| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chia-Fu Chang, Hui-Ju Huang, Hsin-Chen Lee, Kai-Chih Hung, Rong-Tsun Wu, Anya Maan-Yuh Li. Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation. Journal of pineal research. vol 52. issue 3. 2012-07-05. PMID:22212051. |
furthermore, atg7 sirna attenuated ka-induced activation of caspases 3/12 (biomarkers of apoptosis) and hippocampal neuronal loss, suggesting a pro-apoptotic role of autophagy in the ka-induced neurotoxicity. |
2012-07-05 |
2023-08-12 |
mouse |
| Joshua C Bis, Charles DeCarli, Albert Vernon Smith, Fedde van der Lijn, Fabrice Crivello, Myriam Fornage, Stephanie Debette, Joshua M Shulman, Helena Schmidt, Velandai Srikanth, Maaike Schuur, Lei Yu, Seung-Hoan Choi, Sigurdur Sigurdsson, Benjamin F J Verhaaren, Anita L DeStefano, Jean-Charles Lambert, Clifford R Jack, Maksim Struchalin, Jim Stankovich, Carla A Ibrahim-Verbaas, Debra Fleischman, Alex Zijdenbos, Tom den Heijer, Bernard Mazoyer, Laura H Coker, Christian Enzinger, Patrick Danoy, Najaf Amin, Konstantinos Arfanakis, Mark A van Buchem, Renée F A G de Bruijn, Alexa Beiser, Carole Dufouil, Juebin Huang, Margherita Cavalieri, Russell Thomson, Wiro J Niessen, Lori B Chibnik, Gauti K Gislason, Albert Hofman, Aleksandra Pikula, Philippe Amouyel, Kevin B Freeman, Thanh G Phan, Ben A Oostra, Jason L Stein, Sarah E Medland, Alejandro Arias Vasquez, Derrek P Hibar, Margaret J Wright, Barbara Franke, Nicholas G Martin, Paul M Thompson, Michael A Nalls, Andre G Uitterlinden, Rhoda Au, Alexis Elbaz, Richard J Beare, John C van Swieten, Oscar L Lopez, Tamara B Harris, Vincent Chouraki, Monique M B Breteler, Philip L De Jager, James T Becker, Meike W Vernooij, David Knopman, Franz Fazekas, Philip A Wolf, Aad van der Lugt, Vilmundur Gudnason, W T Longstreth, Matthew A Brown, David A Bennett, Cornelia M van Duijn, Thomas H Mosley, Reinhold Schmidt, Christophe Tzourio, Lenore J Launer, M Arfan Ikram, Sudha Seshadr. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nature genetics. vol 44. issue 5. 2012-07-02. PMID:22504421. |
these associations implicate genes related to apoptosis (hrk), development (wif1), oxidative stress (msr3b), ubiquitination (fbxw8) and neuronal migration (astn2), as well as enzymes targeted by new diabetes medications (dpp4), indicating new genetic influences on hippocampal size and possibly the risk of cognitive decline and dementia. |
2012-07-02 |
2023-08-12 |
Not clear |
| Yu-Xian Li, Zuo-Li Xia, Lian-Bi Chen, Wen-Jing Ye, Ming-Feng Yang, Qiao-Ling Su. [The changes of bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 1. 2012-06-28. PMID:15719136. |
[the changes of bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats]. |
2012-06-28 |
2023-08-12 |
rat |
| Yu-Xian Li, Zuo-Li Xia, Lian-Bi Chen, Wen-Jing Ye, Ming-Feng Yang, Qiao-Ling Su. [The changes of bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 1. 2012-06-28. PMID:15719136. |
to investigate the changes in bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics, the model of lymphostatic encephalopathy was established by occluding and removing both the superficial and deep cervical lymph nodes in rats. |
2012-06-28 |
2023-08-12 |
rat |
| Yu-Xian Li, Zuo-Li Xia, Lian-Bi Chen, Wen-Jing Ye, Ming-Feng Yang, Qiao-Ling Su. [The changes of bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 1. 2012-06-28. PMID:15719136. |
h and e staining was used to observe the structure of brain tissues and tunel staining was used to detect in situ cell apoptosis in the hippocampus. |
2012-06-28 |
2023-08-12 |
rat |
| Yu-Xian Li, Zuo-Li Xia, Lian-Bi Chen, Wen-Jing Ye, Ming-Feng Yang, Qiao-Ling Su. [The changes of bcl-2, bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 57. issue 1. 2012-06-28. PMID:15719136. |
these results suggest that lymphostatic encephalopathy following the blockade of cervical lymphatics result in changes in bcl-2 and bax expression in the hippocampus and that apoptosis is the main form of neuron death. |
2012-06-28 |
2023-08-12 |
rat |
| Danielle L Meyer, Daniel R Davies, Jeffrey L Barr, Pasquale Manzerra, Gina L Forste. Mild traumatic brain injury in the rat alters neuronal number in the limbic system and increases conditioned fear and anxiety-like behaviors. Experimental neurology. vol 235. issue 2. 2012-06-28. PMID:22498103. |
findings suggest that mtbi was associated with significant neuronal cell loss in the ca1 region of the dorsal hippocampus and increased cell number in subregions of the amygdala, both of which appear to be related to alterations to apoptosis in these regions following mtbi. |
2012-06-28 |
2023-08-12 |
rat |
| Wang Shuangyan, Shen Ruowu, Ni Hongli, Zhang Bei, Sun Yon. Protective effects of Rg2 on hypoxia-induced neuronal damage in hippocampal neurons. Artificial cells, blood substitutes, and immobilization biotechnology. vol 40. issue 1-2. 2012-06-18. PMID:22082349. |
the apoptosis rate of hippocampal neurons was measured by flow cytometry with staining of pi. |
2012-06-18 |
2023-08-12 |
rat |
| Weiqiao Zhang, Baofeng Wang, Sanquan Zhou, Yongming Qi. The effect of ischemic post-conditioning on hippocampal cell apoptosis following global brain ischemia in rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 4. 2012-06-15. PMID:22300791. |
the effect of ischemic post-conditioning on hippocampal cell apoptosis following global brain ischemia in rats. |
2012-06-15 |
2023-08-12 |
rat |
| Weiqiao Zhang, Baofeng Wang, Sanquan Zhou, Yongming Qi. The effect of ischemic post-conditioning on hippocampal cell apoptosis following global brain ischemia in rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 4. 2012-06-15. PMID:22300791. |
we evaluated the effect of brain ischemic post-conditioning on cell apoptosis in the hippocampus following global brain ischemia in rats. |
2012-06-15 |
2023-08-12 |
rat |
| Anthony Falluel-Morel, Lulu Lin, Katie Sokolowski, Elizabeth McCandlish, Brian Buckley, Emanuel DiCicco-Bloo. N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus. Journal of neuroscience research. vol 90. issue 4. 2012-06-12. PMID:22420031. |
we previously developed an animal model in which we defined the sequence of events underlying neurotoxicity: methylmercury (mehg) injection in postnatal rat acutely induced inhibition of mitosis and stimulated apoptosis in the hippocampus, which later resulted in intermediate-term deficits in structure size and cell number. |
2012-06-12 |
2023-08-12 |
rat |
| D K Thotala, D E Hallahan, E M Yazlovitskay. Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell death and differentiation. vol 19. issue 3. 2012-06-08. PMID:21738215. |
glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating mdm2-p53 pathway. |
2012-06-08 |
2023-08-12 |
Not clear |
| D K Thotala, D E Hallahan, E M Yazlovitskay. Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell death and differentiation. vol 19. issue 3. 2012-06-08. PMID:21738215. |
the pathophysiology of these neurological changes is complex and includes radiation-induced apoptosis in the subgranular zone of the hippocampus. |
2012-06-08 |
2023-08-12 |
Not clear |
| D K Thotala, D E Hallahan, E M Yazlovitskay. Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell death and differentiation. vol 19. issue 3. 2012-06-08. PMID:21738215. |
we have recently found that inhibition of glycogen synthase kinase 3β (gsk-3β) resulted in significant protection from radiation-induced apoptosis in hippocampal neurons. |
2012-06-08 |
2023-08-12 |
Not clear |
| Xiao-Wei Huang, Yan Qing, Yan-fang Liang, Nian Sh. [Protected effects of MG-132 on apoptosis induced by deltamethrin in rat's hippocampus]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 28. issue 7. 2012-06-07. PMID:21114028. |
[protected effects of mg-132 on apoptosis induced by deltamethrin in rat's hippocampus]. |
2012-06-07 |
2023-08-12 |
rat |
| Xiao-Wei Huang, Yan Qing, Yan-fang Liang, Nian Sh. [Protected effects of MG-132 on apoptosis induced by deltamethrin in rat's hippocampus]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 28. issue 7. 2012-06-07. PMID:21114028. |
to study the protective effect of mg-132 on hippocampus cells apoptosis induced by deltamethrin (dm), one kind of pyrethroid pesticide. |
2012-06-07 |
2023-08-12 |
rat |
| Sule Çağlayan Sözmen, Semra Hız Kurul, Uluç Yiş, Kazım Tuğyan, Başak Baykara, Osman Yılma. Neuroprotective effects of recombinant human erythropoietin in the developing brain of rat after lithium-pilocarpine induced status epilepticus. Brain & development. vol 34. issue 3. 2012-06-04. PMID:21600713. |
it also diminished apoptosis in the ca1 and dentate gyrus regions of hippocampus. |
2012-06-04 |
2023-08-12 |
human |
| Wei Pang, Hao Lu, Yan-Dan Hu, Hong-Peng Yang, Xue Leng, Yu-Gang Jian. Depletion of intracellular zinc induced apoptosis in cultured hippocampal neurons through Raf/MEK/ERK pathways. Nutritional neuroscience. vol 15. issue 1. 2012-06-04. PMID:22305649. |
depletion of intracellular zinc induced apoptosis in cultured hippocampal neurons through raf/mek/erk pathways. |
2012-06-04 |
2023-08-12 |
Not clear |
| Wei Pang, Hao Lu, Yan-Dan Hu, Hong-Peng Yang, Xue Leng, Yu-Gang Jian. Depletion of intracellular zinc induced apoptosis in cultured hippocampal neurons through Raf/MEK/ERK pathways. Nutritional neuroscience. vol 15. issue 1. 2012-06-04. PMID:22305649. |
an experiment was performed to observe the changes in raf-1 kinase/mitogen-activated protein kinase erk (mek)/extracellular signal-regulated kinase (erk) signaling pathways in cultured hippocampal neurons and its correlation with neurons apoptosis induced by intracellular zinc depletion. |
2012-06-04 |
2023-08-12 |
Not clear |
| Wei Pang, Hao Lu, Yan-Dan Hu, Hong-Peng Yang, Xue Leng, Yu-Gang Jian. Depletion of intracellular zinc induced apoptosis in cultured hippocampal neurons through Raf/MEK/ERK pathways. Nutritional neuroscience. vol 15. issue 1. 2012-06-04. PMID:22305649. |
cultured hippocampal neurons were exposed to a cell membrane-permeant zinc chelator tpen (2 µm), and to tpen plus zinc sulfate (5 µm) for 24 h. cultures were then processed to detect neuronal viability by the methyl thiazolyl tetrazolium assay, while apoptosis rate was simultaneously observed by the flow cytometric analysis. |
2012-06-04 |
2023-08-12 |
Not clear |