| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X A Alvarez, C Sampedro, R Lozano, R Cacabelo. Citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats. Methods and findings in experimental and clinical pharmacology. vol 21. issue 8. 2000-02-01. PMID:10599052. |
citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats. |
2000-02-01 |
2023-08-12 |
rat |
| X A Alvarez, C Sampedro, R Lozano, R Cacabelo. Citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats. Methods and findings in experimental and clinical pharmacology. vol 21. issue 8. 2000-02-01. PMID:10599052. |
the effects of citicoline on neurodegeneration, apoptosis and learning were investigated in male sprague dawley rats subjected to implants of the beta-amyloid fragment 1-40 (a beta 4: 3 mmol) into the right hippocampus and to permanent unilateral occlusion of the carotid artery. |
2000-02-01 |
2023-08-12 |
rat |
| J Savory, J K Rao, Y Huang, P R Letada, M M Herma. Age-related hippocampal changes in Bcl-2:Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging. Neurotoxicology. vol 20. issue 5. 2000-01-24. PMID:10591516. |
age-related hippocampal changes in bcl-2:bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging. |
2000-01-24 |
2023-08-12 |
Not clear |
| L J Martin, F E Sieber, R J Traystma. Apoptosis and necrosis occur in separate neuronal populations in hippocampus and cerebellum after ischemia and are associated with differential alterations in metabotropic glutamate receptor signaling pathways. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 20. issue 1. 2000-01-13. PMID:10616804. |
apoptosis and necrosis occur in separate neuronal populations in hippocampus and cerebellum after ischemia and are associated with differential alterations in metabotropic glutamate receptor signaling pathways. |
2000-01-13 |
2023-08-12 |
dog |
| L J Martin, F E Sieber, R J Traystma. Apoptosis and necrosis occur in separate neuronal populations in hippocampus and cerebellum after ischemia and are associated with differential alterations in metabotropic glutamate receptor signaling pathways. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 20. issue 1. 2000-01-13. PMID:10616804. |
it was concluded that neuronal death after global ischemia exists as two distinct, temporally overlapping forms in hippocampus and cerebellum: necrosis of pyramidal neurons and purkinje cells and apoptosis of granule neurons. |
2000-01-13 |
2023-08-12 |
dog |
| G W Glazner, A Boland, A E Dresse, D E Brenneman, I Gozes, M P Mattso. Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death. Journal of neurochemistry. vol 73. issue 6. 1999-12-27. PMID:10582592. |
we report that an even smaller, nine-amino acid fragment (adnf9) with the sequence sallrsipa potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by feso4 and trophic factor withdrawal. |
1999-12-27 |
2023-08-12 |
rat |
| W Peissner, M Kocher, H Treuer, F Gillardo. Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain research. Molecular brain research. vol 71. issue 1. 1999-12-22. PMID:10407187. |
ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. |
1999-12-22 |
2023-08-12 |
rat |
| W Peissner, M Kocher, H Treuer, F Gillardo. Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain research. Molecular brain research. vol 71. issue 1. 1999-12-22. PMID:10407187. |
morphology, location and distribution of cells affected by radiation-induced apoptosis in the dentate gyrus subgranular zone, together with neun-immunohistochemistry, support the contention that these cells belong to the immature progenitor population responsible for neurogenesis in the adult rat hippocampus. |
1999-12-22 |
2023-08-12 |
rat |
| A N Moore, A W Kampfl, X Zhao, R L Hayes, P K Das. Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. Neuroscience. vol 94. issue 2. 1999-12-21. PMID:10579204. |
sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. |
1999-12-21 |
2023-08-12 |
Not clear |
| A N Moore, A W Kampfl, X Zhao, R L Hayes, P K Das. Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. Neuroscience. vol 94. issue 2. 1999-12-21. PMID:10579204. |
in this study, we report that mobilization of internal ca2+ by sphingosine-1-phosphate, a metabolite of ceramide, induces apoptosis in cultured hippocampal neurons. |
1999-12-21 |
2023-08-12 |
Not clear |
| A N Moore, A W Kampfl, X Zhao, R L Hayes, P K Das. Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. Neuroscience. vol 94. issue 2. 1999-12-21. PMID:10579204. |
while increases in intracellular calcium are thought to be key mediators of neuronal apoptosis, the biochemical cascade(s) activated as a result of increased ca2+ which mediates apoptosis of hippocampal neurons is (are) not well understood. |
1999-12-21 |
2023-08-12 |
Not clear |
| A N Moore, A W Kampfl, X Zhao, R L Hayes, P K Das. Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. Neuroscience. vol 94. issue 2. 1999-12-21. PMID:10579204. |
the findings presented in this study suggest that mobilization of internal calcium via prolonged exposure of sphingosine-1-phosphate induces apoptosis of hippocampal neurons in culture. |
1999-12-21 |
2023-08-12 |
Not clear |
| A N Moore, A W Kampfl, X Zhao, R L Hayes, P K Das. Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes. Neuroscience. vol 94. issue 2. 1999-12-21. PMID:10579204. |
the expression of genes containing tgagtca-type enhancer sequences appears to be essential for sphingosine-1-phosphate-induced apoptosis of hippocampal neurons. |
1999-12-21 |
2023-08-12 |
Not clear |
| Y Matsuoka, M Okazaki, K Takata, Y Kitamura, S Ohta, Y Sekino, T Taniguch. Endogenous adenosine protects CA1 neurons from kainic acid-induced neuronal cell loss in the rat hippocampus. The European journal of neuroscience. vol 11. issue 10. 1999-12-08. PMID:10564369. |
in this study, we examined the contribution of endogenous adenosine, a potent inhibitory neuromodulator, to the differences in the neuronal vulnerability of the hippocampus, using microtubule-associated protein (map)-2, phosphorylated c-jun, and major histocompatibility complex (mhc) class ii immunoreactivities as markers for neuronal cell loss, neuronal apoptosis and glial activation, respectively. |
1999-12-08 |
2023-08-12 |
rat |
| Y Matsuoka, M Okazaki, K Takata, Y Kitamura, S Ohta, Y Sekino, T Taniguch. Endogenous adenosine protects CA1 neurons from kainic acid-induced neuronal cell loss in the rat hippocampus. The European journal of neuroscience. vol 11. issue 10. 1999-12-08. PMID:10564369. |
although c-jun phosphorylation, a critical step in neuronal apoptosis, was not detected in the vehicle-injected rat hippocampus, c-jun phosphorylation was induced in the ca3 by the injection of ka alone. |
1999-12-08 |
2023-08-12 |
rat |
| J Daly, D K Lahiri, G J Kotwa. Examination of the interactions of the amyloid precursor protein carboxyl terminus to intracellular protein: possible role in apoptosis. Progress in neuro-psychopharmacology & biological psychiatry. vol 23. issue 5. 1999-12-02. PMID:10509380. |
the authors examined hippocampal tissue sections from alzheimer's disease (ad) and age-matched normal control patients for a difference in the number of apoptotic nuclei present using an in situ apoptosis detection kit that labels the numerous free dna ends present in apoptotic nuclei. |
1999-12-02 |
2023-08-12 |
human |
| H Liu, Y Cao, A I Basbaum, A M Mazarati, R Sankar, C G Wasterlai. Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 21. 1999-11-24. PMID:10518582. |
the mice show a reduction in the duration and severity of seizures induced by kainate or pentylenetetrazole, and both necrosis and apoptosis of hippocampal neurons are prevented. |
1999-11-24 |
2023-08-12 |
mouse |
| H Matsuzaki, M Tamatani, N Mitsuda, K Namikawa, H Kiyama, S Miyake, M Tohyam. Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. Journal of neurochemistry. vol 73. issue 5. 1999-11-05. PMID:10537063. |
activation of akt kinase inhibits apoptosis and changes in bcl-2 and bax expression induced by nitric oxide in primary hippocampal neurons. |
1999-11-05 |
2023-08-12 |
Not clear |
| H Matsuzaki, M Tamatani, N Mitsuda, K Namikawa, H Kiyama, S Miyake, M Tohyam. Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. Journal of neurochemistry. vol 73. issue 5. 1999-11-05. PMID:10537063. |
here, we examined the mechanism by which igf-1 inhibits neuronal apoptosis induced by no in primary hippocampal neurons. |
1999-11-05 |
2023-08-12 |
Not clear |
| A E Kingston, M J O'Neill, A Lam, K R Bales, J A Monn, D D Schoep. Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795. European journal of pharmacology. vol 377. issue 2-3. 1999-10-27. PMID:10456425. |
in vivo studies showed that ly354740 was able to mediate a partial protection against apoptosis in ca1 hippocampal cells under ischaemic conditions where substantial ca1 cell loss occurred. |
1999-10-27 |
2023-08-12 |
rat |