| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haibo Zhao, F Patrick Ross, Steven L Teitelbau. Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal. Molecular endocrinology (Baltimore, Md.). vol 19. issue 3. 2005-06-28. PMID:15591537. |
beta3-/- preosteoclasts, in suspension, undergo a rate of apoptosis only 40-60% of that of their wild-type counterparts, indicating that unoccupied alpha(v)beta3 transmits a positive death signal that we find regulated by caspase-8. |
2005-06-28 |
2023-08-12 |
Not clear |
| Haibo Zhao, F Patrick Ross, Steven L Teitelbau. Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal. Molecular endocrinology (Baltimore, Md.). vol 19. issue 3. 2005-06-28. PMID:15591537. |
attesting to specificity of the unoccupied integrin-transmitted death signal, apoptosis in the absence of alpha(v)beta3 is mediated by capsase-9. |
2005-06-28 |
2023-08-12 |
Not clear |
| Haibo Zhao, F Patrick Ross, Steven L Teitelbau. Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal. Molecular endocrinology (Baltimore, Md.). vol 19. issue 3. 2005-06-28. PMID:15591537. |
thus, unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis via a component of the integrin that is different than that regulating resorption. |
2005-06-28 |
2023-08-12 |
Not clear |
| Yun Liu, Zhiguo Liu, Hua Gao, You Zhou, Elliot J Androphy, Jason J Che. Opposing effects of bovine papillomavirus type 1 E6 and E7 genes on Fas-mediated apoptosis. Oncogene. vol 24. issue 24. 2005-06-28. PMID:15782122. |
tumor necrosis factor alpha (tnf) and related cytokines are employed by host defenses to eliminate virally infected cells through induction of apoptosis. |
2005-06-28 |
2023-08-12 |
human |
| Christopher B Weldon, Amy McKee, Bridgette M Collins-Burow, Lilia I Melnik, Aline B Scandurro, John A McLachlan, Matthew E Burow, Barbara S Beckma. PKC-mediated survival signaling in breast carcinoma cells: a role for MEK1-AP1 signaling. International journal of oncology. vol 26. issue 3. 2005-06-17. PMID:15703835. |
here we demonstrate that tumor necrosis factor alpha (tnf)-induced apoptosis is suppressed by treatment with pma in mcf-7 breast carcinoma cells. |
2005-06-17 |
2023-08-12 |
Not clear |
| Mary Jo Atten, Ernesto Godoy-Romero, Bashar M Attar, Thomas Milson, Matthew Zopel, Oksana Holia. Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. Investigational new drugs. vol 23. issue 2. 2005-06-14. PMID:15744586. |
resveratrol regulates cellular pkc alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. |
2005-06-14 |
2023-08-12 |
Not clear |
| Mary Jo Atten, Ernesto Godoy-Romero, Bashar M Attar, Thomas Milson, Matthew Zopel, Oksana Holia. Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. Investigational new drugs. vol 23. issue 2. 2005-06-14. PMID:15744586. |
gastric adenocarcinoma cells respond to resveratrol treatment with suppression of dna synthesis, activation of nitric oxide synthase, induction of apoptosis and inhibition of total pkc and pkc alpha activity. |
2005-06-14 |
2023-08-12 |
Not clear |
| Daniel A Linseman, Brent D Butts, Thomas A Precht, Reid A Phelps, Shoshona S Le, Tracey A Laessig, Ron J Bouchard, Maria L Florez-McClure, Kim A Heidenreic. Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 44. 2005-06-09. PMID:15525785. |
in cerebellar granule neurons undergoing apoptosis, inhibition of gsk-3beta suppressed both the mitochondrial translocation of an expressed green fluorescent protein (gfp)-bax(alpha) fusion protein and the conformational activation of endogenous bax. |
2005-06-09 |
2023-08-12 |
human |
| Daniel A Linseman, Brent D Butts, Thomas A Precht, Reid A Phelps, Shoshona S Le, Tracey A Laessig, Ron J Bouchard, Maria L Florez-McClure, Kim A Heidenreic. Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 44. 2005-06-09. PMID:15525785. |
moreover, cotransfection with constitutively active gsk-3beta promoted the localization of bax(alpha) to mitochondria and induced apoptosis in both transfected hek293 cells and cerebellar granule neurons. |
2005-06-09 |
2023-08-12 |
human |
| S-B Catrina, M Lewitt, C Massambu, A Dricu, J Grünler, M Axelson, P Biberfeld, K Brisma. Insulin-like growth factor-I receptor activity is essential for Kaposi's sarcoma growth and survival. British journal of cancer. vol 92. issue 8. 2005-06-08. PMID:15812560. |
moreover, specific blockade of the receptor (either by alpha ir3 antibody or by picropodophyllin, a recently described selective igf-ir tyrosine phosphorylation inhibitor) induced ksimm apoptosis, suggesting that igf-ir agonists (igf-i and -ii) mediate antiapoptotic signals for these cells. |
2005-06-08 |
2023-08-12 |
human |
| Xianghong Li, Rong Zhang, Dianhong Luo, Sang-Joon Park, Qian Wang, Yongsok Kim, Wang Mi. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15701637. |
the apoptosis signal-regulating kinase 1 (ask1)-jnk/p38 signaling pathway is pivotal component in cell apoptosis and can be activated by a variety of death stimuli including tumor necrosis factor (tnf) alpha and oxidative stress (reactive oxygen species). |
2005-06-07 |
2023-08-12 |
Not clear |
| H M P Wilson, V Lesnikov, S R Plymate, J Ward, H J Dee. High IGFBP-3 levels in marrow plasma in early-stage MDS: effects on apoptosis and hemopoiesis. Leukemia. vol 19. issue 4. 2005-05-26. PMID:15703779. |
tumor necrosis factor (tnf)alpha levels are elevated, particularly in early-stage mds, and apoptosis in marrow cells is upregulated. |
2005-05-26 |
2023-08-12 |
Not clear |
| Dietrich B Conze, Lori Albert, David A Ferrick, David V Goeddel, Wen-Chen Yeh, Tak Mak, Jonathan D Ashwel. Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Molecular and cellular biology. vol 25. issue 8. 2005-05-24. PMID:15798218. |
inhibitor of apoptosis proteins (iaps) c-iap1 and c-iap2 were identified as part of the tumor necrosis factor receptor 2 (tnfr2) signaling complex and have been implicated as intermediaries in tumor necrosis factor alpha signaling. |
2005-05-24 |
2023-08-12 |
mouse |
| William J Kaiser, Margaret K Offerman. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 8. 2005-05-17. PMID:15814722. |
in this study, we investigated the control of apoptosis by the tir domain-containing adapter proteins myd88, tir-domain containing adapter protein (tirap), tir-domain-containing adapter-inducing ifn-beta (trif), trif-related adapter molecule (tram), and sterile alpha motifs and beta-catenin/armadillo repeats (sarm). |
2005-05-17 |
2023-08-12 |
Not clear |
| William J Kaiser, Margaret K Offerman. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 8. 2005-05-17. PMID:15814722. |
the domain that was required for induction of apoptosis could activate nf-kappa b but not ifn regulatory factor-3, yet the activation of nf-kappa b could be blocked by superrepressor i kappa b alpha without blocking apoptosis. |
2005-05-17 |
2023-08-12 |
Not clear |
| Hiroyuki Kumamoto, Kiyoshi Ooy. Expression of tumor necrosis factor alpha, TNF-related apoptosis-inducing ligand, and their associated molecules in ameloblastomas. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 34. issue 5. 2005-05-16. PMID:15817072. |
to clarify the roles of the apoptosis signaling pathway mediated by death receptors in oncogenesis and cytodifferentiation of odontogenic tumors, expression of tumor necrosis factor alpha (tnfalpha), tnf-related apoptosis-inducing ligand (trail), and their associated molecules was analyzed in ameloblastomas as well as in tooth germs. |
2005-05-16 |
2023-08-12 |
Not clear |
| E K Schmitz, D M Kraus, G A Bull. Tissue-specificity of apoptosis in hepatoma-derived cell lines. Apoptosis : an international journal on programmed cell death. vol 9. issue 3. 2005-05-13. PMID:15258469. |
here, we show that dedifferentiated hepatoma cells undergo apoptosis in response to multiple compounds, including sorbitol (to induce hyperosmotic shock), tnf alpha and the microtubule damaging agent vinblastin. |
2005-05-13 |
2023-08-12 |
Not clear |
| Donald L Courter, Lucy Lomas, Marta Scatena, Cecilia M Giachell. Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB. The Journal of biological chemistry. vol 280. issue 13. 2005-05-13. PMID:15695822. |
previous studies indicate that activation of the transcription factor nuclear factor-kappab was necessary for the integrin alpha(v)beta3 ligand osteopontin to protect endothelial cells from apoptosis caused by serum withdrawal. |
2005-05-13 |
2023-08-12 |
mouse |
| Ronan N T Coffey, Colm Morrissey, Cormac T Taylor, John M Fitzpatrick, R William G Watso. Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells. Cancer. vol 103. issue 7. 2005-05-05. PMID:15719438. |
resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells. |
2005-05-05 |
2023-08-12 |
Not clear |
| Carrie Anne Blakey Slatter, Hanif Kanji, Chris Alexander Coutts, Declan William Al. Expression of PKC in the developing zebrafish, Danio rerio. Journal of neurobiology. vol 62. issue 4. 2005-04-28. PMID:15547934. |
our other goal was to determine if pkc alpha was associated with rohon-beard neurons during the first 5 days of development, when they are reported to undergo apoptosis. |
2005-04-28 |
2023-08-12 |
zebrafish |