| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tae-Woon Kim, Hye-Sang Par. Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother. Behavioural brain research. vol 347. 2018-11-13. PMID:29551732. |
the result showed that deficits in spatial learning and memory, and short-term memory in male offspring born to obese mothers was associated with decreases in brain-derived neurotrophic factor (bdnf) levels and neurogenesis, and an increase in apoptosis in the hippocampal dentate gyrus. |
2018-11-13 |
2023-08-13 |
rat |
| Tae-Woon Kim, Hye-Sang Par. Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother. Behavioural brain research. vol 347. 2018-11-13. PMID:29551732. |
physical exercise improved spatial learning and memory, and short-term memory by enhancing bdnf levels and neurogenesis, and by inhibiting apoptosis in the hippocampal dentate gyrus of male offspring born to obese mothers. |
2018-11-13 |
2023-08-13 |
rat |
| Li Chen, Kuan Huang, Rong Wang, Qiong Jiang, Zhenghua Wu, Weidong Liang, Rui Guo, Lifeng Wan. Neuroprotective Effects of Cerebral Ischemic Preconditioning in a Rat Middle Cerebral Artery Occlusion Model: The Role of the Notch Signaling Pathway. BioMed research international. vol 2018. 2018-11-12. PMID:30175143. |
in in vivo experiments, cipc reduces the neurological functional deficit, cerebral infarction, and cellular apoptosis in the hippocampus induced by middle cerebral artery occlusion/reperfusion (mcao/r), thus indicating that cipc can improve neurologic function. |
2018-11-12 |
2023-08-13 |
rat |
| Xiaofeng Ou, Yusi Hua, Xuelian Liao, Cansheng Gong, Yan Kan. Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30066867. |
proteins associated with apoptosis and necroptosis in the hippocampal tissues of sap rats, including caspase‑3, receptor‑interacting protein kinase (rip)1 and rip3, were detected via western blotting. |
2018-11-08 |
2023-08-13 |
rat |
| Xiaofeng Ou, Yusi Hua, Xuelian Liao, Cansheng Gong, Yan Kan. Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30066867. |
the expression levels of tnf‑α, il‑1β, caspase‑3, rip1 and rip3 were significantly increased in the hippocampal tissues of sap rats, thus suggesting that neuroinflammation, apoptosis and necroptosis may be involved in neurodegeneration associated with the development of sap. |
2018-11-08 |
2023-08-13 |
rat |
| Xiaofeng Ou, Yusi Hua, Xuelian Liao, Cansheng Gong, Yan Kan. Cognitive impairments induced by severe acute pancreatitis are attenuated by berberine treatment in rats. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30066867. |
the results of the present study demonstrated that daily treatment with berberine may attenuate cognitive deficits and reduce associated mortality via exhibition of anti‑neuroinflammatory effects and attenuation of neuronal apoptosis and necroptosis in the hippocampal tissues of sap rats. |
2018-11-08 |
2023-08-13 |
rat |
| Lei Wang, Zi Wang, Jiandang Shi, Qian Jiang, Hong Wang, Xu Li, Di Ha. Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates neuronal apoptosis following focal cerebral ischemia via apolipoprotein E receptor 2 downregulation in hyperlipidemic mice. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30066942. |
these protective effects of pcsk9 shrna interference were associated with decreased neuronal apoptosis and a reduced level of apoer2 expression in the hippocampus and cortex. |
2018-11-08 |
2023-08-13 |
mouse |
| b' Kamila Siedlecka-Kroplewska, Agata Wro\\xc5\\x84ska, Grzegorz Stasi\\xc5\\x82oj\\xc4\\x87, Zbigniew Kmie\\xc4\\x8. The Designer Drug 3-Fluoromethcathinone Induces Oxidative Stress and Activates Autophagy in HT22 Neuronal Cells. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29656349.' |
the aim of this study was to investigate whether 3-fluoromethcathinone (3-fmc), a synthetic cathinone, is able to induce oxidative stress, autophagy, and apoptosis in ht22 immortalized mouse hippocampal cells. |
2018-11-06 |
2023-08-13 |
mouse |
| Carolyne Lespay-Rebolledo, Ronald Perez-Lobos, Andrea Tapia-Bustos, Valentina Vio, Paola Morales, Mario Herrera-Marschit. Regionally Impaired Redox Homeostasis in the Brain of Rats Subjected to Global Perinatal Asphyxia: Sustained Effect up to 14 Postnatal Days. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29959728. |
brain samples (mesencephalon, telencephalon and hippocampus) were assayed for glutathione (reduced and oxidated levels; spectrophotometry), tissue reducing capacity (potassium ferricyanide reducing assay, frap), catalase (the key enzyme protecting against oxidative stress and reactive oxygen species, western blots and elisa) and cleaved caspase-3 (the key executioner of apoptosis, western blots) levels. |
2018-11-06 |
2023-08-13 |
rat |
| Marina A Gruden, Alexander M Ratmirov, Zinaida I Storozheva, Olga A Solovieva, Vladimir V Sherstnev, Robert D E Sewel. The Neurogenesis Actuator and NR2B/NMDA Receptor Antagonist Ro25-6981 Consistently Improves Spatial Memory Retraining Via Brain Region-Specific Gene Expression. Journal of molecular neuroscience : MN. vol 65. issue 2. 2018-11-05. PMID:29790100. |
the expression of three genes known to regulate cell proliferation (s100a6), differentiation (ascl1), and apoptosis (casp-3) were concomitantly evaluated in the hippocampus, prefrontal cortex, and cerebellum in relation to the mwm performance protocol. |
2018-11-05 |
2023-08-13 |
rat |
| Qiang Wu, Xuewei Y. Down-regulation of Long Noncoding RNA MALAT1 Protects Hippocampal Neurons Against Excessive Autophagy and Apoptosis via the PI3K/Akt Signaling Pathway in Rats with Epilepsy. Journal of molecular neuroscience : MN. vol 65. issue 2. 2018-11-05. PMID:29858824. |
down-regulation of long noncoding rna malat1 protects hippocampal neurons against excessive autophagy and apoptosis via the pi3k/akt signaling pathway in rats with epilepsy. |
2018-11-05 |
2023-08-13 |
rat |
| Qiang Wu, Xuewei Y. Down-regulation of Long Noncoding RNA MALAT1 Protects Hippocampal Neurons Against Excessive Autophagy and Apoptosis via the PI3K/Akt Signaling Pathway in Rats with Epilepsy. Journal of molecular neuroscience : MN. vol 65. issue 2. 2018-11-05. PMID:29858824. |
in this study, we explore the ability of long noncoding rna (lncrna) metastasis-associated lung adenocarcinoma transcript 1 (malat1) to influence the autophagy and apoptosis of hippocampal neurons in epilepsy and the underlying mechanism involving the pi3k/akt signaling pathway. |
2018-11-05 |
2023-08-13 |
rat |
| Qiang Wu, Xuewei Y. Down-regulation of Long Noncoding RNA MALAT1 Protects Hippocampal Neurons Against Excessive Autophagy and Apoptosis via the PI3K/Akt Signaling Pathway in Rats with Epilepsy. Journal of molecular neuroscience : MN. vol 65. issue 2. 2018-11-05. PMID:29858824. |
the autophagy of hippocampal neurons was evaluated under a transmission electron microscope and their apoptosis was evaluated using tunel staining. |
2018-11-05 |
2023-08-13 |
rat |
| Qiang Wu, Xuewei Y. Down-regulation of Long Noncoding RNA MALAT1 Protects Hippocampal Neurons Against Excessive Autophagy and Apoptosis via the PI3K/Akt Signaling Pathway in Rats with Epilepsy. Journal of molecular neuroscience : MN. vol 65. issue 2. 2018-11-05. PMID:29858824. |
taken together, these findings indicate that down-regulation of malat1 activates the pi3k/akt signaling pathway to protect hippocampal neurons against autophagy and apoptosis in rats with epilepsy. |
2018-11-05 |
2023-08-13 |
rat |
| Xiao-Qian Guo, Yu-Ling Cao, Li Zhao, Xuan Zhang, Zhong-Rui Yan, Wei-Mei Che. p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: An in vitro study. International journal of molecular medicine. vol 42. issue 3. 2018-11-02. PMID:30035800. |
p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: an in vitro study. |
2018-11-02 |
2023-08-13 |
rat |
| Xiao-Qian Guo, Yu-Ling Cao, Li Zhao, Xuan Zhang, Zhong-Rui Yan, Wei-Mei Che. p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: An in vitro study. International journal of molecular medicine. vol 42. issue 3. 2018-11-02. PMID:30035800. |
however, ktm may also induce the apoptosis of hippocampal neurons. |
2018-11-02 |
2023-08-13 |
rat |
| Xiao-Qian Guo, Yu-Ling Cao, Li Zhao, Xuan Zhang, Zhong-Rui Yan, Wei-Mei Che. p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: An in vitro study. International journal of molecular medicine. vol 42. issue 3. 2018-11-02. PMID:30035800. |
therefore, the present study evaluated the effect of lentivirus‑mediated p38mapk gene silencing on ktm‑induced apoptosis of rat hippocampal neurons. |
2018-11-02 |
2023-08-13 |
rat |
| Xiao-Qian Guo, Yu-Ling Cao, Li Zhao, Xuan Zhang, Zhong-Rui Yan, Wei-Mei Che. p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: An in vitro study. International journal of molecular medicine. vol 42. issue 3. 2018-11-02. PMID:30035800. |
furthermore, silencing p38mapk promoted cell viability, cell cycle progression and the telomerase activity of hippocampal neurons, and inhibited the apoptosis of hippocampal neurons. |
2018-11-02 |
2023-08-13 |
rat |
| Xiao-Qian Guo, Yu-Ling Cao, Li Zhao, Xuan Zhang, Zhong-Rui Yan, Wei-Mei Che. p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: An in vitro study. International journal of molecular medicine. vol 42. issue 3. 2018-11-02. PMID:30035800. |
taken together, the results suggested an inhibitory role of lentivirus‑mediated p38mapk gene silencing on ktm‑induced apoptosis of rat hippocampal neurons. |
2018-11-02 |
2023-08-13 |
rat |
| Xiao-Qian Guo, Yu-Ling Cao, Li Zhao, Xuan Zhang, Zhong-Rui Yan, Wei-Mei Che. p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: An in vitro study. International journal of molecular medicine. vol 42. issue 3. 2018-11-02. PMID:30035800. |
thus, p38mapk gene silencing may serve as a potential target for preventing the ktm‑induced apoptosis of hippocampal neurons. |
2018-11-02 |
2023-08-13 |
rat |