| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhaoming Chu, You Lu, Rujie Qin, Yuefu Don. LncRNA KCNQ1OT1 promotes the apoptosis and inflammatory response of microglia by regulating the miR-589-5p/NPTN axis after spinal cord injury. Anais da Academia Brasileira de Ciencias. vol 94. issue 2. 2022-06-15. PMID:35703693. |
spinal cord injury (sci) is a devastating traumatic condition accompanied with excessive inflammatory response and apoptosis of microglia. |
2022-06-15 |
2023-08-14 |
mouse |
| Zhaoming Chu, You Lu, Rujie Qin, Yuefu Don. LncRNA KCNQ1OT1 promotes the apoptosis and inflammatory response of microglia by regulating the miR-589-5p/NPTN axis after spinal cord injury. Anais da Academia Brasileira de Ciencias. vol 94. issue 2. 2022-06-15. PMID:35703693. |
nevertheless, the role of lncrna kcnq1ot1 in microglia apoptosis or inflammatory response after sci remains to be explored. |
2022-06-15 |
2023-08-14 |
mouse |
| Zhaoming Chu, You Lu, Rujie Qin, Yuefu Don. LncRNA KCNQ1OT1 promotes the apoptosis and inflammatory response of microglia by regulating the miR-589-5p/NPTN axis after spinal cord injury. Anais da Academia Brasileira de Ciencias. vol 94. issue 2. 2022-06-15. PMID:35703693. |
inhibition of kcnq1ot1 suppressed the inflammatory response and apoptosis of microglia. |
2022-06-15 |
2023-08-14 |
mouse |
| Zhaoming Chu, You Lu, Rujie Qin, Yuefu Don. LncRNA KCNQ1OT1 promotes the apoptosis and inflammatory response of microglia by regulating the miR-589-5p/NPTN axis after spinal cord injury. Anais da Academia Brasileira de Ciencias. vol 94. issue 2. 2022-06-15. PMID:35703693. |
in summary, these data revealed that kcnq1ot1 promoted inflammatory response and apoptosis of microglia by regulating the mir-589-5p/nptn axis after sci, which may offer a novel promising therapeutic target for sci. |
2022-06-15 |
2023-08-14 |
mouse |
| Kai Guo, Yulin Chang, Yutao Jin, Hong Yuan, Ping Ch. circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-κB Pathway. Journal of molecular neuroscience : MN. 2022-06-10. PMID:35687299. |
circ-ncam2 (mmu_circ_0006413) participates in lps-induced microglia activation and neuronal apoptosis via the tlr4/nf-κb pathway. |
2022-06-10 |
2023-08-14 |
mouse |
| Kai Guo, Yulin Chang, Yutao Jin, Hong Yuan, Ping Ch. circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-κB Pathway. Journal of molecular neuroscience : MN. 2022-06-10. PMID:35687299. |
circ-ncam2 silencing lowered lps-induced microglia activation and neuronal apoptosis via blocking the tlr4/nf-κb pathway through acting as a mir-544-3p sponge, suggesting that circ-ncam2 may be involved in secondary sci. |
2022-06-10 |
2023-08-14 |
mouse |
| Daozhou Liu, Qifeng Ji, Ying Cheng, Miao Liu, Bangle Zhang, Qibing Mei, Menglei Huan, Siyuan Zho. Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice. Journal of nanobiotechnology. vol 20. issue 1. 2022-06-06. PMID:35658867. |
however, when ischemic brain tissue is re-perfused by blood, the mitochondrial permeability transition pore (mptp) in neuron and microglia is excessively opened, resulting in the apoptosis of neuron and nerve inflammation. |
2022-06-06 |
2023-08-14 |
mouse |
| Daozhou Liu, Qifeng Ji, Ying Cheng, Miao Liu, Bangle Zhang, Qibing Mei, Menglei Huan, Siyuan Zho. Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice. Journal of nanobiotechnology. vol 20. issue 1. 2022-06-06. PMID:35658867. |
cyclosporine a (csa) inhibits the over-opening of mptp, subsequently reducing the release of ros and the apoptosis of cerebral ischemia/reperfusion injured neuron and microglia. |
2022-06-06 |
2023-08-14 |
mouse |
| Liang Wen, Ya-Dong Wang, Dong-Feng Shen, Pei-Dong Zheng, Meng-Di Tu, Wen-Dong You, Yuan-Run Zhu, Hao Wang, Jun-Feng Feng, Xiao-Feng Yan. Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury. Neural regeneration research. vol 17. issue 12. 2022-06-06. PMID:35662219. |
our in vivo experiments showed that tail vein injection of exosomes reduced cell apoptosis in cortical tissue of mouse models of traumatic brain injury, inhibited neuroinflammation, and promoted the transformation of microglia to the anti-inflammatory phenotype. |
2022-06-06 |
2023-08-14 |
mouse |
| Liang Wen, Ya-Dong Wang, Dong-Feng Shen, Pei-Dong Zheng, Meng-Di Tu, Wen-Dong You, Yuan-Run Zhu, Hao Wang, Jun-Feng Feng, Xiao-Feng Yan. Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury. Neural regeneration research. vol 17. issue 12. 2022-06-06. PMID:35662219. |
we found that mir181b overexpression effectively reduced apoptosis and neuroinflamatory response after traumatic brain injury and promoted the transformation of microglia to the anti-inflammatory phenotype. |
2022-06-06 |
2023-08-14 |
mouse |
| Hye-Rim Choi, Ji Sun Ha, Eun-A Kim, Sung-Woo Cho, Seung-Ju Yan. MiR-30a-5p and miR-153-3p regulate LPS-induced neuroinflammatory response and neuronal apoptosis by targeting NeuroD1. BMB reports. 2022-06-02. PMID:35651331. |
together, these results indicate that mir-30a-5p and mir-153-3p inhibit mapk/nf-κb pathway in microglia as well as erk/stat-3 pathway in astrocytes to reduce lps-induced neuronal apoptosis. |
2022-06-02 |
2023-08-13 |
Not clear |
| Frauke Seehusen, Jordan J Clark, Parul Sharma, Eleanor G Bentley, Adam Kirby, Krishanthi Subramaniam, Sabina Wunderlin-Giuliani, Grant L Hughes, Edward I Patterson, Benedict D Michael, Andrew Owen, Julian A Hiscox, James P Stewart, Anja Kipa. Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse. Viruses. vol 14. issue 5. 2022-05-28. PMID:35632761. |
microgliosis and immune cell apoptosis indicate a potential role of microglia for pathogenesis and viral effect in covid-19 and the possible impairment of neurological functions, especially in long covid. |
2022-05-28 |
2023-08-13 |
mouse |
| Huichao Feng, Yahuan Cui, Jing Liu, Meiyi Liu, Wei Zhou, Zhenyu Yan, Haixia Zhang, Yingman Wang, Xueming Wang, Xiaomin Liu, Naiyao Che. Effects of 3-Methyladenine on Microglia Autophagy and Neuronal Apoptosis After Radiation-Induced Brain Injury. Dose-response : a publication of International Hormesis Society. vol 20. issue 2. 2022-05-26. PMID:35615570. |
effects of 3-methyladenine on microglia autophagy and neuronal apoptosis after radiation-induced brain injury. |
2022-05-26 |
2023-08-13 |
rat |
| Huichao Feng, Yahuan Cui, Jing Liu, Meiyi Liu, Wei Zhou, Zhenyu Yan, Haixia Zhang, Yingman Wang, Xueming Wang, Xiaomin Liu, Naiyao Che. Effects of 3-Methyladenine on Microglia Autophagy and Neuronal Apoptosis After Radiation-Induced Brain Injury. Dose-response : a publication of International Hormesis Society. vol 20. issue 2. 2022-05-26. PMID:35615570. |
to determine the effect of the autophagy inhibitor, 3-methyladenine (3-ma), on cognitive function changes, microglia activity, neuronal apoptosis, and inflammation in rats following radiation-induced brain injury. |
2022-05-26 |
2023-08-13 |
rat |
| Xiyan Mu, Jia Liu, Hui Wang, Lilai Yuan, Chengju Wang, Yingren Li, Jing Qi. Bisphenol F Impaired Zebrafish Cognitive Ability through Inducing Neural Cell Heterogeneous Responses. Environmental science & technology. 2022-05-26. PMID:35616434. |
cell-specific transcriptomic profiles showed that abnormal phagocytosis, activated brain cell death, and apoptosis occurred in microglia post bpf exposure, which are responsible for the neuron loss. |
2022-05-26 |
2023-08-13 |
zebrafish |
| Hongdan Lu, Shengnan Li, Dongwei Dai, Qi Zhang, Zhiyi Min, Chuanzhou Yang, Shanbo Sun, Lu Ye, Chuanhui Teng, Xiang Cao, Haoyuan Yin, Lingyan Lv, Wei Lv, Hongliang Xi. Enhanced Treatment of Cerebral Ischemia-reperfusion Injury by Intelligent Nanocarriers through the Regulation of Neurovascular Units. Acta biomaterialia. 2022-05-19. PMID:35588994. |
our in vitro and in vivo data showed that the intelligent nanocarrier exerted the ability of pathological signal stimuli-responsive drug release, cerebral ischemia-reperfusion injury site targeting and neurovascular units remodeling through reducing neuron apoptosis, regulating microglia polarization and repairing vascular endothelial cell. |
2022-05-19 |
2023-08-13 |
mouse |
| Yu Zhang, Cheng-Jun Xing, Xiao Liu, Ya-Hong Li, Jing Jia, Jian-Guo Feng, Cheng-Jie Yang, Ye Chen, Jun Zho. Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation. Oxidative medicine and cellular longevity. vol 2022. 2022-05-16. PMID:35571246. |
txnip knockdown dramatically ameliorated the 7-day survival rate, cognitive decline, brain damage, neuronal apoptosis, and the brain water content, inhibited the activation of microglia, downregulated the nlrp3/caspase-1 signaling pathway, and reduced the oxidative stress and the neuroinflammatory cytokine levels at 24 h post-lps injection. |
2022-05-16 |
2023-08-13 |
mouse |
| Tapan Behl, Piyush Madaan, Aayush Sehgal, Sukhbir Singh, Hafiz A Makeen, Mohammed Albratty, Hassan A Alhazmi, Abdulkarim M Meraya, Simona Bunga. Demystifying the Neuroprotective Role of Neuropeptides in Parkinson's Disease: A Newfangled and Eloquent Therapeutic Perspective. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35562956. |
numerous nps, for instance, substance p (sp), ghrelin, neuropeptide y (npy), neurotensin, pituitary adenylate cyclase-activating polypeptide (pacap), nesfatin-1, and somatostatin, have been displayed to exhibit consequential neuroprotection in both in vivo and in vitro pd models via suppressing apoptosis, cytotoxicity, oxidative stress, inflammation, autophagy, neuronal toxicity, microglia stimulation, attenuating disease-associated manifestations, and stimulating chondriosomal bioenergetics. |
2022-05-14 |
2023-08-13 |
human |
| Lin Liu, Tingting Zhou, Tao Li, Zhanhua Liang, Xiaoguang Lu. LncRNA DLX6-AS1 promotes microglial inflammatory response in Parkinson's disease by regulating the miR-223-3p/NRP1 axis. Behavioural brain research. 2022-05-13. PMID:35550840. |
meanwhile, the cell number of th+/caspase3+/iba1+ in substantia nigra, cell viability, and apoptosis rate of bv2 microglia, inflammatory levels, and nlr family pyrin domain containing 3 (nlrp3) inflammasome were determined using immunohistochemistry, mtt assay, flow cytometry, elisa assay, and western blot. |
2022-05-13 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
stat3 activation in microglia increases pericyte apoptosis in diabetic retinas through tnf-ɑ/akt/p70s6 kinase signaling. |
2022-05-13 |
2023-08-13 |
mouse |