| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G P Zhizhina, V G Korobko, A V Alesenk. [Correlation of DNA degradation, induced by tumor necrosis factor-alpha, with accumulation of sphingosine in the nucleus and peroxides in DNA]. Biokhimiia (Moscow, Russia). vol 59. issue 11. 1995-04-03. PMID:7873682. |
the tumour necrosis factor alpha (tnf-alpha) initiates dna degradation in many types of cells, eventually resulting in a programmed cell death (apoptosis). |
1995-04-03 |
2023-08-12 |
mouse |
| M Chen, J Quintans, Z Fuks, C Thompson, D W Kufe, R R Weichselbau. Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide. Cancer research. vol 55. issue 5. 1995-03-30. PMID:7867010. |
recent studies have proposed that tumor necrosis factor alpha (tnf-alpha) and ionizing radiation induce apoptosis by activating hydrolysis of sphingomyelin to ceramide. |
1995-03-30 |
2023-08-12 |
human |
| L M Pilarski, M P Laderoute, D Rutkowsk. Apoptosis among CD45RA-/low CD3+ progeny accompanies differentiation of human multinegative thymocytes. Scandinavian journal of immunology. vol 41. issue 3. 1995-03-30. PMID:7871383. |
in contrast, tcr alpha beta progeny arising in culture appear to be less susceptible to apoptosis, perhaps due to their lack of cd4 and cd8. |
1995-03-30 |
2023-08-12 |
human |
| T Nakajima, N Ohi, T Arai, N Nozaki, A Kikuchi, K Od. Adenovirus E1A-induced apoptosis elicits a steep decrease in the topoisomerase II alpha level during the latent phase. Oncogene. vol 10. issue 4. 1995-03-22. PMID:7862442. |
adenovirus e1a-induced apoptosis elicits a steep decrease in the topoisomerase ii alpha level during the latent phase. |
1995-03-22 |
2023-08-12 |
human |
| T Nakajima, N Ohi, T Arai, N Nozaki, A Kikuchi, K Od. Adenovirus E1A-induced apoptosis elicits a steep decrease in the topoisomerase II alpha level during the latent phase. Oncogene. vol 10. issue 4. 1995-03-22. PMID:7862442. |
these results strongly suggest that e1a or e1a stabilized p53 induces apoptosis by targeting topoisomerase ii alpha to the ubiquitination pathway and e1b 19k alleviates its action. |
1995-03-22 |
2023-08-12 |
human |
| F Rosselli, A Ridet, T Soussi, E Duchaud, C Alapetite, E Moustacch. p53-dependent pathway of radio-induced apoptosis is altered in Fanconi anemia. Oncogene. vol 10. issue 1. 1995-02-14. PMID:7824283. |
since growth factor deprivation, tnf alpha treatment or dna damage can trigger apoptosis, we monitored the apoptotic response of fa cell lines. |
1995-02-14 |
2023-08-12 |
human |
| P C Brooks, A M Montgomery, M Rosenfeld, R A Reisfeld, T Hu, G Klier, D A Cheres. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. vol 79. issue 7. 1995-01-23. PMID:7528107. |
integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. |
1995-01-23 |
2023-08-12 |
human |
| D Shiokawa, H Ohyama, T Yamada, K Takahashi, S Tanum. Identification of an endonuclease responsible for apoptosis in rat thymocytes. European journal of biochemistry. vol 226. issue 1. 1994-12-28. PMID:7957253. |
during the induction of apoptosis, treatment with cycloheximide, which suppressed apoptosis, resulted in marked decreases of deoxyribonucleases alpha and beta activities. |
1994-12-28 |
2023-08-12 |
rat |
| W S May, P G Tyler, T Ito, D K Armstrong, K A Qatsha, N E Davidso. Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis. The Journal of biological chemistry. vol 269. issue 43. 1994-11-23. PMID:7929424. |
interleukin-3 and bryostatin-1 mediate hyperphosphorylation of bcl2 alpha in association with suppression of apoptosis. |
1994-11-23 |
2023-08-12 |
Not clear |
| W S May, P G Tyler, T Ito, D K Armstrong, K A Qatsha, N E Davidso. Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis. The Journal of biological chemistry. vol 269. issue 43. 1994-11-23. PMID:7929424. |
using murine myeloid factor-dependent fdc-p1/er cells, we demonstrate that the hematopoietic growth factors interleukin-3 and erythropoietin and bryostatin-1, a macrocyclic lactone natural product and potent activator of protein kinase c (pkc), suppress apoptosis and induce the rapid serine phosphorylation of bc12 alpha. |
1994-11-23 |
2023-08-12 |
Not clear |
| W S May, P G Tyler, T Ito, D K Armstrong, K A Qatsha, N E Davidso. Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis. The Journal of biological chemistry. vol 269. issue 43. 1994-11-23. PMID:7929424. |
these findings strongly support a role for activated pkc in growth factor-induced bc12 alpha phosphorylation as well as suppression of apoptosis. |
1994-11-23 |
2023-08-12 |
Not clear |
| Y Matsumoto, K Hiromatsu, T Sakai, Y Kobayashi, Y Kimura, J Usami, T Shinzato, K Maeda, Y Yoshika. Co-stimulation with LFA-1 triggers apoptosis in gamma delta T cells on T cell receptor engagement. European journal of immunology. vol 24. issue 10. 1994-11-07. PMID:7925573. |
t cells but not alpha beta t cells undergo apoptosis upon co-cross-linking of tcr and lfa-1 in mrl lpr/lpr mice as well as +/+ mice. |
1994-11-07 |
2023-08-12 |
mouse |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
induction of endothelial cell apoptosis by tnf alpha: modulation by inhibitors of protein synthesis. |
1994-11-04 |
2023-08-12 |
cattle |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
our objective was to examine the induction of endothelial cell apoptosis by the proinflammatory ligand, tnf alpha. |
1994-11-04 |
2023-08-12 |
cattle |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
we hypothesized that tnf alpha influences endothelial cell viability by altering the balance of regulatory molecules that either induce or suppress apoptosis. |
1994-11-04 |
2023-08-12 |
cattle |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
since the identity of these regulators is unknown, our approach was to examine induction of endothelial cell apoptosis by tnf alpha alone and in the context of an inhibitor of transcription or translation. |
1994-11-04 |
2023-08-12 |
cattle |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
tnf alpha was able to induce bovine pulmonary artery endothelial cell apoptosis in a dose-dependent fashion. |
1994-11-04 |
2023-08-12 |
cattle |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
inhibition of transcription with actinomycin d or translation with cycloheximide also resulted in apoptosis, which reached a maximum value of approximately 35 to 40% of cells after 24 h. tnf alpha induction of apoptosis was either potentiated or abrogated by cycloheximide, depending on the timing of tnf alpha exposure in relation to inhibition of protein synthesis. |
1994-11-04 |
2023-08-12 |
cattle |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
when cycloheximide was added concomitantly with midrange concentrations of tnf alpha, there was both a dramatic acceleration and a synergistic increase in the observed apoptotic response, with all endothelial cells dying within 24 h. when cycloheximide was added as a function of time after termination of tnf alpha exposure, the synergistic induction of apoptosis was maintained at > 70% of its maximum value for 1 h, declining monotonically in a time-dependent fashion to baseline values after 6 h. in contrast, when tnf alpha was added after protein synthesis was inhibited, no additional increase in apoptosis above that observed with inhibition of protein synthesis alone was observed. |
1994-11-04 |
2023-08-12 |
cattle |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
our results are consistent with the concept that endothelial cell viability depends on an interaction of inducers and suppressors of apoptosis, which are susceptible to modulation by tnf alpha. |
1994-11-04 |
2023-08-12 |
cattle |