| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Sing. S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology. vol 126. 2023-11-27. PMID:38011768. |
jte013 rescued the palmitate-induced neuronal apoptosis by promoting the anti-inflammatory microglia. |
2023-11-27 |
2023-11-29 |
mouse |
| Madeleine J Smith, Tayla Penny, Yen Pham, Amy E Sutherland, Graham Jenkin, Michael C Fahey, Madison C B Paton, Megan Finch-Edmondson, Suzanne L Miller, Courtney A McDonal. Neuroprotective Action of Tacrolimus before and after Onset of Neonatal Hypoxic-Ischaemic Brain Injury in Rats. Cells. vol 12. issue 22. 2023-11-25. PMID:37998394. |
(3) results: all tacrolimus doses administered pre-hi significantly reduced brain infarct size and neuronal loss, increased the number of resting microglia and reduced cellular apoptosis ( |
2023-11-25 |
2023-11-28 |
rat |
| Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Ya. Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease. Immunobiology. vol 228. issue 6. 2023-11-25. PMID:38006681. |
baicalein promotes the microglia m2 polarization and suppresses apoptosis by targeting hmox1/pde4d to alleviate alzheimer's disease. |
2023-11-25 |
2023-11-28 |
mouse |
| Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Ya. Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease. Immunobiology. vol 228. issue 6. 2023-11-25. PMID:38006681. |
in cell experiments, it was verified that baicalein significantly shifted the bv-2 microglia phenotype from the pro-inflammatory m1 to the anti-inflammatory m2 phenotype, inhibited the microglial apoptosis and pro-inflammatory factors, promoted the microglial aβ uptake and anti-inflammatory factors after lps stimulated. |
2023-11-25 |
2023-11-28 |
mouse |
| Jun Ma, Hao Yin, Zhongying Ran, Tao Luo, Zexin Jin, Li Zheng, Fuyang Zhan. Knockdown of BCL-3 attenuates inflammatory response in intracerebral hemorrhage through an rBMECs/MGs microenvironment. Neuroscience. 2023-11-25. PMID:38006962. |
finally, in the ich animal model, after knockdown of bcl-3, comprehensive evaluations of inflammatory responses in brain tissue, polarization and recruitment of microglia, and apoptosis were conducted. |
2023-11-25 |
2023-11-28 |
rat |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
finally, the recombinant human manf (rhmanf, 20 μg) protein was intraperitoneally administrated to neonatal mice before the sevoflurane anesthesia and the cognitive function, levels of pro-inflammatory cytokine and synapse-associated protein psd95, the status of neural apoptosis, microglia activation and oxidative stress in hippocampus of the mice were investigated. |
2023-11-22 |
2023-11-29 |
mouse |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
mko upregulated the expression of tumor necrosis factor-α (tnf-α), accelerated the neural apoptosis and the activation of microglia in hippocampus in young mice. |
2023-11-22 |
2023-11-29 |
mouse |
| Tianzhi Song, Yishu Zhang, Liangrong Zhu, Yuyan Zhang, Jingmei Son. The role of JAK/STAT signaling pathway in cerebral ischemia-reperfusion injury and the therapeutic effect of traditional Chinese medicine: A narrative review. Medicine. vol 102. issue 46. 2023-11-21. PMID:37986307. |
the inflammatory factors are produced by m1 microglia through the jak/stat pathway, eventually leading to cell apoptosis. |
2023-11-21 |
2023-11-29 |
Not clear |
| Zhongqiu Zhou, Qingqing Ye, Hui Ren, Yuan Zhang, Bing Han, Honghong Yao, Ying Ba. CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression. International journal of biological macromolecules. 2023-11-09. PMID:37944732. |
moreover, lps-induced cebpb nuclear entry downregulates the expression of zc3h4, in which promotes autophagy and apoptosis in microglia. |
2023-11-09 |
2023-11-20 |
mouse |
| Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Che. Glioma-derived S100A9 polarizes M2 microglia to inhibit CD8+T lymphocytes for immunosuppression via αvβ3 integrin/AKT1/TGFβ1. Biochimica et biophysica acta. Molecular cell research. 2023-10-31. PMID:37907196. |
furthermore, we demonstrated that s100a9-induced m2 microglia negatively affected cell viability, il-2 and ifn-γ secretion, together with increased early apoptosis in cd8+t lymphocytes via tgfβ1. |
2023-10-31 |
2023-11-08 |
mouse |
| Amaresh K Ranjan, Anil Gulat. Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy. Journal of clinical medicine. vol 12. issue 20. 2023-10-30. PMID:37892791. |
the primary and secondary phases are characterized by episodes of energy and cell metabolism failures, increased cytotoxicity and apoptosis, and activated microglia and inflammation in the brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| Jing Wang, Lili Wang, Qingjian Wu, Yichen Cai, Chengfu Cui, Ming Yang, Baoliang Sun, Leilei Mao, Yuan Wan. Interleukin-4 Modulates Neuroinflammation by Inducing Phenotypic Transformation of Microglia Following Subarachnoid Hemorrhage. Inflammation. 2023-10-29. PMID:37898992. |
furthermore, exogenous administration of il-4 ameliorates post-sah neurofunctional deficits, attenuates cellular apoptosis, fosters m2 microglia phenotype conversion, and mitigates neuroinflammatory responses. |
2023-10-29 |
2023-11-08 |
Not clear |
| Changjiang Gu, Xiangwu Geng, Yicheng Wu, Yuya Dai, Junkai Zeng, Zhenqiang Wang, Huapan Fang, Yanqing Sun, Xiongsheng Che. Engineered Macrophage Membrane-Coated Nanoparticles with Enhanced CCR2 Expression Promote Spinal Cord Injury Repair by Suppressing Neuroinflammation and Neuronal death. Small (Weinheim an der Bergstrasse, Germany). 2023-10-26. PMID:37884477. |
ccr2 overexpression on mm not only enhanced drug-targeted delivery to the injury site, but also attenuated macrophage infiltration, microglia pro-inflammatory polarization, and neuronal apoptosis by trapping ccl2. |
2023-10-26 |
2023-11-08 |
mouse |
| Yuanlong Li, Hua Fan, Xiong Han, Jun Sun, Ming Ni, Xiaodan Hou, Fengqin Fang, Wei Zhang, Peizhi M. Long Non-Coding RNA MALAT1 Protects Against Spinal Cord Injury via Suppressing microRNA-125b-5p Mediated Microglial M1 Polarization, Neuroinflammation, and Neural Apoptosis. Molecular neurobiology. 2023-10-19. PMID:37858031. |
this study aimed to further explore the relationship between lncrna malat1 and mir-125b-5p, as well as their effect on microglial activation, neuroinflammation, and neural apoptosis in spinal cord injury (sci). primary microglia from sprague dawley rats were stimulated with lipopolysaccharide (lps). |
2023-10-19 |
2023-11-08 |
rat |
| Ru Zhao, Tao He, Yiqiao Xing, Jinyuan Lu. COG1410 regulates microglial states and protects retinal ganglion cells in retinal ischemia-reperfusion injury. Experimental eye research. 2023-10-15. PMID:37839665. |
we observed cd16/32-marked and cd206-marked microglia and rgcs using immunofluorescence staining, detected the expression of inflammatory factors by pcr, and evaluated retinal apoptosis with tunel staining. |
2023-10-15 |
2023-11-08 |
mouse |
| Alicja Maciejska, Bartosz Pomierny, Weronika Krzyżanowska, Beata Starek-Świechowicz, Alicja Skórkowska, Bogusława Budziszewsk. Mechanism of microglial cell activation in the benzophenone-3 exposure model. Neuroscience. 2023-10-12. PMID:37827357. |
this compound increases extracellular glutamate concentrations, lipid peroxidation, the number of microglia cells and induces process of apoptosis. |
2023-10-12 |
2023-10-15 |
rat |
| Li-Li Xu, Jia-Qian Xie, Jian-Jun Shen, Mei-Dan Ying, Xin-Zhong Che. Neuron-derived exosomes mediate sevoflurane-induced neurotoxicity in neonatal mice via transferring lncRNA Gas5 and promoting M1 polarization of microglia. Acta pharmacologica Sinica. 2023-10-06. PMID:37803140. |
we showed that sevoflurane treatment markedly increased the expression of the lncrna growth arrest-specific 5 (gas5) in neuron-derived extracellular vesicles, which inhibited neuronal proliferation and induced neuronal apoptosis by promoting m1 polarization of microglia and the release of inflammatory cytokines. |
2023-10-06 |
2023-10-15 |
mouse |
| Li-Li Xu, Jia-Qian Xie, Jian-Jun Shen, Mei-Dan Ying, Xin-Zhong Che. Neuron-derived exosomes mediate sevoflurane-induced neurotoxicity in neonatal mice via transferring lncRNA Gas5 and promoting M1 polarization of microglia. Acta pharmacologica Sinica. 2023-10-06. PMID:37803140. |
in neonatal mice, intracranial injection of the exosomes derived from sevoflurane-treated neurons into the bilateral hippocampi significantly increased the proportion of m1 microglia, inhibited neuronal proliferation and promoted apoptosis, ultimately leading to neurotoxicity. |
2023-10-06 |
2023-10-15 |
mouse |
| Wei Hu, Jiang Zhou, Yiqing Jiang, Zeyu Bao, Xiaoming H. Silencing of LINC00707 Alleviates Brain Injury by Targeting miR-30a-5p to Regulate Microglia Inflammation and Apoptosis. Neurochemical research. 2023-09-16. PMID:37715822. |
silencing of linc00707 alleviates brain injury by targeting mir-30a-5p to regulate microglia inflammation and apoptosis. |
2023-09-16 |
2023-10-07 |
rat |
| Wei Hu, Jiang Zhou, Yiqing Jiang, Zeyu Bao, Xiaoming H. Silencing of LINC00707 Alleviates Brain Injury by Targeting miR-30a-5p to Regulate Microglia Inflammation and Apoptosis. Neurochemical research. 2023-09-16. PMID:37715822. |
lps decreased microglial cell viability, increased apoptosis, and promoted inflammatory overproduction than control, but the silencing of linc00707 reversed its effect. |
2023-09-16 |
2023-10-07 |
rat |