| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carrie Anne Blakey Slatter, Hanif Kanji, Chris Alexander Coutts, Declan William Al. Expression of PKC in the developing zebrafish, Danio rerio. Journal of neurobiology. vol 62. issue 4. 2005-04-28. PMID:15547934. |
we performed tunel labeling and found no correlation between tunel-labeled and pkc alpha-labeled rohon-beard cells, suggesting that pkc alpha is not involved in rohon-beard apoptosis. |
2005-04-28 |
2023-08-12 |
zebrafish |
| Ute Oltmanns, Maria B Sukkar, Shaoping Xie, Matthias John, K Fan Chun. Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase. American journal of respiratory cell and molecular biology. vol 32. issue 4. 2005-04-28. PMID:15653931. |
the proteolytic activity released by neutrophils was essential for the proapoptotic effect because inhibition of elastase activity by alpha(1)-antitrypsin and meosuc-ala-ala-pro-ala-cmk (msack) reduced hasmc apoptosis. |
2005-04-28 |
2023-08-12 |
human |
| María José De Rosa, María Del Carmen Esandi, Andrés Garelli, Diego Rayes, Cecilia Bouza. Relationship between alpha 7 nAChR and apoptosis in human lymphocytes. Journal of neuroimmunology. vol 160. issue 1-2. 2005-04-28. PMID:15710468. |
relationship between alpha 7 nachr and apoptosis in human lymphocytes. |
2005-04-28 |
2023-08-12 |
human |
| Asha Manohar, Swati Ghosh Shome, John Lamar, Lee Stirling, Vandana Iyer, Kevin Pumiglia, C Michael DiPersi. Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway. Journal of cell science. vol 117. issue Pt 18. 2005-04-26. PMID:15280429. |
in the current study, we exploited keratinocyte cell lines derived from wild-type or alpha 3 integrin knockout mice to reveal a critical role for alpha 3 beta 1 in protecting keratinocytes from apoptosis upon serum withdrawal. |
2005-04-26 |
2023-08-12 |
mouse |
| Asha Manohar, Swati Ghosh Shome, John Lamar, Lee Stirling, Vandana Iyer, Kevin Pumiglia, C Michael DiPersi. Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway. Journal of cell science. vol 117. issue Pt 18. 2005-04-26. PMID:15280429. |
we show that alpha 3 beta 1-mediated adhesion to laminin-5 extracellular matrix inhibits proteolytic activation of caspase-3 and tunel-staining, both hallmarks of apoptosis. |
2005-04-26 |
2023-08-12 |
mouse |
| Asha Manohar, Swati Ghosh Shome, John Lamar, Lee Stirling, Vandana Iyer, Kevin Pumiglia, C Michael DiPersi. Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway. Journal of cell science. vol 117. issue Pt 18. 2005-04-26. PMID:15280429. |
we also show that alpha 3 beta1-mediated adhesion activates focal adhesion kinase (fak) and extracellular signal-regulated kinase (erk), and that inhibition of either fak or erk signaling leads to apoptosis of keratinocytes attached to laminin-5. |
2005-04-26 |
2023-08-12 |
mouse |
| Asha Manohar, Swati Ghosh Shome, John Lamar, Lee Stirling, Vandana Iyer, Kevin Pumiglia, C Michael DiPersi. Alpha 3 beta 1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway. Journal of cell science. vol 117. issue Pt 18. 2005-04-26. PMID:15280429. |
alpha 6 beta 4-mediated adhesion to laminin-5 only partially protects cells from apoptosis in the absence of alpha 3 beta 1, and alpha 6 beta 4 is not necessary for cell survival in the presence of alpha 3 beta 1. |
2005-04-26 |
2023-08-12 |
mouse |
| Heike Hall, Valentin Djonov, Martin Ehrbar, Matthias Hoechli, Jeffrey A Hubbel. Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo. Angiogenesis. vol 7. issue 3. 2005-04-25. PMID:15609076. |
in the presence of mab alpha(v)beta3 or cyclic rgd, apoptosis was induced. |
2005-04-25 |
2023-08-12 |
human |
| Katsunori Iwasaki, Izzettin Hatip-Al-Khatib, Nobuaki Egashira, Yuki Akiyoshi, Takashi Arai, Kenichi Mishima, Yuki Takagaki, Keiichiro Inui, Michihiro Fujiwar. Ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats. Neurotoxicity research. vol 6. issue 4. 2005-04-22. PMID:15545013. |
ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nachr expression without induction of apoptosis in the hippocampus ca1 neurons of rats. |
2005-04-22 |
2023-08-12 |
rat |
| Merideth C Kamradt, Meiling Lu, Michael E Werner, Toni Kwan, Feng Chen, Anne Strohecker, Shayna Oshita, John C Wilkinson, Chunjiang Yu, Patsy G Oliver, Colin S Duckett, Donald J Buchsbaum, Albert F LoBuglio, V Craig Jordan, Vincent L Cryn. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15653686. |
the small heat shock protein alpha b-crystallin is a novel inhibitor of trail-induced apoptosis that suppresses the activation of caspase-3. |
2005-04-21 |
2023-08-12 |
mouse |
| Merideth C Kamradt, Meiling Lu, Michael E Werner, Toni Kwan, Feng Chen, Anne Strohecker, Shayna Oshita, John C Wilkinson, Chunjiang Yu, Patsy G Oliver, Colin S Duckett, Donald J Buchsbaum, Albert F LoBuglio, V Craig Jordan, Vincent L Cryn. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15653686. |
tumor necrosis factor-related apoptosis-inducing ligand (trail) is a member of the tumor necrosis factor alpha family of cytokines that preferentially induces apoptosis in transformed cells, making it a promising cancer therapy. |
2005-04-21 |
2023-08-12 |
mouse |
| Merideth C Kamradt, Meiling Lu, Michael E Werner, Toni Kwan, Feng Chen, Anne Strohecker, Shayna Oshita, John C Wilkinson, Chunjiang Yu, Patsy G Oliver, Colin S Duckett, Donald J Buchsbaum, Albert F LoBuglio, V Craig Jordan, Vincent L Cryn. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15653686. |
stable expression of wild-type alpha b-crystallin, but not a pseudophosphorylation mutant impaired in its assembly and chaperone function, protects cancer cells from trail-induced caspase-3 activation and apoptosis in vitro. |
2005-04-21 |
2023-08-12 |
mouse |
| Merideth C Kamradt, Meiling Lu, Michael E Werner, Toni Kwan, Feng Chen, Anne Strohecker, Shayna Oshita, John C Wilkinson, Chunjiang Yu, Patsy G Oliver, Colin S Duckett, Donald J Buchsbaum, Albert F LoBuglio, V Craig Jordan, Vincent L Cryn. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15653686. |
in addition, wild-type alpha b-crystallin promotes xenograft tumor growth and inhibits trail-induced apoptosis in vivo in nude mice, whereas a pseudophosphorylation alpha b-crystallin mutant impaired in its anti-apoptotic function inhibits xenograft tumor growth. |
2005-04-21 |
2023-08-12 |
mouse |
| Merideth C Kamradt, Meiling Lu, Michael E Werner, Toni Kwan, Feng Chen, Anne Strohecker, Shayna Oshita, John C Wilkinson, Chunjiang Yu, Patsy G Oliver, Colin S Duckett, Donald J Buchsbaum, Albert F LoBuglio, V Craig Jordan, Vincent L Cryn. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15653686. |
collectively, these findings indicate that alpha b-crystallin is a novel regulator of trail-induced apoptosis and tumor growth. |
2005-04-21 |
2023-08-12 |
mouse |
| Merideth C Kamradt, Meiling Lu, Michael E Werner, Toni Kwan, Feng Chen, Anne Strohecker, Shayna Oshita, John C Wilkinson, Chunjiang Yu, Patsy G Oliver, Colin S Duckett, Donald J Buchsbaum, Albert F LoBuglio, V Craig Jordan, Vincent L Cryn. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15653686. |
moreover, these results demonstrate that targeted inhibition of alpha b-crystallin promotes trail-induced apoptosis, thereby suggesting a novel strategy to overcome trail resistance in cancer. |
2005-04-21 |
2023-08-12 |
mouse |
| Lihong Yin, Nabila Bennani-Baiti, C Thomas Powel. Phorbol ester-induced apoptosis of C4-2 cells requires both a unique and a redundant protein kinase C signaling pathway. The Journal of biological chemistry. vol 280. issue 7. 2005-04-18. PMID:15611126. |
previous reports have implicated activation of protein kinase c (pkc) isozymes alpha and delta in pma-induced lncap apoptosis using overexpression, pharmacological inhibitors, and dominant-negative constructs, but have left unresolved if other isozymes are involved, if there are separate requirements for individual pkc isozymes, or if there is redundancy. |
2005-04-18 |
2023-08-12 |
human |
| Anne Tarrade, Julie Bastien, Nathalie Bruck, Annie Bauer, Maurizio Gianni, Cécile Rochette-Egl. Retinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated RXR alpha. Oncogene. vol 24. issue 14. 2005-04-18. PMID:15688020. |
retinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated rxr alpha. |
2005-04-18 |
2023-08-12 |
Not clear |
| Xue Zheng, Yadong Zhang, Yu-Quan Chen, Vince Castranova, Xianglin Shi, Fei Che. Inhibition of NF-kappaB stabilizes gadd45alpha mRNA. Biochemical and biophysical research communications. vol 329. issue 1. 2005-04-13. PMID:15721278. |
growth arrest- and dna damage-inducible protein alpha (gadd45alpha) is an important regulator for cell cycle, genomic stability, and cell apoptosis. |
2005-04-13 |
2023-08-12 |
mouse |
| O Bajenova, B Tang, R Pearse, R Feinman, B H Childs, J Michael. RIP kinase is involved in arsenic-induced apoptosis in multiple myeloma cells. Apoptosis : an international journal on programmed cell death. vol 9. issue 5. 2005-04-12. PMID:15314284. |
rip is a key downstream protein in fasl/ tnf alpha /trail induced apoptosis and a major antiapoptotic adaptor of pathways through nf-kappa b and jnk. |
2005-04-12 |
2023-08-12 |
human |
| G G Chen, N-C Liang, J F Y Lee, U P F Chan, S H Wang, B C S Leung, K L Leun. Over-expression of Bcl-2 against Pteris semipinnata L-induced apoptosis of human colon cancer cells via a NF-kappa B-related pathway. Apoptosis : an international journal on programmed cell death. vol 9. issue 5. 2005-04-12. PMID:15314290. |
furthermore, inhibition of nf-kappa b by i k b alpha sr, which is a powerful inhibitor of nf-kappa b, restored the ability of 5f to induce apoptosis in the cells transfected with bcl-2. |
2005-04-12 |
2023-08-12 |
human |