofol against TNF-α-induced apoptosis was mediated via inhibiting iNOS/NO production and maintaining intracellular Ca Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-26. PMID:28499237. |
we hypothesized that propofol may attenuate tnf-α-induced apoptosis in mouse hippocampal ht22 cells and aimed to explore the underlying mechanisms. |
2018-03-26 |
2023-08-13 |
mouse |
| Hye-Won Hyun, Su-Ji Min, Ji-Eun Ki. CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus. Neuroscience research. vol 119. 2018-03-23. PMID:28153522. |
cdk5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating pka and drp1 phosphorylations in the rat hippocampus. |
2018-03-23 |
2023-08-13 |
rat |
| Cai-Ping Wang, Yun-Wei Shi, Miao Tang, Xiao-Chuan Zhang, Yun Gu, Xin-Miao Liang, Zhi-Wei Wang, Fei Din. Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats. Molecular neurobiology. vol 54. issue 3. 2018-03-14. PMID:26924319. |
in addition, isoquercetin also effectively alleviated hippocampus neuron apoptosis by regulation of cyclic amp responsive element-binding protein (creb), bax, bcl-2, and caspase-3. |
2018-03-14 |
2023-08-13 |
rat |
| Mehmet Cemal Kahya, Mustafa Nazıroğlu, İshak Suat Öve. Modulation of Diabetes-Induced Oxidative Stress, Apoptosis, and Ca Molecular neurobiology. vol 54. issue 3. 2018-03-14. PMID:26957303. |
modulation of diabetes-induced oxidative stress, apoptosis, and ca neuropathic pain and hippocampal injury can arise from the overload of diabetes-induced calcium ion (ca |
2018-03-14 |
2023-08-13 |
Not clear |
| Liang Zhou, Jie Zhang, Chao Wang, Qiangsan Su. Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model. International journal of immunopathology and pharmacology. vol 30. issue 2. 2018-03-12. PMID:28402151. |
after pretreatment with tsn, cerebral infarct volume, cerebral edema, and neurological deficits score were evaluated, as well as cell apoptosis in hippocampus and cortex of the brain was examined with terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) and the levels of interleukin-6 (il-6), tumor necrosis factor-α (tnf-α), and c-reactive protein (crp) were determined by enzyme-linked immunosorbent assay (elisa). |
2018-03-12 |
2023-08-13 |
rat |
| Liang Zhou, Jie Zhang, Chao Wang, Qiangsan Su. Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model. International journal of immunopathology and pharmacology. vol 30. issue 2. 2018-03-12. PMID:28402151. |
cell apoptosis as well as the levels of il-6, tnf-α, and crp in hippocampus and cortex of cerebral infarction rat were inhibited after pretreatment with tsn ( p < 0.05). |
2018-03-12 |
2023-08-13 |
rat |
| Ying Zeng, Yunyun Shen, Ling Hong, Yanfeng Chen, Xiaofang Shi, Qunli Zeng, Peilin Y. Effects of Single and Repeated Exposure to a 50-Hz 2-mT Electromagnetic Field on Primary Cultured Hippocampal Neurons. Neuroscience bulletin. vol 33. issue 3. 2018-03-09. PMID:28265899. |
here, we evaluated the biological effects of different patterns of elf-mf exposure on primary cultured hippocampal neurons in terms of viability, apoptosis, genomic instability, and oxidative stress. |
2018-03-09 |
2023-08-13 |
Not clear |