| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
we identified tnf-α as a potent inducer of pericyte apoptosis in diabetic retinas from the gene expression analysis and found that stat3 activation in microglia increased tnf-α expression in the diabetic retinas. |
2022-05-13 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
we also demonstrated that increased tnf-α expression in microglia caused pericyte apoptosis through downregulating akt/p70s6 kinase signaling. |
2022-05-13 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
moreover, we took advantage of mice lacking stat3 in microglia and demonstrated that stat3 ablation in microglia reduced the pericyte apoptosis and tnf-α expression in the diabetic retinas. |
2022-05-13 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
these results suggest that stat3 activation in microglia plays an important role in pericyte apoptosis in the diabetic retinas through increased tnf-α expression and provide stat3 activation in microglia as a potential therapeutic target for preventing pericyte loss in dr. |
2022-05-13 |
2023-08-13 |
mouse |
| Yuhan Yan, Yu Liu, Yujiao Yang, Yi Ding, Xin Su. Carnosol suppresses microglia cell inflammation and apoptosis through PI3K/AKT/mTOR signaling pathway. Immunopharmacology and immunotoxicology. 2022-05-06. PMID:35521965. |
carnosol suppresses microglia cell inflammation and apoptosis through pi3k/akt/mtor signaling pathway. |
2022-05-06 |
2023-08-13 |
Not clear |
| Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vette. Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. eLife. vol 11. 2022-04-28. PMID:35481836. |
neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. |
2022-04-28 |
2023-08-13 |
mouse |
| Sarah Rose Anderson, Jacqueline M Roberts, Nathaniel Ghena, Emmalyn A Irvin, Joon Schwakopf, Isabelle B Cooperstein, Alejandra Bosco, Monica L Vette. Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence. eLife. vol 11. 2022-04-28. PMID:35481836. |
using early postnatal mouse retina, a cns region undergoing significant developmental remodeling, we performed scrnaseq on microglia from mice that are wild-type, lack neuronal apoptosis (bax ko), or are treated with csf1r inhibitor (plx3397). |
2022-04-28 |
2023-08-13 |
mouse |
| Jiale Cai, Jiayin Liang, Yutong Zhang, Lin Shen, Huiting Lin, Tao Hu, Sikai Zhan, Meixia Xie, Shengwang Liang, Minghua Xian, Shumei Wan. Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviated ischemic stroke reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways. Pharmacological research. 2022-04-28. PMID:35483515. |
the protective effects of sc were dependent on the junb and sox5 to inhibit inflammation and apoptosis in microglia. |
2022-04-28 |
2023-08-13 |
rat |
| Jennifer M Gibson, Tianci Chu, Wenxin Zeng, Ashley C Wethall, Maiying Kong, Nicholas Mellen, Lori A Devlin Phinney, Jun Ca. Perinatal methadone exposure attenuates myelination and induces oligodendrocyte apoptosis in neonatal rat brain. Experimental biology and medicine (Maywood, N.J.). 2022-04-27. PMID:35475383. |
taken together, perinatal mtd exposure reveals global attenuation of myelination, accelerated apoptosis of both differentiated and myelinating oligodendrocytes, and microglia activation, supporting an association between antenatal mtd exposure and impaired myelination in the developing brain. |
2022-04-27 |
2023-08-13 |
rat |
| Xue Xue, Rui Duan, Guoyan Zheng, Hucheng Chen, Weiwei Zhang, Liang Sh. Translocator protein (18 kDa) regulates the microglial phenotype in Parkinson's disease through P47. Bioengineered. vol 13. issue 4. 2022-04-27. PMID:35475466. |
the effect of tspo and pk11195 on lps+ifn-γ-induced microglial cell apoptosis was examined using immunofluorescence (if), flow cytometry, and western blotting. |
2022-04-27 |
2023-08-13 |
Not clear |
| Mei-Ling Gao, Xiao Zhang, Fang Han, Jia Xu, Si-Jian Yu, Kangxin Jin, Zi-Bing Ji. Functional microglia derived from human pluripotent stem cells empower retinal organ. Science China. Life sciences. 2022-04-22. PMID:35451725. |
when co-cultured with three-dimensional human retinal organoids (hros), imgs migrated into the hros, tended to differentiate into resident retinal microglia, and simultaneously induced apoptosis in some neural cells. |
2022-04-22 |
2023-08-13 |
human |
| P De Berdt, K Vanvarenberg, B Ucakar, C Bouzin, A Paquot, V Gratpain, A Loriot, V Payen, B Bearzatto, G G Muccioli, L Gatto, A Diogenes, A des Rieu. The human dental apical papilla promotes spinal cord repair through a paracrine mechanism. Cellular and molecular life sciences : CMLS. vol 79. issue 5. 2022-04-21. PMID:35445984. |
we found that the apical papilla reduced inflammation at the lesion site, had a neuroprotective effect on motoneurons, and increased the apoptosis of activated macrophages/ microglia. |
2022-04-21 |
2023-08-13 |
human |
| Rishabh Khera, Sidharth Mehan, Sumit Kumar, Pranshul Sethi, Sonalika Bhalla, Aradhana Prajapat. Role of JAK-STAT and PPAR-Gamma Signalling Modulators in the Prevention of Autism and Neurological Dysfunctions. Molecular neurobiology. 2022-04-19. PMID:35437700. |
jak activation phosphorylates stat3 in astrocytes and microglia, and this phosphorylation has been linked to mitochondrial damage, apoptosis, neuroinflammation, reactive astrogliosis, and genetic mutations. |
2022-04-19 |
2023-08-13 |
Not clear |
| Fei Wang, Jian-Jun Xia, Li-Juan Shen, Ting-Ting Jiang, Wu-Lin Li, Da-Li You, Qing Chang, Shan-You Hu, Li Wang, Xiao W. Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation by suppressing the JAK1/STAT1 pathway. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2022-04-05. PMID:35381181. |
the results suggested that the m1-type microglia were activated after ich, while the effect was blocked by curcumin treatment, suggesting that curcumin alleviates the neuroinflammation and apoptosis of neurons by suppressing the m1-type polarization of microglia. |
2022-04-05 |
2023-08-13 |
Not clear |
| Chaoying Hu, Xiaoping Chen, Mingyang Wang, Li Zhang, Dan Gao, Lan Zhan. Analgecine protects against cerebral ischemia-reperfusion through apoptosis inhibition and anti-neuroinflammation in rats. Neuropeptides. vol 93. 2022-04-04. PMID:35378359. |
the immunohistochemistry data showed that agc reduced neuronal injury and apoptosis, and inhibited microglia and astrocytes activation. |
2022-04-04 |
2023-08-13 |
rat |
| Ziyu Yu, Yuwen Wen, Nan Jiang, Zhidong Li, Jieying Guan, Yingying Zhang, Caibing Deng, Ling Zhao, Song Guo Zheng, Yingting Zhu, Wenru Su, Yehong Zhu. TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p axis. Biomaterials. vol 284. 2022-04-04. PMID:35378413. |
the present study aimed to elucidate the pathways involving tnf-α-stimulated gingival msc (gmsc)-exosomes (tg-exos), in modulating inflammatory microglia and alleviating apoptosis. |
2022-04-04 |
2023-08-13 |
mouse |
| Yu-Fang Xie, Yan Wang, Yi Rong, Wenjun He, Meijuan Yan, Xinzhi Li, Junqiang Si, Li Li, Yingying Zhang, Ketao M. Hypoxia Induces Apoptosis of Microglia BV2 by Upregulating Kir2.1 to Activate Mitochondrial-Related Apoptotic Pathways. Disease markers. vol 2022. 2022-03-28. PMID:35340413. |
hypoxia induces apoptosis of microglia bv2 by upregulating kir2.1 to activate mitochondrial-related apoptotic pathways. |
2022-03-28 |
2023-08-13 |
Not clear |
| Alejandra Daruich, Emilie Picard, Justine Guégan, Thara Jaworski, Léa Parenti, Kimberley Delaunay, Marie-Christine Naud, Marianne Berdugo, Jeffrey H Boatright, Francine Behar-Cohe. Comparative Analysis of Urso- and Tauroursodeoxycholic Acid Neuroprotective Effects on Retinal Degeneration Models. Pharmaceuticals (Basel, Switzerland). vol 15. issue 3. 2022-03-26. PMID:35337132. |
on retinal explants, either bile acid reduced apoptosis, necroptosis, and microglia activation at 6 h. tudca induced the regulation of 463 genes, whilst 31 genes were regulated by udca. |
2022-03-26 |
2023-08-13 |
human |
| Wenhui Yan, Wuchao Liu, Junlu Wu, Lipei Wu, Shihai Xuan, Weiwei Wang, Anquan Shan. Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats Bioengineered. vol 13. issue 4. 2022-03-22. PMID:35313782. |
moreover, it was revealed that npy2r overexpression promoted the viability while inhibiting the apoptosis of microglia. |
2022-03-22 |
2023-08-13 |
rat |
| Zhong Yang, Xuan Li, Zhipeng Cao, Peng Wang, David S Warner, Huaxin Shen. Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice. Brain research bulletin. 2022-03-19. PMID:35304288. |
infarct volume, apoptosis, and activation of astrocytes and microglia were assessed at 4 weeks by an investigator blinded to groups. |
2022-03-19 |
2023-08-13 |
mouse |