| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Loeffler, R Ringer, M Hablützel, M G Täuber, S L Lei. The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. The Journal of infectious diseases. vol 183. issue 2. 2001-02-22. PMID:11110643. |
however, neuronal apoptosis in the hippocampal dentate gyrus was increased by pbn, compared with that by saline (median score, 1.15 [range, 0.04-1.73] vs. 0.31 [range, 0-0.92]; p<.001). |
2001-02-22 |
2023-08-12 |
rat |
| J M Loeffler, R Ringer, M Hablützel, M G Täuber, S L Lei. The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. The Journal of infectious diseases. vol 183. issue 2. 2001-02-22. PMID:11110643. |
parallel to the increase in hippocampal apoptosis, pbn further impaired learning in infected animals, compared with that in saline-treated animals (p<.02). |
2001-02-22 |
2023-08-12 |
rat |
| L Li, P G Gunasekar, J L Borowitz, G E Iso. Muscarinic receptor-mediated pyridostigmine-induced neuronal apoptosis. Neurotoxicology. vol 21. issue 4. 2001-02-15. PMID:11022862. |
using the in situ terminal deoxynucleotidyl transferase nick-end labeling of dna fragments (tunel) method and electron microscopy, apoptotic brain cell death was noted in cerebral cortex over a dose range of 0.5-1.85 mg/kg and at the higher dose (1.85 mg/kg), apoptosis was also noted in striatum and hippocampus. |
2001-02-15 |
2023-08-12 |
rat |
| B A Citron, I V Smirnova, P M Arnold, B W Festof. Upregulation of neurotoxic serine proteases, prothrombin, and protease-activated receptor 1 early after spinal cord injury. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186232. |
since thrombin induces apoptosis in murine and chick motor and rat hippocampal neurons by activating a member of the novel protease-activated receptor (par) gene family known as par-1, we also analyzed par-1 by similar techniques and found that it, too, was upregulated after sci with the same kinetics as prothrombin. |
2001-02-08 |
2023-08-12 |
human |
| M Djebaïli, G Rondouin, V Baille, J Bockaer. p53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus. Neuroreport. vol 11. issue 13. 2001-01-25. PMID:11006977. |
these results confirm that apoptotic 3'oh dna fragmentations and bax protein induction during nmda-induced apoptosis in adult hippocampal neurons are p53 dependent. |
2001-01-25 |
2023-08-12 |
mouse |
| J Ham, A Eilers, J Whitfield, S J Neame, B Sha. c-Jun and the transcriptional control of neuronal apoptosis. Biochemical pharmacology. vol 60. issue 8. 2000-10-31. PMID:11007936. |
in addition, experiments with jnk(-/-) knockout mice have provided evidence that jnk3 may be required for apoptosis in the hippocampus in vivo following injection of kainic acid, an excitotoxin, and that jnk1 and jnk2 are required for apoptosis in the developing embryonic neural tube. |
2000-10-31 |
2023-08-12 |
mouse |
| I I Kruman, C Culmsee, S L Chan, Y Kruman, Z Guo, L Penix, M P Mattso. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 18. 2000-10-18. PMID:10995836. |
we now report that homocysteine induces apoptosis in rat hippocampal neurons. |
2000-10-18 |
2023-08-12 |
rat |
| W Fu, M Killen, C Culmsee, S Dhar, T K Pandita, M P Mattso. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function. Journal of molecular neuroscience : MN. vol 14. issue 1-2. 2000-10-17. PMID:10854032. |
suppression of tert expression in cultured embryonic hippocampal neurons increases their vulnerability to apoptosis and excitotoxicity. |
2000-10-17 |
2023-08-12 |
Not clear |
| W Duan, Z Guo, M P Mattso. Participation of par-4 in the degeneration of striatal neurons induced by metabolic compromise with 3-nitropropionic acid. Experimental neurology. vol 165. issue 1. 2000-10-04. PMID:10964480. |
here we report that levels of prostate apoptosis response-4 (par-4; a protein recently linked to neuronal apoptosis) increase in striatum, and to a lesser extent in cortex and hippocampus, after systemic administration of 3np to adult rats. |
2000-10-04 |
2023-08-12 |
rat |
| E Vereker, V Campbell, E Roche, E McEntee, M A Lync. Lipopolysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1. The Journal of biological chemistry. vol 275. issue 34. 2000-09-25. PMID:10856294. |
the degenerative changes in hippocampus and entorhinal cortical neurones were consistent with apoptosis because translocation of cytochrome c and poly(adp-ribose) polymerase cleavage were increased. |
2000-09-25 |
2023-08-12 |
rat |
| T Yamashim. Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Progress in neurobiology. vol 62. issue 3. 2000-09-21. PMID:10840150. |
a number of recent studies using lower species animals have suggested that the cornu ammonis (ca) 1 neuronal death after brief global cerebral ischemia occurs by apoptosis, an active and genetically controlled cell suicide process. |
2000-09-21 |
2023-08-12 |
monkey |
| H Nadeau, S McKinney, D J Anderson, H A Leste. ROMK1 (Kir1.1) causes apoptosis and chronic silencing of hippocampal neurons. Journal of neurophysiology. vol 84. issue 2. 2000-09-14. PMID:10938328. |
romk1 (kir1.1) causes apoptosis and chronic silencing of hippocampal neurons. |
2000-09-14 |
2023-08-12 |
rat |
| A P Halestrap, E Doran, J P Gillespie, A O'Tool. Mitochondria and cell death. Biochemical Society transactions. vol 28. issue 2. 2000-08-11. PMID:10816121. |
apoptosis in the hippocampus that occurs after a hypoglycaemic or ischaemic insult is triggered by this means. |
2000-08-11 |
2023-08-12 |
Not clear |
| D Perrelet, A Ferri, A E MacKenzie, G M Smith, R G Korneluk, P Liston, Y Sagot, J Terrado, D Monnier, A C Kat. IAP family proteins delay motoneuron cell death in vivo. The European journal of neuroscience. vol 12. issue 6. 2000-08-11. PMID:10886345. |
these molecules can prevent apoptosis in vitro and the over-expression of naip can decrease ischemic damage in the hippocampus. |
2000-08-11 |
2023-08-12 |
human |
| J A Trauth, F J Seidler, T A Slotki. An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions. Brain research. vol 867. issue 1-2. 2000-08-04. PMID:10837795. |
measurements were made of dna and protein as well as expression of mrnas encoding genes involved in differentiation and apoptosis (p53, c-fos) in cerebral cortex, midbrain and hippocampus. |
2000-08-04 |
2023-08-12 |
human |
| T Böttcher, J Gerber, A Wellmer, A V Smirnov, F Fakhrjanali, E Mix, J Pilz, U K Zettl, R Na. Rifampin reduces production of reactive oxygen species of cerebrospinal fluid phagocytes and hippocampal neuronal apoptosis in experimental Streptococcus pneumoniae meningitis. The Journal of infectious diseases. vol 181. issue 6. 2000-07-27. PMID:10837202. |
rifampin reduces production of reactive oxygen species of cerebrospinal fluid phagocytes and hippocampal neuronal apoptosis in experimental streptococcus pneumoniae meningitis. |
2000-07-27 |
2023-08-12 |
Not clear |
| Y S Zeng, Z C X. Co-existence of necrosis and apoptosis in rat hippocampus following transient forebrain ischemia. Neuroscience research. vol 37. issue 2. 2000-07-19. PMID:10867174. |
co-existence of necrosis and apoptosis in rat hippocampus following transient forebrain ischemia. |
2000-07-19 |
2023-08-12 |
rat |
| G W Glazner, S Camandola, M P Mattso. Nuclear factor-kappaB mediates the cell survival-promoting action of activity-dependent neurotrophic factor peptide-9. Journal of neurochemistry. vol 75. issue 1. 2000-07-17. PMID:10854252. |
a nineamino acid adnf peptide (adnf9) exhibits full neurotrophic activity and potently protects cultured embryonic rat hippocampal neurons from oxidative injury and apoptosis. |
2000-07-17 |
2023-08-12 |
rat |
| T Suuronen, P Kolehmainen, A Salmine. Protective effect of L-deprenyl against apoptosis induced by okadaic acid in cultured neuronal cells. Biochemical pharmacology. vol 59. issue 12. 2000-06-21. PMID:10799657. |
the best protection appeared at the concentration level of 10(-9) m. l-deprenyl also provided a protection against apoptosis after arac (cytosine beta-d-arabinoside) treatment in hippocampal neurons and neuro-2a cells and after etoposide treatment in neuro-2a cells. |
2000-06-21 |
2023-08-12 |
Not clear |
| M Kodaka, T Mori, K Tanaka, M Nomura, T Kawazo. [Depressive effects of propofol on apoptotic injury and delayed neuronal death after forebrain ischemia in the rat--comparison with nitrous oxide-oxygen-isoflurane]. Masui. The Japanese journal of anesthesiology. vol 49. issue 2. 2000-06-07. PMID:10707515. |
the ca-1 cells of hippocampus were then stained with hematoxylin and eosin for the delayed neuronal death (dnd) and with tunel method for the apoptosis. |
2000-06-07 |
2023-08-12 |
rat |