| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Ma, Ning Huang, Jun Tang, Zunjie Zhou, Jing Xu, Yi Chen, Maoxin Zhang, Qin Huang, Yuan Chen. The TRPM4 channel inhibitor 9-phenanthrol alleviates cerebral edema after traumatic brain injury in rats. Frontiers in pharmacology. vol 14. 2023-03-03. PMID:36865920. |
in this experiment, we observed that 9-ph markedly reduced brain water content, bbb disruption, proliferation of microglia and astrocytes, neutrophil infiltration, neuronal apoptosis and neurobehavioral deficits. |
2023-03-03 |
2023-08-14 |
rat |
| Hong Wang, Zhao-Wu Ma, Feng-Ming Ho, Gautam Sethi, Feng Ru Tan. Dual Effects of miR-181b-2-3p/SOX21 Interaction on Microglia and Neural Stem Cells after Gamma Irradiation. Cells. vol 12. issue 4. 2023-02-25. PMID:36831315. |
ionizing radiation induces brain inflammation and the impairment of neurogenesis by activating microglia and inducing apoptosis in neurogenic zones. |
2023-02-25 |
2023-08-14 |
mouse |
| Chouhui Xuan, Haixia Cui, Zhengyong Jin, Yuyang Yue, Shuxia Cao, Songbiao Cui, Dongyuan X. Glutamine ameliorates hyperoxia-induced hippocampal damage by attenuating inflammation and apoptosis Frontiers in pharmacology. vol 14. 2023-02-23. PMID:36817145. |
gln treatment significantly reduced brain tissue water content, oxidative stress levels, microglia activation and inflammatory factor expression, and attenuated tissue damage and apoptosis in the hippocampal region. |
2023-02-23 |
2023-08-14 |
rat |
| Hongyu Yi, Yali Duan, Renjie Song, Yibo Zhou, Yating Cui, Chao Liu, Zhi Mao, Jie Hu, Feihu Zho. Activation of glucagon-like peptide-1 receptor in microglia exerts protective effects against sepsis-induced encephalopathy via attenuating endoplasmic reticulum stress-associated inflammation and apoptosis in a mouse model of sepsis. Experimental neurology. 2023-02-22. PMID:36813224. |
activation of glucagon-like peptide-1 receptor in microglia exerts protective effects against sepsis-induced encephalopathy via attenuating endoplasmic reticulum stress-associated inflammation and apoptosis in a mouse model of sepsis. |
2023-02-22 |
2023-08-14 |
mouse |
| Zheng Peng, Cong Pang, Xiao-Jian Li, Hua-Sheng Zhang, Jia-Tong Zhang, Qi Zhu, Hua-Jie Xu, Yong-Yue Gao, Zong Zhuang, Wei Li, Qing-Rong Zhang, Yue Lu, Chun-Hua Han. Peroxiredoxin 2 Is a Potential Objective Indicator for Severity and the Clinical Status of Subarachnoid Hemorrhage Patients. Disease markers. vol 2023. 2023-02-16. PMID:36793477. |
we have demonstrated that peroxiredoxin 2 (prx2) released from lytic erythrocytes and damaged neurons into the subarachnoid space could activate microglia and then result in neuronal apoptosis. |
2023-02-16 |
2023-08-14 |
Not clear |
| Min An, Yi Qiu, Caixia Wang, Penglei Ma, Yumei Din. Rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating JNK signaling pathway and suppressing SIRT1 expression in chronic constriction injury-induced neuropathic pain. Journal of neuropathology and experimental neurology. 2023-02-13. PMID:36779914. |
rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating jnk signaling pathway and suppressing sirt1 expression in chronic constriction injury-induced neuropathic pain. |
2023-02-13 |
2023-08-14 |
rat |
| Min An, Yi Qiu, Caixia Wang, Penglei Ma, Yumei Din. Rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating JNK signaling pathway and suppressing SIRT1 expression in chronic constriction injury-induced neuropathic pain. Journal of neuropathology and experimental neurology. 2023-02-13. PMID:36779914. |
rac2 overexpression also aggravated the inflammatory response, induced activation of microglia and astrocytes, and enhanced apoptosis whereas knockdown of rac2 had the opposite effects. |
2023-02-13 |
2023-08-14 |
rat |
| Min An, Yi Qiu, Caixia Wang, Penglei Ma, Yumei Din. Rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating JNK signaling pathway and suppressing SIRT1 expression in chronic constriction injury-induced neuropathic pain. Journal of neuropathology and experimental neurology. 2023-02-13. PMID:36779914. |
these findings indicate that rac2 enhances the activation of microglia and astrocytes, inflammatory response, and apoptosis via activating the jnk signaling pathway and suppressing sirt1 expression in cci-induced np. |
2023-02-13 |
2023-08-14 |
rat |
| Byung-Kwon Jung, Yujin Park, Boran Yoon, Jin-Sil Bae, Seung-Woo Han, Ji-Eun Heo, Dong-Eun Kim, Kwon-Yul Ry. Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage. Autophagy. 2023-02-13. PMID:36781380. |
under neuroinflammatory stress conditions, lcn2 is produced and secreted by activated microglia and reactive astrocytes, resulting in neuronal apoptosis. |
2023-02-13 |
2023-08-14 |
Not clear |
| Peipei Cao, Yue Cheng, Zhi Li, Ya-Jia Cheng, Xiaoqi Chu, Chao Geng, Xuebo Yin, Yuhao L. Intraocular delivery of ZIF-90-RhB-GW2580 nanoparticles prevents the progression of photoreceptor degeneration. Journal of nanobiotechnology. vol 21. issue 1. 2023-02-07. PMID:36747224. |
the results showed that in vitro gw2580 treatment promoted phenotypic transformation in microglia and led to the blockade of photoreceptor apoptosis. |
2023-02-07 |
2023-08-14 |
zebrafish |
| Yuanyuan Zhang, Pengyu Jia, Kui Wang, Yan Zhang, Yuying Lv, Pei Fan, Liufei Yang, Shuyue Zhang, Tianyue Wang, Jing Zhao, Haixia Lv, Xinlin Chen, Yong Liu, Haidong Wei, Pengbo Zhan. Lactate modulates microglial inflammatory responses after oxygen-glucose deprivation through HIF-1α-mediated inhibition of NF-κB. Brain research bulletin. 2023-02-06. PMID:36746287. |
finally, and importantly, lactate-treated bv2 microglia increased the viability and decreased the apoptosis of neurons after ogd. |
2023-02-06 |
2023-08-14 |
Not clear |
| Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Che. Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation. Microbiome. vol 11. issue 1. 2023-02-01. PMID:36721179. |
here, we established fecal microbiota transplantation, aeromonas colonization and lps or butyrate supplementation tests to evaluate the role of the intestinal microbiota and its metabolites in melatonin in alleviating sd-induced memory impairment. results: transplantation of the sd-gut microbiota into normal mice induced microglia overactivation and neuronal apoptosis in the hippocampus, cognitive decline, and colonic microbiota disorder, manifesting as increased levels of aeromonas and lps and decreased levels of lachnospiraceae_nk4a136 and butyrate. |
2023-02-01 |
2023-08-14 |
mouse |
| Tsz Ki K. Does Drinking Coffee Reduce the Incidence of Parkinson's Disease? Cureus. vol 15. issue 1. 2023-02-01. PMID:36721713. |
the inhibition of inflammation and microglial cell activation to reduce reactive oxygen species (ros)-induced cellular damage and the resultant mitochondrial dysfunction of the dopaminergic neurons appears to be the main pathway, inducing neuronal loss via the activation of the intrinsic pathway to apoptosis. |
2023-02-01 |
2023-08-14 |
mouse |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
in line with in vivo findings, trem2-overexpressing bv2 microglia following β-amyloid (aβ) stimulation led to a significant increase in the phosphorylation of pi3k, akt, and gsk-3β, accompanied by a decrease in tau hyperphosphorylation and apoptosis in co-cultured sh-sy5y cells. |
2023-01-20 |
2023-08-14 |
mouse |
| Ying Chen, Yan Dong, Zai-Li Zhang, Jie Han, Feng-Shou Chen, Xiang-Yi Tong, Hong M. Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury. Brain pathology (Zurich, Switzerland). vol 33. issue 1. 2023-01-12. PMID:36634215. |
in our study, fra-1 was highly upregulated especially in neurons and microglia and promoted apoptosis by changing the expression of bax/bcl-2 after scii. |
2023-01-12 |
2023-08-14 |
rat |
| Fangzi Ke, Hongyun Wang, Jiaqing Geng, Fang Fang, Xiaoqi Jing, Chengzhi Fang, Bing-Hong Zhan. MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage. Experimental neurology. 2023-01-07. PMID:36608839. |
silencing of sirt1 reversed the effects of mir-155 inhibitor on apoptosis and the nf-κb pathway in ogd/r-treated pc12 cells and microglia (bv2) cells. |
2023-01-07 |
2023-08-14 |
rat |
| Xiao-Yi Wang, Fan Wu, Ren-Ya Zhan, Heng-Jun Zho. Inflammatory role of microglia in brain injury caused by subarachnoid hemorrhage. Frontiers in cellular neuroscience. vol 16. 2022-12-23. PMID:36561497. |
microglia are involved in the occurrence of brain edema, the processes of neuronal apoptosis, and the blood-brain barrier disruption after subarachnoid hemorrhage (sah) through the signaling pathways mediated by receptors such as toll-like receptor 4 (tlr4), calcium-sensing receptor (casr), and triggering receptor expressed on myeloid cells-1 (trem-1), which secrete pro-inflammatory cytokines such as interleukins and tumor necrosis factor α. |
2022-12-23 |
2023-08-14 |
Not clear |
| Jian-Wu Ni, Cai-Xia Li, Xiong-Wei Chen, Wen-Pin Ca. Triggering Receptor Expressed on Myeloid Cell-2 Protects PC12 Cells Injury by Inhibiting BV2 Microglial Activation. Neurology India. vol 70. issue 6. 2022-12-20. PMID:36537419. |
assessment of apoptosis in pc12 cells mediated by bv2 microglia was analyzed using tunel assays. |
2022-12-20 |
2023-08-14 |
Not clear |
| Jian-Wu Ni, Cai-Xia Li, Xiong-Wei Chen, Wen-Pin Ca. Triggering Receptor Expressed on Myeloid Cell-2 Protects PC12 Cells Injury by Inhibiting BV2 Microglial Activation. Neurology India. vol 70. issue 6. 2022-12-20. PMID:36537419. |
it indicated that trem-2 inhibited lps-mediated neuronal apoptosis by down-regulating inos and up-regulating the expression of arg-1 in bv2 microglia. |
2022-12-20 |
2023-08-14 |
Not clear |
| Changqing Yang, Fei Yuan, Wan Shao, Lihong Yao, Shaoju Jin, Fangfang Ha. Protective role of exosomes derived from regulatory T cells against inflammation and apoptosis of BV-2 microglia under oxygen-glucose deprivation/reperfusion challenge. Genetics and molecular biology. vol 45. issue 4. 2022-12-20. PMID:36537744. |
protective role of exosomes derived from regulatory t cells against inflammation and apoptosis of bv-2 microglia under oxygen-glucose deprivation/reperfusion challenge. |
2022-12-20 |
2023-08-14 |
Not clear |