| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Longyu Zhang, Jiao Xu, Shi Yin, Qiang Wang, Zhiwei Jia, Tianlin We. Albiflorin Attenuates Neuroinflammation and Improves Functional Recovery After Spinal Cord Injury Through Regulating LSD1-Mediated Microglial Activation and Ferroptosis. Inflammation. 2024-02-10. PMID:38340239. |
meanwhile, af attenuated neuron apoptosis and microglia activation, reduced the production of pro-inflammatory cytokines and iron accumulation, and inhibited spinal cord ferroptosis following sci in rats. |
2024-02-10 |
2024-02-14 |
rat |
| Xingxing Wang, Changlin Xu, Cunxin Bian, Pengfei Ge, Jie Lei, Jingfan Wang, Tianhao Xiao, Yuanyuan Fan, Qinyuan Gu, Hong-Ying Li, Jingyi Xu, Zizhong Hu, Ping Xi. M2 microglia-derived exosomes promote vascular remodeling in diabetic retinopathy. Journal of nanobiotechnology. vol 22. issue 1. 2024-02-09. PMID:38336783. |
further in vivo and in vitro experiments showed that exosomes derived from m2 polarized microglia (m2-exo) could reduce pericyte apoptosis and promote endothelial cell proliferation, thereby promoting vascular remodeling and reducing vascular leakage from the diabetic retina. |
2024-02-09 |
2024-02-12 |
mouse |
| Long Peng, Xingjia Zhu, Chenxing Wang, Qiaoji Jiang, Shian Yu, Gaochao Song, Qianqian Liu, Peipei Gon. Indole-3-carbinol (I3C) reduces apoptosis and improves neurological function after cerebral ischemia-reperfusion injury by modulating microglia inflammation. Scientific reports. vol 14. issue 1. 2024-02-07. PMID:38326384. |
indole-3-carbinol (i3c) reduces apoptosis and improves neurological function after cerebral ischemia-reperfusion injury by modulating microglia inflammation. |
2024-02-07 |
2024-02-10 |
rat |
| Xu-Jia Chen, Zhou Deng, Le-Le Zhang, Yan Pan, Jia Fu, Liang Zou, Zhaofang Bai, Xiaohe Xiao, Feiya Shen. Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-04. PMID:38310653. |
the underlying mechanisms mainly include inhibiting tau hyperphosphorylation, inhibiting aβ formation, affecting activated microglia, regulating nf-κb/mapk signalling pathway, inhibiting neuronal apoptosis, modulating immune system, and inhibiting acetylcholinesterase, etc. |
2024-02-04 |
2024-02-07 |
Not clear |
| Linyu Wu, Zixuan Tan, Lei Su, Fang Dong, Guangyu Xu, Feng Zhan. Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway. Frontiers in cellular neuroscience. vol 17. 2024-01-26. PMID:38273974. |
this study was to explore whether transcutaneous electrical acupoint stimulation (teas) treatment could mediate inflammation, apoptosis, and pyroptosis of neuronal cells and microglia activation through the tlr4/myd88/nf-κb pathway in the early stage of ischemic stroke. |
2024-01-26 |
2024-01-28 |
Not clear |
| Ching-Tien Lee, Kun-Der Lin, Cheng-Fang Hsieh, Jiz-Yuh Wan. SGLT2 Inhibitor Canagliflozin Alleviates High Glucose-Induced Inflammatory Toxicity in BV-2 Microglia. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255143. |
only cana rescued bv-2 microglia from hg-induced cytotoxicity, including apoptosis or autophagic degradation. |
2024-01-23 |
2024-01-25 |
Not clear |
| Huina Ma, Hehua Huang, Chenyu Li, Shasha Li, Juefang Gan, Chunrong Lian, Yanwu Lin. The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors. NPJ systems biology and applications. vol 10. issue 1. 2024-01-13. PMID:38218856. |
a decrease of cox-2 curtailed bv-2 microglial cell activation, inflammation, and neuron apoptosis by blunting the pge2/il-22 axis. |
2024-01-13 |
2024-01-16 |
mouse |
| Hanxiao Chang, Zheng Li, Weiwei Zhang, Chao Lin, Yuqi Shen, Guangjian Zhang, Lei Mao, Chencheng Ma, Ning Liu, Hua L. Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage. Cell communication and signaling : CCS. vol 22. issue 1. 2024-01-03. PMID:38169382. |
based on our results, the transmission of cyclic gmp-amp (cgamp) from neurons to microglia is a key molecular event that triggers type i interferon response, amplifies neuroinflammation, and leads to neuronal apoptosis. |
2024-01-03 |
2024-01-06 |
Not clear |
| Xueyan Zhao, Ziyu Wang, Jiang Wang, Fenglian Xu, Yi Zhang, Dan Han, Weirong Fan. Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway. International immunopharmacology. vol 127. 2023-12-22. PMID:38134597. |
microglia, resident brain immune cells, is critical in inflammation, apoptosis, neurogenesis and neurological recovery during cerebral ischemia/reperfusion (i/r) injury. |
2023-12-22 |
2023-12-25 |
mouse |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
the microglia showed obvious morphological damage and apoptosis. |
2023-12-17 |
2023-12-21 |
mouse |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
overexcitation of peripheral inflammasome complexes induces hippocampal microglia apoptosis, which hinders the effects of es. |
2023-12-17 |
2023-12-21 |
mouse |
| Fan Sun, Wenbing Liu, Xiaodong Li, Xiaowei Wang, Yali Ou, Xuesong Li, Min Sh. Median nerve electrical stimulation improves traumatic brain injury by reducing TACR1 to inhibit nuclear factor-κB and CCL7 activation in microglia. Histology and histopathology. 2023-12-15. PMID:38098319. |
immunofluorescence and flow cytometry assay were used to detect microglia morphology and neuron apoptosis. |
2023-12-15 |
2023-12-17 |
rat |
| Fan Sun, Wenbing Liu, Xiaodong Li, Xiaowei Wang, Yali Ou, Xuesong Li, Min Sh. Median nerve electrical stimulation improves traumatic brain injury by reducing TACR1 to inhibit nuclear factor-κB and CCL7 activation in microglia. Histology and histopathology. 2023-12-15. PMID:38098319. |
shtacr1 reversed the effects of lps on inflammation-related factors, m1/m2 microglia markers, microglia activation, neuron apoptosis, p-p65/p65 value and ccl7 level. |
2023-12-15 |
2023-12-17 |
rat |
| . Expression of Concern: LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PloS one. vol 18. issue 12. 2023-12-13. PMID:38091319. |
expression of concern: lrrk2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. |
2023-12-13 |
2023-12-17 |
Not clear |
| Xin Gao, Gang Su, Miao Chai, Minghui Shen, Zhenzhen Hu, Wei Chen, Juan Gao, Ruixin Li, Tianfei Ma, Yang An, Zhenchang Zhan. Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia. Neurochemistry international. 2023-12-11. PMID:38081419. |
activated microglia participate in the pathological processes after stroke through polarization, autophagy, phagocytosis, pyroptosis, ferroptosis, apoptosis, and necrosis, thereby influencing the injury and repair following stroke. |
2023-12-11 |
2023-12-17 |
Not clear |
| Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
meanwhile, in a neuron-microglia co-culture system under hypoxic conditions, we found that microglia lost their protective effect against neuronal injury and apoptosis when trem2 was knocked down. |
2023-12-02 |
2023-12-10 |
mouse |
| Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
under in vivo conditions, trem2 knockdown mice express lower tgf-β1 expression levels and a lower number of anti-inflammatory m2 phenotype microglia, resulting in increased cerebral infarct size, exacerbated neuronal apoptosis, and aggravated neuronal impairment. |
2023-12-02 |
2023-12-10 |
mouse |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Sing. S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology. vol 126. 2023-11-27. PMID:38011768. |
jte013 rescued the palmitate-induced neuronal apoptosis by promoting the anti-inflammatory microglia. |
2023-11-27 |
2023-11-29 |
mouse |
| Madeleine J Smith, Tayla Penny, Yen Pham, Amy E Sutherland, Graham Jenkin, Michael C Fahey, Madison C B Paton, Megan Finch-Edmondson, Suzanne L Miller, Courtney A McDonal. Neuroprotective Action of Tacrolimus before and after Onset of Neonatal Hypoxic-Ischaemic Brain Injury in Rats. Cells. vol 12. issue 22. 2023-11-25. PMID:37998394. |
(3) results: all tacrolimus doses administered pre-hi significantly reduced brain infarct size and neuronal loss, increased the number of resting microglia and reduced cellular apoptosis ( |
2023-11-25 |
2023-11-28 |
rat |
| Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Ya. Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease. Immunobiology. vol 228. issue 6. 2023-11-25. PMID:38006681. |
baicalein promotes the microglia m2 polarization and suppresses apoptosis by targeting hmox1/pde4d to alleviate alzheimer's disease. |
2023-11-25 |
2023-11-28 |
mouse |