| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xianghui Zhang, Guan'en Zho. MiR-199a-5p inhibition protects cognitive function of ischemic stroke rats by AKT signaling pathway. American journal of translational research. vol 12. issue 10. 2020-11-17. PMID:33194051. |
in conclusion, silencing mir-199a-5p can effectively improve cognitive function in ischemic stroke rats and decrease neuronal apoptosis in hippocampus by activating the akt signaling pathway. |
2020-11-17 |
2023-08-13 |
rat |
| Wenchong Sun, Jian Wang, Dasheng Cai, Ling Pe. Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits. Experimental neurobiology. vol 29. issue 5. 2020-11-14. PMID:33154198. |
neuroprotection of the developing brain by dexmedetomidine is mediated by attenuating single propofol-induced hippocampal apoptosis and synaptic plasticity deficits. |
2020-11-14 |
2023-08-13 |
rat |
| Wenchong Sun, Jian Wang, Dasheng Cai, Ling Pe. Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits. Experimental neurobiology. vol 29. issue 5. 2020-11-14. PMID:33154198. |
after a single propofol exposure to p7 rats, dex pretreatment effectively rescued the profound apoptosis seen in hippocampal neurocytes, and strongly reversed the aberrant expression levels of bcl2-like 1 (bcl2l1), matrix metallopeptidase 9 (mmp-9) and cleaved caspase 3 (cc3), and sharply enhanced synaptic plasticity. |
2020-11-14 |
2023-08-13 |
rat |
| Peter Baumann, Sonja C Schriever, Stephanie Kullmann, Annemarie Zimprich, Annette Feuchtinger, Oana Amarie, Andreas Peter, Axel Walch, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Wolfgang Wurst, Matthias H Tschöp, Martin Heni, Sabine M Hölter, Paul T Pfluge. Dusp8 affects hippocampal size and behavior in mice and humans. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31862894. |
while dusp8 expression levels are high in limbic areas such as the hippocampus, the functional role of dusp8 in hippocampus morphology, mapk-signaling, neurogenesis and apoptosis as well as in behavior are still unclear. |
2020-11-09 |
2023-08-13 |
mouse |
| Xue Bai, Yan-Li Zhang, Li-Ning Li. Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-κB activation associated inflammation and apoptosis. Experimental cell research. vol 388. issue 2. 2020-11-09. PMID:31917201. |
moreover, trim8 knockdown significantly reduced apoptosis in hippocampus of mice with cerebral ir injury by reducing caspase-3 cleavage. |
2020-11-09 |
2023-08-13 |
mouse |
| Hongyan Zhang, Jiuyun Tao, ShuXia Zhang, XinXin L. LncRNA MEG3 Reduces Hippocampal Neuron Apoptosis via the PI3K/AKT/mTOR Pathway in a Rat Model of Temporal Lobe Epilepsy. Neuropsychiatric disease and treatment. vol 16. 2020-11-06. PMID:33149593. |
lncrna meg3 reduces hippocampal neuron apoptosis via the pi3k/akt/mtor pathway in a rat model of temporal lobe epilepsy. |
2020-11-06 |
2023-08-13 |
rat |
| Cui Ying, Liang Ying, Liu Yanxia, Wang Le, Cao Lil. High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model. Acta histochemica. vol 122. issue 2. 2020-11-05. PMID:31870503. |
tdt-mediated dutp nick-end labeling (tunel) illustrated that cell apoptosis induced by seizures in hippocampus was mitigated by hmgb1 antibody. |
2020-11-05 |
2023-08-13 |
mouse |
| Qiankun Quan, Yihua Qian, Xi Li, Ming L. CDK5 Participates in Amyloid-β Production by Regulating PPARγ Phosphorylation in Primary Rat Hippocampal Neurons. Journal of Alzheimer's disease : JAD. vol 71. issue 2. 2020-11-04. PMID:31403945. |
moreover, silencing of the cdk5 gene via cdk5 shrna-expressing lentiviral vectors in primary hippocampal neurons did not exert any protective effect against normal neuronal apoptosis, nor were significant effects observed on aβ levels, pparγ phosphorylation, or pparγ target gene expression in the cells. |
2020-11-04 |
2023-08-13 |
rat |
| Ming Wang, Jihoon Jo, Juhyun Son. Adiponectin improves long-term potentiation in the 5XFAD mouse brain. Scientific reports. vol 9. issue 1. 2020-11-02. PMID:31222110. |
these findings suggest that adiponectin inhibits neuronal apoptosis and inflammatory mechanisms and promotes hippocampal long-term potentiation. |
2020-11-02 |
2023-08-13 |
mouse |
| Ji-Eun Kim, Hana Park, Tae-Cheon Kan. CDDO-Me Distinctly Regulates Regional Specific Astroglial Responses to Status Epilepticus via ERK1/2-Nrf2, PTEN-PI3K-AKT and NFκB Signaling Pathways. Antioxidants (Basel, Switzerland). vol 9. issue 10. 2020-10-30. PMID:33096818. |
in the present study, we evaluated whether cddo-me affects astroglial responses to status epilepticus (se, a prolonged seizure activity) in the rat hippocampus in order to understand the underlying mechanisms of reactive astrogliosis and astroglial apoptosis. |
2020-10-30 |
2023-08-13 |
rat |
| Xin Guo, Jie Yuan, Jing Wang, Changmeng Cui, Pei Jian. Calcitriol alleviates global cerebral ischemia-induced cognitive impairment by reducing apoptosis regulated by VDR/ERK signaling pathway in rat hippocampus. Brain research. vol 1724. 2020-10-29. PMID:31479649. |
calcitriol alleviates global cerebral ischemia-induced cognitive impairment by reducing apoptosis regulated by vdr/erk signaling pathway in rat hippocampus. |
2020-10-29 |
2023-08-13 |
rat |
| G Akgül, D Abebe, X Q Yuan, K Auville, C J McBai. The Role of AMPARs in the Maturation and Integration of Caudal Ganglionic Eminence-Derived Interneurons into Developing Hippocampal Microcircuits. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:30931998. |
moreover, in glua1-3 kos, the number of interneurons invading the hippocampus increased in the early postnatal period but converged with wt numbers later due to increased apoptosis. |
2020-10-27 |
2023-08-13 |
mouse |
| Kai Guo, Xinyu Yao, Weijing Wu, Ziyi Yu, Zhenzhong Li, Zenglu Ma, Dengxiang Li. HIF-1α/SDF-1/CXCR4 axis reduces neuronal apoptosis via enhancing the bone marrow-derived mesenchymal stromal cell migration in rats with traumatic brain injury. Experimental and molecular pathology. vol 114. 2020-10-27. PMID:32165091. |
consequently, we found sdf-1 elevated the hif-1α/sdf-1/cxcr4 activity and presented protective roles in tbi rat hippocampal neurons with reduced neuronal apoptosis. |
2020-10-27 |
2023-08-13 |
rat |
| Lukas Muri, Simone Oberhänsli, Michelle Buri, Ngoc Dung Le, Denis Grandgirard, Rémy Bruggmann, René M Müri, Stephen L Lei. Repetitive transcranial magnetic stimulation activates glial cells and inhibits neurogenesis after pneumococcal meningitis. PloS one. vol 15. issue 9. 2020-10-27. PMID:32915781. |
hippocampal injury-which compromises neurofunctional outcome-occurs as apoptosis of progenitor cells and immature neurons of the hippocampal dentate granule cell layer thereby impairing the regenerative capacity of the hippocampal stem cell niche. |
2020-10-27 |
2023-08-13 |
rat |
| Yiming Deng, Jingyu Zhang, Xuan Sun, Gaoting Ma, Gang Luo, Zhongrong Miao, Ligang Son. miR-132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway. Experimental and therapeutic medicine. vol 20. issue 6. 2020-10-24. PMID:33093897. |
additionally, hippocampus cell apoptosis was determined using a tunel assay and levels of acetylcholinesterase (ache), reactive oxygen species (ros), malondialdehyde (mda), superoxide dismutase (sod) and glutathione peroxidase (gsh-px) were evaluated in sera via elisa. |
2020-10-24 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
reducing prlr expression and jak2 activity results in an increase in bdnf expression and inhibits the apoptosis of ca3 hippocampal neurons in a chronic mild stress model of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
therefore, the present study was conducted on the effect of prlr gene on brain derived neurotrophic factor (bdnf) expression and hippocampal neuron apoptosis through the establishment of cms-induced depression mouse models, with aims of providing a new and effective therapeutic option for depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
next, the regulatory mechanism by which prlr gene silencing influences hippocampal neuron apoptosis via the jak2-stat5 signaling pathway was detected. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
from the aforementioned findings, we concluded that prlr gene silencing results in the inhibition of hippocampal neuron apoptosis and alleviation of cms-induced depression by inactivating the jak2-stat5 signaling pathway and elevating bdnf expression, providing a new insight for the treatment of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Cai-Hong Liu, Yuan-Zhi Tan, Dan-Dan Li, Su-Su Tang, Xiao-An Wen, Yan Long, Hong-Bin Sun, Hao Hong, Mei H. Zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress. International immunopharmacology. vol 78. 2020-10-21. PMID:31796384. |
zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress. |
2020-10-21 |
2023-08-13 |
mouse |