Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Q Cai, H J Liu, Z Zhan, M C Zh. [A study of apoptosis and related gene bcl-2 and p53 expression in hippocampus of rats exposed to repeated +Gz]. Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering. vol 13. issue 4. 2002-03-22. PMID:11892748. |
it suggests that apoptosis and expression changes of bcl-2 and p53 in rats hippocampus can be induced by repeated +gz exposures and the apoptosis is one of the molecular mechanisms of brain damage induced by repeated +gz exposures. |
2002-03-22 |
2023-08-12 |
rat |
Dori Pelled, Tal Raveh, Christian Riebeling, Mati Fridkin, Hanna Berissi, Anthony H Futerman, Adi Kimch. Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. The Journal of biological chemistry. vol 277. issue 3. 2002-02-13. PMID:11709549. |
death-associated protein (dap) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. |
2002-02-13 |
2023-08-12 |
mouse |
D Perkins, E F R Pereira, M Gober, P J Yarowsky, L Aurelia. The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons, involving activation of the MEK/MAPK survival pathway. Journal of virology. vol 76. issue 3. 2002-02-12. PMID:11773417. |
the herpes simplex virus type 2 r1 protein kinase (icp10 pk) blocks apoptosis in hippocampal neurons, involving activation of the mek/mapk survival pathway. |
2002-02-12 |
2023-08-12 |
human |
D Perkins, E F R Pereira, M Gober, P J Yarowsky, L Aurelia. The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons, involving activation of the MEK/MAPK survival pathway. Journal of virology. vol 76. issue 3. 2002-02-12. PMID:11773417. |
icp10 but not p139 protected neuronally differentiated pc12 cells from death due to nerve growth factor withdrawal, and apoptosis (determined by tunel) and caspase-3 activation were seen in primary hippocampal cultures infected with icp10deltapk but not with hsv-2 or a revertant virus [hsv-2(r)]. |
2002-02-12 |
2023-08-12 |
human |
J N Glasgow, J Qiu, D Rassin, M Grafe, T Wood, J R Perez-Po. Transcriptional regulation of the BCL-X gene by NF-kappaB is an element of hypoxic responses in the rat brain. Neurochemical research. vol 26. issue 6. 2002-01-29. PMID:11519724. |
hypoxia induces apoptosis in the hippocampus where the nf-kappab dimers c-rel/p50 and p50/ps0 bind to the bcl-x promoter nf-kappab site. |
2002-01-29 |
2023-08-12 |
rat |
H J Lee, J W Kim, S V Yim, M J Kim, S A Kim, Y J Kim, C J Kim, J H Chun. Fluoxetine enhances cell proliferation and prevents apoptosis in dentate gyrus of maternally separated rats. Molecular psychiatry. vol 6. issue 6. 2002-01-23. PMID:11673802. |
(5,6) in the present study, fluoxetine was administrated to rats with maternal separation to determine its effects on neuronal development, in particular with respect to cell proliferation and apoptosis in the dentate gyrus of the hippocampus. |
2002-01-23 |
2023-08-12 |
rat |
Z Liu, M Gastard, T Verina, S Bora, P R Mouton, V E Koliatso. Estrogens modulate experimentally induced apoptosis of granule cells in the adult hippocampus. The Journal of comparative neurology. vol 441. issue 1. 2002-01-22. PMID:11745631. |
estrogens modulate experimentally induced apoptosis of granule cells in the adult hippocampus. |
2002-01-22 |
2023-08-12 |
rat |
M C Lee, J L Rho, M K Kim, Y J Woo, J H Kim, S C Nam, J J Suh, W K Chung, J D Moon, H I Ki. c-JUN expression and apoptotic cell death in kainate-induced temporal lobe epilepsy. Journal of Korean medical science. vol 16. issue 5. 2002-01-03. PMID:11641538. |
this study investigated the relationships between prolonged expression of c-jun and hippocampal neuronal apoptosis in a ka-induced epilepsy model. |
2002-01-03 |
2023-08-12 |
rat |
M C Lee, J L Rho, M K Kim, Y J Woo, J H Kim, S C Nam, J J Suh, W K Chung, J D Moon, H I Ki. c-JUN expression and apoptotic cell death in kainate-induced temporal lobe epilepsy. Journal of Korean medical science. vol 16. issue 5. 2002-01-03. PMID:11641538. |
the seizures were associated with c-jun expression in the hippocampal neurons, of which the level showed a positive correlation with that of apoptosis. |
2002-01-03 |
2023-08-12 |
rat |
Z Zhang, R A Sobel, D Cheng, G K Steinberg, M A Yenar. Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia. Brain research. Molecular brain research. vol 95. issue 1-2. 2002-01-03. PMID:11687278. |
following 10 min of forebrain ischemia, hippocampal neurons were examined 72 h later for survival, expression of bcl-2 family proteins and apoptosis. |
2002-01-03 |
2023-08-12 |
rat |
J S Braun, R Novak, P J Murray, C M Eischen, S A Susin, G Kroemer, A Halle, J R Weber, E I Tuomanen, J L Clevelan. Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus. The Journal of infectious diseases. vol 184. issue 10. 2001-12-19. PMID:11679919. |
streptococcus pneumoniae is the major cause of bacterial meningitis and it damages the hippocampus by inducing neuronal apoptosis. |
2001-12-19 |
2023-08-12 |
Not clear |
K Jin, X O Mao, M W Eshoo, T Nagayama, M Minami, R P Simon, D A Greenber. Microarray analysis of hippocampal gene expression in global cerebral ischemia. Annals of neurology. vol 50. issue 1. 2001-12-14. PMID:11456315. |
therefore, we used an oligodeoxynucleotide-based microarray consisting of 374 human genes, most implicated previously in apoptosis or related events, to detect alterations in gene expression in the hippocampus of rats subjected to 15 minutes of global cerebral ischemia followed by up to 72 hours of reperfusion. |
2001-12-14 |
2023-08-12 |
human |
A Fiedorowicz, I Figiel, B Kamińska, M Zaremba, S Wilk, B Oderfeld-Nowa. Dentate granule neuron apoptosis and glia activation in murine hippocampus induced by trimethyltin exposure. Brain research. vol 912. issue 2. 2001-12-07. PMID:11532427. |
dentate granule neuron apoptosis and glia activation in murine hippocampus induced by trimethyltin exposure. |
2001-12-07 |
2023-08-12 |
mouse |
J Xie, X Chang, X Zhang, Q Gu. Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice. Brain research. vol 915. issue 1. 2001-12-07. PMID:11578614. |
aberrant induction of par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 m146v mutant knock-in mice. |
2001-12-07 |
2023-08-12 |
mouse |
S E Stoltzner, N C Berchtold, C W Cotman, C J Pik. Estrogen regulates bcl-x expression in rat hippocampus. Neuroreport. vol 12. issue 13. 2001-12-04. PMID:11588579. |
these data demonstrate that physiological levels of estrogen regulate hippocampal expression of bcl-x, an important modulator of neuronal apoptosis. |
2001-12-04 |
2023-08-12 |
rat |
C Ananth, S Thameem Dheen, P Gopalakrishnakone, C Kau. Domoic acid-induced neuronal damage in the rat hippocampus: changes in apoptosis related genes (bcl-2, bax, caspase-3) and microglial response. Journal of neuroscience research. vol 66. issue 2. 2001-12-04. PMID:11592113. |
domoic acid-induced neuronal damage in the rat hippocampus: changes in apoptosis related genes (bcl-2, bax, caspase-3) and microglial response. |
2001-12-04 |
2023-08-12 |
rat |
B Kaminska, I Figiel, B Pyrzynska, R Czajkowski, G Mosienia. Treatment of hippocampal neurons with cyclosporin A results in calcium overload and apoptosis which are independent on NMDA receptor activation. British journal of pharmacology. vol 133. issue 7. 2001-10-04. PMID:11487508. |
treatment of hippocampal neurons with cyclosporin a results in calcium overload and apoptosis which are independent on nmda receptor activation. |
2001-10-04 |
2023-08-12 |
Not clear |
B M Williams, Y Luo, C Ward, K Redd, R Gibson, S A Kuczaj, J G McCo. Environmental enrichment: effects on spatial memory and hippocampal CREB immunoreactivity. Physiology & behavior. vol 73. issue 4. 2001-10-04. PMID:11495671. |
environmental enrichment has been shown to improve performance in tests of spatial memory, induce neurogenesis in the hippocampus, enhance survival of newly formed granule cells, and inhibit spontaneous apoptosis. |
2001-10-04 |
2023-08-12 |
mouse |
S L Leib, J M Clements, R L Lindberg, C Heimgartner, J M Loeffler, L A Pfister, M G Täuber, D Lepper. Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain : a journal of neurology. vol 124. issue Pt 9. 2001-10-04. PMID:11522576. |
therapy with bb-1101, together with antibiotics, attenuated neuronal necrosis in the cortex and apoptosis in the hippocampus when given as a pretreatment at the time of infection and also when administration was started 18 h after infection. |
2001-10-04 |
2023-08-12 |
rat |
M Dalgaard, A Hossaini, K S Hougaard, U Hass, O Ladefoge. Developmental toxicity of toluene in male rats: effects on semen quality, testis morphology, and apoptotic neurodegeneration. Archives of toxicology. vol 75. issue 2. 2001-09-27. PMID:11354905. |
in the hippocampus, almost no apoptosis was observed in any age group, and there were no differences in apoptotic neurodegeneration between male rats exposed to 1800 ppm and control animals at pnd 11, 21 or 90. |
2001-09-27 |
2023-08-12 |
rat |