| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miao He, Lin Zhao, Min-Jie Wei, Wei-Fan Yao, Hai-Shan Zhao, Fu-Jun Che. Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose. Biological & pharmaceutical bulletin. vol 32. issue 1. 2009-04-15. PMID:19122281. |
tdt-mediated dutp-biotin nick end labeling (tunel) staining method was used to detect neuronal apoptosis, and the activation and expression of proapoptotic protein caspase-3 in the hippocampus were observed and analyzed using immunohistochemical staining and the western blot method to evaluate apoptosis in the brain. |
2009-04-15 |
2023-08-12 |
mouse |
| Miao He, Lin Zhao, Min-Jie Wei, Wei-Fan Yao, Hai-Shan Zhao, Fu-Jun Che. Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose. Biological & pharmaceutical bulletin. vol 32. issue 1. 2009-04-15. PMID:19122281. |
the results indicated that subcutaneous injection of d-gal induced learning and memory impairment in mice, decreased t-sod and gsh-px activities, increased mda contents in the hippocampus, and increased the cell apoptosis index and cleaved caspase-3 protein expression in the hippocampus. |
2009-04-15 |
2023-08-12 |
mouse |
| Miao He, Lin Zhao, Min-Jie Wei, Wei-Fan Yao, Hai-Shan Zhao, Fu-Jun Che. Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactose. Biological & pharmaceutical bulletin. vol 32. issue 1. 2009-04-15. PMID:19122281. |
oral administration of egcg (2 mg/kg or 6 mg/kg) for 4 weeks significantly improved the cognitive deficits in mice and elevated t-sod and gsh-px activities, decreased mda contents in the hippocampus, and reduced the cell apoptosis index and expression of cleaved caspase-3 in the mouse hippocampus. |
2009-04-15 |
2023-08-12 |
mouse |
| Jian-Hua Zhang, Simon J Fung, Mingchu Xi, Sharon Sampogna, Michael H Chas. Recurrent apnea induces neuronal apoptosis in the guinea pig forebrain. Experimental neurology. vol 216. issue 2. 2009-04-15. PMID:19124019. |
the present data indicate that recurrent apnea results in cell death in the hippocampus and related forebrain regions via mechanisms of apoptosis, which may represent the basis for the clinical complications of obstructive sleep apnea and sleep-disordered breathing. |
2009-04-15 |
2023-08-12 |
Not clear |
| He Zhang, Bin Wang, Wen-jun Li, Fei Zo. [Canonical transient receptor potential ion channel is involved in sodium nitroprusside-induced apoptosis of cultured rat hippocampal neurons]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 28. issue 5. 2009-04-13. PMID:18504199. |
[canonical transient receptor potential ion channel is involved in sodium nitroprusside-induced apoptosis of cultured rat hippocampal neurons]. |
2009-04-13 |
2023-08-12 |
rat |
| He Zhang, Bin Wang, Wen-jun Li, Fei Zo. [Canonical transient receptor potential ion channel is involved in sodium nitroprusside-induced apoptosis of cultured rat hippocampal neurons]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 28. issue 5. 2009-04-13. PMID:18504199. |
to understand the role of canonical transient receptor potential (trpc) channel in sodium nitroprusside (snp)-induced apoptosis of primary cultured rat hippocampal neurons. |
2009-04-13 |
2023-08-12 |
rat |
| E Jalalvand, M Javan, A Haeri-Rohani, A Ahmadian. Stress- and non-stress-mediated mechanisms are involved in pain-induced apoptosis in hippocampus and dorsal lumbar spinal cord in rats. Neuroscience. vol 157. issue 2. 2009-04-09. PMID:18822355. |
stress- and non-stress-mediated mechanisms are involved in pain-induced apoptosis in hippocampus and dorsal lumbar spinal cord in rats. |
2009-04-09 |
2023-08-12 |
rat |
| Hui-zhen Zhang, Li-xin Zhang, Yan-fen She, Wen-li Li, Xue-jing Zhang, Rui-juan Zhan. [Effect of electroacupuncture on apoptosis of hippocampus tissue in mice with vascular dementia]. Zhen ci yan jiu = Acupuncture research. vol 33. issue 6. 2009-04-09. PMID:19288897. |
[effect of electroacupuncture on apoptosis of hippocampus tissue in mice with vascular dementia]. |
2009-04-09 |
2023-08-12 |
mouse |
| Hui-zhen Zhang, Li-xin Zhang, Yan-fen She, Wen-li Li, Xue-jing Zhang, Rui-juan Zhan. [Effect of electroacupuncture on apoptosis of hippocampus tissue in mice with vascular dementia]. Zhen ci yan jiu = Acupuncture research. vol 33. issue 6. 2009-04-09. PMID:19288897. |
to observe the effect of electroacupuncture (ea) on hippocampal apoptosis and learning-memory ability in vascular dementia (vd) mice so as to investigate its underlying mechanism in the treatment of vd patients. |
2009-04-09 |
2023-08-12 |
mouse |
| Hui-fang Ma, Xiu-jun Ren, Ya Tu, Cai-xia Li. [Effect of electroacupuncture on caspase-9 expression in hippocampus and neuroethology in hyperlipemia rats with concurrent cerebral ischemia]. Zhen ci yan jiu = Acupuncture research. vol 33. issue 6. 2009-04-09. PMID:19288898. |
to observe the effect of electroacupuncture (ea) on hippocampal apoptosis protein caspase-9 expression and neuroethology in hyperlipemia plus cerebral ischemia (hl-ci) rats. |
2009-04-09 |
2023-08-12 |
rat |
| Johann Brau. Inducible nitric oxide synthase mediates hippocampal caspase-3 activation in pneumococcal meningitis. The International journal of neuroscience. vol 119. issue 4. 2009-04-07. PMID:19229714. |
the most common bacterial meningitis pathogen--streptococcus pneumoniae--causes caspase activation and neuronal apoptosis in the hippocampus via its toxins and extensive inflammatory potential. |
2009-04-07 |
2023-08-12 |
mouse |
| Johann Sellner, Denis Grandgirard, Christian Gianinazzi, Regine M Landmann, Stephen L Lei. Effects of Toll-like receptor 2 agonist Pam(3)CysSK(4) on inflammation and brain damage in experimental pneumococcal meningitis. Journal of neuroimmunology. vol 206. issue 1-2. 2009-04-02. PMID:19012971. |
in infant rats, the tlr2 agonist pam(3)cyssk(4) was applied intracisternally (0.5 microg in 10 microl saline) alone or after induction of pneumococcal meningitis to investigate the effect of tlr2 activation on cerebrospinal fluid (csf) inflammation and hippocampal apoptosis. |
2009-04-02 |
2023-08-12 |
mouse |
| Johann Sellner, Denis Grandgirard, Christian Gianinazzi, Regine M Landmann, Stephen L Lei. Effects of Toll-like receptor 2 agonist Pam(3)CysSK(4) on inflammation and brain damage in experimental pneumococcal meningitis. Journal of neuroimmunology. vol 206. issue 1-2. 2009-04-02. PMID:19012971. |
we conclude that tlr2 signaling triggered by pam(3)cyssk(4) at a dosage capable to induce a neuroinflammatory response does not induce hippocampal apoptosis in the infant rat model of experimental pneumococcal meningitis. |
2009-04-02 |
2023-08-12 |
mouse |
| Xiao-Hong Xu, Yu Chen, Xiao-Xiang Zhen. [Protective effects of breviscapine against cultured rat hippocampal neuronal toxicity induced by glutamate]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 42. issue 6. 2009-03-31. PMID:17702392. |
after 24 h of l-glutamate treatment, flow cytometric analysis of annexin v (marks apoptosis) and pi (propidium iodide, marks necrosis) labeling cells showed that l-glutamate dose-dependently induced hippocampal neuronal apoptosis and necrosis. |
2009-03-31 |
2023-08-12 |
rat |
| P Morales, J L Fiedler, S Andrés, C Berrios, P Huaiquín, D Bustamante, S Cardenas, E Parra, M Herrera-Marschit. Plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis. Journal of neuroscience research. vol 86. issue 12. 2009-03-16. PMID:18512760. |
plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis. |
2009-03-16 |
2023-08-12 |
rat |
| P Morales, J L Fiedler, S Andrés, C Berrios, P Huaiquín, D Bustamante, S Cardenas, E Parra, M Herrera-Marschit. Plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis. Journal of neuroscience research. vol 86. issue 12. 2009-03-16. PMID:18512760. |
we investigated hippocampal plasticity after perinatal asphyxia, measuring postnatal apoptosis and neurogenesis. |
2009-03-16 |
2023-08-12 |
rat |
| P Morales, J L Fiedler, S Andrés, C Berrios, P Huaiquín, D Bustamante, S Cardenas, E Parra, M Herrera-Marschit. Plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis. Journal of neuroscience research. vol 86. issue 12. 2009-03-16. PMID:18512760. |
there was an increase of apoptosis in ca1, ca3, and dentate gyrus (dg) and cell proliferation and neurogenesis in ca1, dg, and hilus regions of hippocampus 1 week after asphyxia. |
2009-03-16 |
2023-08-12 |
rat |
| Ruben K Dagda, Ronald A Merrill, J Thomas Cribbs, Yucui Chen, Johannes W Hell, Yuriy M Usachev, Stefan Strac. The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. The Journal of biological chemistry. vol 283. issue 52. 2009-03-13. PMID:18940801. |
we show here that in pc12 cells and hippocampal neurons, cell stressors induced a rapid translocation of pp2a/bbeta2 to mitochondria to promote apoptosis. |
2009-03-13 |
2023-08-12 |
Not clear |
| Ruben K Dagda, Ronald A Merrill, J Thomas Cribbs, Yucui Chen, Johannes W Hell, Yuriy M Usachev, Stefan Strac. The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. The Journal of biological chemistry. vol 283. issue 52. 2009-03-13. PMID:18940801. |
based on epistasis experiments involving bcl2 and core components of the mitochondrial fission machinery (fis1 and dynamin-related protein 1), mitochondrial fragmentation occurs upstream of apoptosis and is both necessary and sufficient for hippocampal neuron death. |
2009-03-13 |
2023-08-12 |
Not clear |
| Yuanjie Sun, Joo-Hyun Lee, Nam-Ho Kim, Chang-Wook Lee, Min-Ju Kim, Seung-Hyuk Kim, Sung-Oh Hu. Lysophosphatidylcholine-induced apoptosis in H19-7 hippocampal progenitor cells is enhanced by the upregulation of Fas Ligand. Biochimica et biophysica acta. vol 1791. issue 1. 2009-03-12. PMID:19007912. |
lysophosphatidylcholine-induced apoptosis in h19-7 hippocampal progenitor cells is enhanced by the upregulation of fas ligand. |
2009-03-12 |
2023-08-12 |
Not clear |