| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
it is not known whether brain‑derived neurotrophic factor (bdnf) protects hippocampal neurons from high glucose‑induced apoptosis and/or synaptic plasticity dysfunction. |
2019-03-05 |
2023-08-13 |
rat |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
the apoptosis of primary hippocampal neurons was assessed by annexin v‑fluorescein isothiocyanate/propidium iodide staining. |
2019-03-05 |
2023-08-13 |
rat |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
exposure of the hippocampal neurons to high glucose (75 mm for 72 h) resulted in cell apoptosis, decreased mrna and protein expression levels of three synaptic plasticity‑related proteins (syn, arc and cyclic amp response element‑binding protein), and changes in the cellular distribution of syn, indicating loss of synaptic density. |
2019-03-05 |
2023-08-13 |
rat |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
in conclusion, high glucose induced apoptosis and downregulated synaptic plasticity‑related proteins in hippocampal neurons. |
2019-03-05 |
2023-08-13 |
rat |
| Feng Tian, Chao Yuan, Hongmei Yu. MiR-138/SIRT1 axis is implicated in impaired learning and memory abilities of cerebral ischemia/reperfusion injured rats. Experimental cell research. vol 367. issue 2. 2019-03-04. PMID:29614311. |
inhibition of mir-138 ameliorated the impaired learning and memory abilities of rats, and promoted autophagy and thus attenuated apoptosis in the ogd/r-treated hippocampal neurons. |
2019-03-04 |
2023-08-13 |
rat |
| Catherine Fleitas, Gerard Piñol-Ripoll, Pau Marfull, Daniel Rocandio, Isidro Ferrer, Claire Rampon, Joaquim Egea, Carme Espine. proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing. Molecular brain. vol 11. issue 1. 2019-03-04. PMID:30428894. |
contrarily to bdnf, the precursor form of bdnf (probdnf) induces apoptosis through the specific interaction with p75 and its co-receptor, sortilin.we used hippocampal tissue and cerebrospinal fluid from ad patients and controls. |
2019-03-04 |
2023-08-13 |
mouse |
| Catherine Fleitas, Gerard Piñol-Ripoll, Pau Marfull, Daniel Rocandio, Isidro Ferrer, Claire Rampon, Joaquim Egea, Carme Espine. proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing. Molecular brain. vol 11. issue 1. 2019-03-04. PMID:30428894. |
the cerebrospinal fluid from ad patients, but not from controls, induces apoptosis in differentiated hippocampal neurons mainly by the action of age-modified probdnf present in the cerebrospinal fluid of the patients. |
2019-03-04 |
2023-08-13 |
mouse |
| Yushuang Li, Lei Wu, Minhua Yu, Fei Yang, Bo Wu, Shuting Lu, Mengqi Tu, Haibo X. HIF-1α is Critical for the Activation of Notch Signaling in Neurogenesis During Acute Epilepsy. Neuroscience. vol 394. 2019-03-01. PMID:30394322. |
in the present study, we investigated the role of hif-1α in neurogenesis and whether notch signaling is involved in this process during epileptogenesis by assessing hippocampal apoptosis, neuronal injury, and the proliferation and differentiation of neural stem cells (nscs) in four groups, including control, epilepsy, epilepsy+2-methoxyestradiol (2me2) and epilepsy+gsi-ix (dapt) groups. |
2019-03-01 |
2023-08-13 |
Not clear |
| Fang-Zhou Chen, Ying Zhao, Hui-Zhao Che. MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice. International journal of molecular medicine. vol 43. issue 1. 2019-02-28. PMID:30365070. |
finally, hippocampal neuron viability and apoptosis were determined using an mtt assay and flow cytometry, respectively. |
2019-02-28 |
2023-08-13 |
mouse |
| Fang-Zhou Chen, Ying Zhao, Hui-Zhao Che. MicroRNA-98 reduces amyloid β-protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice. International journal of molecular medicine. vol 43. issue 1. 2019-02-28. PMID:30365070. |
mir‑98 suppressed hippocampal neuron apoptosis and promoted hippocampal neuron viability by inactivating the notch signaling pathway via the inhibition of hey2. |
2019-02-28 |
2023-08-13 |
mouse |
| Xiangyang Yu, Lili Jia, Kuoqi Yin, Jingshu Lv, Wenli Yu, Hongyin D. Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. Neuroscience. vol 391. 2019-02-27. PMID:30213765. |
hippocampal neuron apoptosis was increased, and long-term cognitive impairment was found after reperfusion of 1 month. |
2019-02-27 |
2023-08-13 |
mouse |
| Xiangyang Yu, Lili Jia, Kuoqi Yin, Jingshu Lv, Wenli Yu, Hongyin D. Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. Neuroscience. vol 391. 2019-02-27. PMID:30213765. |
inhibition of src and nr2a with pp2 and nvp-aam077 respectively not only down-regulated the levels of p-src and p-nr2a, but also ameliorated hippocampal neurons apoptosis and long-term cognitive impairment after hir. |
2019-02-27 |
2023-08-13 |
mouse |
| Bruna P P Nascimento, Barbara M L C Bocco, Gustavo W Fernandes, Tatiana L Fonseca, Elizabeth A McAninch, Carolina V Cardoso, Eduardo F Bondan, Renata J Nassif, Roberta M Cysneiros, Antonio C Bianco, Miriam O Ribeir. Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice. Endocrinology. vol 159. issue 8. 2019-02-26. PMID:29905787. |
in contrast, in mice with targeted disruption of dio2 in astrocytes (astro d2ko mouse), the highly induced genes in the hippocampus were related to inflammation, apoptosis, and cell death. |
2019-02-26 |
2023-08-13 |
mouse |
| Ahmad Salimi, Jalal Pourahma. In Vivo Analysis of Apoptosis in Embryonic Hippocampus. Methods in molecular biology (Clifton, N.J.). vol 1797. 2019-02-25. PMID:29896714. |
in vivo analysis of apoptosis in embryonic hippocampus. |
2019-02-25 |
2023-08-13 |
mouse |
| Chunxia Huang, John Man-Tak Chu, Yan Liu, Raymond Chuen-Chung Chang, Gordon Tin-Chun Won. Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. Neuropharmacology. vol 143. 2019-02-25. PMID:30273594. |
glia activation, aberrant tau phosphorylation (at8) and accumulation of phosphorylated h2ax in the hippocampus were detectable up to postoperative day 14, with neuronal apoptosis seen in the hippocampus. |
2019-02-25 |
2023-08-13 |
mouse |
| Qingping Zhao, Changyou Yin, Yuan Yuan, Hongtao Zhang, Lu Ten. Down-Regulation of Mir-145 Improves Learning and Memory Abilities in Epileptic Rats by Regulating Hippocampal Neuron Apoptosis. World neurosurgery. vol 122. 2019-02-25. PMID:30465949. |
down-regulation of mir-145 improves learning and memory abilities in epileptic rats by regulating hippocampal neuron apoptosis. |
2019-02-25 |
2023-08-13 |
rat |
| Yinghua Zhao, Hongyan Li, Fang Fang, Tingting Qin, Wei Xiao, Zhenzhong Wang, Shiping M. Geniposide improves repeated restraint stress-induced depression-like behavior in mice by ameliorating neuronal apoptosis via regulating GLP-1R/AKT signaling pathway. Neuroscience letters. vol 676. 2019-02-22. PMID:29626654. |
in addition, gp suppressed the neuronal apoptosis as well as reduced pro-inflammatory cytokines levels including interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α) in the hippocampus of rrs-induced mice. |
2019-02-22 |
2023-08-13 |
mouse |
| Sherif Rashad, Kuniyasu Niizuma, Daisuke Saigusa, Xiaobo Han, Mika Sato-Maeda, Ritsumi Saito, Akira Uruno, Miki Fujimura, Shuntaro Ikawa, Masayuki Yamamoto, Teiji Tominag. Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia. Neuroscience. vol 384. 2019-02-21. PMID:29782904. |
following transient global cerebral ischemia (tgci), only the ca1 subregion of the hippocampus undergoes apoptosis. |
2019-02-21 |
2023-08-13 |
rat |
| Siamak Shahidi, Sara Soleimani Asl, Alireza Komaki, Nasrin Hashemi-Firouz. The effect of chronic stimulation of serotonin receptor type 7 on recognition, passive avoidance memory, hippocampal long-term potentiation, and neuronal apoptosis in the amyloid β protein treated rat. Psychopharmacology. vol 235. issue 5. 2019-02-20. PMID:29637287. |
the effect of chronic stimulation of serotonin receptor type 7 on recognition, passive avoidance memory, hippocampal long-term potentiation, and neuronal apoptosis in the amyloid β protein treated rat. |
2019-02-20 |
2023-08-13 |
rat |
| Jayantee Kalita, Vijay Kumar, Usha K Misra, Himangsu K Bor. Memory and Learning Dysfunction Following Copper Toxicity: Biochemical and Immunohistochemical Basis. Molecular neurobiology. vol 55. issue 5. 2019-02-18. PMID:28536976. |
we report excitotoxicity, apoptosis, and astrocytic reaction of the hippocampus and frontal cortex with memory dysfunction in rat model of cu toxicity. |
2019-02-18 |
2023-08-13 |
human |