| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xudong Zhou, Huiping Song, Jingjing He, Wei Han, Qin L. Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks. Molecular medicine reports. vol 29. issue 6. 2024-04-19. PMID:38639190. |
activated microglia secrete cytokines, including tnf‑α, cxcl‑8 and ccl2, which trigger an inflammatory response and facilitate neuronal apoptosis. |
2024-04-19 |
2024-04-21 |
mouse |
| Xudong Zhou, Huiping Song, Jingjing He, Wei Han, Qin L. Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks. Molecular medicine reports. vol 29. issue 6. 2024-04-19. PMID:38639190. |
tyrobp gene knockout in microglia was demonstrated to reduce this interaction and reduce neuronal cell apoptosis rates. |
2024-04-19 |
2024-04-21 |
mouse |
| Shuang Zhao, Guiling Mo, Qiang Wang, Jin Xu, Shihui Yu, Zhibin Huang, Wei Liu, Wenqing Zhan. Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. vol 10. issue 1. 2024-04-18. PMID:38637503. |
we showed that rb1-deficient mutants exhibit a significant hindbrain neuronal apoptosis, resulting in increased microglia infiltration. |
2024-04-18 |
2024-04-21 |
human |
| Yue Tao, Xiaodong Yi, Yanyan Gu, Rongyi Yang, Zixu Li, Xiangyong Guo, Donglin Zhao, Ying Zhan. Neurotoxicity of dibutyl phthalate in zebrafish larvae: Decreased energy acquisition by neurons. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-04-15. PMID:38621509. |
after 72 hours of exposure to dbp, microglia in the brain were over-activated, reactive oxygen species (ros) formation was increased, and apoptosis was observed. |
2024-04-15 |
2024-04-18 |
zebrafish |
| Chang Liu, Qi Yan, Xuying Ding, Meijun Zhao, Chen Chen, Qian Zheng, Huiying Yang, Yining Xi. Functional modification of recombinant brain-derived neurotrophic factor and its protective effect against neurotoxicity. International journal of biological macromolecules. 2024-04-15. PMID:38621565. |
protein characterization showed that p-tbdnf significantly improved the stability of the recombinant protein and possessed the ability to penetrate the bbb, and in cellular experiments, p-tbdnf prevented mptp-induced nerve cell oxidative stress damage, apoptosis and inflammatory response, and its mechanism of action was closely related to the activation of tyrosine kinase b (trkb) receptor and inhibition of microglia activation. |
2024-04-15 |
2024-04-18 |
mouse |
| Jie Zeng, Wei-Wei Gao, Hao Yang, Ya-Nang Wang, Yang Mei, Ting-Ting Liu, Min Wang, Li Tang, Dong-Chuan Ma, Wei L. Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain. European journal of pharmacology. 2024-03-29. PMID:38552937. |
sts pretreatment inhibited lps-stimulated pro-inflammatory cytokine secretion, reduced stat3 pathway related-proteins and apoptosis, increased mir-125b-5p and proopiomelanocortin expression, and enhanced microglia transformation from m1 to m2 phenotype in bv-2 cells. |
2024-03-29 |
2024-04-01 |
rat |
| Guopeng Chen, Yuhui Zhang, Ruiling Li, Liuyin Jin, Keke Hao, Jingtong Rong, Hao Duan, Yiwei Du, Lihua Yao, Dan Xiang, Zhongchun Li. Environmental enrichment attenuates depressive-like behavior in maternal rats by inhibiting neuroinflammation and apoptosis and promoting neuroplasticity. Neurobiology of stress. vol 30. 2024-03-25. PMID:38524250. |
maternal rats subjected to ms developed depression-like behavior and cognitive dysfunction together with evidence of significant neuroinflammation including microglia activation, neuronal apoptosis, and impaired synaptic plasticity. |
2024-03-25 |
2024-03-27 |
rat |
| Seyedeh Naghmeh Nourirad, Amhr-Hossein Bayat, Moitaba Sani, Amirreza Beirami, Maral Hasanzadeh, Susan Roustaee, Mobina Fathi, Kimia Vakili, Siavash Parvardeh, Gholam Hossein Meftahi, Nahid Sarahian, Fariba Khodagholi, Abbas Aliaghaei, Hojjat-Allah Abbaszadeh, Meysam Hassani Moghadda. Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study. Behavioural brain research. 2024-03-18. PMID:38499158. |
also, in addition to an increase in expression of caspase-3 in the hippocampus, which indicates the susceptibility to apoptosis in ldx-treated rats, the number of microglia and astrocytes went up significantly in the ldx group. |
2024-03-18 |
2024-03-21 |
rat |
| Lanqing Zhao, Jinwei L. Microglial uptake of hADSCs-Exo mitigates neuroinflammation in ICH. Cellular signalling. 2024-03-18. PMID:38499232. |
in the ich mouse model, hadscs-exo significantly improved neurological function, reduced hemorrhage volume, decreased neuronal apoptosis, and regulated microglia polarization. |
2024-03-18 |
2024-03-21 |
mouse |
| Zhiwei Luan, Jingsong Liu, Mi Li, Yangyang Wang, Yansong Wan. Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF-κB/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury. Journal of orthopaedic surgery and research. vol 19. issue 1. 2024-03-16. PMID:38491537. |
moreover, exosomes could inhibit apoptosis and inflammatory reaction and reactive oxygen species (ros) production of bv2 microglia in vitro and in vivo. |
2024-03-16 |
2024-03-19 |
human |
| Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui L. LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease. Journal of cellular physiology. 2024-03-13. PMID:38477420. |
neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (da) neurons in the midbrain are its primary pathological manifestations. |
2024-03-13 |
2024-03-15 |
mouse |
| Yuqin Peng, Qingfan Ren, Huanrong Ma, Chuman Lin, Mingjia Yu, Yongchuan Li, Jiancong Chen, Haihao Xu, Peng Zhao, Suyue Pan, Jia Tao, Kaibin Huan. Covalent organic framework based cytoprotective therapy after ischemic stroke. Redox biology. vol 71. 2024-03-05. PMID:38442647. |
this was achieved by eliminating ros, preventing neuronal loss and apoptosis, suppressing neuroinflammation, modulating microglia activation, and ameliorating blood-brain barrier (bbb) disruption. |
2024-03-05 |
2024-03-08 |
Not clear |
| Swapan K Ra. TUNEL-n-DIFL Method for Detection and Estimation of Apoptosis Specifically in Neurons and Glial Cells in Mixed Culture and Animal Models of Central Nervous System Diseases and Injuries. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427225. |
in situ detection and estimation of amount of apoptosis specifically in neurons or glial cells (astrocytes, oligodendrocytes, and microglia) can unveil valuable information for designing therapeutics for protection of the cns cells and functional recovery. |
2024-03-01 |
2024-03-03 |
Not clear |
| Swapan K Ra. TUNEL-n-DIFL Method for Detection and Estimation of Apoptosis Specifically in Neurons and Glial Cells in Mixed Culture and Animal Models of Central Nervous System Diseases and Injuries. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427225. |
a primary anti-neun (neurons), anti-gfap (astrocytes), anti-mbp (oligodendrocytes), or anti-ox-42 (microglia) igg antibody and a secondary igg antibody conjugated with one of the above fluorophores (other than that of ani-dig antibody) are used for in situ detection of apoptosis in a specific cns cell type in the mixed culture and animal models of the cns diseases and injuries. |
2024-03-01 |
2024-03-03 |
Not clear |
| Judong Kim, Edward Pajarillo, Asha Rizor, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Le. Correction: LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PloS one. vol 19. issue 3. 2024-03-01. PMID:38427617. |
correction: lrrk2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. |
2024-03-01 |
2024-03-04 |
Not clear |
| Hongxia Wang, Jialiang Ma, Xiaoling Li, Yanhui Peng, Manxia Wan. FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury. European journal of pharmacology. 2024-03-01. PMID:38428662. |
next, we established an in vivo mouse model of cerebral ischemia-reperfusion injury (mcao/r) and an in vitro microglia cell of oxygen-glucose deprivation reperfusion (ogd/r) to investigate the role of baicalin in inflammation injury, oxidative stress, and neuronal apoptosis. |
2024-03-01 |
2024-03-04 |
mouse |
| Tingting Chen, Congyao Wang, Wenhui Zhu, Fenfen Yu, Xia Dong, Yihua Su, Jingwen Huang, Lijun Huo, Pengxia Wa. mm9_circ_014683 regulates microglia polarization through canonical NFκB signaling pathway in diabetic retinopathy. Cellular signalling. 2024-02-28. PMID:38417635. |
inhibiting or overexpressing mm9_circ_014683 showed no effect on the proliferation and apoptosis of microglia. |
2024-02-28 |
2024-03-02 |
mouse |
| Carlos Cruchaga, Muhammad Ali, Yuanyuan Shen, Anh Do, Lihua Wang, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Jen Gentsch, Suzanne Schindler, John Morris, David Holtzman, Maria Fernández, Agustín Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Rutledge, Hamilton Oh, Edward Wilson, Yann Le Guen, Rana Khalid, Chloe Robins, David Pulford, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sun. Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease. Research square. 2024-02-27. PMID:38410465. |
the associated proteins cluster in four different protein pseudo-trajectories groups spanning the ad continuum and were enrichment in specific pathways including neuronal death, apoptosis and tau phosphorylation (early stages), microglia dysregulation and endolysosomal dysfuncton(mid-stages), brain plasticity and longevity (mid-stages) and late microglia-neuron crosstalk (late stages). |
2024-02-27 |
2024-03-02 |
Not clear |
| Rui Jiang, Zhichao Lu, Chenxing Wang, WenJun Tu, Qi Yao, Jiabing Shen, Xingjia Zhu, Ziheng Wang, Yixun Chen, Yang Yang, Kaijiang Kang, Peipei Gon. Astrocyte-derived Interleukin-31 causes poor prognosis in elderly patients with intracerebral hemorrhage. Brain pathology (Zurich, Switzerland). 2024-02-14. PMID:38354695. |
the activation of astrocytes after ich releases a large amount of il31, which binds to microglia through il31r, causing a large number of microglia to converge to the hematoma area, leading to the spread of neuroinflammation, apoptosis of neurons, and ultimately resulting in poorer recovery of nerve function. |
2024-02-14 |
2024-02-17 |
human |
| Zifu Li, Tianxiang Gao, Jing Wang, Xiaoxi Zhang, Yongxin Zhang, Lei Zhang, Pengfei Yang, Jianmin Li. Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke. Journal of neurochemistry. 2024-02-12. PMID:38344886. |
we first examined tnfsf9 changes in peripheral blood from stroke patients with successful reperfusion, and constructed oxygen-glucose deprivation-reperfusion (ogd-r) on bv2 microglia, oxygen-glucose deprivation for 6 h followed by reoxygenation and re-glucose for 24 h, and appropriate over-expression or knockdown of tnfsf9 manipulation on bv2 cells and found that in the case of bv2 cells encountering ogd-r over-expression of tnfsf9 resulted in increased bv2 apoptosis. |
2024-02-12 |
2024-02-15 |
mouse |