| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W A Pedersen, H Luo, I Kruman, E Kasarskis, M P Mattso. The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 7. 2000-06-01. PMID:10783145. |
prostate apoptosis response-4 (par-4), a protein containing a leucine zipper domain within a death domain, is up-regulated in prostate cancer cells and hippocampal neurons induced to undergo apoptosis. |
2000-06-01 |
2023-08-12 |
mouse |
| G W Glazner, S L Chan, C Lu, M P Mattso. Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 10. 2000-05-25. PMID:10804206. |
we now report that levels of ampa receptor subunits glur-1 and glur-4 are rapidly decreased in cultured rat hippocampal neurons undergoing apoptosis in response to withdrawal of trophic support (wts), whereas levels of nmda receptor subunits nr1, nr2a, and nr2b are unchanged. |
2000-05-25 |
2023-08-12 |
rat |
| O F Almeida, G L Condé, C Crochemore, B A Demeneix, D Fischer, A H Hassan, M Meyer, F Holsboer, T M Michaelidi. Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744634. |
glucocorticoid receptor (gr) activation induces apoptosis of granule cells in the hippocampus. |
2000-05-01 |
2023-08-12 |
mouse |
| B Ahlemeyer, H Beier, I Semkova, C Schaper, J Krieglstei. S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700604. |
furthermore, s-100beta mediated partially the protective effect of the 5-ht(1a) receptor agonist, bay x 3702, against staurosporine-induced apoptosis in mixed neuronal/glial cultures from neonatal rat hippocampus. |
2000-04-25 |
2023-08-12 |
rat |
| H Tumani, A Smirnov, S Barchfeld, U Olgemöller, K Maier, P Lange, W Brück, R Na. Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus. Glia. vol 30. issue 1. 2000-04-18. PMID:10696140. |
in conclusion, the inability of hippocampal glutamine synthetase to metabolize excess amounts of glutamate may contribute to neuronal apoptosis in the hippocampal formation during meningitis. |
2000-04-18 |
2023-08-12 |
rabbit |
| D Ding, S I Moskowitz, R Li, S B Lee, M Esteban, K Tomaselli, J Chan, P J Bergol. Acidosis induces necrosis and apoptosis of cultured hippocampal neurons. Experimental neurology. vol 162. issue 1. 2000-04-18. PMID:10716884. |
acidosis induces necrosis and apoptosis of cultured hippocampal neurons. |
2000-04-18 |
2023-08-12 |
Not clear |
| B Sakic, I Maric, P D Koeberle, J M Millward, H Szechtman, D Maric, J A Denbur. Increased TUNEL staining in brains of autoimmune Fas-deficient mice. Journal of neuroimmunology. vol 104. issue 2. 2000-04-14. PMID:10713354. |
using the terminal deoxynucleotidyl transferase-mediated dutp nick-end labeled (tunel) method as an indicator of apoptosis, a surprisingly high incidence of tunel-positive cells was observed in the hippocampus, choroid plexus and periventricular regions of mrl-lpr mice, 5-10-fold higher than that found in the mrl +/+ control brain. |
2000-04-14 |
2023-08-12 |
mouse |
| M P Flavin, G Zhao, L T H. Microglial tissue plasminogen activator (tPA) triggers neuronal apoptosis in vitro. Glia. vol 29. issue 4. 2000-04-11. PMID:10652444. |
we previously showed that conditioned medium (cm) harvested from peritoneal macrophages or from activated microglia triggered apoptosis in rat hippocampal neurons in culture. |
2000-04-11 |
2023-08-12 |
human |
| V Viswanath, Z Wu, C Fonck, Q Wei, R Boonplueang, J K Anderse. Transgenic mice neuronally expressing baculoviral p35 are resistant to diverse types of induced apoptosis, including seizure-associated neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 5. 2000-04-11. PMID:10681443. |
organotypic hippocampal cultures isolated from p35 transgenics demonstrated lowered caspase activity and decreased apoptosis compared with wild type when exposed to ka. |
2000-04-11 |
2023-08-12 |
mouse |
| M Holcik, C S Thompson, Z Yaraghi, C A Lefebvre, A E MacKenzie, R G Kornelu. The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 5. 2000-04-11. PMID:10681452. |
the hippocampal neurons of neuronal apoptosis inhibitory protein 1 (naip1)-deleted mice display increased vulnerability to kainic acid-induced injury. |
2000-04-11 |
2023-08-12 |
mouse |
| W A Pedersen, S L Chan, M P Mattso. A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737598. |
this correlated with the differential ability of apoe isoforms to protect against apoptosis induced by hne in cultures of mouse spinal cord motor neurons and by the amyloid beta-peptide in cultures of rat hippocampal neurons. |
2000-04-11 |
2023-08-12 |
mouse |
| K Bulloch, M Sadamatsu, A Patel, B S McEwe. Calcitonin gene-related peptide immunoreactivity in the hippocampus and its relationship to cellular changes following exposure to trimethyltin. Journal of neuroscience research. vol 55. issue 4. 2000-03-29. PMID:10723055. |
we have specifically focused on comparing the changes in cgrp-ir with the pattern of apoptosis (via tunel staining), cell-cycle activation (ki67-ir), and in alteration in microglia (ox-42-ir) and astrocyte (ggfap-ir) immunocytochemistry in tmt-treated hippocampus. |
2000-03-29 |
2023-08-12 |
Not clear |
| K Bulloch, M Sadamatsu, A Patel, B S McEwe. Calcitonin gene-related peptide immunoreactivity in the hippocampus and its relationship to cellular changes following exposure to trimethyltin. Journal of neuroscience research. vol 55. issue 4. 2000-03-29. PMID:10723055. |
our results show a marked change in cgrp-ir in regions of the hippocampus that are temporally and anatomically correlated with the induction of apoptosis and activation of microglia, astrocyte, and the cell-cycle marker. |
2000-03-29 |
2023-08-12 |
Not clear |
| H Ehrenreich, T R Nau, C Dembowski, M Hasselblatt, M Barth, A Hahn, L Schilling, Sirén A-L, W Brüc. Endothelin b receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus. Neuroscience. vol 95. issue 4. 2000-03-21. PMID:10682706. |
hippocampal neuronal cultures also exhibited genotype-dependent apoptosis with the highest rate in neurons from homozygous endothelin b receptor-deficient (sl/sl) rats. |
2000-03-21 |
2023-08-12 |
human |
| E Anguelova, S Boularand, J P Nowicki, J Benavides, T Smirnov. Up-regulation of genes involved in cellular stress and apoptosis in a rat model of hippocampal degeneration. Journal of neuroscience research. vol 59. issue 2. 2000-02-17. PMID:10650879. |
up-regulation of genes involved in cellular stress and apoptosis in a rat model of hippocampal degeneration. |
2000-02-17 |
2023-08-12 |
rat |
| J L Venero, M Revuelta, A Machado, J Can. Delayed apoptotic pyramidal cell death in CA4 and CA1 hippocampal subfields after a single intraseptal injection of kainate. Neuroscience. vol 94. issue 4. 2000-02-14. PMID:10625049. |
during the first two days postinjection, apoptosis in the hippocampus was only evident in the ca3 region. |
2000-02-14 |
2023-08-12 |
rat |
| Y Ito, M Arakawa, K Ishige, H Fukud. Comparative study of survival signal withdrawal- and 4-hydroxynonenal-induced cell death in cerebellar granule cells. Neuroscience research. vol 35. issue 4. 2000-02-07. PMID:10617323. |
the lipid peroxidation product, 4-hydroxynonenal (hne), has been shown to induce apoptosis in pc12 cells and hippocampal neurons. |
2000-02-07 |
2023-08-12 |
Not clear |
| X A Alvarez, C Sampedro, R Lozano, R Cacabelo. Citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats. Methods and findings in experimental and clinical pharmacology. vol 21. issue 8. 2000-02-01. PMID:10599052. |
citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats. |
2000-02-01 |
2023-08-12 |
rat |
| X A Alvarez, C Sampedro, R Lozano, R Cacabelo. Citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats. Methods and findings in experimental and clinical pharmacology. vol 21. issue 8. 2000-02-01. PMID:10599052. |
the effects of citicoline on neurodegeneration, apoptosis and learning were investigated in male sprague dawley rats subjected to implants of the beta-amyloid fragment 1-40 (a beta 4: 3 mmol) into the right hippocampus and to permanent unilateral occlusion of the carotid artery. |
2000-02-01 |
2023-08-12 |
rat |
| J Savory, J K Rao, Y Huang, P R Letada, M M Herma. Age-related hippocampal changes in Bcl-2:Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging. Neurotoxicology. vol 20. issue 5. 2000-01-24. PMID:10591516. |
age-related hippocampal changes in bcl-2:bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging. |
2000-01-24 |
2023-08-12 |
Not clear |