| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carol Ward, Ian Dransfield, Joanna Murray, Stuart N Farrow, Christopher Haslett, Adriano G Ross. Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 12. 2002-07-16. PMID:12055237. |
most natural pgs studied herein (e.g., pge(2), pga(2), pga(1), pgf(2 alpha)) either delayed apoptosis or had no effect, whereas pgd(2) and its metabolite pgj(2) selectively induced eosinophil, but not neutrophil apoptosis. |
2002-07-16 |
2023-08-12 |
Not clear |
| Carol Ward, Ian Dransfield, Joanna Murray, Stuart N Farrow, Christopher Haslett, Adriano G Ross. Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 12. 2002-07-16. PMID:12055237. |
furthermore, delta(12)pgj(2) and 15dpgj(2) inhibited lps-induced i kappa b alpha degradation and subsequent inhibition of neutrophil apoptosis, suggesting that apoptosis is mediated via ppar-gamma-independent inhibition of nf-kappa b activation. |
2002-07-16 |
2023-08-12 |
Not clear |
| Zhiguo Liu, Yun Liu, Yihui Hong, Lisa Rapp, Elliot J Androphy, Jason J Che. Bovine papillomavirus type 1 E6-induced sensitization to apoptosis is distinct from its transforming activity. Virology. vol 295. issue 2. 2002-07-12. PMID:12033781. |
we have previously shown that c127 cells expressing bpv-1 e6 exhibited increased tumor necrosis factor alpha (tnf)-mediated apoptosis. |
2002-07-12 |
2023-08-12 |
cattle |
| Jasvir S Parmar, Ravi Mahadeva, Benjamin J Reed, Neda Farahi, Karen A Cadwallader, Mary T Keogan, Diana Bilton, Edwin R Chilvers, David A Loma. Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema. American journal of respiratory cell and molecular biology. vol 26. issue 6. 2002-07-03. PMID:12034572. |
polymeric alpha(1)-antitrypsin had no effect on basal or n-formyl-met-leu-phe- stimulated superoxide anion release or constitutive apoptosis. |
2002-07-03 |
2023-08-12 |
human |
| Thierry Rabilloud, Manfred Heller, Francoise Gasnier, Sylvie Luche, Catherine Rey, Ruedi Aebersold, Mohamed Benahmed, Pierre Louisot, Joel Lunard. Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. The Journal of biological chemistry. vol 277. issue 22. 2002-07-02. PMID:11904290. |
results obtained in a primary culture of leydig cells challenged with tumor necrosis factor alpha suggested that this oxidized/native balance of peroxiredoxin 2 may play an active role in resistance or susceptibility to tumor necrosis factor alpha-induced apoptosis. |
2002-07-02 |
2023-08-12 |
Not clear |
| Y Azuma, M Sakanashi, K Matsumot. The effect of alpha2,6-linked sialic acid on anti-IgM antibody-induced apoptosis in Ramos cells. Glycoconjugate journal. vol 18. issue 5. 2002-07-02. PMID:11925509. |
we investigated the effects of alpha(1)-acid glycoprotein (agp), which mainly contains alpha2,6-linked sialic acid, on anti-igm antibody (ab)-induced apoptosis in ramos cells, which are derived from burkitt's lymphoma. |
2002-07-02 |
2023-08-12 |
Not clear |
| Guoying Zhou, Bernard Roizma. Cation-independent mannose 6-phosphate receptor blocks apoptosis induced by herpes simplex virus 1 mutants lacking glycoprotein D and is likely the target of antiapoptotic activity of the glycoprotein. Journal of virology. vol 76. issue 12. 2002-07-01. PMID:12021353. |
these results exclude the possibility that to block apoptosis, gd must interact with its hvea receptor, a member of the tumor necrosis factor alpha receptor family. |
2002-07-01 |
2023-08-12 |
human |
| Daisuke Kanda, Hitoshi Takagi, Mitsuo Toyoda, Norio Horiguchi, Hiroaki Nakajima, Toshiyuki Otsuka, Masatomo Mor. Transforming growth factor alpha protects against Fas-mediated liver apoptosis in mice. FEBS letters. vol 519. issue 1-3. 2002-06-24. PMID:12023010. |
transforming growth factor alpha protects against fas-mediated liver apoptosis in mice. |
2002-06-24 |
2023-08-12 |
mouse |
| Daisuke Kanda, Hitoshi Takagi, Mitsuo Toyoda, Norio Horiguchi, Hiroaki Nakajima, Toshiyuki Otsuka, Masatomo Mor. Transforming growth factor alpha protects against Fas-mediated liver apoptosis in mice. FEBS letters. vol 519. issue 1-3. 2002-06-24. PMID:12023010. |
in this study, we demonstrated that overexpression of transforming growth factor alpha (tgfalpha) has a dramatic protective effect on fas-mediated hepatic apoptosis at the biochemical and histological levels. |
2002-06-24 |
2023-08-12 |
mouse |
| M Seve, F Chimienti, A Favie. [Role of intracellular zinc in programmed cell death]. Pathologie-biologie. vol 50. issue 3. 2002-06-10. PMID:11980336. |
zinc addition in cell culture medium prevents the apparition of morphological and biochemical signs induced by intracellular zinc chelation, but also by other apoptosis inducers like etoposide or tumour necrosis factor alpha (tnf alpha). |
2002-06-10 |
2023-08-12 |
Not clear |
| Huang-Ge Zhang, Jinfu Xie, Liang Xu, Pingar Yang, Xin Xu, Sheher Sun, Yongming Wang, David T Curiel, Hui-Chen Hsu, John D Mount. Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver. Journal of virology. vol 76. issue 11. 2002-06-10. PMID:11991997. |
apoptosis of hepatocytes can be induced by the innate immune response by signaling through death domain receptors on hepatocytes including the tumor necrosis factor alpha (tnf-alpha) receptor (tnfr), fas, and death domain receptors dr4 and dr5. |
2002-06-10 |
2023-08-12 |
Not clear |
| Jaroslaw P Maciejewski, Antonio M Risitano, Elaine M Sloand, Laura Wisch, Nancy Geller, John A Barrett, Neal S Young, Antonio M Ristian. A pilot study of the recombinant soluble human tumour necrosis factor receptor (p75)-Fc fusion protein in patients with myelodysplastic syndrome. British journal of haematology. vol 117. issue 1. 2002-05-31. PMID:11918541. |
tumor necrosis factor alpha (tnf-alpha), a potent inhibitor of haematopoiesis, has been hypothesized to mediate suppressive effects in mds: tnf-alpha levels are elevated and correlated with marrow apoptosis and cytopenia. |
2002-05-31 |
2023-08-12 |
human |
| Abujiang Pataer, Stephan A Vorburger, Glen N Barber, Sunil Chada, Abner M Mhashilkar, Helena Zou-Yang, Alexis L Stewart, Siddharth Balachandran, Jack A Roth, Kelly K Hunt, Stephen G Swishe. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer research. vol 62. issue 8. 2002-05-31. PMID:11956076. |
we report that ad-mda7 induces andactivates the double-stranded rna-dependent protein kinase (pkr), which leads to phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eif-2alpha) and the induction of apoptosis in lung cancer cells. |
2002-05-31 |
2023-08-12 |
Not clear |
| Ian W Jeffrey, Martin Bushell, Vivienne J Tilleray, Simon Morley, Michael J Clemen. Inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a DNA-damaging agent for caspases and the double-stranded RNA-dependent protein kinase. Cancer research. vol 62. issue 8. 2002-05-31. PMID:11956083. |
inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a dna-damaging agent for caspases and the double-stranded rna-dependent protein kinase. |
2002-05-31 |
2023-08-12 |
mouse |
| Gianfranco Alpini, Leonardo Baiocchi, Shannon Glaser, Yoshiyuki Ueno, Marco Marzioni, Heather Francis, Jo Lynne Phinizy, Mario Angelico, Gene Lesag. Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. Hepatology (Baltimore, Md.). vol 35. issue 5. 2002-05-24. PMID:11981754. |
the aim of this study was to determine if ursodeoxycholate (udca) or tauroursodeoxycholate (tudca) chronic feeding prevents the increased cholangiocyte growth and secretion in bile duct-ligated (bdl) rats, if udca and tudca effects are associated with increased cholangiocyte apoptosis, and to determine if this inhibition is dependent on increased intracellular ca(2+) ([ca(2+)](i)) and activation of protein kinase c (pkc) alpha. |
2002-05-24 |
2023-08-12 |
rat |
| Francesca Fallarino, Carmine Vacca, Ciriana Orabona, Maria L Belladonna, Roberta Bianchi, Brendan Marshall, Derin B Keskin, Andrew L Mellor, Maria C Fioretti, Ursula Grohmann, Paolo Puccett. Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells. International immunology. vol 14. issue 1. 2002-05-23. PMID:11751753. |
following activation by ifn-gamma, the latter cells, in particular the cd8 alpha(+) subset, exhibit high functional activity and, unlike macrophages, mediate apoptosis of t(h) cells in vitro. |
2002-05-23 |
2023-08-12 |
mouse |
| Patrick Diel, Sabine Olff, Simone Schmidt, Horst Michn. Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. The Journal of steroid biochemistry and molecular biology. vol 80. issue 1. 2002-05-14. PMID:11867264. |
in the presented study, we have analysed effects of the environmental estrogens bisphenol a (bpa), p-tert-octylphenol (oct), o,p'-ddt (ddt) and coumestrol (cou) on cell proliferation, apoptosis induction, progesterone receptor (pr) and androgen receptor (ar) mrna expression and er alpha protein expression in comparison to estradiol (e2) and the selective er modulator (serm) raloxifene (ral) and the pure antiestrogen faslodex (ici 182780) in the human breast cancer cell line mcf-7. |
2002-05-14 |
2023-08-12 |
human |
| M F Lucero Gritti, M Beviacqua, R H Bordenave, L S Rum. Interferon-alpha 2b modulation of doxorubicin sensitivity in a multidrug resistant cell line. Journal of experimental & clinical cancer research : CR. vol 20. issue 3. 2002-05-02. PMID:11718220. |
dox 50 ng/ml - ifn alpha 2b 500 iu/ml treatment inhibited cell proliferation (47.2 +/- 1.4%, p < 0.0001; mtt assay: 40.6 +/- 1.2%, p < 0.0001) and augmented the expression of p-170, bcl-2 and hla-abc, while it didn't exert apoptosis, producing a slight g2/m arrest. |
2002-05-02 |
2023-08-12 |
Not clear |
| Usha P Andley, Harendra C Patel, Jing-Hua X. The R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis. The Journal of biological chemistry. vol 277. issue 12. 2002-04-29. PMID:11756414. |
the r116c mutation in alpha a-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis. |
2002-04-29 |
2023-08-12 |
human |
| Rodolphe Filomenko, Florence Poirson-Bichat, Claire Billerey, Jean-Paul Belon, Carmen Garrido, Eric Solary, Ali Bettaie. Atypical protein kinase C zeta as a target for chemosensitization of tumor cells. Cancer research. vol 62. issue 6. 2002-04-29. PMID:11912160. |
pkczeta inhibition accelerates the occurrence of apoptosis in leukemic cells exposed to etoposide and tumor necrosis factor alpha. |
2002-04-29 |
2023-08-12 |
mouse |