| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Hu, Jiang Zhou, Yiqing Jiang, Zeyu Bao, Xiaoming H. Silencing of LINC00707 Alleviates Brain Injury by Targeting miR-30a-5p to Regulate Microglia Inflammation and Apoptosis. Neurochemical research. 2023-09-16. PMID:37715822. |
mir-30a-5p was the target mirna of linc00707. all in all, the results suggested that inhibiting linc00707/mir-30a-5p axis could alleviate the progression of tbi by suppressing the inflammation and apoptosis of microglia cells. |
2023-09-16 |
2023-10-07 |
rat |
| Aihua Xu, Yang Yang, Yang Shao, Manyu Jiang, Yongxin Sun, Bo Fen. FHL2 regulates microglia M1/M2 polarization after spinal cord injury via PARP14-depended STAT1/6 pathway. International immunopharmacology. vol 124. issue Pt A. 2023-09-14. PMID:37708708. |
fhl2 deficiency facilitated neuronal apoptosis by elevating cleaved caspase 3/9 expression, neuroinflammation by regulating microglia polarization, and bone loss. |
2023-09-14 |
2023-10-07 |
mouse |
| Xihan Gu. A state-of-the-art review on miRNA in prevention and treatment of Alzheimer Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 52. issue 4. 2023-08-29. PMID:37643982. |
rodent ad models have demonstrated that targeting mirnas could block biogenesis and toxicity of amyloid β, inhibit the production and hyper-phosphorylation of τ protein, prevent neuronal apoptosis and promote neurogenesis, maintain neural synaptic and calcium homeostasis, as well as mitigate neuroinflammation mediated by microglia. |
2023-08-29 |
2023-09-07 |
human |
| Yun-Ting Hu, Kai-Xuan Wu, Xiao-Tong Wang, Yuan-Yi Zhao, Xiao-Yong Jiang, Dan Liu, Man-Li Tong, Li-Li Li. Treponema pallidum promoted microglia apoptosis and prevented itself from clearing by human microglia via blocking autophagic flux. PLoS pathogens. vol 19. issue 8. 2023-08-23. PMID:37611054. |
treponema pallidum promoted microglia apoptosis and prevented itself from clearing by human microglia via blocking autophagic flux. |
2023-08-23 |
2023-09-07 |
human |
| Yun-Ting Hu, Kai-Xuan Wu, Xiao-Tong Wang, Yuan-Yi Zhao, Xiao-Yong Jiang, Dan Liu, Man-Li Tong, Li-Li Li. Treponema pallidum promoted microglia apoptosis and prevented itself from clearing by human microglia via blocking autophagic flux. PLoS pathogens. vol 19. issue 8. 2023-08-23. PMID:37611054. |
autophagosome accumulation was demonstrated to be a key mechanism underlying the effects of tp in promoting apoptosis and preventing itself from clearing by human microglia. |
2023-08-23 |
2023-09-07 |
human |
| Xihan Gu. A state-of-the-art review on miRNA in prevention and treatment of Alzheimer Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2023-08-22. PMID:37607839. |
rodent ad models have demonstrated that targeting mirna could block the biogenesis and toxicity of aβ, inhibit the production and hyper-phosphorylation of τprotein, prevent neuron apoptosis and promote neurogenesis, maintain neural synaptic and calcium homeostasis, and mitigate neuroinflammation mediated by microglia. |
2023-08-22 |
2023-09-07 |
human |
| MuLan Bao, RenGui Bade, Hua Liu, Battseren Tsambaa, Guo Shao, Almaz Borjigidai, Yong Chen. Astragaloside IV against Alzheimer's disease via microglia-mediated neuroinflammation using network pharmacology and experimental validation. European journal of pharmacology. 2023-08-20. PMID:37598923. |
bcl2 apoptosis regulator (bcl-2), pro-apoptotic bcl-2 protein bax, epidermal growth factor receptor (egfr), and receptor tyrosine phosphatase type c (ptprc) were screened for inflammation and microglia in the above targets by network pharmacology. |
2023-08-20 |
2023-09-07 |
Not clear |
| Xu Liu, Qingqing Wu, Jingwen Wu, Jianxi Liu, Fuli Zheng, Guangxia Yu, Hong Hu, Zhenkun Guo, Siying Wu, Huangyuan Li, Wenya Sha. Microglia-derived exosomal circZNRF1 alleviates paraquat-induced neuronal cell damage via miR-17-5p. Ecotoxicology and environmental safety. vol 263. 2023-08-17. PMID:37591128. |
it can lead to the activation of microglia and apoptosis of dopaminergic neurons. |
2023-08-17 |
2023-09-07 |
Not clear |
| Xu Liu, Qingqing Wu, Jingwen Wu, Jianxi Liu, Fuli Zheng, Guangxia Yu, Hong Hu, Zhenkun Guo, Siying Wu, Huangyuan Li, Wenya Sha. Microglia-derived exosomal circZNRF1 alleviates paraquat-induced neuronal cell damage via miR-17-5p. Ecotoxicology and environmental safety. vol 263. 2023-08-17. PMID:37591128. |
first, we found that exosomes released from microglia caused a change in neuronal cell vitality and reversed pq-induced neuronal apoptosis. |
2023-08-17 |
2023-09-07 |
Not clear |
| Xu Liu, Qingqing Wu, Jingwen Wu, Jianxi Liu, Fuli Zheng, Guangxia Yu, Hong Hu, Zhenkun Guo, Siying Wu, Huangyuan Li, Wenya Sha. Microglia-derived exosomal circZNRF1 alleviates paraquat-induced neuronal cell damage via miR-17-5p. Ecotoxicology and environmental safety. vol 263. 2023-08-17. PMID:37591128. |
in conclusion, we demonstrated a new intercellular communication mechanism between microglia and neurons, in which circznrf1 plays a key role in protecting against pq-induced neuronal apoptosis through mir-17-5p to regulate the biological process of pd. |
2023-08-17 |
2023-09-07 |
Not clear |
| Xiyan Mu, Zaiteng Liu, Xiaoyu Zhao, Lu Chen, Qi Jia, Chengju Wang, Tiejun Li, Yuanming Guo, Jing Qiu, Yongzhong Qia. Bisphenol analogues induced social defects and neural impairment in zebrafish. The Science of the total environment. 2023-08-16. PMID:37586522. |
these behavioral changes were accompanied by apparent histological injury, microglia activation, enhanced apoptosis and neuron loss in brain. |
2023-08-16 |
2023-09-07 |
zebrafish |
| Xihong Ye, Qinyi Chen, Xingrui Gong, Chunli Zhou, Tian Yuan, Xue Wang, Lin Hong, Jianfeng Zhang, Hua Son. STIM2 Suppression Blocks Glial Activation to Alleviate Brain Ischemia Reperfusion Injury via Inhibition of Inflammation and Pyroptosis. Molecular biotechnology. 2023-08-12. PMID:37572222. |
stim2 knockdown relieved neuronal apoptosis, microglia activation, inflammation and pyroptosis in mcao/r mice, as detected by terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel) staining, enzyme-linked immunosorbent assay (elisa) and western blotting. |
2023-08-12 |
2023-08-16 |
mouse |
| Xihong Ye, Qinyi Chen, Xingrui Gong, Chunli Zhou, Tian Yuan, Xue Wang, Lin Hong, Jianfeng Zhang, Hua Son. STIM2 Suppression Blocks Glial Activation to Alleviate Brain Ischemia Reperfusion Injury via Inhibition of Inflammation and Pyroptosis. Molecular biotechnology. 2023-08-12. PMID:37572222. |
in conclusion, stim2 knockdown in microglia alleviates ciri by inhibiting microglial activation, inflammation, apoptosis, and pyroptosis. |
2023-08-12 |
2023-08-16 |
mouse |
| Daryush Purrahman, Ali Shojaeian, Łukasz A Poniatowski, Bartłomiej Piechowski-Jóźwiak, Mohammad-Reza Mahmoudian-San. The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke. Cellular and molecular neurobiology. 2023-08-10. PMID:37561339. |
it may also have protective effects against nerve and spinal cord injuries by inhibiting neuroinflammatory response and apoptosis or it may be related to the proliferation, accumulation, differentiation, and activation of microglia. |
2023-08-10 |
2023-08-16 |
Not clear |
| Renlong Zhang, Ting Zhou, Soham Samanta, Ziyi Luo, Shaowei Li, Hao Xu, Junle Q. Synergistic photobiomodulation with 808-nm and 1064-nm lasers to reduce the β-amyloid neurotoxicity in the Frontiers in neuroimaging. vol 1. 2023-08-09. PMID:37555169. |
synergistic photobiomodulation with 808-nm and 1064-nm lasers to reduce the β-amyloid neurotoxicity in the in alzheimer's disease (ad), the deposition of β-amyloid (aβ) plaques is closely associated with the neuronal apoptosis and activation of microglia, which may result in the functional impairment of neurons through pro-inflammation and over-pruning of the neurons. |
2023-08-09 |
2023-08-16 |
Not clear |
| Xiyu Gao, Dewei He, Yanting Liu, Mingchi Cui, Zhe Li, Jie Li, Yuan He, Hefei Wang, Bojian Ye, Shoupeng Fu, Dianfeng Li. Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats. International immunopharmacology. vol 123. 2023-08-03. PMID:37536186. |
the excessive autophagy of neurons and hyperactivation of microglia were shown to be involved in the apoptosis of dopaminergic neurons. |
2023-08-03 |
2023-08-14 |
rat |
| Yuan-Yuan Fang, Cui-Liu Gan, Jian-Chao Peng, Yu-Han Xie, Han-Xiao Song, Ya-Qi Mo, Shi-Yan Ou, Michael Aschner, Yue-Ming Jian. Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells. Biological trace element research. 2023-07-27. PMID:37500820. |
the aim of study was to address the effects of manganese and iron, alone and in combination, on apoptosis of bv2 microglia cells, and to determine if combined exposure to these metals augments their individual toxicity. |
2023-07-27 |
2023-08-14 |
Not clear |
| Antonisamy William James, Ghaith A Bahader, Mohammad Albassan, Zahoor A Sha. The ER chaperone, BIP protects Microglia from ER stress-mediated Apoptosis in Hyperglycemia. Neurochemistry international. 2023-07-16. PMID:37454816. |
the er chaperone, bip protects microglia from er stress-mediated apoptosis in hyperglycemia. |
2023-07-16 |
2023-08-14 |
mouse |
| Zhi Ma, Yue Wu, Juan Xu, Hui Cao, Mingyang Du, Haibo Jiang, Feng Qi. Sodium Tanshinone IIA Sulfonate Ameliorates Oxygen-glucose Deprivation/Reoxygenation-induced Neuronal Injury via Protection of Mitochondria and Promotion of Autophagy. Neurochemical research. 2023-07-12. PMID:37436612. |
silencing of pp2a or administration of 3-methyladenine inhibited autophagy and decreased the production of anti-inflammatory factors (il-10, tgf-β and bdnf) and induced the release of proinflammatory cytokines (il-1β, il-2 and tnf-α) by sts-treated microglia, thereby inducing mitochondrial dysfunction and apoptosis of sts-treated neurons. |
2023-07-12 |
2023-08-14 |
Not clear |
| Zhi Ma, Yue Wu, Juan Xu, Hui Cao, Mingyang Du, Haibo Jiang, Feng Qi. Sodium Tanshinone IIA Sulfonate Ameliorates Oxygen-glucose Deprivation/Reoxygenation-induced Neuronal Injury via Protection of Mitochondria and Promotion of Autophagy. Neurochemical research. 2023-07-12. PMID:37436612. |
sts exerts protection against neuron injury, and the pp2a gene plays a crucial role in improving mitochondrial function and inhibiting neuronal apoptosis by regulating autophagy and inflammation in microglia. |
2023-07-12 |
2023-08-14 |
Not clear |