| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hein Min Latt, Hiroaki Matsushita, Miku Morino, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Kazuhito Tomizawa, Hideki Matsu. Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons. Neuroscience. vol 379. 2019-03-18. PMID:29596965. |
ot was unable to protect primary hippocampal neurons prepared from otr ko mice from cort-induced apoptosis. |
2019-03-18 |
2023-08-13 |
mouse |
| Hong Zhou, Hua Tan, Lucien Letourneau, Jun-Feng Wan. Increased thioredoxin-interacting protein in brain of mice exposed to chronic stress. Progress in neuro-psychopharmacology & biological psychiatry. vol 88. 2019-03-18. PMID:30138646. |
cus also increased protein cysteine sulfenylation, protein cysteine nitrosylation and apoptosis signal-regulating kinase 1 phosphorylation in mouse hippocampus and frontal cortex. |
2019-03-18 |
2023-08-13 |
mouse |
| Xian Wu, Yang-Ge Lv, Yi-Feng Du, Mei Hu, Miranda N Reed, Yan Long, Vishnu Suppiramaniam, Hao Hong, Su-Su Tan. Inhibitory effect of INT-777 on lipopolysaccharide-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 88. 2019-03-18. PMID:30144494. |
in addition, int-777 treatment also suppressed neuronal apoptosis, as indicated by the reduction of tunel-positive cells, decreased activation of caspase-3, increased the ratio of bcl-2/bax, and ameliorated synaptic dysfunction as evidenced by the upregulation of psd95 and synaptophysin in the hippocampus and frontal cortex. |
2019-03-18 |
2023-08-13 |
mouse |
| Jin-Tao Liu, Sheng-Xi Wu, Hua Zhang, Fang Kuan. Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 15. issue 4. 2019-03-12. PMID:30112701. |
inhibition of myd88 signaling skews microglia/macrophage polarization and attenuates neuronal apoptosis in the hippocampus after status epilepticus in mice. |
2019-03-12 |
2023-08-13 |
mouse |
| Jin-Tao Liu, Sheng-Xi Wu, Hua Zhang, Fang Kuan. Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 15. issue 4. 2019-03-12. PMID:30112701. |
myd88 inhibition also augmented glutamate transporter 1 expression and reduced n-methyl-d-aspartate receptor nr1 subunit expression in the hippocampus to protect pyramidal neurons from apoptosis. |
2019-03-12 |
2023-08-13 |
mouse |
| Sufang Jiang, Xuze Li, Wei Jin, Xiaofeng Duan, Lijun Bo, Jiangli Wu, Rui Zhang, Ying Wang, Rongtian Kang, Lining Huan. Ketamine-induced neurotoxicity blocked by N-Methyl-d-aspartate is mediated through activation of PKC/ERK pathway in developing hippocampal neurons. Neuroscience letters. vol 673. 2019-03-11. PMID:29501685. |
on the other hand, ketamine administration alters early and late apoptosis of cultured hippocampus neurons by inhibiting pkc/erk pathway, whereas excitatory nmda receptor activation reverses these effects. |
2019-03-11 |
2023-08-13 |
Not clear |
| Xiaolong Wang, Hao Yu, Jiabin You, Changliang Wang, Chunmei Feng, Zhaodi Liu, Ya Li, Rucheng Wei, Siqi Xu, Rui Zhao, Xu Wu, Guohua Zhan. Memantine can improve chronic ethanol exposure-induced spatial memory impairment in male C57BL/6 mice by reducing hippocampal apoptosis. Toxicology. vol 406-407. 2019-03-11. PMID:29800586. |
memantine can improve chronic ethanol exposure-induced spatial memory impairment in male c57bl/6 mice by reducing hippocampal apoptosis. |
2019-03-11 |
2023-08-13 |
mouse |
| Xiaolong Wang, Hao Yu, Jiabin You, Changliang Wang, Chunmei Feng, Zhaodi Liu, Ya Li, Rucheng Wei, Siqi Xu, Rui Zhao, Xu Wu, Guohua Zhan. Memantine can improve chronic ethanol exposure-induced spatial memory impairment in male C57BL/6 mice by reducing hippocampal apoptosis. Toxicology. vol 406-407. 2019-03-11. PMID:29800586. |
the results revealed that chronic ethanol exposure induced spatial memory impairment in mice, as well as increasing the expression of nr1, ip3r1 and serca1, the activation of caspase-3 and apoptosis in hippocampus. |
2019-03-11 |
2023-08-13 |
mouse |
| Xiaolong Wang, Hao Yu, Jiabin You, Changliang Wang, Chunmei Feng, Zhaodi Liu, Ya Li, Rucheng Wei, Siqi Xu, Rui Zhao, Xu Wu, Guohua Zhan. Memantine can improve chronic ethanol exposure-induced spatial memory impairment in male C57BL/6 mice by reducing hippocampal apoptosis. Toxicology. vol 406-407. 2019-03-11. PMID:29800586. |
memantine decreased ethanol-induced spatial memory impairment, caspase-3 activation and apoptosis in the mouse hippocampus. |
2019-03-11 |
2023-08-13 |
mouse |
| Lin Zhao, Huicong Ren, Shina Gu, Xiaodan Li, Cuihong Jiang, Juan Li, Mengmeng Zhang, Junlin Mu, Wenqiang Li, Wensheng Wang, Zhaohui Zhang, Jinggui Son. rTMS ameliorated depressive-like behaviors by restoring HPA axis balance and prohibiting hippocampal neuron apoptosis in a rat model of depression. Psychiatry research. vol 269. 2019-03-11. PMID:30145293. |
rtms ameliorated depressive-like behaviors by restoring hpa axis balance and prohibiting hippocampal neuron apoptosis in a rat model of depression. |
2019-03-11 |
2023-08-13 |
rat |
| Congjie Bi, Qiuping Cai, Yangyang Shan, Fan Yang, Shiwei Sun, Xiuying Wu, Hongtao Li. Sevoflurane induces neurotoxicity in the developing rat hippocampus by upregulating connexin 43 via the JNK/c-Jun/AP-1 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-11. PMID:30372849. |
overall, our findings suggested that sevoflurane increased cx43 expression and induced to apoptosis by activating the jnk/c-jun signaling pathway in the hippocampus of p7 rats. |
2019-03-11 |
2023-08-13 |
rat |
| Feng Xu, Rongji Ma, Guixing Zhang, Sheng Wang, Jiangwen Yin, Erqiang Wang, Erfeng Xiong, Qingtong Zhang, Yan L. Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-11. PMID:30372862. |
endoplasmic reticulum stress (ers) is vital in inducing apoptosis via caspase-12 and c/ebp homologous protein (chop) apoptotic pathway in the hippocampus after ischemia-reperfusion injury. |
2019-03-11 |
2023-08-13 |
Not clear |
| Feng Xu, Rongji Ma, Guixing Zhang, Sheng Wang, Jiangwen Yin, Erqiang Wang, Erfeng Xiong, Qingtong Zhang, Yan L. Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-11. PMID:30372862. |
the study aimed to estimate the efficacy of estrogen and propofol combination therapy against ers-induced apoptosis after cerebral ischemia-reperfusion injury and oxygen-glucose deprivation (ogd) injury in the hippocampus in vivo and in vitro. |
2019-03-11 |
2023-08-13 |
Not clear |
| Caitlin E Millett, Brett E Phillips, Erika F H Saunder. The Sex-specific Effects of LPS on Depressive-like Behavior and Oxidative Stress in the Hippocampus of the Mouse. Neuroscience. vol 399. 2019-03-11. PMID:30553795. |
we hypothesized that (1) lipopolysaccharide (lps) would induce depressive-like behavior and hippocampal oxidative stress after 1 day in males, and (2) that a single lps exposure would result in hippocampal apoptosis at 28 days. |
2019-03-11 |
2023-08-13 |
mouse |
| Alessandra Borsini, Annamaria Cattaneo, Chiara Malpighi, Sandrine Thuret, Neil A Harrison, Patricia A Zunszain, Carmine M Pariant. Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms. The international journal of neuropsychopharmacology. vol 21. issue 2. 2019-03-08. PMID:29040650. |
interferon-alpha reduces human hippocampal neurogenesis and increases apoptosis via activation of distinct stat1-dependent mechanisms. |
2019-03-08 |
2023-08-13 |
human |
| Qi Zhang, Yanan Li, Yongjuan Bao, Chunping Yin, Xi Xin, Yangyang Guo, Fang Gao, Shuping Huo, Xiuli Wang, Qiujun Wan. Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats. BMC anesthesiology. vol 18. issue 1. 2019-03-08. PMID:29661144. |
calcineurin (can) having a high expression in hippocampal neurons is closely related to apoptosis. |
2019-03-08 |
2023-08-13 |
rat |
| Qi Zhang, Yanan Li, Yongjuan Bao, Chunping Yin, Xi Xin, Yangyang Guo, Fang Gao, Shuping Huo, Xiuli Wang, Qiujun Wan. Pretreatment with nimodipine reduces incidence of POCD by decreasing calcineurin mediated hippocampal neuroapoptosis in aged rats. BMC anesthesiology. vol 18. issue 1. 2019-03-08. PMID:29661144. |
pretreatment with nimodipine can lower the apoptosis rate of hippocampal neuron to reduce the incidence of postoperative cognitive dysfunction (pocd). |
2019-03-08 |
2023-08-13 |
rat |
| Lingrong Zeng, Jianmei Gao, Yuanyuan Deng, Jingshan Shi, Qihai Gon. CZ2HF mitigates β-amyloid 25-35 fragment-induced learning and memory impairment through inhibition of neuroinflammation and apoptosis in rats. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365041. |
morris water maze test was used to determine spatial learning and memory ability in aβ25‑35‑induced ad rats and hippocampal neuronal damage and apoptosis were observed using hematoxylin and eosin staining, nissl staining and terminal deoxynucleotidyltransferase‑mediated dutp nick‑end labeling (tunel) assays, respectively. |
2019-03-05 |
2023-08-13 |
rat |
| Lingrong Zeng, Jianmei Gao, Yuanyuan Deng, Jingshan Shi, Qihai Gon. CZ2HF mitigates β-amyloid 25-35 fragment-induced learning and memory impairment through inhibition of neuroinflammation and apoptosis in rats. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365041. |
these findings suggested that cz2hf treatment improved aβ25‑35‑induced learning and memory impairment and hippocampal neuronal injury, and its underlying mechanism may be due to the inhibition of neuroinflammation and neuronal apoptosis. |
2019-03-05 |
2023-08-13 |
rat |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the pi3k/akt pathway. |
2019-03-05 |
2023-08-13 |
rat |