| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthias D Sury, Lorianne Vorlet-Fawer, Claudia Agarinis, Shida Yousefi, Denis Grandgirard, Stephen L Leib, Stephan Christe. Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20875857. |
here, we studied the role of the pi3k/akt (protein kinase b) survival pathway in hippocampal apoptosis in a well-characterized infant rat model of pneumococcal meningitis. |
2011-09-27 |
2023-08-12 |
rat |
| Matthias D Sury, Lorianne Vorlet-Fawer, Claudia Agarinis, Shida Yousefi, Denis Grandgirard, Stephen L Leib, Stephan Christe. Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20875857. |
treatment with the pten inhibitor bpv(pic) restored akt activity and significantly attenuated hippocampal apoptosis. |
2011-09-27 |
2023-08-12 |
rat |
| Matthias D Sury, Lorianne Vorlet-Fawer, Claudia Agarinis, Shida Yousefi, Denis Grandgirard, Stephen L Leib, Stephan Christe. Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20875857. |
co-treatment with the specific pi3k inhibitor ly294002 reversed the restoration of akt activity and attenuation of hippocampal apoptosis, while it had no significant effect on these parameters on its own. |
2011-09-27 |
2023-08-12 |
rat |
| Eddy S Yang, Somaira Nowsheen, Tong Wang, Dinesh K Thotala, Fen Xi. Glycogen synthase kinase 3beta inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons. Neuro-oncology. vol 13. issue 5. 2011-09-27. PMID:21398658. |
previously, we have shown that inhibition of glycogen synthase kinase 3β (gsk3β) results in protection of hippocampal neurons from radiation (ir)-induced apoptosis and attenuation of neurocognitive dysfunction resulting from cranial ir. |
2011-09-27 |
2023-08-12 |
mouse |
| Eddy S Yang, Somaira Nowsheen, Tong Wang, Dinesh K Thotala, Fen Xi. Glycogen synthase kinase 3beta inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons. Neuro-oncology. vol 13. issue 5. 2011-09-27. PMID:21398658. |
taken together, these results suggested that enhanced repair of ir-induced dna damage may be a novel mechanism by which inhibition of gsk3β specifically protects hippocampal neurons from ir-induced apoptosis. |
2011-09-27 |
2023-08-12 |
mouse |
| Feiyu Ma, Hu Wang, Bin Chen, Feng Wang, Haixiong X. Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8). Arquivos de neuro-psiquiatria. vol 69. issue 1. 2011-09-21. PMID:21359432. |
metallothionein 3 attenuated the apoptosis of neurons in the ca1 region of the hippocampus in the senescence-accelerated mouse/prone8 (samp8). |
2011-09-21 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. |
2011-09-21 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
previous studies demonstrate that the exposure to titanium dioxide nanoparticles (tio(2) nps) damages the central nervous system of mice; however, very little is known about the effects of tio(2) nps on hippocampal apoptosis or its molecular mechanism. |
2011-09-21 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
the present study investigated the molecular mechanism associated with hippocampal apoptosis in mice induced by intragastric administration of tio(2) nps for consecutive 60 days. |
2011-09-21 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
our findings indicate that tio(2) nps accumulate in the mouse hippocampus, and this accumulation, in turn, led to hippocampal apoptosis and impairment in spatial recognition memory in mice. |
2011-09-21 |
2023-08-12 |
mouse |
| Renping Hu, Lei Zheng, Ting Zhang, Guodong Gao, Yaling Cui, Zhe Cheng, Jie Cheng, Mengmeng Hong, Meng Tang, Fashui Hon. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Journal of hazardous materials. vol 191. issue 1-3. 2011-09-21. PMID:21570177. |
these findings suggest that tio(2) np-induced apoptosis in the mouse hippocampus may result from an intrinsic pathway, and workers and consumers should take great caution when handling nanomaterials. |
2011-09-21 |
2023-08-12 |
mouse |
| Li Gong, Shu-Ling Li, Hui Li, Lei Zhan. Ginsenoside Rg1 protects primary cultured rat hippocampal neurons from cell apoptosis induced by β-amyloid protein. Pharmaceutical biology. vol 49. issue 5. 2011-08-18. PMID:21438847. |
ginsenoside rg1 protects primary cultured rat hippocampal neurons from cell apoptosis induced by β-amyloid protein. |
2011-08-18 |
2023-08-12 |
rat |
| Li Gong, Shu-Ling Li, Hui Li, Lei Zhan. Ginsenoside Rg1 protects primary cultured rat hippocampal neurons from cell apoptosis induced by β-amyloid protein. Pharmaceutical biology. vol 49. issue 5. 2011-08-18. PMID:21438847. |
this study was performed to assess the neuroprotective effect of ginsenoside rg1 against apoptosis induced by β-amyloid protein 25-35 (aβ(25-35)) in primary cultured rat hippocampal neuronal cells as well as in the underlying mechanisms. |
2011-08-18 |
2023-08-12 |
rat |
| Yajun Liu, Xiaonan Chen, Kejing Liu, Qiang Chai, Jingxin Li, Zhixiang Liu, Dong Sun, Lianbi Che. Protection by 3'-methoxypuerarin of rat hippocampal neurons against ischemia/reperfusion injury. The Chinese journal of physiology. vol 53. issue 2. 2011-08-18. PMID:21793321. |
in conclusion, 3'-mop can protect hippocampal neurons against i/r injury by inhibiting apoptosis. |
2011-08-18 |
2023-08-12 |
rat |
| Takeshi Kanno, Tomoyuki Nishizak. Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c. Journal of cellular physiology. vol 226. issue 9. 2011-08-17. PMID:21660956. |
sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to sdk/14-3-3 protein/bax/cytochrome c. the present study examined sphingosine-induced apoptosis in cultured rat hippocampal neurons and astrocytes. |
2011-08-17 |
2023-08-12 |
rat |
| Takeshi Kanno, Tomoyuki Nishizak. Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c. Journal of cellular physiology. vol 226. issue 9. 2011-08-17. PMID:21660956. |
taken together, the results of the present study indicate that sphingosine activates sdk, produced through proteolytic processing of an active form of pkc-δ, to phosphorylate 14-3-3 protein and transform into a monomeric structure, causing bax dissociation from 14-3-3 protein and accumulation in the mitochondria, which perturbs mitochondrial membrane potentials allowing cytochrome c release into the cytosol, to activate caspase-9 and the effector caspase-3, responsible for apoptosis in hippocampal neurons and astrocytes. |
2011-08-17 |
2023-08-12 |
rat |
| Kevin Wai Yin Chong, Minghui Jessica Chen, Evelyn S C Koay, Boon Seng Wong, Alan Yiu-Wah Lee, Françoise Russo-Marie, Nam Sang Cheun. Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury. Neuroscience letters. vol 485. issue 2. 2011-08-15. PMID:20831894. |
massive neuronal apoptosis and accumulation of protein aggregates in the cortex and hippocampus of the brain are hallmarks of several neurodegenerative disorders, indicating ubiquitin proteasome system (ups) dysfunction. |
2011-08-15 |
2023-08-12 |
mouse |
| Junhao Yan, Li Li, Nikan H Khatibi, Lei Yang, Ke Wang, Weiguang Zhang, Robert D Martin, Jingyan Han, John Zhang, Changman Zho. Blood-brain barrier disruption following subarchnoid hemorrhage may be faciliated through PUMA induction of endothelial cell apoptosis from the endoplasmic reticulum. Experimental neurology. vol 230. issue 2. 2011-08-15. PMID:21586287. |
immunohistochemical staining and western blot analysis demonstrated an increased expression of puma, bax, bak, grp78 and drp1 in the microvascular endothelial cells of the hippocampus, which was accompanied with endothelium apoptosis. |
2011-08-15 |
2023-08-12 |
rat |
| Guo-Hua Wang, Xiang-Gen Zhang, Zheng-Lin Jiang, Xia Li, Liang-Liang Peng, Yong-Cai Li, Yong Wan. Neuroprotective effects of hyperbaric oxygen treatment on traumatic brain injury in the rat. Journal of neurotrauma. vol 27. issue 9. 2011-08-08. PMID:20568957. |
neurological behavior score, brain water content, neuronal loss in the hippocampus, and cell apoptosis in brain tissue surrounding the primary injury site were examined to determine brain damage severity. |
2011-08-08 |
2023-08-12 |
rat |
| Xiao-Jun Cai, Hui-Qin Xu, Yi L. C-peptide and diabetic encephalopathy. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. vol 26. issue 2. 2011-08-04. PMID:21703121. |
administration of c-peptide partially improves the condition of the igf system in the brain and prevents neuronal apoptosis in the hippocampus of diabetic patients. |
2011-08-04 |
2023-08-12 |
Not clear |