| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark F McCarty, Aaron Lerne. The second phase of brain trauma can be controlled by nutraceuticals that suppress DAMP-mediated microglial activation. Expert review of neurotherapeutics. vol 21. issue 5. 2021-05-17. PMID:33749495. |
these microglia can promote apoptosis or necrosis in neighboring neurons by producing a range of pro-inflammatory cytokines and the deadly oxidant peroxynitrite. |
2021-05-17 |
2023-08-13 |
Not clear |
| Nathalia R Dragano, Milena Monfort-Pires, Licio A Vellos. Mechanisms Mediating the Actions of Fatty Acids in the Hypothalamus. Neuroscience. vol 447. 2021-05-14. PMID:31689488. |
they can be metabolized inside neurons, producing signals that control the expression of neurotransmitters involved in energy homeostasis; moreover, excessive amounts of certain fatty acids can activate inflammatory signaling in microglia, astrocytes, and neurons, leading to functional abnormalities and, eventually, neuronal apoptosis. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yang He, Yang Gao, Qiang Zhang, Guiyin Zhou, Fang Cao, Shengtao Ya. IL-4 Switches Microglia/macrophage M1/M2 Polarization and Alleviates Neurological Damage by Modulating the JAK1/STAT6 Pathway Following ICH. Neuroscience. vol 437. 2021-05-14. PMID:32224230. |
furthermore, we discovered that pathway components and apoptosis-related proteins showed consistent trends based on their respective roles, and inferred that the process that tnf-α activates caspase-3 may be the crosstalk that microglia phagocytosis developed into accelerate apoptosis of cells in ich. |
2021-05-14 |
2023-08-13 |
mouse |
| Ya-Jie Ji, Hui-Lin Wang, Bian-Li Yin, Xiang-Yang Re. Down-regulation of DJ-1 Augments Neuroinflammation via Nrf2/Trx1/NLRP3 Axis in MPTP-induced Parkinson's Disease Mouse Model. Neuroscience. vol 442. 2021-05-14. PMID:32526245. |
dj-1 and nrf2 knockdown promoted inflammation and cell apoptosis in bv2 microglia, while nlrp3 knockdown had opposite effects. |
2021-05-14 |
2023-08-13 |
mouse |
| Jay Sibbitts, Christopher T Culbertso. Measuring stimulation and inhibition of intracellular nitric oxide production in SIM-A9 microglia using microfluidic single-cell analysis. Analytical methods : advancing methods and applications. vol 12. issue 38. 2021-05-14. PMID:32909562. |
under pathological conditions microglia produce inflammatory signaling molecules, such as nitric oxide (no), that can damage dna and proteins and ultimately induce neuronal apoptosis. |
2021-05-14 |
2023-08-13 |
Not clear |
| Jialiang Lin, Xiangxiang Pan, Chongan Huang, Mingbao Gu, Ximiao Chen, Xuanqi Zheng, Zhenxuan Shao, Sunli Hu, Ben Wang, Hao Lin, Yaosen Wu, Naifeng Tian, Yan Wu, Weiyang Gao, Yifei Zhou, Xiaolei Zhang, Xiangyang Wan. Dual regulation of microglia and neurons by Astragaloside IV-mediated mTORC1 suppression promotes functional recovery after acute spinal cord injury. Journal of cellular and molecular medicine. vol 24. issue 1. 2021-05-10. PMID:31675186. |
inflammation and neuronal apoptosis contribute to the progression of secondary injury after spinal cord injury (sci) and are targets for sci therapy; autophagy is reported to suppress apoptosis in neuronal cells and m2 polarization may attenuate inflammatory response in microglia, while both are negatively regulated by mtorc1 signalling. |
2021-05-10 |
2023-08-13 |
rat |
| Chao Xu, Yun-Feng Diao, Jing Wang, Jun Liang, Hai-Huan Xu, Ming-Liang Zhao, Bin Zheng, Zuo Luan, Jing-Jing Wang, Xi-Ping Yang, Meng-Guang Wei, Jing-Hao Duan, Ke-Qiang Wang, Chong Chen, Feng Chen, Dong Ming, Sai Zhang, Hong-Tao Sun, Xiao-Hong L. Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury. Stem cells and development. vol 29. issue 4. 2021-05-10. PMID:31830866. |
asc-st ameliorated tbi-induced neuroinflammatory environments that caused the edema, the apoptosis of the neural cells, and the nerve fiber damage by increasing the number of m2 phenotypes present while reducing the number of m1 phenotype microglia present. |
2021-05-10 |
2023-08-13 |
rat |
| LongEn Yang, Jingtao Wang, Dongmei Wang, Guojun Hu, ZiYuan Liu, Dongni Yan, Nazar Serikuly, Erik T Alpyshov, Konstantin A Demin, Tatyana Strekalova, Murilo S de Abreu, Cai Song, Allan V Kaluef. Delayed behavioral and genomic responses to acute combined stress in zebrafish, potentially relevant to PTSD and other stress-related disorders: Focus on neuroglia, neuroinflammation, apoptosis and epigenetic modulation. Behavioural brain research. vol 389. 2021-05-06. PMID:32344037. |
specifically, one week after adult zebrafish were exposed to a complex combined 90-min stress, we assessed their behaviors in the novel tank and the light-dark box tests, as well as whole-body cortisol and brain gene expression, focusing on genomic biomarkers of microglia, astrocytes, neuroinflammation, apoptosis and epigenetic modulation. |
2021-05-06 |
2023-08-13 |
human |
| Fumou Deng, Lily Cai, Bin Zhou, Zhidong Zhou, GuoHai X. Whole transcriptome sequencing reveals dexmedetomidine-improves postoperative cognitive dysfunction in rats via modulating lncRNA. 3 Biotech. vol 10. issue 5. 2021-05-02. PMID:32309111. |
microglia proliferation and apoptosis were assessed using cck-8 assay and flow cytometry, respectively. |
2021-05-02 |
2023-08-13 |
rat |
| Xiaoyun Guo, Ruizhi Mao, Lvchun Cui, Fan Wang, Rubai Zhou, Yun Wang, Jia Huang, Yuncheng Zhu, Yamin Yao, Guoqing Zhao, Zezhi Li, Jun Chen, Jinhui Wang, Yiru Fan. PAID study design on the role of PKC activation in immune/inflammation-related depression: a randomised placebo-controlled trial protocol. General psychiatry. vol 34. issue 2. 2021-04-30. PMID:33912799. |
microglia activation can lead to an increase in the levels of proinflammatory cytokines, including tnf-α, which leads to neuronal apoptosis in the specific neural circuits of some brain regions, abnormal cognition and treatment-resistant depression (trd). |
2021-04-30 |
2023-08-13 |
Not clear |
| Xiaoyun Guo, Ruizhi Mao, Lvchun Cui, Fan Wang, Rubai Zhou, Yun Wang, Jia Huang, Yuncheng Zhu, Yamin Yao, Guoqing Zhao, Zezhi Li, Jun Chen, Jinhui Wang, Yiru Fan. PAID study design on the role of PKC activation in immune/inflammation-related depression: a randomised placebo-controlled trial protocol. General psychiatry. vol 34. issue 2. 2021-04-30. PMID:33912799. |
we assume that the abnormality in pkc might result in abnormal microglia activation, neuronal apoptosis, significant changes in emotional and cognitive neural circuits, and trd. |
2021-04-30 |
2023-08-13 |
Not clear |
| Jae-Hwan Jang, Mi-Jung Yeom, Sora Ahn, Ju-Young Oh, Suhwan Ji, Tae-Hong Kim, Hi-Joon Par. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32827699. |
acupuncture also restored the overexpression of microglia and astrocyte as well as conversion of bax and bcl-2 expression in both the striatum and the substantia nigra, indicating that inflammatory responses and apoptosis were blocked by acupuncture. |
2021-04-27 |
2023-08-13 |
mouse |
| Wenna Gao, Jiantong Du, Ying Chi, Ruilin Zhu, Xinran Gao, Liu Yan. Minocycline prevents the inflammatory response after retinal detachment, where microglia phenotypes being regulated through A20. Experimental eye research. vol 203. 2021-04-23. PMID:33326811. |
photoreceptor cells apoptosis, inflammatory response and microglia activity following rd with or without minocycline were evaluated. |
2021-04-23 |
2023-08-13 |
Not clear |
| J Jia, C Liu, Y Han, H Han, M Zhong, Y Ga. miR-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting TRAF6. Human & experimental toxicology. vol 39. issue 12. 2021-04-22. PMID:32633138. |
mir-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting traf6. |
2021-04-22 |
2023-08-13 |
Not clear |
| J Jia, C Liu, Y Han, H Han, M Zhong, Y Ga. miR-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting TRAF6. Human & experimental toxicology. vol 39. issue 12. 2021-04-22. PMID:32633138. |
to identify the role of mir-146a and tumor necrosis factor receptor-associated factor 6 (traf6) for improving the apoptosis of hippocampal neurons induced by microglia activation. |
2021-04-22 |
2023-08-13 |
Not clear |
| Xiajing Zhang, Yan Feng, Jiangjing Li, Ling Zheng, Yongping Shao, Fangyun Zhu, Xude Su. MicroRNA-665-3p attenuates oxygen-glucose deprivation-evoked microglial cell apoptosis and inflammatory response by inhibiting NF-κB signaling via targeting TRIM8. International immunopharmacology. vol 85. 2021-04-21. PMID:32512270. |
microrna-665-3p attenuates oxygen-glucose deprivation-evoked microglial cell apoptosis and inflammatory response by inhibiting nf-κb signaling via targeting trim8. |
2021-04-21 |
2023-08-13 |
Not clear |
| Chuan-Fang Wang, Cheng-Cheng Zhao, Wen-Lan Liu, Xian-Jian Huang, Yue-Fei Deng, Ji-Yao Jiang, Wei-Ping L. Depletion of Microglia Attenuates Dendritic Spine Loss and Neuronal Apoptosis in the Acute Stage of Moderate Traumatic Brain Injury in Mice. Journal of neurotrauma. vol 37. issue 1. 2021-04-12. PMID:31397209. |
depletion of microglia attenuates dendritic spine loss and neuronal apoptosis in the acute stage of moderate traumatic brain injury in mice. |
2021-04-12 |
2023-08-13 |
mouse |
| Chuan-Fang Wang, Cheng-Cheng Zhao, Wen-Lan Liu, Xian-Jian Huang, Yue-Fei Deng, Ji-Yao Jiang, Wei-Ping L. Depletion of Microglia Attenuates Dendritic Spine Loss and Neuronal Apoptosis in the Acute Stage of Moderate Traumatic Brain Injury in Mice. Journal of neurotrauma. vol 37. issue 1. 2021-04-12. PMID:31397209. |
depletion of microglia promoted neurite outgrowth, preserved dendritic spines and reduced total brain cell and neuronal apoptosis after fpi, which was accompanied by decreased the protein levels of endoplasmic reticulum stress marker proteins, c/ebp-homologous protein and inositol-requiring kinase 1α. |
2021-04-12 |
2023-08-13 |
mouse |
| Jinqiang Zhang, Hui He, Yan Qiao, Tao Zhou, Haili He, Saini Yi, Lijuan Zhang, Li Mo, Yahui Li, Weike Jiang, Zili Yo. Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Glia. vol 68. issue 12. 2021-04-06. PMID:32652855. |
microglia isolated from the hippocampus of ifn-γ-injected mice suppressed nspcs proliferation and stimulated apoptosis of immature neurons. |
2021-04-06 |
2023-08-13 |
mouse |
| Rumana Akhter, Yvonne Shao, Shane Formica, Maria Khrestian, Lynn M Bekri. TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ Molecular immunology. vol 131. 2021-03-30. PMID:33461764. |
trem2 has been strongly implicated in basic microglia function including, phagocytosis, apoptosis, and the inflammatory response to aβ in mouse brain and primary cells. |
2021-03-30 |
2023-08-13 |
mouse |