| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhaoda Duan, Haolun Chen, Wei Miao, Jing He, Dongyao Xu, Zhi Qi, Li Yang, Wenji Jia, Chunyun W. Scutellarin alleviates microglia-mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3 Journal of cell communication and signaling. vol 18. issue 2. 2024-07-01. PMID:38946727. |
scutellarin alleviates microglia-mediated neuroinflammation and apoptosis after ischemic stroke through the pi3k/akt/gsk3 microglia are resident immune cells in the central nervous system that are rapidly activated to mediate neuroinflammation and apoptosis, thereby aggravating brain tissue damage after ischemic stroke (is). |
2024-07-01 |
2024-07-03 |
rat |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
further analysis showed that this decrease in microglia was mediated by the initial response of microglia to unpredictable stress in the dentate gyrus of the hippocampus and their subsequent apoptosis. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
blocking the initial response of microglia to unpredictable stress by pretreatment with minocycline was able to prevent apoptosis and microglial decline as well as the development of depression-like behaviors in adult mice induced by adolescent cus. |
2024-06-21 |
2024-06-24 |
mouse |
| Xintian Ding, Chun Chen, Heng Zhao, Bin Dai, Lei Ye, Tao Song, Shuai Huang, Jia Wang, Tao Yo. Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model. Neural regeneration research. vol 20. issue 3. 2024-06-18. PMID:38886958. |
the results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting shp2 expression mitigated these effects. |
2024-06-18 |
2024-06-21 |
mouse |
| Zhao-Da Duan, Li-Yang Zheng, Qiu-Ye Jia, Hao-Lun Chen, Dong-Yao Xu, Yu-Jia Yang, Zhi Qi, Li Yang, Chun-Yun W. Effect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway. Scientific reports. vol 14. issue 1. 2024-06-11. PMID:38862696. |
previous studies have shown that scutellarin inhibits the excessive activation of microglia, reduces neuronal apoptosis, and exerts neuroprotective effects. |
2024-06-11 |
2024-06-14 |
Not clear |
| Zhao-Da Duan, Li-Yang Zheng, Qiu-Ye Jia, Hao-Lun Chen, Dong-Yao Xu, Yu-Jia Yang, Zhi Qi, Li Yang, Chun-Yun W. Effect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway. Scientific reports. vol 14. issue 1. 2024-06-11. PMID:38862696. |
this study aimed to investigate whether scutellarin can attenuate pc12 cell apoptosis induced by activated microglia via the jak2/stat3 signalling pathway. |
2024-06-11 |
2024-06-14 |
Not clear |
| Zhao-Da Duan, Li-Yang Zheng, Qiu-Ye Jia, Hao-Lun Chen, Dong-Yao Xu, Yu-Jia Yang, Zhi Qi, Li Yang, Chun-Yun W. Effect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway. Scientific reports. vol 14. issue 1. 2024-06-11. PMID:38862696. |
microglia were cultured in oxygen-glucose deprivation (ogd) medium, which acted as a conditioning medium (cm) to activate pc12 cells, to investigate the expression of apoptosis and jak2/stat3 signalling-related proteins. |
2024-06-11 |
2024-06-14 |
Not clear |
| Jing-Ya Wang, Peng Ren, Lin-Yu Cui, Jing-Yao Duan, Hong-Lei Chen, Zhi-Rui Zeng, Yun-Feng L. Astrocyte-specific inhibition of sigma-1 receptor leads to depressive-like behaviors in mice via activation of NF-κB-induced neuroinflammation. Brain, behavior, and immunity. 2024-06-09. PMID:38852761. |
in addition, astrocytic σ-1 receptor deficiency led to activation of the nf-κb inflammatory pathway, and crosstalk between reactive astrocytes and activated microglia amplified neuroinflammation, exacerbating stress-induced neuronal apoptosis. |
2024-06-09 |
2024-06-14 |
mouse |
| Yueyue Huang, Yongyi Li, Danni Guan, Yaru Pan, Chao Yang, Huina Liu, Chaoyan Chen, Weitao Chen, Jinman Liu, Ting Wan, Lixing Zhuang, Qi Wang, Yifan Zhan. Acorus tatarinowii oils exert protective effects on microglia-mediated inflammatory injury via restoring gut microbiota composition in experimental stroke rats. Brain research bulletin. 2024-05-31. PMID:38821245. |
the compositions of at oils were identified by gc-ms. our results demonstrated that at oils could effectively relieve cerebral infarction, inhibit neuronal apoptosis, degrade the release of pro-inflammatory factors (tnf-α, il-17, il-6 and ifn-γ), and mediate the polarization of microglia. |
2024-05-31 |
2024-06-02 |
rat |
| Xi Liu, Jia Gu, Cheng Wang, Min Peng, Jilin Zhou, Xiyun Fei, Zhijun Zhong, Bo L. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell cycle (Georgetown, Tex.). 2024-05-26. PMID:38796716. |
hippocampal neurons cultured in a medium containing lps, ginsenoside rg3, and nam-treated microglia showed improved viability and reduced apoptosis compared to those cultured in a medium with lps and ginsenoside rg3-treated microglia alone. |
2024-05-26 |
2024-05-31 |
mouse |
| Erin K Nagy, Paula F Overby, Jonna M Leyrer-Jackson, Vincent F Carfagno, Amanda M Acuña, M Foster Oliv. Methamphetamine and the Synthetic Cathinone 3,4-Methylenedioxypyrovalerone (MDPV) Produce Persistent Effects on Prefrontal and Striatal Microglial Morphology and Neuroimmune Signaling Following Repeated Binge-like Intake in Male and Female Rats. Brain sciences. vol 14. issue 5. 2024-05-25. PMID:38790414. |
the microglial cell density was decreased in the pfc of meth self-administering animals, accompanied by evidence of microglial apoptosis. |
2024-05-25 |
2024-05-27 |
rat |
| Xu Zhao, Jiancong Lu, Jingyi Zhang, Ce Liu, Huijun Wang, Yan Wang, Qingfeng D. Sleep restriction promotes brain oxidative stress and inflammation, and aggravates cognitive impairment in insulin-resistant mice. Psychoneuroendocrinology. vol 166. 2024-05-08. PMID:38718616. |
compared with control group, ir mice showed impaired cognitive capacity, meanwhile, sr not only promoted bax/bcl2-induced hippocampal neuronal cell apoptosis and nrf2/ho1- induced oxidative stress, but also increased microglia activation and inflammatory factor levels and bbb permeability, thus aggravating the cognitive impairment in ir mice. |
2024-05-08 |
2024-05-27 |
mouse |
| Jingshu Hong, Yue Li, Lei Chen, Dengyang Han, Yitong Li, Xinning Mi, Kaixi Liu, Qian Wang, Yanan Song, Taotao Liu, Ning Yang, Yajie Liu, Zhengqian Li, Xiangyang Gu. A53T α-synuclein mutation increases susceptibility to postoperative delayed neurocognitive recovery via hippocampal Ang-(1-7)/MasR axis. Biochemical pharmacology. 2024-05-05. PMID:38705534. |
we respectively examined molecular changes at 6 h, 1 day, and 2 days after partial hepatectomy and observed that cognitive changes were accompanied by weakened angiotensin-(1-7)/mas receptor [ang-(1-7)/masr] axis, increased alpha-synuclein (α-syn) expression and phosphorylation, decreased methylated protein phosphatase-2a (me-pp2a), and prompted microglia m1 polarization and neuronal apoptosis in the hippocampus at 1 day after surgery. |
2024-05-05 |
2024-05-08 |
mouse |
| Tao Wen, Jing Wen, Cuicui Ya. Remimazolam inhibits postoperative cognitive impairment after cardiopulmonary bypass by alleviating neuroinflammation and promoting microglia M2 polarization. Brain research. 2024-05-03. PMID:38702024. |
cpb rats and lps-treated microglia showed increased apoptosis, pro-inflammatory cytokines level, and inflammasome expression as well as decreased microglia activation, while the results were reversed after remimazolam treatment. |
2024-05-03 |
2024-05-06 |
rat |
| Ying Yang, Ying Lai, Xueli Tong, Zipei Li, Yuanyuan Cheng, Li-Wen Tia. Arjunolic acid ameliorates lipopolysaccharide-induced depressive behavior by inhibiting neuroinflammation via microglial SIRT1/AMPK/Notch1 signaling pathway. Journal of ethnopharmacology. 2024-04-26. PMID:38670408. |
neuroinflammation is involved in the pathogenesis of depression disorder by activating microglia cells, increasing proinflammatory cytokines, effecting serotonin synthesis and metabolism, and neuronal apoptosis and neurogenesis. |
2024-04-26 |
2024-04-29 |
Not clear |
| Zhihua Chen, Wei Hu, Jiahong Wang, Donggen Rao, Jianming Zh. Knockdown of lncRNA AU020206 could inhibit microglia apoptosis in ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 3. 2024-04-23. PMID:38650139. |
knockdown of lncrna au020206 could inhibit microglia apoptosis in ischemic stroke. |
2024-04-23 |
2024-04-26 |
Not clear |
| Zhihua Chen, Wei Hu, Jiahong Wang, Donggen Rao, Jianming Zh. Knockdown of lncRNA AU020206 could inhibit microglia apoptosis in ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 3. 2024-04-23. PMID:38650139. |
knockdown of lncrna au020206 inhibited microglia apoptosis in ogd cell model. |
2024-04-23 |
2024-04-26 |
Not clear |
| Zhihua Chen, Wei Hu, Jiahong Wang, Donggen Rao, Jianming Zh. Knockdown of lncRNA AU020206 could inhibit microglia apoptosis in ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 3. 2024-04-23. PMID:38650139. |
we constructed a lncrnas-mediated cerna network and found that lncrna au020206 inhibited microglia apoptosis in ogd cell model. |
2024-04-23 |
2024-04-26 |
Not clear |
| Hongtao Shen, Jiaao Gu, Xing Liu, Mowei Son. Small nucleolar RNA host gene 1 silence inhibits the lipopolysaccharide-induced microglial apoptosis and inflammation. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 3. 2024-04-23. PMID:38650136. |
this study was designed to investigate the role of small nucleolar rna host gene 1 (snhg1) on the apoptosis and inflammatory response of microglial cell bv-2 and its underlying molecular mechanism. |
2024-04-23 |
2024-04-26 |
mouse |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
overall, our study here revealed that msa induced tau phosphorylation and neuron apoptosis based on msa-activated microglia and astrocytes, respectively, showing the critical roles of msa in initiating the occurrence of tauopathies and cognitive decline, and providing potential therapeutic targets for msa-induced neuropathology in multiple neurodegenerative disorders. |
2024-04-23 |
2024-04-26 |
mouse |