| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jahan Salma, John C McDermot. Suppression of a MEF2-KLF6 survival pathway by PKA signaling promotes apoptosis in embryonic hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 8. 2012-04-16. PMID:22357862. |
initially, we observed that experimental induction of camp/pka signaling promotes apoptosis in primary hippocampal neurons as indicated by tunel and facs analysis. |
2012-04-16 |
2023-08-12 |
rat |
| Mingyue Qu, Zhou Zhou, Chunhai Chen, Min Li, Liping Pei, Fang Chu, Ju Yang, Yuan Wang, Li Li, Chuan Liu, Lei Zhang, Guangbin Zhang, Zhengping Yu, Denggao Wan. Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway. Neurochemistry international. vol 59. issue 8. 2012-04-09. PMID:22032970. |
lycopene pretreatment improved cell viability in tmt-treated hippocampal neurons and inhibited neuronal apoptosis. |
2012-04-09 |
2023-08-12 |
rat |
| Seung-Soo Baek, Tae-Won Jun, Ki-Jeong Kim, Mal-Soon Shin, Sun-Young Kang, Chang-Ju Ki. Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal-separated rat pups. Brain & development. vol 34. issue 1. 2012-03-30. PMID:21353411. |
in this study, we investigated the effects of postnatal treadmill exercise on the long-term memory capability, spatial learning ability, and depressive state, on the 5-hydroxytryptamine (5-ht, serotonin) synthesis and tryptophan hydroxylase (tph) expression in the dorsal raphe nuclei, and on the apoptosis and cell proliferation in the hippocampal dentate gyrus of rat pups following maternal separation. |
2012-03-30 |
2023-08-12 |
rat |
| Seung-Soo Baek, Tae-Won Jun, Ki-Jeong Kim, Mal-Soon Shin, Sun-Young Kang, Chang-Ju Ki. Effects of postnatal treadmill exercise on apoptotic neuronal cell death and cell proliferation of maternal-separated rat pups. Brain & development. vol 34. issue 1. 2012-03-30. PMID:21353411. |
in contrast, apoptotic neuronal cell death in the hippocampal dentate gyrus was significantly increased in the maternal-separated rat pups, and postnatal treadmill exercise suppressed the maternal separation-induced apoptosis. |
2012-03-30 |
2023-08-12 |
rat |
| Li-li Ren, Di Wu, Qing-jun L. [Effect of allicin on hippocampal neuronal apoptosis induced by globe cerebral ischemia/reperfusion]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 23. issue 4. 2012-03-29. PMID:21180117. |
[effect of allicin on hippocampal neuronal apoptosis induced by globe cerebral ischemia/reperfusion]. |
2012-03-29 |
2023-08-12 |
Not clear |
| Leila Seddik, Thierno Madjou Bah, Abdelkader Aoues, Miloud Slimani, Mohamed Benderdou. Elucidation of mechanisms underlying the protective effects of olive leaf extract against lead-induced neurotoxicity in Wistar rats. The Journal of toxicological sciences. vol 36. issue 6. 2012-03-27. PMID:22129743. |
in the hippocampus, the examination of markers of apoptosis and inflammation revealed an increase in caspase-3 activity and dna fragmentation as well as tumor necrosis factor alpha, interleukin-1 beta and prostaglandin e2 in pb-exposed rats. |
2012-03-27 |
2023-08-12 |
rat |
| He Xu, Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Shu-Ling Bai, Zhan-You Wan. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus. vol 21. issue 5. 2012-03-26. PMID:20101602. |
lactational zinc deficiency-induced hippocampal neuronal apoptosis by a bdnf-independent trkb signaling pathway. |
2012-03-26 |
2023-08-12 |
mouse |
| He Xu, Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Shu-Ling Bai, Zhan-You Wan. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus. vol 21. issue 5. 2012-03-26. PMID:20101602. |
here we tested the hypothesis that changes in the trkb signaling pathway are involved in hippocampal neuronal apoptosis of suckling offspring with maternal zinc deficiency. |
2012-03-26 |
2023-08-12 |
mouse |
| He Xu, Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Shu-Ling Bai, Zhan-You Wan. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus. vol 21. issue 5. 2012-03-26. PMID:20101602. |
at p7, p14, and p21, changes in hippocampal neuronal apoptosis were assessed by nissl and tunel staining. |
2012-03-26 |
2023-08-12 |
mouse |
| He Xu, Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Shu-Ling Bai, Zhan-You Wan. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus. vol 21. issue 5. 2012-03-26. PMID:20101602. |
lactational zinc deficiency resulted in lower levels of p-trkb and p-erk, and higher levels of bax/bcl-2 and caspase-3 in the hippocampus, suggesting that zinc deficiency-induced low levels of trkb phosphorylation would abrogate the downstream erk signaling pathway, leading to hippocampal neuronal apoptosis. |
2012-03-26 |
2023-08-12 |
mouse |
| He Xu, Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Shu-Ling Bai, Zhan-You Wan. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus. vol 21. issue 5. 2012-03-26. PMID:20101602. |
the present data indicate that zinc depletion-induced hippocampal neuronal apoptosis is likely through modulation of the trkb neurotrophic signaling pathway by a bdnf-independent and src-dependent mechanism, whereas higher expression of bdnf is considered as a protective response, which cannot fully compensate for the injury caused by maternal zinc deficiency. |
2012-03-26 |
2023-08-12 |
mouse |
| Yanzhen Zhu, Yanjun Zen. Electroacupuncture protected pyramidal cells in hippocampal CA1 region of vascular dementia rats by inhibiting the expression of p53 and Noxa. CNS neuroscience & therapeutics. vol 17. issue 6. 2012-03-25. PMID:20950325. |
the aim of this study was to determine whether ea protects pyramidal cells from apoptosis in hippocampus of a vd rat model by inhibiting the expression of p53 and noxa. |
2012-03-25 |
2023-08-12 |
rat |
| Beatrice D'Orsi, Helena Bonner, Liam P Tuffy, Heiko Düssmann, Ina Woods, Michael J Courtney, Manus W Ward, Jochen H M Preh. Calpains are downstream effectors of bax-dependent excitotoxic apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 5. 2012-03-22. PMID:22302823. |
oxygen/glucose deprivation-induced injury in organotypic hippocampal slice cultures confirmed that calpains were specifically activated during bax-dependent apoptosis and in this setting function as downstream cell-death executioners. |
2012-03-22 |
2023-08-12 |
Not clear |
| Wen Liu, Joseph A D'Ercole, Ping Y. Blunting type 1 insulin-like growth factor receptor expression exacerbates neuronal apoptosis following hypoxic/ischemic injury. BMC neuroscience. vol 12. 2012-03-20. PMID:21718528. |
to directly examine the role of neuronal igf1r following h/i injury, we utilized conditional mutant nes-igf1r(-/wt) mice and determined the impact of igf1r haplodeficiency specifically in nestin-expressing neuronal precursors and their progeny on h/i-induced neuronal damage and apoptosis in hippocampus. |
2012-03-20 |
2023-08-12 |
mouse |
| b' Noem\\xc3\\xad Rueda, Jes\\xc3\\xbas Fl\\xc3\\xb3rez, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl-X(L) antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 29. issue 7. 2012-03-19. PMID:21684326.' |
since fibroblast cultures from ts mice and human ds hippocampal regions show increased apoptotic cell death it has been suggested that alterations in cerebral apoptosis might be implicated in the cognitive deficits found in ts mice and in people with ds. |
2012-03-19 |
2023-08-12 |
mouse |
| b' Noem\\xc3\\xad Rueda, Jes\\xc3\\xbas Fl\\xc3\\xb3rez, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl-X(L) antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 29. issue 7. 2012-03-19. PMID:21684326.' |
although bcl-x(l) downregulation suggests that the hippocampus of ts mice is less protected against programmed cell death, we did not find any evidence for increased apoptosis in ts mice since neither tunel-positive cells nor active caspase-3 expression were found in cortex or hippocampus of ts or co mice. |
2012-03-19 |
2023-08-12 |
mouse |
| Carlos Ramirez, Inmaculada Tercero, Antonia Pineda, Javier S Burgo. Simvastatin is the statin that most efficiently protects against kainate-induced excitotoxicity and memory impairment. Journal of Alzheimer's disease : JAD. vol 24. issue 1. 2012-03-06. PMID:21224519. |
simvastatin was the most effective statin in reducing the deleterious effects caused by kainate, including the severity of seizures, excitotoxicity, oxidative damage, neuritic dystrophy and apoptosis in the hippocampus and other limbic structures of the brain cortex. |
2012-03-06 |
2023-08-12 |
mouse |
| Hui-Fang Yang, Yin-E Zhang, Ling-Qin Zh. [Effects of regular exercise on apoptosis of CA3 region of hippocampal neurons in rats of chronic psychological stress]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 26. issue 6. 2012-02-27. PMID:18771626. |
[effects of regular exercise on apoptosis of ca3 region of hippocampal neurons in rats of chronic psychological stress]. |
2012-02-27 |
2023-08-12 |
rat |
| Zhaohui Liu, Li Gong, Xiaofang Li, Lin Ye, Bin Wang, Jing Liu, Jianyong Qiu, Huiduo Jiao, Wendong Zhang, Jingzao Chen, Jiuping Wan. Infrasound increases intracellular calcium concentration and induces apoptosis in hippocampi of adult rats. Molecular medicine reports. vol 5. issue 1. 2012-02-27. PMID:21946944. |
in the present study, we determined the effect of infrasonic exposure on apoptosis and intracellular free ca²⁺ ([ca²⁺]i) levels in the hippocampus of adult rats. |
2012-02-27 |
2023-08-12 |
rat |
| Zhaohui Liu, Li Gong, Xiaofang Li, Lin Ye, Bin Wang, Jing Liu, Jianyong Qiu, Huiduo Jiao, Wendong Zhang, Jingzao Chen, Jiuping Wan. Infrasound increases intracellular calcium concentration and induces apoptosis in hippocampi of adult rats. Molecular medicine reports. vol 5. issue 1. 2012-02-27. PMID:21946944. |
meanwhile, apoptosis in hippocampal neurons was found to increase on day 7 following 90 db spl infrasound exposure, and significantly increased on day 14. |
2012-02-27 |
2023-08-12 |
rat |