| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
exposing bend.3 endothelial cells (ecs) and primary cortical neurons to ogd, the impact of evs from ogd-preconditioned microglia on angiogenesis and neuronal apoptosis by the tube formation assay and tunel staining was assessed. |
2021-11-17 |
2023-08-13 |
mouse |
| Xiang-Long Li, Bin Wang, Fu-Bing Yang, Li-Gang Chen, Jian Yo. HOXA11-AS aggravates microglia-induced neuroinflammation after traumatic brain injury. Neural regeneration research. vol 17. issue 5. 2021-11-10. PMID:34558538. |
the results revealed that overexpression of hoxa11-as aggravated neurological deficits in traumatic brain injury rats, increased brain edema and apoptosis, promoted the secretion of proinflammatory factors interleukin-1β, interleukin-6, and tumor necrosis factor α, and promoted the activation of astrocytes and microglia. |
2021-11-10 |
2023-08-13 |
rat |
| Yimin Wang, Xiaohuan Zhao, Min Gao, Xiaoling Wan, Yinong Guo, Yingying Qu, Yuhong Chen, Tong Li, Haiyun Liu, Mei Jiang, Feng Wang, Xiaodong Su. Myosin 1f-mediated activation of microglia contributes to the photoreceptor degeneration in a mouse model of retinal detachment. Cell death & disease. vol 12. issue 10. 2021-11-09. PMID:34628463. |
deficiency of myosin 1f protected against photoreceptor apoptosis by inhibiting microglia activation. |
2021-11-09 |
2023-08-13 |
mouse |
| Rong Rong, Rongliang Yang, Haibo Li, Mengling You, Zhuotao Liang, Zhou Zeng, Rongrong Zhou, Xiaobo Xia, Dan J. The roles of mitochondrial dynamics and NLRP3 inflammasomes in the pathogenesis of retinal light damage. Annals of the New York Academy of Sciences. 2021-11-06. PMID:34741555. |
further experiments revealed that dynamin-related protein 1 (drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the nlrp3 inflammasome. |
2021-11-06 |
2023-08-13 |
mouse |
| Xiaolang Lu, Fengfeng Lu, Jiachen Yu, Xinghe Xue, Hongyi Jiang, Liting Jiang, Yang Yan. Gramine promotes functional recovery after spinal cord injury via ameliorating microglia activation. Journal of cellular and molecular medicine. vol 25. issue 16. 2021-10-29. PMID:34382745. |
moreover, gramine prevented apoptosis of pc12 cells which was caused by activated hapi microglia, and the inflammatory secretion ability of microglia was inhibited by gramine through nf-κb pathway. |
2021-10-29 |
2023-08-13 |
rat |
| Hui Peng, Brock T Harvey, Christopher I Richards, Kimberly Nixo. Neuron-Derived Extracellular Vesicles Modulate Microglia Activation and Function. Biology. vol 10. issue 10. 2021-10-28. PMID:34681047. |
when ndevs were added to primary cultured rat microglia, we found significantly improved microglia viability via inhibition of apoptosis. |
2021-10-28 |
2023-08-13 |
rat |
| Clara Voelz, Pardes Habib, Stefan Köberlein, Cordian Beyer, Alexander Slowi. Alteration of miRNA Biogenesis Regulating Proteins in the Human Microglial Cell Line HMC-3 After Ischemic Stress. Molecular neurobiology. vol 58. issue 4. 2021-10-27. PMID:33210205. |
micrornas (mirna) are small noncoding sequences that control apoptosis, proliferation, and neuroinflammatory pathways in microglia cells. |
2021-10-27 |
2023-08-13 |
human |
| Hongxin Chen, Nizar Souaya. Immunoglobulins reduced oxidative stress in human microglial cells induced by high dose of acetoacetate. Brain research. vol 1748. 2021-10-26. PMID:32818529. |
overall, these results supported that ketone bodies induced microglia activation with early and selective impairment of mitochondrial function, increased cytokines expression and delayed increase in apoptosis. |
2021-10-26 |
2023-08-13 |
human |
| Hongxin Chen, Nizar Souaya. Immunoglobulins reduced oxidative stress in human microglial cells induced by high dose of acetoacetate. Brain research. vol 1748. 2021-10-26. PMID:32818529. |
ig suppressed microglia activation and transiently inhibited cytokines expression without affecting apoptosis. |
2021-10-26 |
2023-08-13 |
human |
| Zahra Pourmohammadi-Bejarpasi, Amaneh Mohammadi Roushandeh, Alia Saberi, Mojdeh Kheirandish Rostami, Seyyed Mohammadtaghi Razavi Toosi, Ali Jahanian-Najafabadi, Kazuo Tomita, Yoshikazu Kuwahara, Tomoaki Sato, Mehryar Habibi Roudkena. Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute ischemia stroke rat model. Brain research bulletin. vol 165. 2021-10-26. PMID:33010349. |
here we report that the mitochondrial transplantation ameliorated the reperfusion/ischemia-induced damages as reflected by declined blood creatine phosphokinase level, abolished apoptosis, decreased astroglyosis and microglia activation, reduced infarct size, and improved motor function. |
2021-10-26 |
2023-08-13 |
human |
| HuiMin Li, Yan Wang, Bin Wang, Min Li, JiPing Liu, HongLian Yang, YongHeng Sh. Baicalin and Geniposide Inhibit Polarization and Inflammatory Injury of OGD/R-Treated Microglia by Suppressing the 5-LOX/LTB4 Pathway. Neurochemical research. vol 46. issue 7. 2021-10-18. PMID:33891262. |
the effects of different concentrations of bc, gp, and bc/gp (6.25 μm, 12.5 μm, and 25 μm) on cell viability and apoptosis of microglia were evaluated by mtt and flow cytometry. |
2021-10-18 |
2023-08-13 |
Not clear |
| Jeesan Lee, Oscar David Villarreal, Xiaoru Chen, Stéphanie Zandee, Yoon Kow Young, Cynthia Torok, Nathalie Lamarche-Vane, Alexandre Prat, Serge Rivest, David Gosselin, Stéphane Richar. QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis. Cell reports. vol 33. issue 13. 2021-10-13. PMID:33378678. |
during the cuprizone diet, mice with qki-deficient microglia are inefficient at supporting central nervous system (cns) remyelination and cause the recruited oligodendrocyte precursor cells to undergo apoptosis. |
2021-10-13 |
2023-08-13 |
mouse |
| Shotaro Hayashida, Katsuhisa Masaki, Satoshi O Suzuki, Ryo Yamasaki, Mitsuru Watanabe, Sachiko Koyama, Noriko Isobe, Takuya Matsushita, Kazuya Takahashi, Takeshi Tabira, Toru Iwaki, Jun-Ichi Kir. Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Baló's disease and neuromyelitis optica spectrum disorders. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:32902014. |
these findings suggest that activated microglia expressing tmem119 and glut5, but not p2ry12, are associated with apoptosis of oligodendrocytes in the leading edge of baló's concentric lesions with do, whereas tmem119-, glut5- and p2ry12-positive microglia with ramified morphology are associated with myelin preservation in concentric lesions without do in baló's disease and nmosd. |
2021-10-06 |
2023-08-13 |
Not clear |
| Quan Chen, Hongjian Lu, Chengwei Duan, Xiangyang Zhu, Yi Zhang, Mengmeng Li, Dongmei Zhan. PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation. Inflammation. 2021-10-06. PMID:34613548. |
pdcd4 simultaneously promotes microglia activation via pdcd4-mapk-nf-κb positive loop and facilitates neuron apoptosis during neuroinflammation. |
2021-10-06 |
2023-08-13 |
mouse |
| Yener Akyuva, Mustafa Nazıroğlu, Kenan Yıldızha. Selenium prevents interferon-gamma induced activation of TRPM2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia. Metabolic brain disease. vol 36. issue 2. 2021-10-05. PMID:33044639. |
selenium prevents interferon-gamma induced activation of trpm2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia. |
2021-10-05 |
2023-08-13 |
Not clear |
| Qing-Peng Hu, Xiang-Yi Huang, Fang Peng, Hui Yang, Can W. MS275 reduces seizure-induced brain damage in developing rats by regulating p38 MAPK signaling pathways and epigenetic modification. Brain research. vol 1745. 2021-10-04. PMID:32522630. |
neuronal apoptosis and microglia activation significantly increased after ptz treatment. |
2021-10-04 |
2023-08-13 |
rat |
| Yunwei Lu, Renjuan Hao, Yingchao Hu, Yuyan Wei, Yuyan Xie, Yu Shen, Qinglin Rui, Guran Y. Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro. Chemico-biological interactions. vol 348. 2021-09-30. PMID:34516974. |
ang ii-mediated inflammation microglia further led to neuronal apoptosis and bbb damage. |
2021-09-30 |
2023-08-13 |
Not clear |
| Xiaolong Yao, Shengbo Wang, Yingchun Chen, Liuqing Sheng, Huanhuan Li, Huichao You, Jianfeng Ye, Qing Zhang, Jun L. Sodium houttuyfonate attenuates neurological defects after traumatic brain injury in mice via inhibiting NLRP3 inflammasomes. Journal of biochemical and molecular toxicology. vol 35. issue 9. 2021-09-29. PMID:34405489. |
intraperitoneal injection of sh into tbi mice significantly reduced the modified neurological severity score (mnss), as well as the degree of microglia apoptosis post-controlled cortical impact (cci). |
2021-09-29 |
2023-08-13 |
mouse |
| Chaosheng Li, Changyan Fan, Jilai Zhao, Meiqi Di, Chenyan Sui, Likun Han, Lingling H. Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32725513. |
pts promoted m2 polarization in microglia cells by activating the stat3 pathway, thereby reducing cell inflammation and apoptosis after glucose/oxygen deprivation. |
2021-09-21 |
2023-08-13 |
Not clear |
| Elissa L Wong, Alexandra Strohm, Jason Atlas, Cassandra Lamantia, Ania K Majewsk. Dynamics of microglia and dendritic spines in early adolescent cortex after developmental alcohol exposure. Developmental neurobiology. vol 81. issue 6. 2021-09-17. PMID:34228891. |
rodent studies have shown that alcohol exposure during the brain growth spurt (bgs) can lead to acute neuronal apoptosis and an immunological response by microglia in the somatosensory cortex. |
2021-09-17 |
2023-08-13 |
mouse |