| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Zhong, Yufeng Zou, Hongchao Liu, Ting Chen, Feng Zheng, Yifei Huang, Chang Chen, Zongze Zhan. Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice. Molecular brain. vol 13. issue 1. 2021-02-12. PMID:32059688. |
in summary, our results support the tlr4 contributes to b2m-induced age-related cognitive decline due to neuroinflammation and apoptosis through tlr4/myd88/nf-κb signaling pathway via a modulation of hippocampal neurogenesis and synaptic function. |
2021-02-12 |
2023-08-13 |
mouse |
| Tae-Woon Kim, Sang-Seo Park, Joon-Young Park, Hye-Sang Par. Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice. International journal of molecular sciences. vol 21. issue 9. 2021-02-01. PMID:32384696. |
we then analyzed spatial learning and memory, long-term memory, hippocampal gsk3β/tau proteins, synaptic proteins, mitochondrial function, apoptosis, and neurogenesis. |
2021-02-01 |
2023-08-13 |
mouse |
| Tae-Woon Kim, Sang-Seo Park, Joon-Young Park, Hye-Sang Par. Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice. International journal of molecular sciences. vol 21. issue 9. 2021-02-01. PMID:32384696. |
in the hippocampus of 3xtg-ad mice, infusion of plasma from exercised mice improved neuroplasticity and mitochondrial function and suppressed apoptosis, ultimately improving cognitive function. |
2021-02-01 |
2023-08-13 |
mouse |
| Ying Wang, Chun-Ping Yin, Yan-Lei Tai, Zi-Jun Zhao, Zhi-Yong Hou, Qiu-Jun Wan. Apoptosis inhibition is involved in improvement of sevoflurane-induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats. Experimental and therapeutic medicine. vol 21. issue 3. 2021-01-29. PMID:33500697. |
normobaric hyperoxia preconditioning improved prolonged escape latency and raised the number of platform crossings induced by sevoflurane in the morris water maze test, increased the level of bcl-2 protein, and decreased the level of bax and active caspase-3 protein, the apoptosis rate and cytosolic calcium concentration in the hippocampus 24 h after sevoflurane exposure. |
2021-01-29 |
2023-08-13 |
rat |
| Ying Wang, Chun-Ping Yin, Yan-Lei Tai, Zi-Jun Zhao, Zhi-Yong Hou, Qiu-Jun Wan. Apoptosis inhibition is involved in improvement of sevoflurane-induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats. Experimental and therapeutic medicine. vol 21. issue 3. 2021-01-29. PMID:33500697. |
the findings of the present study may imply that normobaric hyperoxia preconditioning attenuates sevoflurane-induced spatial learning and memory impairment, and this effect may be partly related to apoptosis inhibition in the hippocampus. |
2021-01-29 |
2023-08-13 |
rat |
| Ying Wang, Chun-Ping Yin, Yan-Lei Tai, Zi-Jun Zhao, Zhi-Yong Hou, Qiu-Jun Wan. Apoptosis inhibition is involved in improvement of sevoflurane-induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats. Experimental and therapeutic medicine. vol 21. issue 3. 2021-01-29. PMID:33500697. |
in conclusion, normobaric hyperoxia preconditioning may be a promising strategy against sevoflurane-induced cognitive impairment by inhibiting the hippocampal neuron apoptosis. |
2021-01-29 |
2023-08-13 |
rat |
| Expression of concern: "Alpha-naphthoflavone induces apoptosis through endoplasmic reticulum stress via c-Src-, ROS-, MAPKs-, and arylhydrocarbon receptor-dependent pathways in HT22 hippocampal neuronal cells" [NeuroToxicology March 2019, Pages 39-51]. Neurotoxicology. vol 81. 2021-01-26. PMID:33075398. |
expression of concern: "alpha-naphthoflavone induces apoptosis through endoplasmic reticulum stress via c-src-, ros-, mapks-, and arylhydrocarbon receptor-dependent pathways in ht22 hippocampal neuronal cells" [neurotoxicology march 2019, pages 39-51]. |
2021-01-26 |
2023-08-13 |
Not clear |
| Jie Kang, Di Wang, Yongchang Duan, Lin Zhai, Lin Shi, Fei Gu. Aerobic Exercise Prevents Depression via Alleviating Hippocampus Injury in Chronic Stressed Depression Rats. Brain sciences. vol 11. issue 1. 2021-01-26. PMID:33374661. |
(3) results: ae intervention significantly improved cums-induced depressive behaviors, e.g., running square numbers and immobility time assessed by the open field and forced swimming test, suppressed hippocampal neuron apoptosis, reduced levels of phosphorylation of nmda receptor and homocysteine in hippocampus, as well as serum glucocorticoids, compared to the cums rats. |
2021-01-26 |
2023-08-13 |
rat |
| Zhaoshi Zheng, Yayun Yan, Qi Guo, Libo Wang, Xuemei Han, Songyan Li. Genetic Interaction of Pharmacogenomics and personalized medicine. vol 14. 2021-01-26. PMID:33488113. |
genetic interaction of long non-coding rna h19 was highly expressed in the latent period of epilepsy, contributing to apoptosis of hippocampal neurons by targeting let-7b. |
2021-01-26 |
2023-08-13 |
Not clear |
| Qiong Pan, Ke Guo, Min Xue, Qiuyun T. Estrogen protects neuroblastoma cell from amyloid-β 42 (Aβ42)-induced apoptosis via TXNIP/TRX axis and AMPK signaling. Neurochemistry international. vol 135. 2021-01-25. PMID:31931042. |
consistently, in the hippocampus in female ad mice, apoptosis and txnip expression were enhanced while trx expression was suppressed. |
2021-01-25 |
2023-08-13 |
mouse |
| Yifan Tong, Kaijie Wang, Shuhai Sheng, Jianzhong Cu. Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats. Bioscience, biotechnology, and biochemistry. vol 84. issue 6. 2021-01-25. PMID:31992173. |
furthermore, pld suppressed dox-induced oxidative stress through up-regulating nrf2, inhibited inflammatory response by activating the nf-κb pathway, and reduced hippocampal apoptosis. |
2021-01-25 |
2023-08-13 |
rat |
| Panwen Liu, Lingyu Cui, Bo Liu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Takashi Ikejim. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiology & behavior. vol 213. 2021-01-22. PMID:31669775. |
moreover, silibinin significantly decreased stz-induced tau hyperphosphorylation (ser404) in hippocampus and cerebral cortex, markedly inhibited apoptosis of neurons induced by stz, and up-regulated insulin signal transduction pathway. |
2021-01-22 |
2023-08-13 |
rat |
| Utano Tomaru, Tomoki Ito, Yu Ohmura, Kei Higashikawa, Syota Miyajima, Ruka Tomatsu, Tsunehito Higashi, Akihiro Ishizu, Yuji Kuge, Mitsuhiro Yoshioka, Masanori Kasahar. Decreased Proteasomal Function Induces Neuronal Loss and Memory Impairment. The American journal of pathology. vol 191. issue 1. 2021-01-22. PMID:33339546. |
impaired proteasomal activity also activated er stress-related apoptosis pathways in ht-22, a murine hippocampal neuronal cell line. |
2021-01-22 |
2023-08-13 |
mouse |
| Marwa El-Sayed El-Shamarka, Rabab H Sayed, Naglaa Assaf, Hala M Zeidan, Adel F Hashis. Combined neurotoxic effects of cannabis and nandrolone decanoate in adolescent male rats. Neurotoxicology. vol 76. 2021-01-20. PMID:31704101. |
in conclusion, abuse of both can and nan conferred greater neurotoxic effects than either drug alone that were at least partially attributed to oxidative stress, inflammation, and intrinsic and extrinsic apoptosis in the hippocampus and pfc of rats. |
2021-01-20 |
2023-08-13 |
human |
| Jun Yang, Jingyan Gao, Dan Han, Qinqing Li, Chengde Liao, Jindan Li, Rui Wang, Yueyuan Lu. Hippocampal changes in inflammasomes, apoptosis, and MEMRI after radiation-induced brain injury in juvenile rats. Radiation oncology (London, England). vol 15. issue 1. 2021-01-18. PMID:32276638. |
hippocampal changes in inflammasomes, apoptosis, and memri after radiation-induced brain injury in juvenile rats. |
2021-01-18 |
2023-08-13 |
rat |
| Jun Yang, Jingyan Gao, Dan Han, Qinqing Li, Chengde Liao, Jindan Li, Rui Wang, Yueyuan Lu. Hippocampal changes in inflammasomes, apoptosis, and MEMRI after radiation-induced brain injury in juvenile rats. Radiation oncology (London, England). vol 15. issue 1. 2021-01-18. PMID:32276638. |
the aim of this study was to characterize changes in hippocampal inflammasomes, pyroptosis and apoptosis in juvenile rats after brain irradiation and to assess whether manganese-enhanced magnetic resonance imaging (memri) reflected those changes. |
2021-01-18 |
2023-08-13 |
rat |
| Zhi-Hong Ji, Hong Zhao, Chao Liu, Xin-Yu Y. In-vitro neuroprotective effect and mechanism of 2β-hydroxy-δ-cadinol against amyloid β-induced neuronal apoptosis. Neuroreport. vol 31. issue 3. 2021-01-15. PMID:31895745. |
based on the antiglutamate excitotoxicity effect of hoc, in this study, we investigated the potential benefit of hoc in preventing aβ(1-42)-induced neuronal apoptosis in cultured rat hippocampal neurons. |
2021-01-15 |
2023-08-13 |
rat |
| Song Han, Priya Nandy, Quillan Austria, Sandra L Siedlak, Sandy Torres, Hisashi Fujioka, Wenzhang Wang, Xiongwei Zh. Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death. Cells. vol 9. issue 1. 2021-01-15. PMID:31947766. |
apoptosis (terminal deoxynucleotidyl transferase dutp nick end labeling, tunel) begins to occur at 9 weeks, and by 12 weeks, most hippocampal neurons are degenerated, confirmed by loss of neun. |
2021-01-15 |
2023-08-13 |
mouse |
| Qian-Juan Fang, Bing-Huan Chi, Qi-Cheng Lin, Chen-Miao Huang, Shao-Wu Jin, Jia-Jing Cai, Ke Nan, Yuan Han, Yuan-Xiang Tao, Hong Cao, Jun L. Surgery-induced downregulation of hippocampal sirtuin-1 contributes to cognitive dysfunction by inhibiting autophagy and activating apoptosis in aged mice. American journal of translational research. vol 12. issue 12. 2021-01-14. PMID:33437385. |
surgery-induced downregulation of hippocampal sirtuin-1 contributes to cognitive dysfunction by inhibiting autophagy and activating apoptosis in aged mice. |
2021-01-14 |
2023-08-13 |
mouse |
| Da-Peng Wang, Shu-Hui Chen, Di Wang, Kai Kang, Yi-Fang Wu, Shao-Hua Su, Ying-Ying Zhang, Jian Ha. Neuroprotective effects of andrographolide on chronic cerebral hypoperfusion-induced hippocampal neuronal damage in rats possibly via PTEN/AKT signaling pathway. Acta histochemica. vol 122. issue 3. 2021-01-11. PMID:32019701. |
moreover, the neuronal apoptosis of hippocampus tissues was detected via terminal deoxynucleotidyl transferase- mediated dutp nick end labeling (tunel) staining. |
2021-01-11 |
2023-08-13 |
rat |