| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francele Valente Piazza, Ethiane Segabinazi, André Luís Ferreira de Meireles, Filipe Mega, Christiano de Figueiredo Spindler, Otávio Américo Augustin, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Maria Sol Kruse, Héctor Coirini, Simone Marcuzz. Severe Uncontrolled Maternal Hyperglycemia Induces Microsomia and Neurodevelopment Delay Accompanied by Apoptosis, Cellular Survival, and Neuroinflammatory Deregulation in Rat Offspring Hippocampus. Cellular and molecular neurobiology. vol 39. issue 3. 2019-05-06. PMID:30739252. |
severe uncontrolled maternal hyperglycemia induces microsomia and neurodevelopment delay accompanied by apoptosis, cellular survival, and neuroinflammatory deregulation in rat offspring hippocampus. |
2019-05-06 |
2023-08-13 |
rat |
| Francele Valente Piazza, Ethiane Segabinazi, André Luís Ferreira de Meireles, Filipe Mega, Christiano de Figueiredo Spindler, Otávio Américo Augustin, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Maria Sol Kruse, Héctor Coirini, Simone Marcuzz. Severe Uncontrolled Maternal Hyperglycemia Induces Microsomia and Neurodevelopment Delay Accompanied by Apoptosis, Cellular Survival, and Neuroinflammatory Deregulation in Rat Offspring Hippocampus. Cellular and molecular neurobiology. vol 39. issue 3. 2019-05-06. PMID:30739252. |
in order to elucidate the short- and long-term biological basis of the developmental outcomes caused by the severe uncontrolled maternal hyperglycemia, we studied apoptosis, neurogenesis, and neuroinflammation pathways in the hippocampus of neonates and young rats born to diabetic dams. |
2019-05-06 |
2023-08-13 |
rat |
| Francele Valente Piazza, Ethiane Segabinazi, André Luís Ferreira de Meireles, Filipe Mega, Christiano de Figueiredo Spindler, Otávio Américo Augustin, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Maria Sol Kruse, Héctor Coirini, Simone Marcuzz. Severe Uncontrolled Maternal Hyperglycemia Induces Microsomia and Neurodevelopment Delay Accompanied by Apoptosis, Cellular Survival, and Neuroinflammatory Deregulation in Rat Offspring Hippocampus. Cellular and molecular neurobiology. vol 39. issue 3. 2019-05-06. PMID:30739252. |
this study showed significant short- and long-term commitments on the development, apoptosis, cell survival, and neuroinflammation in the offspring hippocampus induced by severe uncontrolled maternal hyperglycemia. |
2019-05-06 |
2023-08-13 |
rat |
| Duangkamol Mantor, Wasana Pratchayasakul, Wanitchaya Minta, Wissuta Sutham, Siripong Palee, Jirapas Sripetchwandee, Sasiwan Kerdphoo, Thidarat Jaiwongkum, Sirawit Sriwichaiin, Warunsorn Krintratun, Nipon Chattipakorn, Siriporn C Chattipakor. Both oophorectomy and obesity impaired solely hippocampal-dependent memory via increased hippocampal dysfunction. Experimental gerontology. vol 108. 2019-05-03. PMID:29678475. |
increased hippocampal oxidative stress level, increased hippocampal apoptosis, increased hippocampal synaptic dysfunction, decreased hippocampal estrogen level and impaired hippocampal-dependent memory were observed in hfs, ndo, and hfo rats. |
2019-05-03 |
2023-08-13 |
rat |
| Michael S Hester, Natalia Tulina, Amy Brown, Guillermo Barila, Michal A Elovit. Intrauterine inflammation reduces postnatal neurogenesis in the hippocampal subgranular zone and leads to accumulation of hilar ectopic granule cells. Brain research. vol 1685. 2019-04-19. PMID:29448014. |
intrauterine inflammation had no effect on hippocampal astrocyte or microglia density or on apoptosis rate at the postnatal time points examined. |
2019-04-19 |
2023-08-13 |
mouse |
| Li-Gang Huang, Jing Zou, Qin-Chi L. Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3. Brain research. vol 1689. 2019-04-17. PMID:29191771. |
importantly, injection of an antagomir of rno-mir-155-5p in vivo resulted in a reduction of the pathophysiological features associated with the status epilepticus, which was accompanied by decrease of apoptosis in the hippocampus. |
2019-04-17 |
2023-08-13 |
rat |
| Pan Jiang, Lei Chen, Jing Sun, Jingsong Li, Jian Xu, Wenyuan Liu, Feng Feng, Wei Q. Chotosan ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia via activating the Nrf2-mediated antioxidant pathway. Journal of pharmacological sciences. vol 139. issue 2. 2019-04-17. PMID:30642751. |
furthermore, chotosan could significantly reverse reactive oxygen species production, neuronal apoptosis and microglia over-activation in hippocampus. |
2019-04-17 |
2023-08-13 |
Not clear |
| Mo Dan, Hairuo Wen, Anliang Shao, Liming X. Silver Nanoparticle Exposure Induces Neurotoxicity in the Rat Hippocampus Without Increasing the Blood-Brain Barrier Permeability. Journal of biomedical nanotechnology. vol 14. issue 7. 2019-04-16. PMID:29944106. |
ag-nps decreased c1qtnf3 expression and increased adra1d expression to affect mapk signaling pathway, which promoted inflammation and apoptosis in the hippocampus. |
2019-04-16 |
2023-08-13 |
rat |
| Huisheng Wu, Chaoliang Tang, Lydia Wai Tai, Weifeng Yao, Peipei Guo, Junmou Hong, Xin Yang, Xinyi Li, Zhao Jin, Jianjuan Ke, Yanlin Wan. Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion. Bioscience reports. vol 38. issue 4. 2019-04-15. PMID:29540536. |
global cerebral ischemia was achieved by occlusion of bilateral common carotid arteries combined with hypotension for 20 min followed by reperfusion for 72 h. then the neurological deficit score, hippocampal cell apoptosis, levels of aquaporin (aqp) 4, aqp9, intercellular cell adhesion molecule-1 (icam-1), nuclear factor-κb (nf-κb), tumor necrosis factor (tnf-α), interleukin-1 β (il-1β), thromboxane b2 (txb2), and 6-keto-pgi1α were assessed. |
2019-04-15 |
2023-08-13 |
rat |
| Mohamed A El-Missiry, Azza I Othman, Mamdouh R El-Sawy, Mohamad F Lebed. Neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced damage and apoptosis in the rat hippocampus. International journal of radiation biology. vol 94. issue 9. 2019-04-15. PMID:29939076. |
neuroprotective effect of epigallocatechin-3-gallate (egcg) on radiation-induced damage and apoptosis in the rat hippocampus. |
2019-04-15 |
2023-08-13 |
rat |
| Ruisi Tian, Shu Wan. Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway. Journal of molecular neuroscience : MN. vol 67. issue 3. 2019-04-15. PMID:30726543. |
electroacupuncture reduced apoptosis of hippocampal neurons in mice with cerebral infarction by regulating the notch3 signaling pathway. |
2019-04-15 |
2023-08-13 |
mouse |
| Ruisi Tian, Shu Wan. Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway. Journal of molecular neuroscience : MN. vol 67. issue 3. 2019-04-15. PMID:30726543. |
this study is designed to explore the effect of electric acupuncture on the apoptosis of hippocampal neurons through the notch3 signaling pathway. |
2019-04-15 |
2023-08-13 |
mouse |
| Ruisi Tian, Shu Wan. Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway. Journal of molecular neuroscience : MN. vol 67. issue 3. 2019-04-15. PMID:30726543. |
apoptosis of hippocampal neurons was identified by tunel staining and flow cytometry. |
2019-04-15 |
2023-08-13 |
mouse |
| Ruisi Tian, Shu Wan. Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway. Journal of molecular neuroscience : MN. vol 67. issue 3. 2019-04-15. PMID:30726543. |
electroacupuncture therapy reduced the cerebral infarction area in mice and decreased the apoptosis of hippocampal neurons. |
2019-04-15 |
2023-08-13 |
mouse |
| Ruisi Tian, Shu Wan. Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway. Journal of molecular neuroscience : MN. vol 67. issue 3. 2019-04-15. PMID:30726543. |
the apoptosis rate of hippocampal neurons and the area of cerebral infarction were significantly lower in the electroacupuncture group than in the mcao group (p < 0.01), while the apoptosis rate of hippocampal neurons and the area of cerebral infarction were significantly higher in the inhibitor group than in the electroacupuncture group (p < 0.01). |
2019-04-15 |
2023-08-13 |
mouse |
| Ruisi Tian, Shu Wan. Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway. Journal of molecular neuroscience : MN. vol 67. issue 3. 2019-04-15. PMID:30726543. |
the results showed that electroacupuncture inhibited the apoptosis of hippocampal neurons through the notch3 signaling pathway, while the expression levels of genes related to the notch3 signaling pathway were significantly higher in the inhibitor group than in the electroacupuncture group (p < 0.01). |
2019-04-15 |
2023-08-13 |
mouse |
| Ruisi Tian, Shu Wan. Electroacupuncture Reduced Apoptosis of Hippocampal Neurons in Mice with Cerebral Infarction by Regulating the Notch3 Signaling Pathway. Journal of molecular neuroscience : MN. vol 67. issue 3. 2019-04-15. PMID:30726543. |
electroacupuncture inhibited the apoptosis of hippocampal neurons in mice with cerebral infarction by stimulating the notch3 signaling pathway and triggering corresponding protein expression. |
2019-04-15 |
2023-08-13 |
mouse |
| Yunbo Jia, Yunhe Han, Xinyue Wang, Fang Ha. Role of apoptosis in the Post-traumatic stress disorder model-single prolonged stressed rats. Psychoneuroendocrinology. vol 95. 2019-04-10. PMID:29843020. |
recent studies, using the single prolonged stress (sps) model, an animal model of ptsd, have found that abnormal apoptosis in certain brain regions, including the hippocampus, the amygdala, and the medial prefrontal cortex (mpfc); these areas are closely associated with emotion and cognition. |
2019-04-10 |
2023-08-13 |
rat |
| Ai-Qin Qi, Yan-Hui Zhang, Qin-De Qi, Ye-Hui Liu, Jun-Ling Zh. Overexpressed HspB6 Underlines a Novel Inhibitory Role in Kainic Acid-Induced Epileptic Seizure in Rats by Activating the cAMP-PKA Pathway. Cellular and molecular neurobiology. vol 39. issue 1. 2019-04-08. PMID:30511325. |
results showed that hspb6 was poorly expressed, resulting in the inactivation of the camp-pka pathway in rats post ka, as well as an aggravated inflammatory response and hippocampal neuronal apoptosis. |
2019-04-08 |
2023-08-13 |
rat |
| Ai-Qin Qi, Yan-Hui Zhang, Qin-De Qi, Ye-Hui Liu, Jun-Ling Zh. Overexpressed HspB6 Underlines a Novel Inhibitory Role in Kainic Acid-Induced Epileptic Seizure in Rats by Activating the cAMP-PKA Pathway. Cellular and molecular neurobiology. vol 39. issue 1. 2019-04-08. PMID:30511325. |
hspb6 overexpression and the camp-pka pathway activation decreased the expression of inflammatory factors and inhibited hippocampal neuronal apoptosis. |
2019-04-08 |
2023-08-13 |
rat |