| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Changqing Yang, Fei Yuan, Wan Shao, Lihong Yao, Shaoju Jin, Fangfang Ha. Protective role of exosomes derived from regulatory T cells against inflammation and apoptosis of BV-2 microglia under oxygen-glucose deprivation/reperfusion challenge. Genetics and molecular biology. vol 45. issue 4. 2022-12-20. PMID:36537744. |
protective role of exosomes derived from regulatory t cells against inflammation and apoptosis of bv-2 microglia under oxygen-glucose deprivation/reperfusion challenge. |
2022-12-20 |
2023-08-14 |
Not clear |
| Changqing Yang, Fei Yuan, Wan Shao, Lihong Yao, Shaoju Jin, Fangfang Ha. Protective role of exosomes derived from regulatory T cells against inflammation and apoptosis of BV-2 microglia under oxygen-glucose deprivation/reperfusion challenge. Genetics and molecular biology. vol 45. issue 4. 2022-12-20. PMID:36537744. |
inhibition of the pi3k/akt signaling by ly294002 partly reversed the effects of tregs-exos on cell apoptosis and inflammation in ogd/r-exposed bv-2 microglia. |
2022-12-20 |
2023-08-14 |
Not clear |
| Yanrui Zhang, Taian Jin, Zhangqi Dou, Boxing Wei, Buyi Zhang, Chongran Su. The dual role of the CD95 and CD95L signaling pathway in glioblastoma. Frontiers in immunology. vol 13. 2022-12-12. PMID:36505426. |
cd95l is also expressed by other types of cells, such as endothelial cells, polymorphonuclear myeloid-derived suppressor cells, cancer-associated fibroblasts, and tumor-associated microglia, and macrophages, which are educated by the tumor microenvironment and can induce apoptosis of tumor-infiltrating lymphocytes, which recognize and kill cancer cells. |
2022-12-12 |
2023-08-14 |
Not clear |
| Riyun Yang, Jingying Pan, Yankai Wang, Panhui Xia, Mingliang Tai, Zhihao Jiang, Gang Che. Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment. Frontiers in cellular neuroscience. vol 16. 2022-12-05. PMID:36467604. |
after sci, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes, oligodendrocytes, microglia and other non-neuronal cells become dysfunctional, hindering the repair of the injured spinal cord. |
2022-12-05 |
2023-08-14 |
Not clear |
| Bina Lee, Ingabire Ines, Jihyun Je, Eun Jung Park, Hyemin Seong, Min Gi Jo, Hwajin Kim, Seon-Hee Kim, Seong Jae Kim, Hye Jung Kim, Minkyeong Kim, Sang Won Park, Seung Pil Yu. Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation. Biomedicines. vol 10. issue 11. 2022-11-26. PMID:36428560. |
the activation of astrocytes and microglia in the hippocampus and cerebral cortex, which are responsible for important functions, including memory, learning, concentration, and language, can trigger nerve cell apoptosis. |
2022-11-26 |
2023-08-14 |
Not clear |
| Katrin Möller, Max Brambach, Ambra Villani, Elisa Gallo, Darren Gilmour, Francesca Per. A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo. eLife. vol 11. 2022-11-18. PMID:36398880. |
during brain development, many newborn neurons undergo apoptosis and are engulfed by microglia, the tissue-resident phagocytes of the brain, in a process known as efferocytosis. |
2022-11-18 |
2023-08-14 |
zebrafish |
| Muhammad Bilal Tariq, Juneyoung Lee, Louise D McCulloug. Sex differences in the inflammatory response to stroke. Seminars in immunopathology. 2022-11-10. PMID:36355204. |
after the onset of ischemic injury, necrosis and apoptosis occur, which activate microglia and other glial cells within the central nervous system, promoting the release of cytokines and chemokines and neuroinflammation. |
2022-11-10 |
2023-08-14 |
Not clear |
| Sima M Chokr, Giedre Milinkeviciute, Gisselle A Jimenez, Hakeem Abubakr, Karina S Crame. Long-term microglia depletion impairs synapse elimination and auditory brainstem function. Scientific reports. vol 12. issue 1. 2022-11-03. PMID:36323869. |
many of these functions are carried out by microglia, immune cells that aid in regulating neurogenesis, synaptogenesis, apoptosis, and synaptic removal. |
2022-11-03 |
2023-08-14 |
mouse |
| Jingjing Shao, Xiaoxuan Ma, Linlin Qu, Pei Ma, Rong Huang, Daidi Fa. Ginsenoside Rh4 remodels the periphery microenvironment by targeting the brain-gut axis to alleviate depression-like behaviors. Food chemistry. vol 404. issue Pt B. 2022-10-25. PMID:36283312. |
concurrently, rh4 inhibits hippocampal neuronal apoptosis and synaptic structural damage due to the overexpression of proinflammatory cytokines and overactivation of microglia and astrocytes by inhibiting the immune-inflammatory response and signaling molecular interaction pathways. |
2022-10-25 |
2023-08-14 |
mouse |
| Lei Tang, Guo-Tong Xu, Jing-Fa Zhan. Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254977. |
in addition, retinal cell types including microglia, müller glia, astrocytes, retinal pigment epithelial cells, and others are activated, to secrete inflammatory mediators, aggravating cell apoptosis and subsequent vascular leakage. |
2022-10-18 |
2023-08-14 |
Not clear |
| Zahra Nazari, Khadijeh Bahrehbar, Mohammad Jafar Golalipou. Effect of MDMA exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum. Iranian journal of basic medical sciences. vol 25. issue 9. 2022-10-17. PMID:36246062. |
effect of mdma exposure during pregnancy on cell apoptosis, astroglia, and microglia activity in rat offspring striatum. |
2022-10-17 |
2023-08-14 |
rat |
| Miao Chai, Gang Su, Juan Gao, Wei Chen, Qionghui Wu, Ying Dong, He Wang, Deyi Chen, Yonghong Li, Xin Gao, Ruixin Li, Tianfei Ma, Zhenchang Zhan. Molecular Mechanism of the Protective Effects of M2 Microglia on Neurons: A Review Focused on Exosomes and Secretory Proteins. Neurochemical research. 2022-10-12. PMID:36222957. |
they exert neuroprotective effects by various mechanisms, e.g., suppressing inflammation, promoting the degradation of misfolded and aggregated proteins, promoting neurite growth, enhancing neurogenesis, inhibiting autophagy and apoptosis, promoting myelination, maintaining blood-brain barrier integrity, and enhancing phagocytic activity.this review summarizes the molecular mechanisms by which m2 microglia exert protective effects on neurons and provides a reference for the selection of therapeutic targets for cns diseases. |
2022-10-12 |
2023-08-14 |
Not clear |
| Meghna Bains, Jaspreet Kaur, Ansab Akhtar, Anurag Kuhad, Sangeeta Pilkhwal Sa. Anti-inflammatory effects of ellagic acid and vanillic acid against quinolinic acid-induced rat model of Huntington's disease by targeting IKK-NF-κB pathway. European journal of pharmacology. 2022-10-09. PMID:36209926. |
hd striatum has increased conversion of kynurenine to quinolinic acid (qa) which activates nmda receptors leading to activation of microglia and increased levels of nuclear factor kappa b (nf-κb) leading to elevated transcription of inducible nitric oxide synthase (inos) and various cytokines causing neuronal death via neuroinflammation, oxidative stress, mitochondrial dysfunction and apoptosis. |
2022-10-09 |
2023-08-14 |
rat |
| De-Qi Jiang, Qing-Min Zang, Li-Lin Jiang, Cheng-Shu Lu, Shi-Hua Zhao, Lan-Cheng X. SIRT3 expression alleviates microglia activation‑induced dopaminergic neuron injury through the mitochondrial pathway. Experimental and therapeutic medicine. vol 24. issue 5. 2022-09-28. PMID:36168411. |
in our previous studies, microglia activation-associated cytotoxicity was observed to promote the apoptosis of dacs, along with the decrease of sirt3 expression. |
2022-09-28 |
2023-08-14 |
Not clear |
| De-Qi Jiang, Qing-Min Zang, Li-Lin Jiang, Cheng-Shu Lu, Shi-Hua Zhao, Lan-Cheng X. SIRT3 expression alleviates microglia activation‑induced dopaminergic neuron injury through the mitochondrial pathway. Experimental and therapeutic medicine. vol 24. issue 5. 2022-09-28. PMID:36168411. |
however, sirt3 sirna-mediated knockdown further aggravated microglia activation-mediated cytotoxicity, including ros accumulation, increased cell apoptosis and mptp opening, elevated the cypd level, enhanced mitochondrial ΔΨm depolarization, concomitant to cell cycle arrest at g |
2022-09-28 |
2023-08-14 |
Not clear |
| Bao-Dong He, Chang-Mei Liu, Zhao-Qian Ten. A Mouse Model of Neurodegeneration Induced by Blade Penetrating Stab Wound to the Hippocampus. Biology. vol 11. issue 9. 2022-09-23. PMID:36138848. |
mice with a hippocampal blade stab injury (hbsi) displayed the activation of microglia and astrocytes, inflammation, neuronal apoptosis, and deficits in spatial learning and memory. |
2022-09-23 |
2023-08-14 |
mouse |
| Noah Goshi, Hyehyun Kim, Erkin Seke. Primary Cortical Cell Tri-Culture-Based Screening of Neuroinflammatory Response in Toll-like Receptor Activation. Biomedicines. vol 10. issue 9. 2022-09-23. PMID:36140221. |
we demonstrate that microglia are required for observation of neurotoxic neuroinflammatory responses, such as increased cell death and apoptosis, in response to tlr2, 3, 4, and 7/8 activation. |
2022-09-23 |
2023-08-14 |
rat |
| Sheng Gao, Luyue Bai, Shu Jia, Chunyang Men. Small Extracellular Vesicles of M1-BV2 Microglia Induce Neuronal PC12 Cells Apoptosis via the Competing Endogenous Mechanism of CircRNAs. Genes. vol 13. issue 9. 2022-09-23. PMID:36140770. |
small extracellular vesicles of m1-bv2 microglia induce neuronal pc12 cells apoptosis via the competing endogenous mechanism of circrnas. |
2022-09-23 |
2023-08-14 |
Not clear |
| Sheng Gao, Luyue Bai, Shu Jia, Chunyang Men. Small Extracellular Vesicles of M1-BV2 Microglia Induce Neuronal PC12 Cells Apoptosis via the Competing Endogenous Mechanism of CircRNAs. Genes. vol 13. issue 9. 2022-09-23. PMID:36140770. |
taken together, the results suggest that polarized m1-bv2 microglia can induce apoptosis of neuronal pc12 cells through secreted sevs, and this regulatory effect may be achieved by the circrnas circ_0000705, circ_0001313, circ_0000229, circ_0001123, circ_0000621, and circ_0000735 through cernas regulatory networks. |
2022-09-23 |
2023-08-14 |
Not clear |
| Zongxin Cheng, Xinming Li, Xiaohua Ye, Rong Yu, Youqing Den. Purpurogallin Reverses Neuronal Apoptosis and Enhances "M2" Polarization of Microglia Under Ischemia via Mediating the miR-124-3p/TRAF6/NF-κB Axis. Neurochemical research. 2022-09-21. PMID:36131212. |
purpurogallin reverses neuronal apoptosis and enhances "m2" polarization of microglia under ischemia via mediating the mir-124-3p/traf6/nf-κb axis. |
2022-09-21 |
2023-08-14 |
mouse |