| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zongxin Cheng, Xinming Li, Xiaohua Ye, Rong Yu, Youqing Den. Purpurogallin Reverses Neuronal Apoptosis and Enhances "M2" Polarization of Microglia Under Ischemia via Mediating the miR-124-3p/TRAF6/NF-κB Axis. Neurochemical research. 2022-09-21. PMID:36131212. |
after being dealt with ppg, the neurological functions, brain edema, neuronal apoptosis, and microglia activation of the mice were evaluated. |
2022-09-21 |
2023-08-14 |
mouse |
| Wen-Jun Zhan. Contribution of P2X purinergic receptor in cerebral ischemia injury. Brain research bulletin. 2022-09-16. PMID:36113681. |
p2x receptors activation can mediate the information exchange between microglia and neurons, induce neuronal apoptosis, and aggravate neurological dysfunction after cerebral ischemia. |
2022-09-16 |
2023-08-14 |
Not clear |
| Chong Song, Wei Wei, Tong Wang, Min Zhou, Yunshi Li, Bing Xiao, Dongyi Huang, Junwei Gu, Linyong Shi, Junjie Peng, Dianshi Ji. Microglial infiltration mediates cognitive dysfunction in rat models of hypothalamic obesity Frontiers in cellular neuroscience. vol 16. 2022-09-08. PMID:36072565. |
furthermore, neuronal apoptosis and activated microglia in the downstream of the lesion area (the lha) induced microglial infiltration into the intact hippocampus |
2022-09-08 |
2023-08-14 |
rat |
| Xiaodan Zhou, Shuhui Zhou, Jian Tao, Yanan Gao, Gaoqiang Meng, Duo Cao, Lin Ga. HIV-1 Tat drives the Fabp4/NF-κB feedback loop in microglia to mediate inflammatory response and neuronal apoptosis. Journal of neurovirology. 2022-09-07. PMID:36070137. |
hiv-1 tat drives the fabp4/nf-κb feedback loop in microglia to mediate inflammatory response and neuronal apoptosis. |
2022-09-07 |
2023-08-14 |
mouse |
| Tingting Zhou, Suli He, Xin Ye, Zhaolan Wei, Jian Wan, Hongmao Zhang, Shumao Din. Exposure to dibutyl phthalate adsorbed to multi-walled carbon nanotubes causes neurotoxicity in mice by inducing the release of BDNF. The Science of the total environment. 2022-08-30. PMID:36041608. |
the experimental results demonstrated that the mechanism of the combined-exposure injury to neurons in the hippocampus of mice may be that mwcnts with adsorbed dbp can induce the release of bdnf, accelerate the apoptosis of neurons, and reduce the number of nerve cells, which activates microglia, causing neuroinflammation and nervous system toxicity. |
2022-08-30 |
2023-08-14 |
mouse |
| Cheng-Jie Yang, Xin Li, Xiao-Qing Feng, Ye Chen, Jian-Guo Feng, Jing Jia, Ji-Cheng Wei, Jun Zho. Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice. Oxidative medicine and cellular longevity. vol 2022. 2022-08-29. PMID:36035210. |
interestingly, cog1410 inhibited microglia proinflammatory polarization and promoted anti-inflammatory polarization, decreased oxidative stress, attenuated apoptosis, and inhibited the expression of the txnip/nlrp3 signaling pathway. |
2022-08-29 |
2023-08-14 |
mouse |
| Giuseppe Carota, Alfio Distefano, Mariarita Spampinato, Cesarina Giallongo, Giuseppe Broggi, Lucia Longhitano, Giuseppe A Palumbo, Rosalba Parenti, Rosario Caltabiano, Sebastiano Giallongo, Michelino Di Rosa, Riccardo Polosa, Vincenzo Bramanti, Nunzio Vicario, Giovanni Li Volti, Daniele Tibull. Neuroprotective Role of α-Lipoic Acid in Iron-Overload-Mediated Toxicity and Inflammation in In Vitro and In Vivo Models. Antioxidants (Basel, Switzerland). vol 11. issue 8. 2022-08-26. PMID:36009316. |
ala was found to revert iron-overload-induced toxicity in hmc3 microglia cell line, preventing cell apoptosis, reactive oxygen species generation and reducing glutathione depletion. |
2022-08-26 |
2023-08-14 |
zebrafish |
| Zhi-Qiang Cui, Xiao-Ying Hu, Tuo Yang, Jing-Wei Guan, Ying Gu, Hui-Yuan Li, Hui-Yu Zhang, Qing-Huan Xiao, Xiao-Hong Su. TMEM16F may be a new therapeutic target for Alzheimer's disease. Neural regeneration research. vol 18. issue 3. 2022-08-26. PMID:36018189. |
after tmem16f knockdown in mice, spatial memory ability was improved, microglia polarization to the m2 phenotype was promoted, nlrp3 inflammasome activation was inhibited, cell apoptosis and aβ plaque deposition in brain tissue were reduced, and brain injury was alleviated. |
2022-08-26 |
2023-08-14 |
mouse |
| Zuo Zhang, Xiaolong Li, Hongli Zhou, Jiyin Zho. NG2-glia crosstalk with microglia in health and disease. CNS neuroscience & therapeutics. 2022-08-24. PMID:36000202. |
ng2-glia proliferation, migration, differentiation, and apoptosis are influenced by factors released from the microglia. |
2022-08-24 |
2023-08-14 |
Not clear |
| Bo Hei, Jia Ouyang, Jingru Zhou, Dongliang Wang, Zeyu Miao, Ru-En Li. Raddeanin A (RA) reduced acute inflammatory injury in mouse experimental cerebral hemorrhage by suppression of TLR4. International journal of medical sciences. vol 19. issue 8. 2022-08-05. PMID:35928716. |
mechanistically, ra downregulated the tlr4-mediated pro-inflammatory effectors, reduced infiltration of microglia in peri-intracerebral hemorrhage and inhibited apoptosis of neurons co-cultured with activated microglia. |
2022-08-05 |
2023-08-14 |
mouse |
| Magdalena Patrycy, Marcin Chodkowski, Malgorzata Krzyzowsk. Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration. Pathogens (Basel, Switzerland). vol 11. issue 7. 2022-07-27. PMID:35890053. |
herpesviruses express several molecular mechanisms, which can modulate apoptosis of infected neurons, astrocytes and microglia but also divert immune response initiated by the infected cells. |
2022-07-27 |
2023-08-14 |
Not clear |
| Xiaoyu Gao, Zilong Cao, Haifeng Tan, Peiling Li, Wenen Su, Teng Wan, Weiming Gu. LncRNA, an Emerging Approach for Neurological Diseases Treatment by Regulating Microglia Polarization. Frontiers in neuroscience. vol 16. 2022-07-21. PMID:35860297. |
their pro-inflammatory (m1)/anti-inflammatory (m2) phenotype microglia are closely associated with neuronal apoptosis, synaptic plasticity, blood-brain barrier integrity, resistance to iron death, and astrocyte regulation. |
2022-07-21 |
2023-08-14 |
human |
| Qing Li, Xianjie Zhang, Siyuan Li, Wen Li, Yunpeng Teng, Yukai Zhou, Hongfei Xion. Carnosol alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats. Drug development research. 2022-07-05. PMID:35781309. |
the effects of carnosol on the expression of inflammatory factors in rat hippocampus mediated by sev were determined by enzyme-linked immunoassay and polymerase chain reaction experiments; the effects of carnosol on the expressions of iba-1 and glial fibrillary acidic protein after sev-mediated activation of rat microglia were clarified by immunofluorescence and western blotting (wb); the effects of carnosol on sev-mediated neuronal apoptosis were studied by terminal deoxynucleotidyl transferase dutp nick end labeling and wb; the specific signaling pathways regulated by carnosol were elucidated by wb. |
2022-07-05 |
2023-08-14 |
rat |
| Qing Li, Xianjie Zhang, Siyuan Li, Wen Li, Yunpeng Teng, Yukai Zhou, Hongfei Xion. Carnosol alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats. Drug development research. 2022-07-05. PMID:35781309. |
the results showed that carnosol can improve the cognitive dysfunction and reduce neuroinflammation in aged rats induced by sev; carnosol can reduce the activation of microglia and inhibit neuronal apoptosis in aged rats induced by sev; carnosol can phosphorylate p65 and nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, alpha regulates the nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) pathway. |
2022-07-05 |
2023-08-14 |
rat |
| Yuanyuan Zeng, Wei Zhang, Tengteng Xue, Dayong Zhang, Manhua Lv, Yongjia Jian. Sphk1-induced autophagy in microglia promotes neuronal injury following cerebral ischemia-reperfusion. The European journal of neuroscience. 2022-06-29. PMID:35766986. |
it was found that ciri up-regulated sphk1 and induced autophagy in microglia, while inhibiting these changes significantly impaired to prevented neuronal apoptosis. |
2022-06-29 |
2023-08-14 |
rat |
| Roberto Iorio, Giuseppe Celenza, Sabrina Petricc. Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation. Antioxidants (Basel, Switzerland). vol 11. issue 6. 2022-06-24. PMID:35740096. |
bcp and ca can readily cross the bbb and accumulate in brain regions, giving rise to neuroprotective effects by preventing mitochondrial dysfunction and inhibiting activated microglia, substantially through the activation of pro-survival signalling pathways, including regulation of apoptosis and autophagy, and molecular mechanisms related to mitochondrial quality control. |
2022-06-24 |
2023-08-14 |
Not clear |
| Feng Zhou, Zhenzhi Wang, Kang Xiong, Meiling Zhang, Yuan Wang, Maode Wan. Alantolactone reduced neuron injury via activating PI3K/Akt signaling pathway after subarachnoid hemorrhage in rats. PloS one. vol 17. issue 6. 2022-06-24. PMID:35749405. |
in this study, we found that atl treatment attenuated the neurologic deficits, inhibited neuronal apoptosis and inflammatory reaction, promoted polarization of microglia toward the m2 phenotype, and activated the pi3k/akt signaling pathway. |
2022-06-24 |
2023-08-14 |
rat |
| Xue Jiang, Saini Yi, Qin Liu, Jinqiang Zhan. The secretome of microglia induced by IL-4 of IFN-γ differently regulate proliferation, differentiation and survival of adult neural stem/progenitor cell by targeting the PI3K-Akt pathway. Cytotechnology. vol 74. issue 3. 2022-06-23. PMID:35733698. |
the secretome from the il-4-treated microglia promoted nspcs proliferation, survival and differentiation into neurons and oligodendrocytes, while factors secreted by the inf-γ-treated microglia stimulated the nspcs differentiation into astrocyte, inhibited the neurogenesis and oligodendrogliogenesis, and induced nspcs apoptosis. |
2022-06-23 |
2023-08-14 |
Not clear |
| Jinqiang Zhang, Dapeng Su, Qin Liu, Qingsong Yuan, Zhen Ouyang, Yuan Wei, Chenghong Xiao, Liangyuan Li, Changgui Yang, Weike Jiang, Lanping Guo, Tao Zho. Gasdermin D-mediated microglial pyroptosis exacerbates neurotoxicity of aflatoxins B1 and M1 in mouse primary microglia and neuronal cultures. Neurotoxicology. 2022-06-18. PMID:35716928. |
here we evaluated the toxicity of afb1 and afm1 against primary microglia and found that both aflatoxins decreased the viability of primary microglia and increased the leakage of lactate dehydrogenase, gamma-h2ax expression, nuclear lysis, necrosis and apoptosis in a dose-dependent manner. |
2022-06-18 |
2023-08-14 |
mouse |
| Zhaoming Chu, You Lu, Rujie Qin, Yuefu Don. LncRNA KCNQ1OT1 promotes the apoptosis and inflammatory response of microglia by regulating the miR-589-5p/NPTN axis after spinal cord injury. Anais da Academia Brasileira de Ciencias. vol 94. issue 2. 2022-06-15. PMID:35703693. |
lncrna kcnq1ot1 promotes the apoptosis and inflammatory response of microglia by regulating the mir-589-5p/nptn axis after spinal cord injury. |
2022-06-15 |
2023-08-14 |
mouse |