| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baojun Liu, Hongying Zhang, Changqing Xu, Guang Yang, Jiang Tao, Jianhua Huang, Jinfeng Wu, Xiaohong Duan, Yuxue Cao, Jingcheng Don. Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons. Brain research. vol 1375. 2011-05-23. PMID:21182828. |
taken together, the present results suggest that the protective effects of icariin on apoptosis in hippocampal neuronal cells are potentially mediated through blockade of p38 mapk phosphorylation. |
2011-05-23 |
2023-08-12 |
rat |
| Yadong Liu, Shiping Ma, Rong Q. SCLM, total saponins extracted from Chaihu-jia-longgu-muli-tang, reduces chronic mild stress-induced apoptosis in the hippocampus in mice. Pharmaceutical biology. vol 48. issue 8. 2011-05-17. PMID:20673169. |
sclm, total saponins extracted from chaihu-jia-longgu-muli-tang, reduces chronic mild stress-induced apoptosis in the hippocampus in mice. |
2011-05-17 |
2023-08-12 |
mouse |
| Yadong Liu, Shiping Ma, Rong Q. SCLM, total saponins extracted from Chaihu-jia-longgu-muli-tang, reduces chronic mild stress-induced apoptosis in the hippocampus in mice. Pharmaceutical biology. vol 48. issue 8. 2011-05-17. PMID:20673169. |
in the present study, we investigated the neuroprotective action of sclm, the total saponins extracted from chaihu-jia-longgu-muli-tang, a traditional chinese medicinal formula which was prescribed 1000 years ago, in the reduction of apoptosis in hippocampal neurons using an experimental chronic mild stress (cms) model. |
2011-05-17 |
2023-08-12 |
mouse |
| Yadong Liu, Shiping Ma, Rong Q. SCLM, total saponins extracted from Chaihu-jia-longgu-muli-tang, reduces chronic mild stress-induced apoptosis in the hippocampus in mice. Pharmaceutical biology. vol 48. issue 8. 2011-05-17. PMID:20673169. |
the present results suggest that sclm possesses a significant antidepressant-like property, and this effect may be through protection against stress-induced neuronal apoptosis by affecting the expression of bax and caspase-3 proteins in the hippocampus. |
2011-05-17 |
2023-08-12 |
mouse |
| Benjamin Eovaldi, Claude Zanett. Hyperbaric oxygen ameliorates worsening signs and symptoms of post-traumatic stress disorder. Neuropsychiatric disease and treatment. vol 6. 2011-05-17. PMID:21212826. |
we propose that hyperbaric oxygen was effective in improving the patient's neuropsychiatric symptoms by reducing cerebral oxidative stress, inflammation, vasogenic edema, and hippocampal neuronal apoptosis. |
2011-05-17 |
2023-08-12 |
Not clear |
| Qi Zhang, Mi Shen, Mei Ding, Dingding Shen, Fei Din. The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway. Toxicology and applied pharmacology. vol 252. issue 1. 2011-05-16. PMID:21320517. |
the neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of pi3k/akt pathway. |
2011-05-16 |
2023-08-12 |
Not clear |
| Qi Zhang, Mi Shen, Mei Ding, Dingding Shen, Fei Din. The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway. Toxicology and applied pharmacology. vol 252. issue 1. 2011-05-16. PMID:21320517. |
we found that glutamate-induced apoptosis in cultured hippocampal neurons was significantly attenuated by the ensuing pqq treatment, which also inhibited the glutamate-induced increase in ca²+ influx, caspase-3 activity, and ros production, and reversed the glutamate-induced decrease in bcl-2/bax ratio. |
2011-05-16 |
2023-08-12 |
Not clear |
| Takuro Tsuchiya, Helena P Bonner, Tobias Engel, Ina Woods, Satoshi Matsushima, Manus W Ward, Waro Taki, David C Henshall, Caoimhín G Concannon, Jochen H M Preh. Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo. The European journal of neuroscience. vol 33. issue 3. 2011-05-12. PMID:21198986. |
stereotactic intrahippocampal microinjection of the selective proteasome inhibitor epoxomicin (2.5 nmol) induced a delayed apoptosis within only the ca1 hippocampal neurons and not neurons within the ca3 or dentate gyrus regions, a selective vulnerability similar to that seen during ischaemia. |
2011-05-12 |
2023-08-12 |
Not clear |
| Takuro Tsuchiya, Helena P Bonner, Tobias Engel, Ina Woods, Satoshi Matsushima, Manus W Ward, Waro Taki, David C Henshall, Caoimhín G Concannon, Jochen H M Preh. Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo. The European journal of neuroscience. vol 33. issue 3. 2011-05-12. PMID:21198986. |
in summary, we demonstrate that the bh3-only proteins puma and bim mediate the delayed apoptosis of ca1 hippocampal neurons induced by proteasome inhibition in vivo, and that either bh3-only protein can only partly compensate for the deficiency of the other. |
2011-05-12 |
2023-08-12 |
Not clear |
| Arabinda Das, Misty McDowell, Casey M O'Dell, Megan E Busch, Joshua A Smith, Swapan K Ray, Naren L Bani. Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons. Neurochemical research. vol 35. issue 12. 2011-04-28. PMID:21127971. |
post-treatment with voltage-gated na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons. |
2011-04-28 |
2023-08-12 |
human |
| Arabinda Das, Misty McDowell, Casey M O'Dell, Megan E Busch, Joshua A Smith, Swapan K Ray, Naren L Bani. Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons. Neurochemical research. vol 35. issue 12. 2011-04-28. PMID:21127971. |
in this study, we investigated the effect and signaling mediators of voltage-gated na(+) channel blockers (lamotrigine, rufinamide, oxcarbazepine, valproic acid, and zonisamide) on ka-induced apoptosis in rat primary hippocampal neurons. |
2011-04-28 |
2023-08-12 |
human |
| Arabinda Das, Misty McDowell, Casey M O'Dell, Megan E Busch, Joshua A Smith, Swapan K Ray, Naren L Bani. Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons. Neurochemical research. vol 35. issue 12. 2011-04-28. PMID:21127971. |
exposure of hippocampal neurons to 10 μm ka for 24 h caused significant increases in morphological and biochemical features of apoptosis, as determined by wright staining and apoptag assay, respectively. |
2011-04-28 |
2023-08-12 |
human |
| Arabinda Das, Misty McDowell, Casey M O'Dell, Megan E Busch, Joshua A Smith, Swapan K Ray, Naren L Bani. Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons. Neurochemical research. vol 35. issue 12. 2011-04-28. PMID:21127971. |
post-treatment with one of these anti-epileptic drugs (500 nm) attenuated production of ros and prevented apoptosis in hippocampal neurons. |
2011-04-28 |
2023-08-12 |
human |
| Sang-Bin Baek, Geonho Bahn, Su-Jin Moon, Jiah Lee, Khae-Hawn Kim, Il-Gyu Ko, Sung-Eun Kim, Yun-Hee Sung, Bo-Kyun Kim, Tae-Soo Kim, Chang-Ju Kim, Mal-Soon Shi. The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups. Neuroscience letters. vol 488. issue 1. 2011-04-25. PMID:21056623. |
the phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups. |
2011-04-25 |
2023-08-12 |
rat |
| Sang-Bin Baek, Geonho Bahn, Su-Jin Moon, Jiah Lee, Khae-Hawn Kim, Il-Gyu Ko, Sung-Eun Kim, Yun-Hee Sung, Bo-Kyun Kim, Tae-Soo Kim, Chang-Ju Kim, Mal-Soon Shi. The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups. Neuroscience letters. vol 488. issue 1. 2011-04-25. PMID:21056623. |
in this study, we investigated the effects of tadalafil on apoptosis and cell proliferation in the hippocampal dentate gyrus of rat pups following maternal separation. |
2011-04-25 |
2023-08-12 |
rat |
| Sang-Bin Baek, Geonho Bahn, Su-Jin Moon, Jiah Lee, Khae-Hawn Kim, Il-Gyu Ko, Sung-Eun Kim, Yun-Hee Sung, Bo-Kyun Kim, Tae-Soo Kim, Chang-Ju Kim, Mal-Soon Shi. The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups. Neuroscience letters. vol 488. issue 1. 2011-04-25. PMID:21056623. |
apoptotic cell death in the hippocampal dentate gyrus was significantly increased in the maternal-separated rat pups, and tadalafil treatment suppressed maternal separation-induced apoptosis. |
2011-04-25 |
2023-08-12 |
rat |
| Jun Lu, Dong-mei Wu, Zi-hui Zheng, Yuan-lin Zheng, Bin Hu, Zi-feng Zhan. Troxerutin protects against high cholesterol-induced cognitive deficits in mice. Brain : a journal of neurology. vol 134. issue Pt 3. 2011-04-15. PMID:21252113. |
moreover, troxerutin significantly inhibited endoplasmic reticulum stress-induced apoptosis and decreased the activation of caspase-12 and caspase-3, and reduced the mean optical density of the terminal deoxyribonucleotidyl transferase-mediated dutp-digoxigenin nick end label-positive cells in the hippocampus. |
2011-04-15 |
2023-08-12 |
mouse |
| Zhu-Ying Zhou, Guang-Qian L. [Effects of W-7 on the expression of GRP78 and neuronal apoptosis in immature rat hippocampus after status convulsion]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 13. issue 1. 2011-04-13. PMID:21251387. |
[effects of w-7 on the expression of grp78 and neuronal apoptosis in immature rat hippocampus after status convulsion]. |
2011-04-13 |
2023-08-12 |
rat |
| Zhu-Ying Zhou, Guang-Qian L. [Effects of W-7 on the expression of GRP78 and neuronal apoptosis in immature rat hippocampus after status convulsion]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 13. issue 1. 2011-04-13. PMID:21251387. |
to investigate the effects of the calmodulin inhibitor w-7 on the expression of the key marker of ers grp78 and neuronal apoptosis in the immature rat hippocampus after status convulsion (sc). |
2011-04-13 |
2023-08-12 |
rat |
| Gonglu Liu, Hui Guo, Chunni Guo, Shengjie Zhao, Deshan Gong, Yongbo Zha. Involvement of IRE1α signaling in the hippocampus in patients with mesial temporal lobe epilepsy. Brain research bulletin. vol 84. issue 1. 2011-04-11. PMID:20965234. |
cumulative evidence suggests that programmed cell death (apoptosis) may contribute to the progressive hippocampal sclerosis seen in patients with refractory mesial temporal lobe epilepsy (mtle). |
2011-04-11 |
2023-08-12 |
Not clear |