| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José L Cechella, Marlon R Leite, Simone Pinton, Gilson Zeni, Cristina W Nogueir. Neuroprotective Benefits of Aerobic Exercise and Organoselenium Dietary Supplementation in Hippocampus of Old Rats. Molecular neurobiology. vol 55. issue 5. 2019-02-18. PMID:28540659. |
the results of this study demonstrate that the association of diphenyl diselenide-supplemented diet and swimming exercise increased the levels of proteins involved in neuroprotection and decreased the activation of those related to apoptosis and neuroinflammation in the hippocampus of old rats. |
2019-02-18 |
2023-08-13 |
rat |
| Yi-Ru Wang, Yi-Hui Zhang, Zhi-Yu Chen, Dong-Mei Xu, Xiang Chen, Xiao-Yan Zhang, Hai-Yan H. [Effect of Active Ingredients of Qingxin Kaiqiao Recipe on Spatial Learning and Memory Capacities, and Expressions of Bax, Bcl-2, Caspase-3, and PAPP in Hippocampus of AD Model Rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 37. issue 2. 2019-02-18. PMID:30650272. |
conclusion three active ingredients (spaonins, benzene, and polysaccharides) of qkr could improve spatial memory and learning capacities to different degrees, which might be possibly achieved by decreasing expressions of bax, caspase-3, papp in hippocampal ca1 region, elevating bcl-2 expression, and inhibiting apoptosis in hippocampus. |
2019-02-18 |
2023-08-13 |
rat |
| Chen-Yi-Yu Zhang, Min-Jie Zeng, Li-Ping Zhou, Ya-Qin Li, Fan Zhao, Zhi-Yuan Shang, Xue-Yang Deng, Zhan-Qiang Ma, Qiang Fu, Shi-Ping Ma, Rong Q. Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression. International immunopharmacology. vol 64. 2019-02-15. PMID:30195108. |
finally, administration of ba significantly decreased cums-induced apoptosis and inflammatory cytokines (caspase-1 and il-1β) in hippocampus. |
2019-02-15 |
2023-08-13 |
rat |
| Xiaowei Huang, Yanfang Liang, Yan Qing, Dan Chen, Nian Sh. Proteasome inhibition by MG-132 protects against deltamethrin-induced apoptosis in rat hippocampus. Life sciences. vol 220. 2019-02-15. PMID:30695709. |
proteasome inhibition by mg-132 protects against deltamethrin-induced apoptosis in rat hippocampus. |
2019-02-15 |
2023-08-13 |
rat |
| Liying Lv, Jinping Liu, Zunshu Du, Yizhi Song, Hui Li, Xue Li, Lirong Chang, Yan W. Expression alterations of apoptosis repressor with caspase recruitment domain in Aβ25-35-induced hippocampal neurotoxicity. Neuroreport. vol 30. issue 1. 2019-02-13. PMID:30395005. |
expression alterations of apoptosis repressor with caspase recruitment domain in aβ25-35-induced hippocampal neurotoxicity. |
2019-02-13 |
2023-08-13 |
Not clear |
| Zhijian Wang, Shengbing Liu, Weiwei Pan, Yanjun Guo, Zhongfei She. Bafilomycin A1 alleviates depression‑like symptoms in chronic unpredictable mild stress rats. Molecular medicine reports. vol 18. issue 5. 2019-02-12. PMID:30221667. |
the present study demonstrated that bafilomycin a1 resulted in antidepressant effects in rats, which may be mediated by the reversal of apoptosis, autophagy and neuroinflammation in the hippocampus. |
2019-02-12 |
2023-08-13 |
rat |
| Fei-Juan Kong, Lei-Lei Ma, Jun-Jie Guo, Lin-Hao Xu, Yun Li, Shen Q. Endoplasmic reticulum stress/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice. Clinical science (London, England : 1979). vol 132. issue 1. 2019-02-11. PMID:29212786. |
here, a streptozotocin-induced diabetic mouse model and primary cultured mouse hippocampal neurons were employed to investigate the possible role of er stress and autophagy in diabetes-induced neuronal apoptosis and cognitive impairments, and further explore the potential molecular mechanisms. |
2019-02-11 |
2023-08-13 |
mouse |
| Wei Yang, Qi X. Hippocampal Apoptosis and Cognitive Function in Dysbindin-1B Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 39. issue 3. 2019-02-08. PMID:28695798. |
hippocampal apoptosis and cognitive function in dysbindin-1b objective to explore the apoptosis in the hippocampus of dysbindin-1b |
2019-02-08 |
2023-08-13 |
Not clear |
| Kemal Ertilav, Fuat Uslusoy, Serdar Ataizi, Mustafa Nazıroğl. Long term exposure to cell phone frequencies (900 and 1800 MHz) induces apoptosis, mitochondrial oxidative stress and TRPV1 channel activation in the hippocampus and dorsal root ganglion of rats. Metabolic brain disease. vol 33. issue 3. 2019-02-05. PMID:29332300. |
long term exposure to cell phone frequencies (900 and 1800 mhz) induces apoptosis, mitochondrial oxidative stress and trpv1 channel activation in the hippocampus and dorsal root ganglion of rats. |
2019-02-05 |
2023-08-13 |
rat |
| Farideh Baghishani, Abbas Mohammadipour, Hossain Hosseinzadeh, Mahmoud Hosseini, Alireza Ebrahimzadeh-Bideska. The effects of tramadol administration on hippocampal cell apoptosis, learning and memory in adult rats and neuroprotective effects of crocin. Metabolic brain disease. vol 33. issue 3. 2019-02-05. PMID:29470767. |
the effects of tramadol administration on hippocampal cell apoptosis, learning and memory in adult rats and neuroprotective effects of crocin. |
2019-02-05 |
2023-08-13 |
rat |
| Qing Zhou, Suiqiang Zhu, Yuchen Guo, Lifei Lian, Qi Hu, Xiaoyan Liu, Feng Xu, Na Zhang, Huicong Kan. Adenosine A1 Receptors Play an Important Protective Role Against Cognitive Impairment and Long-Term Potentiation Inhibition in a Pentylenetetrazol Mouse Model of Epilepsy. Molecular neurobiology. vol 55. issue 4. 2019-02-04. PMID:28492982. |
to reveal the mechanisms underlying these effects, neuronal loss, cell apoptosis, and relevant synaptic protein levels in hippocampus were assessed. |
2019-02-04 |
2023-08-13 |
mouse |
| Tahir Ali, Taehyun Kim, Shafiq Ur Rehman, Muhammad Sohail Khan, Faiz Ul Amin, Mehtab Khan, Muhammad Ikram, Myeong Ok Ki. Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29170981. |
both in vivo (app/ps1 mice) and in vitro (mouse hippocampal ht22 cells) results demonstrated that anthocyanins regulate the phosphorylated-phosphatidylinositol 3-kinase-akt-glycogen synthase kinase 3 beta (p-pi3k/akt/gsk3β) pathways and consequently attenuate amyloid beta oligomer (aβo)-induced elevations in ros level and oxidative stress via stimulating the master endogenous anti-oxidant system of nuclear factor erythroid 2-related factor 2 (nrf2) and heme oxygenase-1 (nrf2/ho-1) pathways and prevent apoptosis and neurodegeneration by suppressing the apoptotic and neurodegenerative markers such as activation of caspase-3 and parp-1 expression as well as the tunel and fluoro-jade b-positive neuronal cells in the app/ps1 mice. |
2019-02-04 |
2023-08-13 |
mouse |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
we found that this esi-induced loss of hippocampal microglia was mediated by both microglial activation and apoptosis. |
2019-02-04 |
2023-08-13 |
mouse |
| Yu Gong, Lijuan Tong, Rongrong Yang, Wenfeng Hu, Xingguo Xu, Wenjing Wang, Peng Wang, Xu Lu, Minhui Gao, Yue Wu, Xing Xu, Yaru Zhang, Zhuo Chen, Chao Huan. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation. Neuropharmacology. vol 135. 2019-02-04. PMID:29574097. |
this was demonstrated by the following results: (i) 1 day of esi induced an obvious activation of hippocampal microglia followed by their apoptosis, and (ii) the blockade of the initial activation of hippocampal microglia by minocycline pretreatment suppressed the esi-induced apoptosis and loss as well as esi-induced depressive-like behavior. |
2019-02-04 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. |
2019-01-31 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
a high-fat diet induces obesity in mice, leading to insulin resistance, decreased mitochondrial function, and increased apoptosis in the hippocampus, which eventually result in memory loss. |
2019-01-31 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
the present study investigated the effect of physical exercise on memory, hippocampal mitochondrial function, and apoptosis in mice with in insulin resistance caused by obesity due to high-fat diet. |
2019-01-31 |
2023-08-13 |
mouse |
| Hye-Sang Park, Han-Sam Cho, Tae-Woon Ki. Physical exercise promotes memory capability by enhancing hippocampal mitochondrial functions and inhibiting apoptosis in obesity-induced insulin resistance by high fat diet. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29185193. |
mitochondrial function and apoptosis were also examined in the hippocampus and dentate gyrus. |
2019-01-31 |
2023-08-13 |
mouse |
| Fateme Ghanbari, Mehdi Khaksari, Golamhassan Vaezi, Vida Hojati, Abdolhossein Shirav. Hydrogen Sulfide Protects Hippocampal Neurons Against Methamphetamine Neurotoxicity Via Inhibition of Apoptosis and Neuroinflammation. Journal of molecular neuroscience : MN. vol 67. issue 1. 2019-01-31. PMID:30456731. |
hydrogen sulfide protects hippocampal neurons against methamphetamine neurotoxicity via inhibition of apoptosis and neuroinflammation. |
2019-01-31 |
2023-08-13 |
Not clear |
| Xuze Li, Zhifang Zhao, Lining Huang, Rongtian Kang, Xuefang Liu, Zhenming Don. The anti-apoptotic effect of nerve growth factor on propofol-induced neurotoxicity in hippocampal neurons is Rac1 dependent. Die Pharmazie. vol 73. issue 12. 2019-01-31. PMID:30522553. |
in the present study, we found that ngf alleviated the apoptosis induced by propofol in hippocampal neurons. |
2019-01-31 |
2023-08-13 |
Not clear |