| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanqiu Zhou, Siyuan Wang, Hanlin Luo, Feibo Xu, Jingjing Liang, Chenxu Ma, Luyu Ren, Hui Wang, Yun Ho. Aflatoxin B1 induces microglia cells apoptosis mediated by oxidative stress through NF-κB signaling pathway in mice spinal cords. Environmental toxicology and pharmacology. 2021-12-31. PMID:34971797. |
aflatoxin b1 induces microglia cells apoptosis mediated by oxidative stress through nf-κb signaling pathway in mice spinal cords. |
2021-12-31 |
2023-08-13 |
mouse |
| Yanqiu Zhou, Siyuan Wang, Hanlin Luo, Feibo Xu, Jingjing Liang, Chenxu Ma, Luyu Ren, Hui Wang, Yun Ho. Aflatoxin B1 induces microglia cells apoptosis mediated by oxidative stress through NF-κB signaling pathway in mice spinal cords. Environmental toxicology and pharmacology. 2021-12-31. PMID:34971797. |
in addition, afb1 significantly increased the oxidative stress, promoted apoptosis and cell cycle arrest in g2-m phase, and activated nf-κb phosphorylation in bv2 microglia cells. |
2021-12-31 |
2023-08-13 |
mouse |
| Yanqiu Zhou, Siyuan Wang, Hanlin Luo, Feibo Xu, Jingjing Liang, Chenxu Ma, Luyu Ren, Hui Wang, Yun Ho. Aflatoxin B1 induces microglia cells apoptosis mediated by oxidative stress through NF-κB signaling pathway in mice spinal cords. Environmental toxicology and pharmacology. 2021-12-31. PMID:34971797. |
however, the addition of active oxygen scavenger n-acetylcysteine can significantly reduce the ros production, improve cell cycle arrest, reduce apoptosis, and the expression of phosphorylated nf-κb in bv2 microglia cells. |
2021-12-31 |
2023-08-13 |
mouse |
| Yanqiu Zhou, Siyuan Wang, Hanlin Luo, Feibo Xu, Jingjing Liang, Chenxu Ma, Luyu Ren, Hui Wang, Yun Ho. Aflatoxin B1 induces microglia cells apoptosis mediated by oxidative stress through NF-κB signaling pathway in mice spinal cords. Environmental toxicology and pharmacology. 2021-12-31. PMID:34971797. |
these results indicate that afb1 induces microglia cells apoptosis through oxidative stress by activating nf-κb signaling pathway. |
2021-12-31 |
2023-08-13 |
mouse |
| Chia-Li Chung, Hung-Pei Tsai, Yu-Hua Huang, Shu-Chuan Wu, Chee-Yin Chai, Aij-Lie Kwa. Attenuation in Proinflammatory Factors and Reduction in Neuronal Cell Apoptosis and Cerebral Vasospasm by Minocycline during Early Phase after Subarachnoid Hemorrhage in the Rat. BioMed research international. vol 2021. 2021-12-16. PMID:34912890. |
however, the role of microglia and astrocytes in the development of inflammation and neuronal cell apoptosis during the early phase after sah has not been thoroughly investigated. |
2021-12-16 |
2023-08-13 |
rat |
| Erin Clough, Joseph Inigo, Dhyan Chandra, Lee Chaves, Jessica L Reynolds, Ravikumar Aalinkeel, Stanley A Schwartz, Alexander Khmaladze, Supriya D Mahaja. Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021-12-11. PMID:34599743. |
the goal of our study was to determine the effect of sars-cov2 on mitochondrial biogenesis and to monitor cell apoptosis in human microglia non-invasively in real time using raman spectroscopy, providing a unique spatio-temporal information on mitochondrial function in live cells. |
2021-12-11 |
2023-08-13 |
human |
| Bang-Xu Nie, Gang Zhao, Xiao-Feng Yuan, Lin-Xin Yu, Jin Zhang, Yong Yuan, Yao Liu, Jun Hu, En Song, Yu-Cheng Zhou, Jun Sh. Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo. Journal of chemical neuroanatomy. vol 119. 2021-12-11. PMID:34839004. |
in conclusion, cdk1 downregulation suppressed the activation of anterior horn astrocytes and microglia, promoted motor neuron repair, and inhibited neurons apoptosis and autophagy to promote the recovery of motor function after spinal cord injury. |
2021-12-11 |
2023-08-13 |
rat |
| Ruoqi Li, Yuan Zhou, Shanshan Zhang, Jieying Li, Yingyi Zheng, Xiang Fa. The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-κB pathway exert anti-inflammatory activity in ischemic stroke. European journal of pharmacology. vol 914. 2021-12-11. PMID:34863710. |
m1 microglia produce pro-inflammatory cytokines to exacerbate neural death, astrocyte apoptosis, and blood brain barrier (bbb) disruption, while m2 microglia play the opposite role. |
2021-12-11 |
2023-08-13 |
Not clear |
| Masood Sadiq Butt, Urwa Tariq, Iahtisham-Ul-Haq, Ambreen Naz, Muhammad Rizwa. Neuroprotective effects of oleuropein: Recent developments and contemporary research. Journal of food biochemistry. vol 45. issue 12. 2021-12-10. PMID:34716610. |
several mechanisms have been reported for the neuroprotective role of oleuropein including induction of apoptosis and autophagy, enhancing the antioxidant pool of the cerebral region, decreasing the unnecessary release of proinflammatory cytokines and chemokines by deactivating the microglia cells and astrocytes thus preventing the occurrence of neuroinflammation. |
2021-12-10 |
2023-08-13 |
Not clear |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
stat3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also demonstrated that stat3 activation in microglia increased tumor necrosis factor-α (tnf-α) expression; subsequently, tnf-α increased neuronal apoptosis by increasing reactive oxygen species (ros) levels in the neuronal cells. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also took advantage of mice lacking stat3 in microglia and demonstrated that depletion of microglial stat3 reduced neuronal apoptosis in the diabetic hippocampus. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
taken together, these results suggest that stat3 activation in microglia plays an important role in hyperglycemia-induced neuronal apoptosis in the diabetic hippocampus and provide a potential therapeutic benefit of stat3 inhibition in microglia for preventing diabetic neuronal lesions. |
2021-11-29 |
2023-08-13 |
mouse |
| Takeshi Okada, Hidenori Suzuki, Zachary D Travis, John H Zhan. The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target. Current neuropharmacology. vol 18. issue 12. 2021-11-25. PMID:32484111. |
secondary products arising from stroke-induced tissue damage provide transformation of myeloid cells such as microglia and macrophages to pro-inflammatory phenotype followed by further bbb disruption via neuroinflammation and apoptosis of endothelial cells. |
2021-11-25 |
2023-08-13 |
Not clear |
| Enyi Gu, Weikun Pan, Kangyao Chen, Zhong Zheng, Guoling Chen, Pengde Ca. LncRNA H19 Regulates Lipopolysaccharide (LPS)-Induced Apoptosis and Inflammation of BV2 Microglia Cells Through Targeting miR-325-3p/NEUROD4 Axis. Journal of molecular neuroscience : MN. vol 71. issue 6. 2021-11-23. PMID:33205379. |
lncrna h19 regulates lipopolysaccharide (lps)-induced apoptosis and inflammation of bv2 microglia cells through targeting mir-325-3p/neurod4 axis. |
2021-11-23 |
2023-08-13 |
Not clear |
| Enyi Gu, Weikun Pan, Kangyao Chen, Zhong Zheng, Guoling Chen, Pengde Ca. LncRNA H19 Regulates Lipopolysaccharide (LPS)-Induced Apoptosis and Inflammation of BV2 Microglia Cells Through Targeting miR-325-3p/NEUROD4 Axis. Journal of molecular neuroscience : MN. vol 71. issue 6. 2021-11-23. PMID:33205379. |
furthermore, h19 in bv2 cells regulated neurod4 expression through targeting mir-325-3p. our results identified that the silencing of h19 attenuated lps-evoked microglia cell apoptosis and inflammation after sci at least partially through targeting the mir-325-3p/neurod4 axis, highlighting a novel approach for sci management. |
2021-11-23 |
2023-08-13 |
Not clear |
| Min Li, Junwen Hu, Yucong Peng, Jingbo Li, Reng Re. CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-11-23. PMID:33952191. |
circptk2-mir-181c-5p-hmgb1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. |
2021-11-23 |
2023-08-13 |
mouse |
| Xingmei Luo, Jing Wu, Guofeng W. PPARγ activation suppresses the expression of MMP9 by downregulating NF-κB post intracerebral hemorrhage. Neuroscience letters. vol 752. 2021-11-22. PMID:33636289. |
we have previously reported that rosiglitazone, an agonist of pparγ, was effective to prevent microglia from apoptosis and ameliorate neuronal injuries post intracerebral hemorrhage (ich) with suppression of matrix metalloproteinase-9 (mmp9) expression. |
2021-11-22 |
2023-08-13 |
Not clear |
| Xin Zhou, Qinglu Guo, Mingming Guo, Bowen Li, Wenchang Peng, Deping Wang, Dong Ming, Bin Zhen. Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease. Journal of controlled release : official journal of the Controlled Release Society. vol 338. 2021-11-22. PMID:34517041. |
then, we also explored the specific mechanism of lcb to improve the behavior of murine models of pd, including abating inflammatory effects, reducing neuronal apoptosis, regulating the activity of dopaminergic neurons and microglia. |
2021-11-22 |
2023-08-13 |
Not clear |
| Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R Doeppne. Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34753919. |
extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the tgf-β/smad2/3 pathway. |
2021-11-17 |
2023-08-13 |
mouse |