| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Gozal, J M Daniel, G P Dohanic. Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 7. 2001-06-28. PMID:11264318. |
marked increases in apoptosis occurred in the ca1 hippocampal region (sevenfold) and cortex (cx; eightfold) after 1-2 d of ehyp but not in ca3 and were followed by decreases toward normoxic levels by 14 d. double labeling for nmda nr1 and c-fos revealed marked architectural disorganization in ca1 and cx with increases in c-fos over time. |
2001-06-28 |
2023-08-12 |
rat |
| B A Citron, K S SantaCruz, P J Davies, B W Festof. Intron-exon swapping of transglutaminase mRNA and neuronal Tau aggregation in Alzheimer's disease. The Journal of biological chemistry. vol 276. issue 5. 2001-06-21. PMID:11013236. |
although apoptosis in ad hippocampus is now an established mode of neuronal cell death, no definite underlying mechanism(s) is known. |
2001-06-21 |
2023-08-12 |
Not clear |
| F Malchiodi-Albedi, M R Domenici, S Paradisi, A Bernardo, M A Ajmone-Cat, L Minghett. Astrocytes contribute to neuronal impairment in beta A toxicity increasing apoptosis in rat hippocampal neurons. Glia. vol 34. issue 1. 2001-06-14. PMID:11284021. |
astrocytes contribute to neuronal impairment in beta a toxicity increasing apoptosis in rat hippocampal neurons. |
2001-06-14 |
2023-08-12 |
rat |
| K Domańska-Janik, A Bronisz-Kowalczyk, H Zajac, B Zabłock. Interrelations between nuclear-factor kappa B activation, glial response and neuronal apoptosis in gerbil hippocampus after ischemia. Acta neurobiologiae experimentalis. vol 61. issue 1. 2001-05-21. PMID:11315321. |
interrelations between nuclear-factor kappa b activation, glial response and neuronal apoptosis in gerbil hippocampus after ischemia. |
2001-05-21 |
2023-08-12 |
Not clear |
| C Culmsee, Y Zhu, J Krieglstein, M P Mattso. Evidence for the involvement of Par-4 in ischemic neuron cell death. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 4. 2001-05-17. PMID:11323519. |
the authors recently identified prostate apoptosis response-4 (par-4) as a protein that participates in the death of cultured hippocampal neurons induced by trophic factor withdrawal and exposure to glutamate. |
2001-05-17 |
2023-08-12 |
mouse |
| C Culmsee, Y Zhu, J Krieglstein, M P Mattso. Evidence for the involvement of Par-4 in ischemic neuron cell death. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 4. 2001-05-17. PMID:11323519. |
here, the authors show that par-4 levels increase in vulnerable populations of hippocampal and striatal neurons in rats after transient forebrain ischemia; par-4 levels increased within 6 hours of reperfusion and remained elevated in neurons undergoing apoptosis 3 days later. |
2001-05-17 |
2023-08-12 |
mouse |
| C Culmsee, Y Zhu, J Krieglstein, M P Mattso. Evidence for the involvement of Par-4 in ischemic neuron cell death. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 4. 2001-05-17. PMID:11323519. |
a par-4 antisense oligonucleotide protected cultured hippocampal neurons against apoptosis induced by chemical hypoxia and significantly reduced focal ischemic damage in mice. |
2001-05-17 |
2023-08-12 |
mouse |
| L Korhonen, N Belluardo, D Lindhol. Regulation of X-chromosome-linked inhibitor of apoptosis protein in kainic acid-induced neuronal death in the rat hippocampus. Molecular and cellular neurosciences. vol 17. issue 2. 2001-05-10. PMID:11178873. |
regulation of x-chromosome-linked inhibitor of apoptosis protein in kainic acid-induced neuronal death in the rat hippocampus. |
2001-05-10 |
2023-08-12 |
rat |
| Y Zhu, B Ahlemeyer, E Bauerbach, J Krieglstei. TGF-beta1 inhibits caspase-3 activation and neuronal apoptosis in rat hippocampal cultures. Neurochemistry international. vol 38. issue 3. 2001-04-19. PMID:11099781. |
tgf-beta1 inhibits caspase-3 activation and neuronal apoptosis in rat hippocampal cultures. |
2001-04-19 |
2023-08-12 |
rat |
| Y Zhu, B Ahlemeyer, E Bauerbach, J Krieglstei. TGF-beta1 inhibits caspase-3 activation and neuronal apoptosis in rat hippocampal cultures. Neurochemistry international. vol 38. issue 3. 2001-04-19. PMID:11099781. |
the present study attempted to identify whether tgf-beta1 can prevent neuronal apoptosis and interrupt caspase-3 activation in rat primary hippocampal cultures after staurosporine treatment. |
2001-04-19 |
2023-08-12 |
rat |
| Y Zhu, B Ahlemeyer, E Bauerbach, J Krieglstei. TGF-beta1 inhibits caspase-3 activation and neuronal apoptosis in rat hippocampal cultures. Neurochemistry international. vol 38. issue 3. 2001-04-19. PMID:11099781. |
this study provides evidence that tgf-beta1 is able to efficiently inhibit caspase-3 activation, and thereby protects cultured hippocampal neurons against apoptosis. |
2001-04-19 |
2023-08-12 |
rat |
| P J Lucassen, M B Müller, F Holsboer, J Bauer, A Holtrop, J Wouda, W J Hoogendijk, E R De Kloet, D F Swaa. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. The American journal of pathology. vol 158. issue 2. 2001-04-05. PMID:11159183. |
hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. |
2001-04-05 |
2023-08-12 |
human |
| P J Lucassen, M B Müller, F Holsboer, J Bauer, A Holtrop, J Wouda, W J Hoogendijk, E R De Kloet, D F Swaa. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. The American journal of pathology. vol 158. issue 2. 2001-04-05. PMID:11159183. |
to study possible gc-related pathology, we investigated hippocampal tissue of 15 major-depressed patients, 16 matched controls, and 9 steroid-treated patients, using in situ-end-labeling for dna fragmentation and apoptosis, and heat-shock protein 70 and nuclear transcription factor kappab immunocytochemistry for damage-related responses. |
2001-04-05 |
2023-08-12 |
human |
| P J Lucassen, M B Müller, F Holsboer, J Bauer, A Holtrop, J Wouda, W J Hoogendijk, E R De Kloet, D F Swaa. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. The American journal of pathology. vol 158. issue 2. 2001-04-05. PMID:11159183. |
the detection in 11 of 15 depressed patients, in three steroid-treated, and in one control patient, demonstrates for the first time that apoptosis is involved in steroid-related changes in the human hippocampus. |
2001-04-05 |
2023-08-12 |
human |
| A Eilers, J Whitfield, B Shah, C Spadoni, H Desmond, J Ha. Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238729. |
studies with jnk: knockout mice suggest that jnk activity may be required for excitotoxin-induced apoptosis in the adult hippocampus and for apoptosis in the developing embryonic neural tube. |
2001-04-05 |
2023-08-12 |
mouse |
| b' P Kerokoski, T Suuronen, A Salminen, H Soininen, T Pirttil\\xc3\\xa. The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis. Biochemical and biophysical research communications. vol 280. issue 4. 2001-03-29. PMID:11162625.' |
we studied the expression of the protein levels of cdk5 and the neuron-specific cdk5 activator p35 as well as cdk5 activity and tau phosphorylation during apoptosis in rat hippocampal neuronal cultures. |
2001-03-29 |
2023-08-12 |
rat |
| K Kolasa, L E Harrel. Apoptotic protein expression and activation of caspases is changed following cholinergic denervation and hippocampal sympathetic ingrowth in rat hippocampus. Neuroscience. vol 101. issue 3. 2001-03-01. PMID:11113303. |
in our studies in the rat hippocampus, we have measured the expression of inducers and blockers of apoptosis in membrane, cytosolic and mitochondrial fractions, and the activity of caspases. |
2001-03-01 |
2023-08-12 |
rat |
| K Kolasa, L E Harrel. Apoptotic protein expression and activation of caspases is changed following cholinergic denervation and hippocampal sympathetic ingrowth in rat hippocampus. Neuroscience. vol 101. issue 3. 2001-03-01. PMID:11113303. |
from the present results, we suggest that cholinergic denervation may be responsible for pro-apoptotic responses, while hippocampal sympathetic ingrowth may protect neurons from apoptosis in rat dorsal hippocampus. |
2001-03-01 |
2023-08-12 |
rat |
| Y Bozzi, D Vallone, E Borrell. Neuroprotective role of dopamine against hippocampal cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 22. 2001-02-22. PMID:11069974. |
in ka-treated d2r-/- mice, hippocampal neurons die by apoptosis, as indicated by the presence of fragmented dna and the induction of the proapoptotic protein bax. |
2001-02-22 |
2023-08-12 |
mouse |
| J M Loeffler, R Ringer, M Hablützel, M G Täuber, S L Lei. The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. The Journal of infectious diseases. vol 183. issue 2. 2001-02-22. PMID:11110643. |
the free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. |
2001-02-22 |
2023-08-12 |
rat |