| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Huang, Wei Zhang, Weishuai Li, Yan Gao, Dongming Zheng, Guorong B. Overexpressing circ_0000831 is sufficient to inhibit neuroinflammation and vertigo in cerebral ischemia through a miR-16-5p-dependent mechanism. Experimental neurology. 2022-03-18. PMID:35300972. |
consistently, circ_0000831, adipor2, or pparγ upregulation or mir-16-5p downregulation diminished apoptosis and inflammation of ogd-induced microglia. |
2022-03-18 |
2023-08-13 |
mouse |
| Wei He, Qian Wang, Weiping Sha, Liming Wang, Di Li, Gang Che. P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 99. 2022-03-15. PMID:35290938. |
p2x4 inhibition reduces microglia inflammation and apoptosis by nlrp3 and improves nervous system defects in rat brain trauma model. |
2022-03-15 |
2023-08-13 |
rat |
| Wei He, Qian Wang, Weiping Sha, Liming Wang, Di Li, Gang Che. P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 99. 2022-03-15. PMID:35290938. |
the inhibition of p2x4 effectively reduced the inflammation and apoptosis of microglia, and nlrp3 may be involved in this process. |
2022-03-15 |
2023-08-13 |
rat |
| Wei He, Qian Wang, Weiping Sha, Liming Wang, Di Li, Gang Che. P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 99. 2022-03-15. PMID:35290938. |
our results indicate that inhibition of p2x4 may be a potential therapeutic approach for tbi by reducing the occurrence of inflammation and apoptosis of microglia, alleviating brain edema, and improving neurological deficits. |
2022-03-15 |
2023-08-13 |
rat |
| Jun-Feng Zhao, Tong Ren, Xiang-Yu Li, Tian-Lin Guo, Chun-Hui Liu, Xun Wan. Research Progress on the Role of Microglia Membrane Proteins or Receptors in Neuroinflammation and Degeneration. Frontiers in cellular neuroscience. vol 16. 2022-03-14. PMID:35281298. |
they can then allosterically activate the downstream signal transduction and produce a series of complex cascade reactions that can activate microglia, promote microglia chemotactic migration and stimulate the release of proinflammatory factor such as tnf-α, il-β to effectively damage the nervous system and cause apoptosis of neurons. |
2022-03-14 |
2023-08-13 |
Not clear |
| Kuang Zheng, Yuliang Zhang, Chengwei Zhang, Wangyang Ye, Chenxing Ye, Xianxi Tan, Ye Xion. PRMT8 Attenuates Cerebral Ischemia/Reperfusion Injury via Modulating Microglia Activation and Polarization to Suppress Neuroinflammation by Upregulating Lin28a. ACS chemical neuroscience. 2022-03-11. PMID:35275616. |
in conclusion, prmt8 promoted m2 phenotype polarization of microglia and suppressed neuronal apoptosis to ameliorate cerebral ischemia/reperfusion injury through upregulation of lin28a. |
2022-03-11 |
2023-08-13 |
mouse |
| Andrea N Nortey, Kimberly N Garces, Abigail S Hacka. Exploring the role of interleukin-27 as a regulator of neuronal survival in central nervous system diseases. Neural regeneration research. vol 17. issue 10. 2022-03-09. PMID:35259821. |
interleukin-27 is secreted from and binds to infiltrating microglia, macrophage, astrocytes, and even neurons and it promotes neuronal survival by regulating pro- and anti-inflammatory cytokines, neuroinflammatory pathways, oxidative stress, apoptosis, autophagy, and epigenetic modifications. |
2022-03-09 |
2023-08-13 |
mouse |
| Danielle Beckman, Adele M H Seelke, Jeffrey Bennett, Paige Dougherty, Koen K A Van Rompay, Rebekah Keesler, Patricia A Pesavento, Lark L A Coffey, John H Morrison, Eliza Bliss-Morea. Neuroanatomical abnormalities in a nonhuman primate model of congenital Zika virus infection. eLife. vol 11. 2022-03-09. PMID:35261339. |
ihc staining revealed the presence of zikv in the frontal lobe, which contained activated microglia and showed increased apoptosis of immature neurons. |
2022-03-09 |
2023-08-13 |
human |
| Qian Xia, Gaofeng Zhan, Meng Mao, Yin Zhao, Xing L. TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury. Experimental & molecular medicine. 2022-02-26. PMID:35217833. |
in an in vitro coculture transwell system, downregulation of trim45 expression also inhibited the ogd/r-induced activation of microglia and alleviated neuronal apoptosis. |
2022-02-26 |
2023-08-13 |
mouse |
| Jingwen Xie, Lin Liu, Hao Guo, Qi Bao, Penglong Hu, Hongyan Li, Hongxia Che, Wancui Xi. Orally administered melanin from Sepiapharaonis ink ameliorates depression-anxiety-like behaviors in DSS-induced colitis by mediating inflammation pathway and regulating apoptosis. International immunopharmacology. vol 106. 2022-02-18. PMID:35180627. |
further mechanism studies indicated that msi alleviated inflammatory response by adjusting cytokines tnf-α, il-1β, ifn-γ, and il-10, and proteins nlrp3/asc/caspase-1 inflammasome), inhibited the activation of microglia, restored brain synaptic density, reduced oxidative stress (sod, mda) and regulated apoptosis (tunel staining, caspase-3). |
2022-02-18 |
2023-08-13 |
mouse |
| Rafael de la Hoz-Camacho, Ana Luisa Rivera-Lazarín, Jose Manuel Vázquez-Guillen, Diana Caballero-Hernández, Edgar Mendoza-Gamboa, Ana Carolina Martínez-Torres, Cristina Rodríguez-Padill. Cyclophosphamide and epirubicin induce high apoptosis in microglia cells while epirubicin provokes DNA damage and microglial activation at sub-lethal concentrations. EXCLI journal. vol 21. 2022-02-11. PMID:35145370. |
cyclophosphamide and epirubicin induce high apoptosis in microglia cells while epirubicin provokes dna damage and microglial activation at sub-lethal concentrations. |
2022-02-11 |
2023-08-13 |
Not clear |
| Chunyan Fu, Qincui Shuang, Yonghui Liu, Li Zeng, Wen S. Baihe Extracts Reduce the Activation and Apoptosis of Microglia in the Hippocampus of Mice with Depression-like Behaviors by Downregulating MYC. ACS chemical neuroscience. 2022-02-09. PMID:35139304. |
baihe extracts reduce the activation and apoptosis of microglia in the hippocampus of mice with depression-like behaviors by downregulating myc. |
2022-02-09 |
2023-08-13 |
mouse |
| Ping Zheng, Qingke Bai, Jiugeng Feng, Bing Zhao, Jian Duan, Lin Zhao, Ning Liu, Dabin Ren, Shufeng Zou, Wei Che. Neonatal microglia and proteinase inhibitors-treated adult microglia improve traumatic brain injury in rats by resolving the neuroinflammation. Bioengineering & translational medicine. vol 7. issue 1. 2022-01-26. PMID:35079627. |
the injection of neonatal microglia inhibited cell apoptosis, reduced astrocytosis and microgliosis, decreased the level of chemokines and cytokines in cortex and ipsilateral hippocampus, and improved cognitive function of tbi rat model. |
2022-01-26 |
2023-08-13 |
rat |
| Ping Zheng, Qingke Bai, Jiugeng Feng, Bing Zhao, Jian Duan, Lin Zhao, Ning Liu, Dabin Ren, Shufeng Zou, Wei Che. Neonatal microglia and proteinase inhibitors-treated adult microglia improve traumatic brain injury in rats by resolving the neuroinflammation. Bioengineering & translational medicine. vol 7. issue 1. 2022-01-26. PMID:35079627. |
the transplantation of peptidase inhibitors-treated adult microglia also inhibited cell apoptosis, reduced astrocytosis and microgliosis, and improved cognitive function of rats with tbi. |
2022-01-26 |
2023-08-13 |
rat |
| Mengmeng Jiang, Hai Xie, Chaoyang Zhang, Tianqin Wang, Haibin Tian, Lixia Lu, Jing-Ying Xu, Guo-Tong Xu, Lin Liu, Jingfa Zhan. Enhancing fractalkine/CX3CR1 signalling pathway can reduce neuroinflammation by attenuating microglia activation in experimental diabetic retinopathy. Journal of cellular and molecular medicine. 2022-01-13. PMID:35023309. |
to characterize the effect of fkn on microglia activation in dr, we employed streptozotocin-induced diabetic rats, glyoxal-treated r28 cells and hypoxia-treated bv2 cells to mimic diabetic conditions and explored retinal neuronal apoptosis, reactive oxygen species (ros), as well as the expressions of fkn, iba-1, tspo, nf-κb, nrf2 and inflammation-related cytokines. |
2022-01-13 |
2023-08-13 |
rat |
| Matylda Barbara Mielcarska, Katarzyna Skowrońska, Zbigniew Wyżewski, Felix Ngosa Tok. Disrupting Neurons and Glial Cells Oneness in the Brain-The Possible Causal Role of Herpes Simplex Virus Type 1 (HSV-1) in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008671. |
we describe the changes in neurons, astrocytes, microglia, and oligodendrocytes related to the production of inflammatory factors, transition of glial cells into a reactive state, oxidative damage, aβ secretion, tau hyperphosphorylation, apoptosis, and autophagy. |
2022-01-11 |
2023-08-13 |
Not clear |
| Urszula Hohmann, Christoph Walsleben, Chalid Ghadban, Frank Kirchhoff, Faramarz Dehghani, Tim Hohman. Interaction of Glia Cells with Glioblastoma and Melanoma Cells under the Influence of Phytocannabinoids. Cells. vol 11. issue 1. 2022-01-11. PMID:35011711. |
glioblastoma and brain metastasis can contain 30-40% of tumor-associated macrophages, microglia, and astrocytes, affecting migration, proliferation, and apoptosis. |
2022-01-11 |
2023-08-13 |
human |
| Utpal Kumar Adhikari, Elif Sakiz, Umma Habiba, Meena Mikhael, Matteo Senesi, Monique Antoinette David, Gilles J Guillemin, Lezanne Ooi, Tim Karl, Steven Collins, Mourad Tayeb. Treatment of microglia with Anti-PrP monoclonal antibodies induces neuronal apoptosis Heliyon. vol 7. issue 12. 2022-01-10. PMID:35005289. |
treatment of microglia with anti-prp monoclonal antibodies induces neuronal apoptosis previous reports highlighted the neurotoxic effects caused by some motif-specific anti-prp |
2022-01-10 |
2023-08-13 |
Not clear |
| Dan Fu, Cai Chen, Liang He, Jingjuan Li, Aiguo L. Protective Effect of Mild Hypothermia on Spinal Cord Ischemia-Induced Delayed Paralysis and Spinal Cord Injury. Neurochemical research. 2022-01-07. PMID:34993705. |
in in vitro experiments, primary microglial cells were treated under hypothermic condition, in which m1/m2 polarization and microglia apoptosis, the levels of inos, cd86, cd206, arg-1 and inflammatory cytokines were assessed. |
2022-01-07 |
2023-08-13 |
rat |
| Jie Liu, Wei Ma, Cheng-Hao Zang, Guo-Dong Wang, Si-Jia Zhang, Hong-Jie Wu, Ke-Wei Zhu, Xiang-Lin Xiang, Chun-Yan Li, Kuang-Pin Liu, Jian-Hui Guo, Li-Yan L. Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway. Annals of translational medicine. vol 9. issue 22. 2022-01-06. PMID:34988203. |
salidroside inhibits nlrp3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the tlr4/nf-κb signaling pathway. |
2022-01-06 |
2023-08-13 |
Not clear |