| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Volosin, Christy Trotter, Andrea Cragnolini, Rajappa S Kenchappa, Matthew Light, Barbara L Hempstead, Bruce D Carter, Wilma J Friedma. Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 39. 2008-11-12. PMID:18815271. |
induction of proneurotrophins and activation of p75ntr-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. |
2008-11-12 |
2023-08-12 |
mouse |
| Marta Volosin, Christy Trotter, Andrea Cragnolini, Rajappa S Kenchappa, Matthew Light, Barbara L Hempstead, Bruce D Carter, Wilma J Friedma. Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 39. 2008-11-12. PMID:18815271. |
after seizure-induced injury, nrif(-/-) mice showed an increase in p75(ntr) expression in the hippocampus; however, these neurons failed to undergo apoptosis in contrast to wild-type mice. |
2008-11-12 |
2023-08-12 |
mouse |
| Marta Volosin, Christy Trotter, Andrea Cragnolini, Rajappa S Kenchappa, Matthew Light, Barbara L Hempstead, Bruce D Carter, Wilma J Friedma. Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 39. 2008-11-12. PMID:18815271. |
overall, these studies demonstrate the requirement for nrif to signal p75(ntr)-mediated apoptosis of hippocampal neurons and that blocking pro-ngf can inhibit neuronal loss after seizures. |
2008-11-12 |
2023-08-12 |
mouse |
| Hajira B Koeller, M Elizabeth Ross, Sara B Glickstei. Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity. Neurobiology of disease. vol 31. issue 2. 2008-11-07. PMID:18585919. |
these findings suggest that basal cd1 expression may render hippocampal circuits more susceptible to particular epileptogenic agents and excitotoxic cell death, though cd1 is not a direct precipitant in apoptosis. |
2008-11-07 |
2023-08-12 |
mouse |
| Gennaro Giordano, Terrance J Kavanagh, Lucio G Cost. Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicology and applied pharmacology. vol 232. issue 2. 2008-11-06. PMID:18656495. |
an analysis of de-71-induced cytotoxicity and apoptosis in neurons and astrocytes from different brain areas (cerebellum, hippocampus, cerebral cortex) in both mouse genotypes showed a significant correlation with intracellular gsh levels. |
2008-11-06 |
2023-08-12 |
mouse |
| Gennaro Giordano, Terrance J Kavanagh, Lucio G Cost. Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicology and applied pharmacology. vol 232. issue 2. 2008-11-06. PMID:18656495. |
as an example, de-71 caused cytotoxicity in hippocampal neurons with ic50s of 2.2 and 0.3 microm, depending on genotype, and apoptosis with ic50s of 2.3 and 0.4 microm, respectively. |
2008-11-06 |
2023-08-12 |
mouse |
| Eun Cheng Suh, Yeon Joo Jung, Yul A Kim, Eun Mi Park, Kyung Eun Le. A beta 25-35 induces presynaptic changes in organotypic hippocampal slice cultures. Neurotoxicology. vol 29. issue 4. 2008-11-05. PMID:18502514. |
these suggest that a beta 25-35-induced apoptosis via triggering caspase-3 activation and lead to synaptic dysfunction in organotypic hippocampal slice cultures. |
2008-11-05 |
2023-08-12 |
Not clear |
| Rui Chen, Junji Moriya, Jun-ichi Yamakawa, Takashi Takahashi, Qian Li, Shigeto Morimoto, Kunimitsu Iwai, Hiroyuki Sumino, Nobuo Yamaguchi, Tsugiyasu Kand. Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41). Neurochemical research. vol 33. issue 9. 2008-10-31. PMID:18317925. |
in this model, reduced daily activity might have been associated with decreased hippocampal bdnf mrna expression, hippocampal apoptosis and brain atrophy. |
2008-10-31 |
2023-08-12 |
mouse |
| Gouda K Hela. Systemic administration of Zn2+ during the reperfusion phase of transient cerebral ischaemia protects rat hippocampus against iron-catalysed postischaemic injury. Clinical and experimental pharmacology & physiology. vol 35. issue 7. 2008-10-20. PMID:18215188. |
cerebral ischaemia induced an increase in the iron content, lipidic peroxidation, apoptosis and metallothionein (mt) in the hippocampus. |
2008-10-20 |
2023-08-12 |
rat |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry. vol 104. issue 5. 2008-10-17. PMID:18348255. |
the effects of erdosteine, n-acetylcysteine, and vitamin e on nicotine-induced apoptosis of hippocampal neural cells. |
2008-10-17 |
2023-08-12 |
rat |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry. vol 104. issue 5. 2008-10-17. PMID:18348255. |
this study investigated the frequency of apoptosis in rat hippocampal neural cells after intraperitoneal nicotine injection, examining the roles of the inflammatory markers myeloperoxidase (mpo) and tumor necrosis factor alpha (tnf-alpha) in nicotine-induced brain damage and the protective effects of three known antioxidant agents, n-acetylcysteine (nac), erdosteine, and vitamin e. female wistar rats were divided into seven groups, each composed of nine rats: 2 negative control groups, 2 positive control groups, one erdosteine-treated group (500 mg/kg), one nac-treated group (500 mg/kg), and one vitamin e-treated group (500 mg/kg). |
2008-10-17 |
2023-08-12 |
rat |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry. vol 104. issue 5. 2008-10-17. PMID:18348255. |
apoptosis level in hippocampal neural cells was determined by using tunel (terminal deoxynucleotidyl transferase-mediated dutp nick endlabeling) method. |
2008-10-17 |
2023-08-12 |
rat |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry. vol 104. issue 5. 2008-10-17. PMID:18348255. |
the treatments with erdosteine, nac and vitamin e significantly reduced the rate of nicotine-induced hippocampal neural cell apoptosis. |
2008-10-17 |
2023-08-12 |
rat |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry. vol 104. issue 5. 2008-10-17. PMID:18348255. |
this findings suggest that erdosteine and nac can be as effective as vitamin e in protecting against nicotine-induced hippocampal neural cell apoptosis. |
2008-10-17 |
2023-08-12 |
rat |
| Uluç Yiş, Semra Hiz Kurul, Abdullah Kumral, Serap Cilaker, Kazim Tuğyan, Sermin Genç, Osman Yilma. Hyperoxic exposure leads to cell death in the developing brain. Brain & development. vol 30. issue 9. 2008-10-15. PMID:18329209. |
the neuronal density and apoptosis in ca1 and dentate gyrus of hippocampus, prefrontal cortex, parietal cortex, subiculum, and retrosplenial cortex were assessed by immunohistochemistry and elisa cell death assay. |
2008-10-15 |
2023-08-12 |
rat |
| Anna Fiedorowicz, Izabela Figiel, Małgorzata Zaremba, Karolina Dzwonek, Reinhard Schliebs, Barbara Oderfeld-Nowa. Trimethyltin-evoked apoptosis of murine hippocampal granule neurons is accompanied by the expression of interleukin-1beta and interleukin-1 receptor antagonist in cells of ameboid phenotype, the majority of which are NG2-positive. Brain research bulletin. vol 77. issue 1. 2008-09-11. PMID:18639741. |
trimethyltin-evoked apoptosis of murine hippocampal granule neurons is accompanied by the expression of interleukin-1beta and interleukin-1 receptor antagonist in cells of ameboid phenotype, the majority of which are ng2-positive. |
2008-09-11 |
2023-08-12 |
Not clear |
| S Kaloustian, B P Wann, T M Bah, S A Girard, A Apostolakis, S Ishak, S Mathieu, P Ryvlin, R Godbout, G Roussea. Apoptosis time course in the limbic system after myocardial infarction in the rat. Brain research. vol 1216. 2008-09-08. PMID:18495089. |
both apoptosis parameters were increased throughout, although in different structures: the ca1 region of the hippocampus and the medial amygdala at day 1, the ca1 region of the hippocampus and the lateral amygdala at day 2, and the frontal cortex at day 7. |
2008-09-08 |
2023-08-12 |
rat |
| S Kaloustian, B P Wann, T M Bah, S A Girard, A Apostolakis, S Ishak, S Mathieu, P Ryvlin, R Godbout, G Roussea. Apoptosis time course in the limbic system after myocardial infarction in the rat. Brain research. vol 1216. 2008-09-08. PMID:18495089. |
these data indicate that post-mi apoptosis in the limbic system is a dynamic process occurring mainly in the hippocampus and amygdala during the first days after mi. |
2008-09-08 |
2023-08-12 |
rat |
| HongYu Xue, LiJi Jin, Lei Jin, Peng Zhang, DanQing Li, YanQiu Xia, YaNan Lu, YongPing X. Neuroprotection of aucubin in primary diabetic encephalopathy. Science in China. Series C, Life sciences. vol 51. issue 6. 2008-09-03. PMID:18488169. |
hippocampal neuronal apoptosis accompanied by impairment of cognitive function occurs in primary diabetic encephalopathy. |
2008-09-03 |
2023-08-12 |
rat |
| Hong Jiang, Lin-Jing Li, Jun Wang, Jun-Xia Xi. Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. Experimental neurology. vol 212. issue 2. 2008-09-02. PMID:18577498. |
recent evidence has shown that ghrelin can also inhibit neuronal apoptosis of the hypothalamus and the hippocampus. |
2008-09-02 |
2023-08-12 |
mouse |