| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Cheng, Yue Geng, Yeting Chen, Yongjie Zhang, Runjie Guo, Hong Xu, Jianfeng Liang, Jiajun Xie, Zean Zhang, Xuesong Tia. δ-Opioid receptor activation ameliorates lipopolysaccharide-induced inflammation and apoptosis by inhibiting the MAPK/caspase-3 pathway in BV2 microglial cells. Experimental brain research. vol 239. issue 2. 2021-07-28. PMID:33206235. |
dor activation can activate microglia to switch to the beneficial phenotype and inhibit lps-induced inflammation and apoptosis via the mitogen-activated protein kinase (mapk)/caspase-3 pathway in bv2 microglial cells. |
2021-07-28 |
2023-08-13 |
mouse |
| Xudan Liu, Yao Chen, Huanhuan Wang, Yuting Wei, Ye Yuan, Qianqian Zhou, Fang Fang, Sainan Shi, Xiaojing Jiang, Yinqiao Dong, Xin L. Microglia-derived IL-1β promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2α/ATF4/CHOP upon arsenic exposure. Journal of hazardous materials. vol 417. 2021-07-28. PMID:34229406. |
our findings demonstrated that arsenic-induced cognitive dysfunction, microglia activation, up-regulation and release of il-1β and er stress-mediated apoptosis could be attenuated by minocycline, a recognized inhibitor of microglia activation. |
2021-07-28 |
2023-08-13 |
Not clear |
| Xudan Liu, Yao Chen, Huanhuan Wang, Yuting Wei, Ye Yuan, Qianqian Zhou, Fang Fang, Sainan Shi, Xiaojing Jiang, Yinqiao Dong, Xin L. Microglia-derived IL-1β promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2α/ATF4/CHOP upon arsenic exposure. Journal of hazardous materials. vol 417. 2021-07-28. PMID:34229406. |
our findings provided evidences that arsenic-induced microglia activation also contributed to neuronal apoptosis through pro-inflammatory cytokine. |
2021-07-28 |
2023-08-13 |
Not clear |
| Xudan Liu, Yao Chen, Huanhuan Wang, Yuting Wei, Ye Yuan, Qianqian Zhou, Fang Fang, Sainan Shi, Xiaojing Jiang, Yinqiao Dong, Xin L. Microglia-derived IL-1β promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2α/ATF4/CHOP upon arsenic exposure. Journal of hazardous materials. vol 417. 2021-07-28. PMID:34229406. |
neuronal apoptosis induced by prolonged activation of microglia was partially involved in the arsenic-induced cognitive dysfunction. |
2021-07-28 |
2023-08-13 |
Not clear |
| Min Zhang, Jian-Kai Yang, Jing M. Regulation of the long noncoding RNA XIST on the inflammatory polarization of microglia in cerebral infarction. Experimental and therapeutic medicine. vol 22. issue 3. 2021-07-27. PMID:34306193. |
the lncrna xist-tnf-α feedback promoted the proinflammatory polarization of microglia, thereby exacerbating cerebral neuron apoptosis. |
2021-07-27 |
2023-08-13 |
mouse |
| Zachary I Blume, Jared M Lambert, Anna G Lovel, Diana M Mitchel. Microglia in the developing retina couple phagocytosis with the progression of apoptosis via P2RY12 signaling. Developmental dynamics : an official publication of the American Association of Anatomists. vol 249. issue 6. 2021-07-26. PMID:32072708. |
microglia in the developing retina couple phagocytosis with the progression of apoptosis via p2ry12 signaling. |
2021-07-26 |
2023-08-13 |
zebrafish |
| Zachary I Blume, Jared M Lambert, Anna G Lovel, Diana M Mitchel. Microglia in the developing retina couple phagocytosis with the progression of apoptosis via P2RY12 signaling. Developmental dynamics : an official publication of the American Association of Anatomists. vol 249. issue 6. 2021-07-26. PMID:32072708. |
microglia colonize the developing vertebrate central nervous system coincident with the detection of developmental apoptosis. |
2021-07-26 |
2023-08-13 |
zebrafish |
| Zachary I Blume, Jared M Lambert, Anna G Lovel, Diana M Mitchel. Microglia in the developing retina couple phagocytosis with the progression of apoptosis via P2RY12 signaling. Developmental dynamics : an official publication of the American Association of Anatomists. vol 249. issue 6. 2021-07-26. PMID:32072708. |
our understanding of apoptosis in intact tissue in relation to microglial clearance of dying cells is largely based on fixed samples, which is limiting given that microglia are highly motile and mobile phagocytes. |
2021-07-26 |
2023-08-13 |
zebrafish |
| Yu Xiao, Ying Dai, Li Li, Fang Geng, Yisha Xu, Jinqiu Wang, Shu Wang, Junning Zha. Tetrahydrocurcumin ameliorates Alzheimer's pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-07-26. PMID:34243602. |
tetrahydrocurcumin ameliorates alzheimer's pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via ras/erk signaling. |
2021-07-26 |
2023-08-13 |
mouse |
| Yu Xiao, Ying Dai, Li Li, Fang Geng, Yisha Xu, Jinqiu Wang, Shu Wang, Junning Zha. Tetrahydrocurcumin ameliorates Alzheimer's pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 139. 2021-07-26. PMID:34243602. |
for the first time, we identified that the action of thc in preventing ad was associated with inhibition of cell cycle arrest and apoptosis of microglia via the ras/erk signaling pathway, shedding new light on the role of thc in alleviating the progression of ad. |
2021-07-26 |
2023-08-13 |
mouse |
| Yanan Shen, Lihai Chen, Yuan Zhang, Jiayue Du, Jing Hu, Hongguang Bao, Yan Xing, Yanna S. Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder. Neuroscience. vol 468. 2021-07-21. PMID:34166762. |
surgically treated mice had increased expression of pten, ampk, bax, il-1β, and tnf-α, as well as increasing number of activated microglia and apoptosis neurons in the hippocampus. |
2021-07-21 |
2023-08-13 |
mouse |
| Bo Song, Jing Xu, Ping Zhong, Lei Fan. MiR-125a-5p silencing inhibits cerebral ischemia-induced injury through targeting IGFBP3. Folia neuropathologica. vol 59. issue 2. 2021-07-21. PMID:34284540. |
ogd/r triggered bv2 microglial cell apoptosis, whereas downregulation of mirna-125a-5p suppressed the apoptosis rate in ogd/r-induced bv2 microglial cells. |
2021-07-21 |
2023-08-13 |
rat |
| Yujie Li, Xucong Teng, Chunrong Yang, Yongji Wang, Lingxiao Wang, Yicong Dai, Hua Sun, Jinghong L. Ultrasound Controlled Anti-Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy. Angewandte Chemie (International ed. in English). vol 60. issue 10. 2021-07-20. PMID:33259112. |
satisfied prognoses were achieved with reduced apoptosis, promoted neurogenesis, and functional recovery, indicating the implications of the microglia platform for stroke therapy. |
2021-07-20 |
2023-08-13 |
Not clear |
| Jiao Tang, Rui Chen, Lingling Wang, Lu Yu, Dandan Zuo, Guiyun Cui, Xiaoqian Gon. Melatonin Attenuates Thrombin-induced Inflammation in BV2 Cells and Then Protects HT22 Cells from Apoptosis. Inflammation. vol 43. issue 5. 2021-07-15. PMID:32705396. |
in further experiments investigating the protection conferred by melatonin, incubating ht22 cells with conditioned medium (cm) from thrombin-stimulated microglia induced ht22 cell apoptosis, and this effect was reversed after treating cm with either melatonin or n-acetyl-l-cysteine (nac). |
2021-07-15 |
2023-08-13 |
Not clear |
| Niels Haan, Laura J Westacott, Jenny Carter, Michael J Owen, William P Gray, Jeremy Hall, Lawrence S Wilkinso. Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms. Translational psychiatry. vol 11. issue 1. 2021-07-14. PMID:34031371. |
we show this is due to a cell autonomous failure of microglia to induce apoptosis through the secretion of the appropriate factors, a previously undescribed mechanism. |
2021-07-14 |
2023-08-13 |
Not clear |
| Sheng-Yu Cui, Wei Zhang, Zhi-Ming Cui, Hong Yi, Da-Wei Xu, Wei Liu, Xin-Hui Zh. Knockdown of long non-coding RNA LEF1-AS1 attenuates apoptosis and inflammatory injury of microglia cells following spinal cord injury. Journal of orthopaedic surgery and research. vol 16. issue 1. 2021-07-12. PMID:33407665. |
knockdown of long non-coding rna lef1-as1 attenuates apoptosis and inflammatory injury of microglia cells following spinal cord injury. |
2021-07-12 |
2023-08-13 |
Not clear |
| Yusuke Hirata, Yuki Nada, Yuto Yamada, Takashi Toyama, Kohji Fukunaga, Gi-Wook Hwang, Takuya Noguchi, Atsushi Matsuzaw. Elaidic Acid Potentiates Extracellular ATP-Induced Apoptosis via the P2X Biological & pharmaceutical bulletin. vol 43. issue 10. 2021-07-06. PMID:32999166. |
we found that extracellular atp, one of the damage-associated molecular patterns (damps) leaked from injured cells, induced activation of the apoptosis signal-regulating kinase 1 (ask1)-p38 pathway, which is one of the major stress-responsive mitogen-activated protein (map) kinase signaling pathways, and subsequent caspase-3 cleavage and dna ladder formation (hallmarks of apoptosis) in mouse microglial cell lines including bv2 and mg6 cells. |
2021-07-06 |
2023-08-13 |
mouse |
| Yusuke Hirata, Yuki Nada, Yuto Yamada, Takashi Toyama, Kohji Fukunaga, Gi-Wook Hwang, Takuya Noguchi, Atsushi Matsuzaw. Elaidic Acid Potentiates Extracellular ATP-Induced Apoptosis via the P2X Biological & pharmaceutical bulletin. vol 43. issue 10. 2021-07-06. PMID:32999166. |
furthermore, we found that in these microglial cell lines, ea, but not its cis isomer oleic acid, facilitated extracellular atp-induced ask1/p38 activation and apoptosis, which was suppressed by pharmacological inhibition of either p38, reactive oxygen species (ros) generation, p2x purinoceptor 7 (p2x |
2021-07-06 |
2023-08-13 |
mouse |
| Chia-Li Chung, Chieh-Hsin Wu, Yu-Hua Huang, Shu-Chuan Wu, Chee-Yin Chai, Hung-Pei Tsai, Aij-Lie Kwa. Blocking Hepatoma-Derived Growth Factor Attenuates Vasospasm and Neuron Cell Apoptosis in Rats Subjected to Subarachnoid Hemorrhage. Translational stroke research. 2021-07-06. PMID:34227049. |
immunofluorescence staining for iba-1, gfap, tunel, and neun was detected proliferation of microglia and astrocyte and apoptosis of neuron cells. |
2021-07-06 |
2023-08-13 |
rat |
| Chia-Li Chung, Chieh-Hsin Wu, Yu-Hua Huang, Shu-Chuan Wu, Chee-Yin Chai, Hung-Pei Tsai, Aij-Lie Kwa. Blocking Hepatoma-Derived Growth Factor Attenuates Vasospasm and Neuron Cell Apoptosis in Rats Subjected to Subarachnoid Hemorrhage. Translational stroke research. 2021-07-06. PMID:34227049. |
the result from immunofluorescence staining showed that sah induced proliferation of microglia and astrocyte and apoptosis of neuron cells. |
2021-07-06 |
2023-08-13 |
rat |