| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuhan Li, Zhanpeng Zhu, Tian Lan, Yuhan Wu, Ye Li, Changmin Wang, Wencheng Jian, Shu Yan Y. Levomilnacipran ameliorates lipopolysaccharide-induced depression-like behaviors and suppressed the TLR4/Ras signaling pathway. International immunopharmacology. vol 122. 2023-07-06. PMID:37413934. |
activation of microglia and apoptosis of neurons verified by immunofluorescence. |
2023-07-06 |
2023-08-14 |
rat |
| Jingyi Luo, Qing Lian, Deliang Zhu, Minglei Zhao, Tingfang Mei, Bizhi Shang, Zeqiu Yang, Chujun Liu, Wenchang Xu, Lan Zhou, Keling Wu, Xinqi Liu, Yuhua Lai, Fuxiang Mao, Weihua Li, Chengguo Zuo, Kang Zhang, Mingkai Lin, Yehong Zhuo, Yizhi Liu, Lin Lu, Ling Zha. PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis. Genes & diseases. vol 10. issue 4. 2023-07-03. PMID:37397520. |
in the pathogenesis of glaucoma, activated microglia can lead to retinal ganglion cells (rgcs) apoptosis and death, however, the molecular mechanisms remain largely unknown. |
2023-07-03 |
2023-08-14 |
mouse |
| Jingyi Luo, Qing Lian, Deliang Zhu, Minglei Zhao, Tingfang Mei, Bizhi Shang, Zeqiu Yang, Chujun Liu, Wenchang Xu, Lan Zhou, Keling Wu, Xinqi Liu, Yuhua Lai, Fuxiang Mao, Weihua Li, Chengguo Zuo, Kang Zhang, Mingkai Lin, Yehong Zhuo, Yizhi Liu, Lin Lu, Ling Zha. PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis. Genes & diseases. vol 10. issue 4. 2023-07-03. PMID:37397520. |
we demonstrate that phospholipid scramblase 1 (plscr1) is a key regulator promoting rgcs apoptosis and their clearance by microglia. |
2023-07-03 |
2023-08-14 |
mouse |
| Igor Henrique Rodrigues de Paiva, Rodrigo Soares da Silva, Ingrid Prata Mendonça, Eduardo Duarte-Silva, José Roberto Botelho de Souza, Christina Alves Peixot. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Improve Neuroinflammation and Cognition By Up-regulating IRS/PI3K/AKT Signaling Pathway in Diet-induced Obese Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-29. PMID:37382830. |
these obese mice also showed activation of microglia and astrocytes and significant immunoreactivity of neuroinflammatory and apoptosis markers, such as tnf-α, cox-2, and caspase-3, in addition to lower expression of neurogenesis and synaptic plasticity markers, such as neun, ki-67, creb-p, and bdnf. |
2023-06-29 |
2023-08-14 |
mouse |
| Yishen Wang, Yiwen Hong, Shudi Mao, Jianying Pan, Yamei Cui, Jing Lu, Tao Wen, Xiao Wang, Yan Lu. Downregulation of miR-124-3p suppresses the development of the deep retinal blood vessels by enhancing the Stat1/Ripk1 pathway in mouse retinal microglia. Experimental eye research. 2023-06-25. PMID:37356537. |
the microglia penetrated deep into the retina and the activation of ripk1(+) microglia significantly increased, which was accompanied by an increased level of apoptosis to inhibit the deep vascular sprout. |
2023-06-25 |
2023-08-14 |
mouse |
| Yishen Wang, Yiwen Hong, Shudi Mao, Jianying Pan, Yamei Cui, Jing Lu, Tao Wen, Xiao Wang, Yan Lu. Downregulation of miR-124-3p suppresses the development of the deep retinal blood vessels by enhancing the Stat1/Ripk1 pathway in mouse retinal microglia. Experimental eye research. 2023-06-25. PMID:37356537. |
downregulation of mir-124-3p during the early retinal development can suppress the development of the deep retinal blood vessels by enhancing the expression level of the stat1/irf9/eif2ak2/ripk1 axis and inducing the cell apoptosis of the activation of ripk1(+) microglia. |
2023-06-25 |
2023-08-14 |
mouse |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. |
2023-06-21 |
2023-08-14 |
mouse |
| Grant R Campbell, Pratima Rawat, Rachel K To, Stephen A Specto. HIV-1 Tat Upregulates TREM1 Expression in Human Microglia. Journal of immunology (Baltimore, Md. : 1950). 2023-06-16. PMID:37326481. |
in this article, we show that hiv-infected human microglia express increased levels of trem1 and are resistant to hiv-induced apoptosis. |
2023-06-16 |
2023-08-14 |
human |
| Menglong Wang, Jishou Zhang, Zheng Yin, Wen Ding, Mengmeng Zhao, Jianfang Liu, Yao Xu, Shuwan Xu, Wei Pan, Cheng Wei, Hong Jiang, Jun Wa. Microglia-Mediated Neuroimmune Response Regulates Cardiac Remodeling After Myocardial Infarction. Journal of the American Heart Association. 2023-06-15. PMID:37318008. |
microglia depletion, which was induced by plx3397 treatment via intragastric injection or intracerebroventricular injection, improved cardiac function, reduced infarction size, and attenuated cardiomyocyte apoptosis, fibrosis, pathological electrical remodeling, and myocardial inflammation after mi. |
2023-06-15 |
2023-08-14 |
Not clear |
| Yuan Wang, Wan-Yun Qin, Qi Wang, Xin-Na Liu, Xiang-Hui Li, Xin-Qi Ye, Ying Bai, Yan Zhang, Pan Liu, Xin-Lin Wang, Yu-Hang Zhou, Zheng-Bo Shao, Hui-Ping Yua. Young Sca-1 Journal of nanobiotechnology. vol 21. issue 1. 2023-06-15. PMID:37322478. |
young sca-1 polarization of microglia, the resident retinal immune cells, plays important roles in mediating both injury and repair responses post-retinal ischemia-reperfusion (i/r) injury, which is one of the main pathological mechanisms behind ganglion cell apoptosis. |
2023-06-15 |
2023-08-14 |
Not clear |
| Boru Hou, Dengfeng Wang, Cheng Jiang, Gang Wang, Dong Wang, Guizhong Yan, Xiumei Guo, Lixia Zhao, Zhuangzhuang Wan, Chenlong Fan, Wencheng Cao, Haijun Re. Neuroprotective Effects of Vinpocetine against Ischemia-Reperfusion Injury via Inhibiting NLRP3 Inflammasome Signaling Pathway. Neuroscience. 2023-06-08. PMID:37290685. |
vinpocetine can effectively inhibit the apoptosis of peri-infarct neurons, promote the expression of bcl-2, inhibit the expression of bax and cleaved caspase-3, and reduce the proliferation of peri-infarct microglia. |
2023-06-08 |
2023-08-14 |
mouse |
| Jing Qiu, Jun Guo, Liang Liu, Xin Liu, Xianhui Sun, Huisheng Che. Neural regeneration research. vol 18. issue 11. 2023-06-07. PMID:37282474. |
taken together, these findings show that silencing vav1 attenuates inflammation and neuronal apoptosis in rats subjected to cerebral ischemia/reperfusion through inhibiting the activation of microglia and nlrp3 inflammasome. |
2023-06-07 |
2023-08-14 |
rat |
| Fredrik H G Ahlstrà M, Hanna Viisanen, Leena Karhinen, Kert Mã Tlik, Kim J Blomqvist, Tuomas Lilius, Yulia A Sidorova, Vinko Palada, Pekka Rauhala, Eija Kals. The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord. Molecular pain. 2023-06-07. PMID:37285551. |
this was associated with decreased staining of spinal microglia, suggesting either decreased activation or apoptosis. |
2023-06-07 |
2023-08-14 |
rat |
| Peiyao Mao, Yinchen Shen, Xiying Mao, Kun Liu, Jiawei Zhon. The single-cell landscape of alternative transcription start sites of diabetic retina. Experimental eye research. 2023-05-26. PMID:37236522. |
furthermore, by comparing tss expression between healthy and diabetic retina, we identified elevated apoptosis signal in müller glia and microglia, which can be served as a putative early sign of diabetic retinopathy. |
2023-05-26 |
2023-08-14 |
Not clear |
| Luchen Wang, Lingmin Song, Juan Ma, Huimei Wang, Yingzhi Li, Danfei Huan. Alcohol induces apoptosis and autophagy in microglia BV-2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-05-22. PMID:37217066. |
alcohol induces apoptosis and autophagy in microglia bv-2 cells. |
2023-05-22 |
2023-08-14 |
Not clear |
| Zheyu Zhang, Ruozheng Pi, Yuheng Jiang, Mashaal Ahmad, Heng Luo, Jieya Luo, Jie Yang, Baofei Su. Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury. Human & experimental toxicology. vol 42. 2023-05-08. PMID:37154515. |
cathepsin b mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury. |
2023-05-08 |
2023-08-14 |
Not clear |
| Masatoshi Ohnishi, Aoi Machida, Moemi Deguchi, Nami Takiyama, Yuri Kurose, Atsuko Inou. Long-term Stimulation of α7 Nicotinic Acetylcholine Receptor Rescues Hemorrhagic Neuron Loss via Apoptosis of M1 Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-05-05. PMID:37145341. |
long-term stimulation of α7 nicotinic acetylcholine receptor rescues hemorrhagic neuron loss via apoptosis of m1 microglia. |
2023-05-05 |
2023-08-14 |
Not clear |
| Masatoshi Ohnishi, Aoi Machida, Moemi Deguchi, Nami Takiyama, Yuri Kurose, Atsuko Inou. Long-term Stimulation of α7 Nicotinic Acetylcholine Receptor Rescues Hemorrhagic Neuron Loss via Apoptosis of M1 Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-05-05. PMID:37145341. |
repeated intraperitoneal administration of α7 agonist pnu-282987 for 14 days selectively evoked the apoptosis of inos-positive m1 microglia at the perihematomal area and showed a neuroprotective effect in an in vivo intracerebral hemorrhage model. |
2023-05-05 |
2023-08-14 |
Not clear |
| Masatoshi Ohnishi, Aoi Machida, Moemi Deguchi, Nami Takiyama, Yuri Kurose, Atsuko Inou. Long-term Stimulation of α7 Nicotinic Acetylcholine Receptor Rescues Hemorrhagic Neuron Loss via Apoptosis of M1 Microglia. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-05-05. PMID:37145341. |
these findings revealed that long-term stimulation of α7 receptor causes suppression of thrombin-induced activation of p38 mapk followed by apoptosis in neuropathic m1 microglia. |
2023-05-05 |
2023-08-14 |
Not clear |
| Tingting Zhang, Weilun Pang, Tuancheng Feng, Jennifer Guo, Kenton Wu, Mariela Nunez Santos, Akshayakeerthi Arthanarisami, Alissa L Nana, Quynh Nguyen, Peter J Kim, Joanna L Jankowsky, William W Seeley, Fenghua H. TMEM106B regulates microglial proliferation and survival in response to demyelination. Science advances. vol 9. issue 18. 2023-05-05. PMID:37146150. |
here, we report that tmem106b deficiency in mice leads to reduced microglia proliferation and activation and increased microglial apoptosis in response to demyelination. |
2023-05-05 |
2023-08-14 |
mouse |