| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Maeda, F Horiuchi, J Miyatake, H Sono, Y Tatsumi, F Urase, K Irimajiri, A Horiuch. Inhibition of growth and induction of apoptosis by all-trans retinoic acid in lymphoid cell lines transfected with the PML/RAR alpha fusion gene. British journal of haematology. vol 93. issue 4. 1996-09-12. PMID:8703836. |
the exogenous pml/rar alpha fusion gene therefore probably mediates the effects of atra on cell growth and apoptosis in these cell lines. |
1996-09-12 |
2023-08-12 |
Not clear |
| G Q Chen, J Zhu, X G Shi, J H Ni, H J Zhong, G Y Si, X L Jin, W Tang, X S Li, S M Xong, Z X Shen, G L Sun, J Ma, P Zhang, T D Zhang, C Gazin, T Naoe, S J Chen, Z Y Wang, Z Che. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood. vol 88. issue 3. 1996-09-12. PMID:8704214. |
moreover, this apoptosis induction occurs independently of the retinoid pathway and may be mediated, at least partly, through the modulation of bcl-2, as well as pml-rar alpha and/ or pml proteins. |
1996-09-12 |
2023-08-12 |
Not clear |
| A Takahashi, E S Alnemri, Y A Lazebnik, T Fernandes-Alnemri, G Litwack, R D Moir, R D Goldman, G G Poirier, S H Kaufmann, W C Earnsha. Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 16. 1996-09-12. PMID:8710882. |
cleavage of lamin a by mch2 alpha but not cpp32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. |
1996-09-12 |
2023-08-12 |
human |
| L Y Romanova, I A Alexandrov, G Schwab, D M Hilbert, J F Mushinski, R P Norda. Mechanism of apoptosis suppression by phorbol ester in IL-6-starved murine plasmacytomas: role of PKC modulation and cell cycle. Biochemistry. vol 35. issue 30. 1996-09-10. PMID:8703964. |
we show here that the mode of cell death in il-6-starved t1165 and t1198 plasmacytoma cell lines is apoptosis, and that it can be suppressed by phorbol ester (pma) treatment in a protein kinase c (pkc)-mediated process that involves alpha and/or delta isozymes. |
1996-09-10 |
2023-08-12 |
Not clear |
| M Dobbelstein, T Shen. Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product. Journal of virology. vol 70. issue 9. 1996-09-10. PMID:8709286. |
infection by vaccinia virus protects hela cells against apoptosis that is induced by an immunoglobulin m antibody against the fas receptor or by tumor necrosis factor alpha. |
1996-09-10 |
2023-08-12 |
Not clear |
| A Bettaieb, M Record, M G Côme, A C Bras, H Chap, G Laurent, J P Jaffrézo. Opposite effects of tumor necrosis factor alpha on the sphingomyelin-ceramide pathway in two myeloid leukemia cell lines: role of transverse sphingomyelin distribution in the plasma membrane. Blood. vol 88. issue 4. 1996-09-05. PMID:8695867. |
our results show that tnf alpha induced apoptosis in u937 but not in kg1a cells. |
1996-09-05 |
2023-08-12 |
Not clear |
| A M Gardner, G L Johnso. Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase. The Journal of biological chemistry. vol 271. issue 24. 1996-08-20. PMID:8662985. |
treatment of l929 cells with tumor necrosis factor alpha (tnfalpha) activates a programmed cell death pathway resulting in apoptosis. |
1996-08-20 |
2023-08-12 |
Not clear |
| V Modur, G A Zimmerman, S M Prescott, T M McIntyr. Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and -independent mitogen-activated protein kinase cascades. The Journal of biological chemistry. vol 271. issue 22. 1996-08-15. PMID:8662702. |
ceramide generation by stimulated sphingomyelinase activity has been implicated in tumor necrosis factor alpha (tnf) signaling of apoptosis and differentiation. |
1996-08-15 |
2023-08-12 |
Not clear |
| K L Anderson, G Anderson, R H Michell, E J Jenkinson, J J Owe. Intracellular signaling pathways involved in the induction of apoptosis in immature thymic T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 11. 1996-08-08. PMID:8666773. |
inhibition of protein synthesis (with cycloheximide or emetine) prevents the apoptosis induced by anti-cd3 and elevated camp, but not that induced by anti-fas, whereas protease inhibition (with 3,4-dichloroisocoumarin or n(alpha)-tosyl-phenylalanine chloromethyl ketone) prevents the apoptosis caused by all of the effective stimuli. |
1996-08-08 |
2023-08-12 |
mouse |
| J Matuszy. [Use of anti-H-Y/Db transgenic mice in studies on T-lymphocyte development and mechanisms of leukemogenesis]. Postepy higieny i medycyny doswiadczalnej. vol 49. issue 1. 1996-07-30. PMID:8657619. |
during the development of t cells in the thymus, the alpha beta t-cell receptor (tcr) mediated interactions of immature cd4+ cd8+ cells with thymic major histocompatibility complex (mhc) molecules in the absence of specific antigens are required for their survival and further maturation (positive selection) whereas interactions with mhc molecules presenting specific antigens result in their death by apoptosis (negative selection). |
1996-07-30 |
2023-08-12 |
mouse |
| E Ruoslaht. Integrin signaling and matrix assembly. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 17. issue 2. 1996-07-26. PMID:8658014. |
the alpha 5 beta 1 integrin appears to be a growth-suppressing integrin, and it protects cells from apoptosis when growth factors are absent. |
1996-07-26 |
2023-08-12 |
Not clear |
| Y Tokoro, S Tsuda, S Tanaka, H Nakauchi, Y Takaham. CD3-induced apoptosis of CD4+CD8+ thymocytes in the absence of clonotypic T cell antigen receptor. European journal of immunology. vol 26. issue 5. 1996-07-25. PMID:8647161. |
the present study shows that the cd3-induced apoptosis of cd4+cd8+ thymocytes can occur even in tcr alpha- mutant mice which do not express the tcr alpha beta/cd3 antigen receptor. |
1996-07-25 |
2023-08-12 |
mouse |
| A Morikawa, T Sugiyama, Y Kato, N Koide, G Z Jiang, K Takahashi, Y Tamada, T Yokoch. Apoptotic cell death in the response of D-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model. Infection and immunity. vol 64. issue 3. 1996-07-16. PMID:8641774. |
the hepatocyte apoptosis induced by lipopolysaccharide was completely prevented by an anti-tumor necrosis factor alpha antibody but not by an anti-gamma interferon antibody. |
1996-07-16 |
2023-08-12 |
mouse |
| A Gillio Tos, A Cignetti, G Rovera, R Fo. Retroviral vector-mediated transfer of the tumor necrosis factor alpha gene into human cancer cells restores an apoptotic cell death program and induces a bystander-killing effect. Blood. vol 87. issue 6. 1996-07-02. PMID:8630415. |
tumor necrosis factor alpha (tnfalpha) may induce tumor cell death by apoptosis, the physiologic program of cell death usually lost during neoplastic progression. |
1996-07-02 |
2023-08-12 |
human |
| D Leszczynski, S Joenväärä, M L Foeg. Protein kinase C-alpha regulates proliferation but not apoptosis in rat coronary vascular smooth muscle cells. Life sciences. vol 58. issue 7. 1996-07-01. PMID:8632713. |
in the present study we analysed whether selective depletion of alpha isozyme of pkc would affect smc proliferation and/or apoptosis. |
1996-07-01 |
2023-08-12 |
rat |
| K Ueda, D Gane. Apoptosis is induced by N-myc expression in hepatocytes, a frequent event in hepadnavirus oncogenesis, and is blocked by insulin-like growth factor II. Journal of virology. vol 70. issue 3. 1996-06-27. PMID:8627653. |
expression of the woodchuck hepatitis virus x gene in alpha ml cells does not alter the growth phenotype of the cells and has no effect upon n-myc-dependent apoptosis. |
1996-06-27 |
2023-08-12 |
mouse |
| K Ueda, D Gane. Apoptosis is induced by N-myc expression in hepatocytes, a frequent event in hepadnavirus oncogenesis, and is blocked by insulin-like growth factor II. Journal of virology. vol 70. issue 3. 1996-06-27. PMID:8627653. |
however, apoptosis in n-myc2-expressing alpha ml cells is strongly inhibited by insulin-like growth factor ii (igf ii). |
1996-06-27 |
2023-08-12 |
mouse |
| B Nag, S Arimilli, P V Mukku, I Astafiev. Functionally active recombinant alpha and beta chain-peptide complexes of human major histocompatibility class II molecules. The Journal of biological chemistry. vol 271. issue 17. 1996-06-21. PMID:8626615. |
the present study describes that individual recombinant alpha and beta chains of human mhc class ii molecules lacking the transmembrane region (alpha-tm and beta-tm) are capable of binding antigenic peptide and that these complexes of chain-peptide are recognized by tcrs to induce antigen-specific apoptosis in restricted t cells. |
1996-06-21 |
2023-08-12 |
human |
| H M Beere, C M Chresta, J A Hickma. Selective inhibition of topoisomerase II by ICRF-193 does not support a role for topoisomerase II activity in the fragmentation of chromatin during apoptosis of human leukemia cells. Molecular pharmacology. vol 49. issue 5. 1996-06-19. PMID:8622634. |
the induction of apoptosis by both etoposide and nmf was associated with a reduction in the cellular levels of topoisomerases ii alpha and ii beta. |
1996-06-19 |
2023-08-12 |
human |
| N Boudreau, Z Werb, M J Bissel. Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 8. 1996-06-18. PMID:8622967. |
in the absence of three-dimensional alveolar structures, mammary epithelial cells secrete a number of factors including transforming growth factor alpha and tenascin, which when added exogenously to quiescent cells induced expression of c-myc and interleukin-beta1-converting enzyme (ice) mrna and led to apoptosis. |
1996-06-18 |
2023-08-12 |
Not clear |